The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Mutational profile and prognostic significance of TP53 in diffuse large B-cell lymphoma patients treated with R-CHOP: report from an International DLBCL Rituximab-CHOP Consortium Program Study
Open accessAbstract
TP53 mutation is an independent marker of poor prognosis in patients with diffuse large B-cell lymphoma (DLBCL) treated with cyclophosphamide, hydroxydaunorubicin, vincristine, and prednisone (CHOP) therapy. However, its prognostic value in the rituximab immunochemotherapy era remains undefined. In the present study of a large cohort of DLBCL patients treated with rituximab plus CHOP (R-CHOP), we show that those with TP53 mutations had worse overall and progression-free survival compared with those without. Unlike earlier studies of patients treated with CHOP, TP53 mutation has predictive value for R-CHOP–treated patients with either the germinal center B-cell or activated B-cell DLBCL subtypes. Furthermore, we identified the loop-sheet-helix and L3 motifs in the DNA-binding domain to be the most critical structures for maintaining p53 function. In contrast, TP53 deletion and loss of heterozygosity did not confer worse survival. If gene mutation data are not available, immunohistochemical analysis showing > 50% cells expressing p53 protein is a useful surrogate and was able to stratify patients with significantly different prognoses. We conclude that assessment of TP53 mutation status is important for stratifying R-CHOP–treated patients into distinct prognostic subsets and has significant value in the design of future therapeutic strategies.
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Cites
Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
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Cited by
Chapuy, B., Stewart, C., Dunford, A. J., Kim, J., Kamburov, A., Redd, R. A., Lawrence, M. S., Roemer, M. G. M., Li, A. J., Ziepert, M., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0016-8 · Cited by 1,941
Li, S., Young, K. H., & Medeiros, L. J. (2018) · Pathology · doi:10.1016/j.pathol.2017.09.006 · Cited by 649
Self-citationOncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphoma
Song, T. L., Nairismägi, M.-L., Laurensia, Y., Lim, J.-Q., Tan, J., Li, Z.-M., Pang, W.-L., Kizhakeyil, A., Wijaya, G.-C., Huang, D.-C., et al. (2018) · Blood · doi:10.1182/blood-2018-01-829424 · Cited by 326
Diffuse large B-cell lymphoma: R-CHOP failure—what to do?
Coiffier, B., & Sarkozy, C. (2016) · Hematology · doi:10.1182/asheducation-2016.1.366 · Cited by 292
Diffuse large B-cell lymphoma genotyping on the liquid biopsy
Rossi, D., Diop, F., Spaccarotella, E., Monti, S., Zanni, M., Rasi, S., Deambrogi, C., Spina, V., Bruscaggin, A., Favini, C., et al. (2017) · Blood · doi:10.1182/blood-2016-05-719641 · Cited by 256
Metadata
- Authors
- Xu-Monette, Z. Y., Wu, L., Visco, C., Tai, Y. C., Tzankov, A., Liu, W.-M., Montes-Moreno, S., Dybkær, K., Chiu, A., Orazi, A., Zu, Y., Bhagat, G., Richards, K. L., Hsi, E. D., Zhao, X. F., Choi, W. W. L., Zhao, X., van Krieken, J. H., Huang, Q., Huh, J., Ai, W., Ponzoni, M., Ferreri, A. J. M., Zhou, F., Kahl, B. S., Winter, J. N., Xu, W., Li, J., Go, R. S., Li, Y., Piris, M. A., Møller, M. B., Miranda, R. N., Abruzzo, L. V., Medeiros, L. J., & Young, K. H.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2012-11-08
- Volume
- 120
- Issue
- 19
- Pages
- 3986-3996
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2096596684
- Cited by
- 388
- References
- 48
- FWCI
- 12.05
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Mutational profile and prognostic significance of TP53 in diffuse large B-cell lymphoma patients treated with R-CHOP: report from an International DLBCL Rituximab-CHOP Consortium Program Study. https://app.cochat.ai/papers/10.1182/blood-2012-05-433334
- The paper
- Xu-Monette, Z. Y., Wu, L., Visco, C., Tai, Y. C., Tzankov, A., Liu, W.-M., Montes-Moreno, S., Dybkær, K., Chiu, A., Orazi, A., Zu, Y., Bhagat, G., Richards, K. L., Hsi, E. D., Zhao, X. F., Choi, W. W. L., Zhao, X., van Krieken, J. H., Huang, Q., . . . Young, K. H. (2012). Mutational profile and prognostic significance of TP53 in diffuse large B-cell lymphoma patients treated with R-CHOP: report from an International DLBCL Rituximab-CHOP Consortium Program Study. Blood. https://doi.org/10.1182/blood-2012-05-433334
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
