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Antibiotics impair murine hematopoiesis by depleting the intestinal microbiota
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Key Points: Antibiotics cause multilineage alterations in murine hematopoiesis, with marked suppression of multipotent progenitors. Suppression of bone marrow populations results from depletion of intestinal microbiota.
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“The gut microbiota constantly communicates with vital organ systems of the host, such as the brain6, bone marrow7, vasculature8, kidney9, immune system10 and autonomic nervous system (ANS)11,12.”
From The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease (2018) · cites this paper as [7]
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Metadata
- Authors
- Josefsdottir, K. S., Baldridge, M. T., Kadmon, C. S., & King, K. Y.
- Affiliations
- Baylor College of Medicine (US)
- Washington University in St. Louis (US)
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2017-02-09
- Volume
- 129
- Issue
- 6
- Pages
- 729-739
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC5301822
- OpenAlex
- W2554797838
- Cited by
- 343
- References
- 34
- Citations by year
- 2026: 25 · 2025: 42 · 2024: 46 · 2023: 31 · 2022: 50 · 2021: 43 · 2020: 40 · 2019: 30 · 2018: 25 · 2017: 11
- FWCI
- 11.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- March of Dimes Foundation
- Texas Children's Hospital
- National Institutes of Health
- National Cancer Institute (T32CA009547, P30CA125123)
- National Institute of Allergy and Infectious Diseases (P30AI036211, R01AI141716, U19AI109725)
- National Center for Research Resources (S10RR024574)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
- Keywords
- antibiotics, hematopoiesis, gut microbiota, fecal microbiota transplantation, germ-free mice, STAT1 signaling, T cell homeostasis, granulocyte maturation, myelosuppression
- MeSH terms
- Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Anemia, Animals, Anti-Bacterial Agents, B-Lymphocytes, Bone Marrow Cells, Germ-Free Life, Granulocytes, Hematopoiesis, Hematopoietic Stem Cells, Leukopenia, Macrophages, Mice, Inbred C57BL, Thrombocytosis, Signal Transduction, Gene Expression, Mice, Knockout, CD8-Positive T-Lymphocytes, STAT1 Transcription Factor, Mice
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