CoChat
Sign Up
Cited by 847

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Properties of mouse and human IgG receptors and their contribution to disease models

Bruhns, Pierre·2012·Blood
DOI 10.1182/blood-2012-01-380121
Open this paper in CoChat — free account

Abstract

Impressive advances in defining the properties of receptors for the Fc portion of immunoglobulins (FcR) have been made over the past several years. Ligand specificities were systematically analyzed for both human and mouse FcRs that revealed novel receptors for specific IgG subclasses. Expression patterns were redefined using novel specific anti-FcR mAbs that revealed major differences between human and mouse systems. The in vivo roles of IgG receptors have been addressed using specific FcR knockout mice or in mice expressing a single FcR, and have demonstrated a predominant contribution of mouse activating IgG receptors FcγRIII and FcγRIV to models of autoimmunity (eg, arthritis) and allergy (eg, anaphylaxis). Novel blocking mAbs specific for these activating IgG receptors have enabled, for the first time, the investigation of their roles in vivo in wild-type mice. In parallel, the in vivo properties of human FcRs have been reported using transgenic mice and models of inflammatory and allergic reactions, in particular those of human activating IgG receptor FcγRIIA (CD32A). Importantly, these studies led to the identification of specific cell populations responsible for the induction of various inflammatory diseases and have revealed, in particular, the unexpected contribution of neutrophils and monocytes to the induction of anaphylactic shock.

