Antibiotics impair murine hematopoiesis by depleting the intestinal microbiota

Role of the microbiota in immunity and inflammation.

Belkaid, Y., & Hand, T. W. (2014) · Cell · doi:10.1016/j.cell.2014.03.011 · Cited by 5,385

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

Wilson, A., Laurenti, E., Oser, G., van der Wath, R. C., Blanco-Bose, W., Jaworski, M., Offner, S., Dunant, C. F., Eshkind, L., Bockamp, E., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.048 · Cited by 1,908

Commensal bacteria calibrate the activation threshold of innate antiviral immunity

Abt, M. C., Osborne, L. C., Monticelli, L. A., Doering, T. A., Alenghat, T., Sonnenberg, G. F., Paley, M. A., Antenus, M., Williams, K. L., Erikson, J., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.04.011 · Cited by 993

Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection

Baldridge, M. T., King, K. Y., Boles, N. C., Weksberg, D. C., & Goodell, M. A. (2010) · Nature · doi:10.1038/nature09135 · Cited by 877

Neutrophil ageing is regulated by the microbiome

Zhang, D., Chen, G., Manwani, D., Mortha, A., Xu, C., Faith, J. J., Burk, R. D., Kunisaki, Y., Jang, J.-E., Scheiermann, C., et al. (2015) · Nature · doi:10.1038/nature15367 · Cited by 839

Clonal dynamics of native haematopoiesis

Sun, J., Ramos, A., Chapman, B., Johnnidis, J. B., Le, L., Ho, Y.-J., Klein, A. M., Hofmann, O., & Camargo, F. D. (2014) · Nature · doi:10.1038/nature13824 · Cited by 803

The microbiome in infectious disease and inflammation

Honda, K., & Littman, D. R. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074937 · Cited by 791

Fundamental properties of unperturbed haematopoiesis from stem cells in vivo

Busch, K., Klapproth, K., Barile, M., Flossdorf, M., Holland-Letz, T., Schlenner, S. M., Reth, M., Höfer, T., & Rodewald, H.-R. (2015) · Nature · doi:10.1038/nature14242 · Cited by 769

Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions

Pietras, E. M., Reynaud, D., Kang, Y.-A., Carlin, D., Calero-Nieto, F. J., Leavitt, A. D., Stuart, J. M., Göttgens, B., & Passegué, E. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.05.003 · Cited by 723

Gut Microbiota Promote Hematopoiesis to Control Bacterial Infection

Khosravi, A., Yáñez, A., Price, J. G., Chow, A. T., Mérad, M., Goodridge, H. S., & Mazmanian, S. K. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.02.006 · Cited by 668

Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease

Chu, H., Khosravi, A., Kusumawardhani, I. P., Kwon, A. H. K., Vasconcelos, A. C., Cunha, L. D., Mayer, A. E., Shen, Y., Wu, W.-L., Kambal, A., et al. (2016) · Science · doi:10.1126/science.aad9948 · Cited by 647

Probiotics for the prevention of pediatric antibiotic-associated diarrhea

Goldenberg, J. Z., Lytvyn, L., Steurich, J., Parkin, P. C., Mahant, S., & Johnston, B. C. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004827.pub4 · Cited by 635

Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response

King, K. Y., & Goodell, M. A. (2011) · Nature reviews. Immunology · doi:10.1038/nri3062 · Cited by 576

An enteric virus can replace the beneficial function of commensal bacteria

Kernbauer, E., Ding, Y., & Cadwell, K. (2014) · Nature · doi:10.1038/nature13960 · Cited by 527

Commensal microbes and interferon-λ determine persistence of enteric murine norovirus infection

Baldridge, M. T., Nice, T. J., McCune, B. T., Yokoyama, C. C., Kambal, A., Wheadon, M. J., Diamond, M., Ivanova, Y., Artyomov, M. N., & Virgin, H. W. (2014) · Science · doi:10.1126/science.1258025 · Cited by 419

Conversion of Danger Signals into Cytokine Signals by Hematopoietic Stem and Progenitor Cells for Regulation of Stress-Induced Hematopoiesis

Zhao, J. L., Ma, C., O’Connell, R. M., Mehta, A., DiLoreto, R., Heath, J. R., & Baltimore, D. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.01.007 · Cited by 339

Regulation of hematopoietic stem cells by bone marrow stromal cells

Anthony, B. A., & Link, D. C. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.10.002 · Cited by 301

Microbiota-Derived Compounds Drive Steady-State Granulopoiesis via MyD88/TICAM Signaling

Balmer, M. L., Schürch, C. M., Saito, Y., Geuking, M. B., Li, H., Miguelangel Cuenca, V., Kovtonyuk, L. V., McCoy, K. D., Hapfelmeier, S., Ochsenbein, A. F., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400762 · Cited by 280

IFNs and STATs in innate immunity to microorganisms

Decker, T., Stockinger, S., Karaghiosoff, M., Müller, M. M., & Kovarik, P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15770 · Cited by 237

The OP9-DL1 System: Generation of T-Lymphocytes from Embryonic or Hematopoietic Stem Cells In VitroPreprint

Holmes, R. B., & Zúñiga‐Pflücker, J. C. (2009) · Cold Spring Harbor Protocols · doi:10.1101/pdb.prot5156 · Cited by 206

Inhibition of Granulopoiesis in Vivo and in Vitro by -Lactam Antibiotics

Neftel, K., Hauser, S. P., & Müller, M. R. A. (1985) · The Journal of Infectious Diseases · doi:10.1093/infdis/152.1.90 · Cited by 199

IFNs and STATs in innate immunity to microorganisms

Decker, T., Stockinger, S., Karaghiosoff, M., Müller, M. M., & Kovarik, P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215770 · Cited by 197

