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mpeg1 promoter transgenes direct macrophage-lineage expression in zebrafish

Open access
Ellett, Felix, Pase, Luke, Hayman, John W., Andrianopoulos, Alex, Lieschke, Graham J.·2011·Blood
DOI 10.1182/blood-2010-10-314120
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Abstract

Macrophages and neutrophils play important roles during the innate immune response, phagocytosing invading microbes and delivering antimicrobial compounds to the site of injury. Functional analyses of the cellular innate immune response in zebrafish infection/inflammation models have been aided by transgenic lines with fluorophore-marked neutrophils. However, it has not been possible to study macrophage behaviors and neutrophil/macrophage interactions in vivo directly because there has been no macrophage-only reporter line. To remove this roadblock, a macrophage-specific marker was identified (mpeg1) and its promoter used in mpeg1-driven transgenes. mpeg1-driven transgenes are expressed in macrophage-lineage cells that do not express neutrophil-marking transgenes. Using these lines, the different dynamic behaviors of neutrophils and macrophages after wounding were compared side-by-side in compound transgenics. Macrophage/neutrophil interactions, such as phagocytosis of senescent neutrophils, were readily observed in real time. These zebrafish transgenes provide a new resource that will contribute to the fields of inflammation, infection, and leukocyte biology.

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Cites

Research works printed but not linked: 39

  1. van der Sar, 2004, A star with stripes: zebrafish as an infection model., Trends Microbiol, 12, 451, 10.1016/j.tim.2004.08.001 · DOI
  2. Renshaw, 2006, A transgenic zebrafish model of neutrophilic inflammation., Blood, 108, 3976, 10.1182/blood-2006-05-024075 · DOI · Paper page
  3. Mathias, 2006, Resolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafish., J Leukoc Biol, 80, 1281, 10.1189/jlb.0506346 · DOI · Paper page
  4. Hall, 2007, The zebrafish lysozyme C promoter drives myeloid-specific expression in transgenic fish., BMC Dev Biol, 7, 42, 10.1186/1471-213X-7-42 · DOI · Paper page
  5. Zhang, 2008, In vivo interstitial migration of primitive macrophages mediated by JNK-matrix metalloproteinase 13 signaling in response to acute injury., J Immunol, 181, 2155, 10.4049/jimmunol.181.3.2155 · DOI
  6. Phennicie, 2010, Specific resistance to Pseudomonas aeruginosa infection in zebrafish is mediated by the cystic fibrosis transmembrane conductance regulator., Infect Immun, 78, 4542, 10.1128/IAI.00302-10 · DOI
  7. Vergunst, 2010, Burkholderia cenocepacia creates an intramacrophage replication niche in zebrafish embryos, followed by bacterial dissemination and establishment of systemic infection., Infect Immun, 78, 1495, 10.1128/IAI.00743-09 · DOI
  8. Mathias, 2007, Live imaging of chronic inflammation caused by mutation of zebrafish Hai1., J Cell Sci, 120, 3372, 10.1242/jcs.009159 · DOI
  9. Clay, 2007, Dichotomous role of the macrophage in early Mycobacterium marinum infection of the zebrafish., Cell Host Microbe, 2, 29, 10.1016/j.chom.2007.06.004 · DOI
  10. Volkman, 2010, Tuberculous granuloma induction via interaction of a bacterial secreted protein with host epithelium., Science, 327, 466, 10.1126/science.1179663 · DOI · Paper page
  11. Davis, 2009, The role of the granuloma in expansion and dissemination of early tuberculous infection., Cell, 136, 37, 10.1016/j.cell.2008.11.014 · DOI · Paper page
  12. Ellett, 2010, Zebrafish as a model for vertebrate hematopoiesis., Curr Opin Pharmacol, 10, 563, 10.1016/j.coph.2010.05.004 · DOI
  13. Levraud, 2009, Real-time observation of listeria monocytogenes-phagocyte interactions in living zebrafish larvae., Infect Immun, 77, 3651, 10.1128/IAI.00408-09 · DOI
  14. Herbomel, 1999, Ontogeny and behaviour of early macrophages in the zebrafish embryo., Development, 126, 3735, 10.1242/dev.126.17.3735 · DOI · Paper page
  15. Davis, 2002, Real-time visualization of mycobacterium-macrophage interactions leading to initiation of granuloma formation in zebrafish embryos., Immunity, 17, 693, 10.1016/S1074-7613(02)00475-2 · DOI · Paper page
  16. van der Sar, 2006, MyD88 innate immune function in a zebrafish embryo infection model., Infect Immun, 74, 2436, 10.1128/IAI.74.4.2436-2441.2006 · DOI · Paper page
  17. Lawson, 2002, In vivo imaging of embryonic vascular development using transgenic zebrafish., Dev Biol, 248, 307, 10.1006/dbio.2002.0711 · DOI · Paper page