Overview

Integrity signals

Registry

Crossref · 10.1182/blood-2012-01-380121

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 100

  1. Daëron, 1997, Fc receptor biology., Annu Rev Immunol, 15, 203, 10.1146/annurev.immunol.15.1.203 · DOI · Paper page
  2. Tsuboi, 2008, Human neutrophil Fcgamma receptors initiate and play specialized nonredundant roles in antibody-mediated inflammatory diseases., Immunity, 28, 833, 10.1016/j.immuni.2008.04.013 · DOI
  3. Yoshida, 2004, Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells., Immunity, 20, 769, 10.1016/j.immuni.2004.05.007 · DOI
  4. Vidarsson, 2006, FcRn: an IgG receptor on phagocytes with a novel role in phagocytosis., Blood, 108, 3573, 10.1182/blood-2006-05-024539 · DOI
  5. Ra, 1989, A macrophage Fc gamma receptor and the mast cell receptor for IgE share an identical subunit., Nature, 341, 752, 10.1038/341752a0 · DOI
  6. Daëron, 2008, Immunoreceptor tyrosine-based inhibition motifs: a quest in the past and future., Immunol Rev, 224, 11, 10.1111/j.1600-065X.2008.00666.x · DOI
  7. Smith, 2010, FcgammaRIIB in autoimmunity and infection: evolutionary and therapeutic implications., Nat Rev Immunol, 10, 328, 10.1038/nri2762 · DOI
  8. Metes, 1998, Expression of functional CD32 molecules on human NK cells is determined by an allelic polymorphism of the FcgammaRIIC gene., Blood, 91, 2369, 10.1182/blood.V91.7.2369 · DOI
  9. van der Heijden, 2012, Phenotypic variation in IgG receptors by nonclassical FCGR2C alleles., J Immunol, 188, 1318, 10.4049/jimmunol.1003945 · DOI
  10. Magnusson, 2007, High synovial expression of the inhibitory FcgammaRIIb in rheumatoid arthritis., Arthritis Res Ther, 9, R51, 10.1186/ar2206 · DOI
  11. Veri, 2007, Monoclonal antibodies capable of discriminating the human inhibitory Fcgamma-receptor IIB (CD32B) from the activating Fcgamma-receptor IIA (CD32A): biochemical, biological and functional characterization., Immunology, 121, 392, 10.1111/j.1365-2567.2007.02588.x · DOI
  12. Ravetch, 1991, Fc receptors., Annu Rev Immunol, 9, 457, 10.1146/annurev.iy.09.040191.002325 · DOI
  13. Okayama, 2000, Expression of a functional high-affinity IgG receptor, Fc gamma RI, on human mast cells: up-regulation by IFN-gamma., J Immunol, 164, 4332, 10.4049/jimmunol.164.8.4332 · DOI
  14. Zhao, 2006, Fc gamma RIIa, not Fc gamma RIIb, is constitutively and functionally expressed on skin-derived human mast cells., J Immunol, 177, 694, 10.4049/jimmunol.177.1.694 · DOI
  15. Meknache, 2009, Human basophils express the glycosylphosphatidylinositol-anchored low-affinity IgG receptor FcgammaRIIIB (CD16B)., J Immunol, 182, 2542, 10.4049/jimmunol.0801665 · DOI
  16. Zhu, 2001, MHC class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages, and dendritic cells., J Immunol, 166, 3266, 10.4049/jimmunol.166.5.3266 · DOI
  17. Bruhns, 2009, Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses., Blood, 113, 3716, 10.1182/blood-2008-09-179754 · DOI · Paper page
  18. Tao, 1993, Structural features of human immunoglobulin G that determine isotype-specific differences in complement activation., J Exp Med, 178, 661, 10.1084/jem.178.2.661 · DOI
  19. Clynes, 2006, Antitumor antibodies in the treatment of cancer: Fc receptors link opsonic antibody with cellular immunity., Hematol Oncol Clin North Am, 20, 585, 10.1016/j.hoc.2006.02.010 · DOI
  20. Lu, 2011, Crystal structure of Fcgamma receptor I and its implication in high affinity gamma-immunoglobulin binding., J Biol Chem, 286, 40608, 10.1074/jbc.M111.257550 · DOI
  21. Goebl, 2008, Neonatal Fc receptor mediates internalization of Fc in transfected human endothelial cells., Mol Biol Cell, 19, 5490, 10.1091/mbc.e07-02-0101 · DOI
  22. West, 2000, Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor., Biochemistry, 39, 9698, 10.1021/bi000749m · DOI
  23. Nimmerjahn, 2005, Fc gamma RIV: a novel FcR with distinct IgG subclass specificity., Immunity, 23, 41, 10.1016/j.immuni.2005.05.010 · DOI
  24. Hirano, 2007, IgE(b) immune complexes activate macrophages through Fc gamma RIV binding., Nat Immunol, 8, 762, 10.1038/ni1477 · DOI
  25. Mancardi, 2008, FcgammaRIV is a mouse IgE receptor that resembles macrophage FcepsilonRI in humans and promotes IgE-induced lung inflammation., J Clin Invest, 118, 3738, 10.1172/JCI36452 · DOI
