The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Notch signaling: switching an oncogene to a tumor suppressor
Open accessAbstract
The Notch signaling pathway is a regulator of self-renewal and differentiation in several tissues and cell types. Notch is a binary cell-fate determinant, and its hyperactivation has been implicated as oncogenic in several cancers including breast cancer and T-cell acute lymphoblastic leukemia (T-ALL). Recently, several studies also unraveled tumor-suppressor roles for Notch signaling in different tissues, including tissues where it was before recognized as an oncogene in specific lineages. Whereas involvement of Notch as an oncogene in several lymphoid malignancies (T-ALL, B-chronic lymphocytic leukemia, splenic marginal zone lymphoma) is well characterized, there is growing evidence involving Notch signaling as a tumor suppressor in myeloid malignancies. It therefore appears that Notch signaling pathway’s oncogenic or tumor-suppressor abilities are highly context dependent. In this review, we summarize and discuss latest advances in the understanding of this dual role in hematopoiesis and the possible consequences for the treatment of hematologic malignancies.
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Cites
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Notch signaling pathway in cancer: from mechanistic insights to targeted therapies
Shi, Q., Xue, C., Zeng, Y., Yuan, X., Chu, Q., Jiang, S., Wang, J., Zhang, Y., Zhu, D., & Li, L. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01828-x · Cited by 401
Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors
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Therapies targeting cancer stem cells: Current trends and future challenges
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Metadata
- Authors
- Lobry, C., Oh, P., Mansour, M. R., Look, A. T., & Aifantis, I.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2014-04-17
- Volume
- 123
- Issue
- 16
- Pages
- 2451-2459
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2014952486
- Cited by
- 249
- References
- 14
- FWCI
- 10.83
- Type
- journal article
- Language
- en
- Open access
- green
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