Trends and Seasonal Variation in Outpatient Antibiotic Prescription Rates in the United States, 2006 to 2010

Suda, K. J., Hicks, L. A., Roberts, R. M., Hunkler, R. J., & Taylor, T. H. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02239-13 · Cited by 164

Probiotics for the Prevention of Pediatric Antibiotic-Associated Diarrhea

Hayes, S. R., & Vargas, A. J. (2016) · EXPLORE · doi:10.1016/j.explore.2016.08.015 · Cited by 123

Memory Stem T Cells in Autoimmune Disease: High Frequency of Circulating CD8+ Memory Stem Cells in Acquired Aplastic Anemia

Hosokawa, K. T., Muranski, P. J., Feng, X., Townsley, D. M., Liu, B., Knickelbein, J. E., Keyvanfar, K., Dumitriu, B., Ito, S., Kajigaya, S., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501739 · Cited by 102

Pathophysiologic Mechanisms in Acquired Aplastic Anemia

Young, N. S. (2006) · Hematology · doi:10.1182/asheducation-2006.1.72 · Cited by 100

The human microbiome in hematopoiesis and hematologic disorders

Manzo, V. E., & Bhatt, A. S. (2015) · Blood · doi:10.1182/blood-2015-04-574392 · Cited by 95

Inflammation triggers emergency granulopoiesis through a density-dependent feedback mechanism

Cain, D. W., Snowden, P. B., Sempowski, G. D., & Kelsoe, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019957 · Cited by 95

Incidence of β-Lactam–Induced Delayed Hypersensitivity and Neutropenia During Treatment of Infective Endocarditis

Olaison, L., Belin, L., Hogevik, H., & Alestig, K. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.6.607 · Cited by 81

Saccharomyces boulardii to Prevent Antibiotic-Associated Diarrhea: A Randomized, Double-Masked, Placebo-Controlled Trial

Ehrhardt, S., Guo, N., Hinz, R., Schoppen, S., May, J., Reiser, M., Schroeder, M. P., Schmiedel, S., Keuchel, M., Reisinger, E. C., et al. (2016) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofw011 · Cited by 69

Neutropenia after penicillins: Toxic or immune-mediated?

Neftel, K., Wälti, M., Spengler, H., von Felten, A., Weitzman, S. A., Bürgi, H., & WECK, A. L. D. (1981) · Journal of Molecular Medicine · doi:10.1007/bf01721921 · Cited by 51

Increased CD4+ and CD8+ effector memory T cells in patients with aplastic anemia

Hu, X., Gu, Y., Wang, Y., Cong, Y., Qu, X., & Xu, C. (2009) · Haematologica · doi:10.3324/haematol.13412 · Cited by 29

Agranulocytosis associated with chronic oral administration of cloxacillin for suppression of staphylococcal osteomyelitis

Shah, I. A., Kumar, K. S., & Lerner, A. M. (1982) · American Journal of Hematology · doi:10.1002/ajh.2830120213 · Cited by 12

Neonatal microbial colonization in mice promotes prolonged dominance of CD11b+Gr‐1+ cells and accelerated establishment of the CD4+ T cell population in the spleen

Kristensen, M. B., Metzdorff, S. B., Bergström, A., Damlund, D. S. M., Fink, L. N., Licht, T. R., & Frøkiær, H. (2015) · Immunity Inflammation and Disease · doi:10.1002/iid3.70 · Cited by 10

Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease

Pickard, J. M., Zeng, M. Y., Caruso, R., & Núñez, G. (2017) · Immunological Reviews · doi:10.1111/imr.12567 · Cited by 1,699

Microbes, Metabolites, and the Gut-Lung Axis

Dang, A. T., & Marsland, B. J. (2019) · Mucosal Immunology · doi:10.1038/s41385-019-0160-6 · Cited by 1,028

The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease

Yang, T., Richards, E. M., Pepine, C. J., & Raizada, M. K. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0018-2 · Cited by 753

Mouse Microbiota Models: Comparing Germ-Free Mice and Antibiotics Treatment as Tools for Modifying Gut Bacteria

Kennedy, E. A., King, K. Y., & Baldridge, M. T. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01534 · Cited by 602

Vaccination in the elderly: The challenge of immune changes with aging

Ciabattini, A., Nardini, C., Santoro, F., Garagnani, P., Franceschi, C., & Medaglini, D. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2018.10.010 · Cited by 411

Antibiotics Impair Murine Hematopoiesis by Depleting Intestinal Microbiota

King, K. Y., Josefsdottir, K. S., & Baldridge, M. T. (2016) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofw172.1778

Antibiotics Cause Multilineage Alteration of Hematopoiesis in Mice

Josefsdottir, K. S., Baldridge, M. T., Virgin, H. W., & King, K. Y. (2015) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofv133.604

The Bacterial Microbiota Promotes Normal Hematopoiesis Via Interferon Alpha and NOD1 Signaling Pathways

Yan, H. H., Walker, F. C., Han, H., Baldridge, M. T., & King, K. Y. (2021) · Blood · doi:10.1182/blood-2021-151494

Antibiotic treatment limits survival of peripheral and bone marrow B-cell populations

Sanning, L. S., Walker, F. C., Maknojia, A., Wang, L., Jin, H., Kalugotla, G., Lovato, C., King, K. Y., & Baldridge, M. T. (2025) · Blood Advances · doi:10.1182/bloodadvances.2024013694 · Cited by 1

Broad-Spectrum Antibiotics Deplete Bone Marrow Regulatory T Cells

Han, H., Yan, H. H., & King, K. Y. (2021) · Cells · doi:10.3390/cells10020277 · Cited by 33