  26. Gavin, 1998, Identification of the mouse IgG3 receptor: implications for antibody effector function at the interface between innate and adaptive immunity., J Immunol, 160, 20, 10.4049/jimmunol.160.1.20 · DOI
  27. Takizawa, 1992, Identification of the low affinity receptor for immunoglobulin E on mouse mast cells and macrophages as Fc gamma RII and Fc gamma RIII., J Exp Med, 176, 469, 10.1084/jem.176.2.469 · DOI
  28. Holmes, 1985, Alleles of the Ly-17 alloantigen define polymorphisms of the murine IgG Fc receptor., Proc Natl Acad Sci U S A, 82, 7706, 10.1073/pnas.82.22.7706 · DOI
  29. Andren, 2005, IgG Fc receptor polymorphisms and association with autoimmune disease., Eur J Immunol, 35, 3020, 10.1002/eji.200526291 · DOI
  30. Junghans, 1996, The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptor., Proc Natl Acad Sci U S A, 93, 5512, 10.1073/pnas.93.11.5512 · DOI
  31. Yoshida, 2006, Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria., J Clin Invest, 116, 2142, 10.1172/JCI27821 · DOI
  32. Tan, 2003, Unique monoclonal antibodies define expression of Fc gamma RI on macrophages and mast cell lines and demonstrate heterogeneity among subcutaneous and other dendritic cells., J Immunol, 170, 2549, 10.4049/jimmunol.170.5.2549 · DOI
  33. Langlet, 2012, CD64 expression distinguishes monocyte-derived and conventional dendritic cells and reveals their distinct role during intramuscular immunization., J Immunol, 188, 1751, 10.4049/jimmunol.1102744 · DOI
  34. Biburger, 2011, Monocyte subsets responsible for immunoglobulin G-dependent effector functions in vivo., Immunity, 35, 932, 10.1016/j.immuni.2011.11.009 · DOI
  35. Kim, 2006, FcgammaRIII engagement provides activating signals to NKT cells in antibody-induced joint inflammation., J Clin Invest, 116, 2484
  36. Montoyo, 2009, Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice., Proc Natl Acad Sci U S A, 106, 2788, 10.1073/pnas.0810796106 · DOI · Paper page
  37. Jönsson, 2011, Mouse and human neutrophils induce anaphylaxis., J Clin Invest, 121, 1484, 10.1172/JCI45232 · DOI
  38. Ober, 2001, Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies., Int Immunol, 13, 1551, 10.1093/intimm/13.12.1551 · DOI
  39. Petkova, 2006, Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease., Int Immunol, 18, 1759, 10.1093/intimm/dxl110 · DOI
  40. Mancardi, 2011, The murine high-affinity IgG receptor Fc(gamma)RIV is sufficient for autoantibody-induced arthritis., J Immunol, 186, 1899, 10.4049/jimmunol.1003642 · DOI
  41. Mechetina, 2002, Identification of CD16-2, a novel mouse receptor homologous to CD16/Fc gamma RIII., Immunogenetics, 54, 463, 10.1007/s00251-002-0486-0 · DOI
  42. Takai, 1994, FcR gamma chain deletion results in pleiotrophic effector cell defects., Cell, 76, 519, 10.1016/0092-8674(94)90115-5 · DOI
  43. Yamasaki, 2008, Mincle is an ITAM-coupled activating receptor that senses damaged cells., Nat Immunol, 9, 1179, 10.1038/ni.1651 · DOI · Paper page
  44. Merck, 2004, OSCAR is an FcRgamma-associated receptor that is expressed by myeloid cells and is involved in antigen presentation and activation of human dendritic cells., Blood, 104, 1386, 10.1182/blood-2004-03-0850 · DOI
  45. Takai, 1996, Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice., Nature, 379, 346, 10.1038/379346a0 · DOI
  46. Hazenbos, 1996, Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice., Immunity, 5, 181, 10.1016/S1074-7613(00)80494-X · DOI
  47. Ujike, 1999, Modulation of immunoglobulin (Ig)E-mediated systemic anaphylaxis by low-affinity Fc receptors for IgG., J Exp Med, 189, 1573, 10.1084/jem.189.10.1573 · DOI
  48. Barnes, 2002, FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses., Immunity, 16, 379, 10.1016/S1074-7613(02)00287-X · DOI
  49. Ioan-Facsinay, 2002, Fc gamma RI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection., Immunity, 16, 391, 10.1016/S1074-7613(02)00294-7 · DOI
  50. Nimmerjahn, 2010, FcgammaRIV deletion reveals its central role for IgG2a and IgG2b activity in vivo., Proc Natl Acad Sci U S A, 107, 19396, 10.1073/pnas.1014515107 · DOI
  51. Syed, 2009, Both FcgammaRIV and FcgammaRIII are essential receptors mediating type II and type III autoimmune responses via FcRgamma-LAT-dependent generation of C5a., Eur J Immunol, 39, 3343, 10.1002/eji.200939884 · DOI