  18. Redd, 2006, Imaging macrophage chemotaxis in vivo: studies of microtubule function in zebrafish wound inflammation., Cell Motil Cytoskeleton, 63, 415, 10.1002/cm.20133 · DOI
  19. Mathias, 2009, Characterization of zebrafish larval inflammatory macrophages., Dev Comp Immunol, 33, 1212, 10.1016/j.dci.2009.07.003 · DOI
  20. Spilsbury, 1995, Isolation of a novel macrophage-specific gene by differential cDNA analysis., Blood, 85, 1620, 10.1182/blood.V85.6.1620.bloodjournal8561620 · DOI
  21. Karlsson, 2008, Homogeneous monocytes and macrophages from human embryonic stem cells following coculture-free differentiation in M-CSF and IL-3., Exp Hematol, 36, 1167, 10.1016/j.exphem.2008.04.009 · DOI · Paper page
  22. Zakrzewska, 2010, Macrophage-specific gene functions in Spi1-directed innate immunity., Blood, 116, e1, 10.1182/blood-2010-01-262873 · DOI · Paper page
  23. Scott, 2007, Targeting neural circuitry in zebrafish using GAL4 enhancer trapping., Nat Methods, 4, 323, 10.1038/nmeth1033 · DOI · Paper page
  24. Lieschke, 2002, Zebrafish SPI-1 (PU.1) marks a site of myeloid development independent of primitive erythropoiesis: implications for axial patterning., Dev Biol, 246, 274, 10.1006/dbio.2002.0657 · DOI · Paper page
  25. Oates, 1999, Gene duplication of zebrafish JAK2 homologs is accompanied by divergent embryonic expression patterns: only jak2a is expressed during erythropoiesis., Blood, 94, 2622, 10.1182/blood.V94.8.2622.420k39_2622_2636 · DOI
  26. Lieschke, 2001, Morphologic and functional characterization of granulocytes and macrophages in embryonic and adult zebrafish., Blood, 98, 3087, 10.1182/blood.V98.10.3087 · DOI · Paper page
  27. Kwan, 2007, The Tol2kit: a multisite gateway-based construction kit for Tol2 transposon transgenesis constructs., Dev Dyn, 236, 3088, 10.1002/dvdy.21343 · DOI · Paper page
  28. Canovas, 2006, Developmental regulation of the glyoxylate cycle in the human pathogen Penicillium marneffei., Mol Microbiol, 62, 1725, 10.1111/j.1365-2958.2006.05477.x · DOI
  29. Lin, 2009, Streptolysin S inhibits neutrophil recruitment during the early stages of Streptococcus pyogenes infection., Infect Immun, 77, 5190, 10.1128/IAI.00420-09 · DOI
  30. Rhodes, 2005, Interplay of PU.1 and gata1 determines myelo-erythroid progenitor cell fate in zebrafish., Dev Cell, 8, 97, 10.1016/j.devcel.2004.11.014 · DOI · Paper page
  31. Liongue, 2009, Zebrafish granulocyte colony-stimulating factor receptor signaling promotes myelopoiesis and myeloid cell migration., Blood, 113, 2535, 10.1182/blood-2008-07-171967 · DOI
  32. Cvejic, 2008, Analysis of WASp function during the wound inflammatory response: live-imaging studies in zebrafish larvae., J Cell Sci, 121, 3196, 10.1242/jcs.032235 · DOI
  33. Loynes, 2010, Pivotal advance: pharmacological manipulation of inflammation resolution during spontaneously resolving tissue neutrophilia in the zebrafish., J Leukoc Biol, 87, 203, 10.1189/jlb.0409255 · DOI
  34. Walters, 2010, Live imaging of neutrophil motility in a zebrafish model of WHIM syndrome., Blood, 116, 2803, 10.1182/blood-2010-03-276972 · DOI
  35. Ward, 2003, The zebrafish spi1 promoter drives myeloid-specific expression in stable transgenic fish., Blood, 102, 3238, 10.1182/blood-2003-03-0966 · DOI
  36. Meijer, 2008, Identification and real-time imaging of a myc-expressing neutrophil population involved in inflammation and mycobacterial granuloma formation in zebrafish., Dev Comp Immunol, 32, 36, 10.1016/j.dci.2007.04.003 · DOI
  37. Koster, 2001, Tracing transgene expression in living zebrafish embryos., Dev Biol, 233, 329, 10.1006/dbio.2001.0242 · DOI · Paper page
  38. Goll, 2009, Transcriptional silencing and reactivation in transgenic zebrafish., Genetics, 182, 747, 10.1534/genetics.109.102079 · DOI
  39. Pisharath, 2007, Validation of nitroreductase, a prodrug-activating enzyme, mediated cell death in embryonic zebrafish (Danio rerio)., Comp Med, 57, 241

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Metadata

Authors
Ellett, F., Pase, L., Hayman, J. W., Andrianopoulos, A., & Lieschke, G. J.
Venue
Blood
Publisher
American Society of Hematology
Published
2011-01-27
Volume
117
Issue
4
Pages
e49-e56
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
DOI
10.1182/blood-2010-10-314120
OpenAlex
W2050195517
Cited by
1,077
References
3
FWCI
8.73
Type
journal article
Language
en
Open access
green

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