  52. Miyajima, 1997, Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc gammaRIII: assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis., J Clin Invest, 99, 901, 10.1172/JCI119255 · DOI
  53. Ji, 2002, Arthritis critically dependent on innate immune system players., Immunity, 16, 157, 10.1016/S1074-7613(02)00275-3 · DOI
  54. Bruhns, 2003, Colony-stimulating factor-1-dependent macrophages are responsible for IVIG protection in antibody-induced autoimmune disease., Immunity, 18, 573, 10.1016/S1074-7613(03)00080-3 · DOI
  55. Diaz de Ståhl, 2002, Expression of FcgammaRIII is required for development of collagen-induced arthritis., Eur J Immunol, 32, 2915, 10.1002/1521-4141(2002010)32:10<2915::AID-IMMU2915>3.0.CO;2-4 · DOI
  56. Akilesh, 2004, The MHC class I-like Fc receptor promotes humorally mediated autoimmune disease., J Clin Invest, 113, 1328
  57. Samuelsson, 2001, Anti-inflammatory activity of IVIG mediated through the inhibitory Fc receptor., Science, 291, 484, 10.1126/science.291.5503.484 · DOI
  58. Nimmerjahn, 2008, Anti-inflammatory actions of intravenous immunoglobulin., Annu Rev Immunol, 26, 513, 10.1146/annurev.immunol.26.021607.090232 · DOI
  59. Siragam, 2006, Intravenous immunoglobulin ameliorates ITP via activating Fc gamma receptors on dendritic cells., Nat Med, 12, 688, 10.1038/nm1416 · DOI
  60. Park-Min, 2007, FcgammaRIII-dependent inhibition of interferon-gamma responses mediates suppressive effects of intravenous immune globulin., Immunity, 26, 67, 10.1016/j.immuni.2006.11.010 · DOI
  61. Araujo, 2011, Cutting edge: intravenous Ig inhibits invariant NKT cell-mediated allergic airway inflammation through FcgammaRIIIA-dependent mechanisms., J Immunol, 186, 3289, 10.4049/jimmunol.1003076 · DOI
  62. Aloulou, 2012, IgG1 and IVIg induce inhibitory ITAM signaling through FcgammaRIII controlling inflammatory responses., Blood, 119, 3084, 10.1182/blood-2011-08-376046 · DOI
  63. Boross, 2008, Destructive arthritis in the absence of both FcgammaRI and FcgammaRIII., J Immunol, 180, 5083, 10.4049/jimmunol.180.7.5083 · DOI
  64. Korganow, 1999, From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins., Immunity, 10, 451, 10.1016/S1074-7613(00)80045-X · DOI
  65. Heijnen, 1996, Antigen targeting to myeloid-specific human Fc gamma RI/CD64 triggers enhanced antibody responses in transgenic mice., J Clin Invest, 97, 331, 10.1172/JCI118420 · DOI
  66. McKenzie, 1999, The role of the human Fc receptor Fc gamma RIIA in the immune clearance of platelets: a transgenic mouse model., J Immunol, 162, 4311, 10.4049/jimmunol.162.7.4311 · DOI
  67. Li, 2011, Inhibitory Fcgamma receptor engagement drives adjuvant and anti–tumor activities of agonistic CD40 antibodies., Science, 333, 1030, 10.1126/science.1206954 · DOI
  68. Li, 1996, Reconstitution of human Fc gamma RIII cell type specificity in transgenic mice., J Exp Med, 183, 1259, 10.1084/jem.183.3.1259 · DOI
  69. Repp, 1991, Neutrophils express the high affinity receptor for IgG (Fc gamma RI, CD64) after in vivo application of recombinant human granulocyte colony-stimulating factor., Blood, 78, 885, 10.1182/blood.V78.4.885.885 · DOI
  70. Smith, 2012, Mouse model recapitulating human Fcgamma receptor structural and functional diversity., Proc Natl Acad Sci U S A, 109, 6181, 10.1073/pnas.1203954109 · DOI
  71. Tan Sardjono, 2005, Development of spontaneous multisystem autoimmune disease and hypersensitivity to antibody-induced inflammation in Fcgamma receptor IIa-transgenic mice., Arthritis Rheum, 52, 3220, 10.1002/art.21344 · DOI
  72. McIntosh, 2007, The importance of human FcgammaRI in mediating protection to malaria., PLoS Pathog, 3, e72, 10.1371/journal.ppat.0030072 · DOI
  73. Pietersz, 2009, Inhibition of destructive autoimmune arthritis in FcgammaRIIa transgenic mice by small chemical entities., Immunol Cell Biol, 87, 3, 10.1038/icb.2008.82 · DOI
  74. Jönsson, 2012, Human FcgammaRIIA induces anaphylactic and allergic reactions., Blood, 119, 2533, 10.1182/blood-2011-07-367334 · DOI
  75. Monach, 2008, The K/BxN arthritis model., Curr Protoc Immunol, 10.1002/0471142735.im1522s81 · DOI
  76. Solomon, 2005, A crucial role for macrophages in the pathology of K/B x N serum-induced arthritis., Eur J Immunol, 35, 3064, 10.1002/eji.200526167 · DOI
  77. Wipke, 2001, Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis., J Immunol, 167, 1601, 10.4049/jimmunol.167.3.1601 · DOI
  78. Monach, 2010, Neutrophils in a mouse model of autoantibody-mediated arthritis: critical producers of Fc receptor gamma, the receptor for C5a, and lymphocyte function-associated antigen 1., Arthritis Rheum, 62, 753, 10.1002/art.27238 · DOI
  79. Elliott, 2011, Deletion of Syk in neutrophils prevents immune complex arthritis., J Immunol, 187, 4319, 10.4049/jimmunol.1100341 · DOI
  80. Lee, 2002, Mast cells: a cellular link between autoantibodies and inflammatory arthritis., Science, 297, 1689, 10.1126/science.1073176 · DOI
  81. Feyerabend, 2011, Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity., Immunity, 35, 832, 10.1016/j.immuni.2011.09.015 · DOI
  82. Tsuboi, 2011, Regulation of human neutrophil Fcgamma receptor IIa by C5a receptor promotes inflammatory arthritis in mice., Arthritis Rheum, 63, 467, 10.1002/art.30141 · DOI
  83. Zhou, 2007, Mast cell deficiency in Kit(W-sh) mice does not impair antibody-mediated arthritis., J Exp Med, 204, 2797, 10.1084/jem.20071391 · DOI
  84. Dombrowicz, 1993, Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor alpha chain gene., Cell, 75, 969, 10.1016/0092-8674(93)90540-7 · DOI
  85. Tsujimura, 2008, Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis., Immunity, 28, 581, 10.1016/j.immuni.2008.02.008 · DOI
  86. Makabe-Kobayashi, 2002, The control effect of histamine on body temperature and respiratory function in IgE-dependent systemic anaphylaxis., J Allergy Clin Immunol, 110, 298, 10.1067/mai.2002.125977 · DOI
  87. Kimura, 1998, Suppressive effects of antihistaminic and/or anti–PAF agents on passive anaphylactic shock in mice sensitized with allogeneic monoclonal IgE and IgG1 antibodies and hyperimmune serum., Immunol Invest, 27, 379, 10.3109/08820139809022711 · DOI
  88. Ohnmacht, 2010, Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths., Immunity, 33, 364, 10.1016/j.immuni.2010.08.011 · DOI
  89. Oettgen, 1994, Active anaphylaxis in IgE-deficient mice., Nature, 370, 367, 10.1038/370367a0 · DOI · Paper page
  90. Strait, 2002, Pathways of anaphylaxis in the mouse., J Allergy Clin Immunol, 109, 658, 10.1067/mai.2002.123302 · DOI
  91. Jouvin-Marche, 1984, Biosynthesis of Paf-acether (platelet-activating factor): VII. Precursors of Paf-acether and acetyl-transferase activity in human leukocytes., J Immunol, 133, 892, 10.4049/jimmunol.133.2.892 · DOI
  92. Gounni, 2001, Human neutrophils express the high-affinity receptor for immunoglobulin E (Fc epsilon RI): role in asthma., FASEB J, 15, 940, 10.1096/fj.00-0378com · DOI
  93. Dombrowicz, 1996, Anaphylaxis mediated through a humanized high affinity IgE receptor., J Immunol, 157, 1645, 10.4049/jimmunol.157.4.1645 · DOI
  94. Arimura, 1990, Active and passive cutaneous anaphylaxis in WBB6F1 mouse, a mast cell-deficient strain., Immunol Invest, 19, 227, 10.3109/08820139009041837 · DOI
  95. Bolland, 2000, Spontaneous autoimmune disease in Fc(gamma)RIIB-deficient mice results from strain-specific epistasis., Immunity, 13, 277, 10.1016/S1074-7613(00)00027-3 · DOI
  96. Finkelman, 2005, Molecular mechanisms of anaphylaxis: lessons from studies with murine models., J Allergy Clin Immunol, 115, 449, 10.1016/j.jaci.2004.12.1125 · DOI
  97. Lowell, 2011, Neutrophils give us a shock., J Clin Invest, 121, 1260, 10.1172/JCI57296 · DOI
  98. Bordon, 2011, Allergy: shocking behaviour., Nat Rev Immunol, 11, 302, 10.1038/nri2980 · DOI
  99. Vadas, 2008, Platelet-activating factor, PAF acetylhydrolase, and severe anaphylaxis., N Engl J Med, 358, 28, 10.1056/NEJMoa070030 · DOI · Paper page
  100. Mukai, 2009, New insights into the roles for basophils in acute and chronic allergy., Allergol Int, 58, 11, 10.2332/allergolint.08-RAI-0059 · DOI

Cited by

Sorted by citations

See all 847

Metadata

Authors
Bruhns, P.
Venue
Blood
Publisher
American Society of Hematology
Published
2012-06-14
Volume
119
Issue
24
Pages
5640-5649
ISSN
  • 0006-4971
  • 1528-0020
DOI
10.1182/blood-2012-01-380121
Cited by
847
References
2
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review