Cited by 186Phagocytosis and Immune RegulationIron Metabolism and DisordersBlood transfusion and management

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

Increased erythrophagocytosis induces ferroptosis in red pulp macrophages in a mouse model of transfusion

Open access

Youssef, Lyla A., Rebbaa, Abdelhadi, Pampou, Sergey, Weisberg, Stuart P., Stockwell, Brent R., Hod, Eldad A., Spitalnik, Steven L.·2018·Blood

DOI 10.1182/blood-2017-12-822619PMC PMC5992863

Open this paper in CoChat — free account

Abstract

monocytes, suggests that, following RPM depletion induced by robust erythrophagocytosis, there is a coordinated effort to restore homeostasis of the RPM population by local self-maintenance and contributions from circulating monocytes. In conclusion, these findings may be clinically relevant to pathological conditions that can arise as a result of increased erythrophagocytosis, such as transfusion-related immunomodulation and impaired host immunity.

Integrity signals

Registry

Crossref · 10.1182/blood-2017-12-822619

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691
Self-citation
Regulation of Ferroptotic Cancer Cell Death by GPX4
Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713
Self-citation
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732
Self-citation
Ferroptosis: process and function
Xie, Y., Hou, W., Song, X., Yu, Y., Huang, J., Sun, X., Kang, R., & Tang, D. (2016) · Cell Death & Differentiation · doi:10.1038/cdd.2015.158 · Cited by 3,727
Monocyte recruitment during infection and inflammation
Shi, C., & Pamer, E. G. (2011) · Nature Reviews Immunology · doi:10.1038/nri3070 · Cited by 3,015
The ferritins: molecular properties, iron storage function and cellular regulation
Harrison, P. M., & Arosio, P. (1996) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(96)00022-9 · Cited by 2,667
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578
The role of iron and reactive oxygen species in cell death
Dixon, S. J., & Stockwell, B. R. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1416 · Cited by 2,381
Self-citation
Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes
Hashimoto, D., Chow, A., Noizat, C., Teo, P., Beasley, M. B., Leboeuf, M., Becker, C. D., See, P., Price, J., Lucas, D., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.004 · Cited by 2,311
Glutaminolysis and transferrin regulate ferroptosis
Gao, M., Monian, P., Quadri, N., Ramasamy, R., & Jiang, X. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.06.011 · Cited by 2,069

Show all 51 references

Sorted by citations

Ferroptosis in infection, inflammation, and immunity
Chen, X., Kang, R., Kroemer, G., & Tang, D. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20210518 · Cited by 844
Unsolved mysteries: How does lipid peroxidation cause ferroptosis?
Feng, H., & Stockwell, B. R. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2006203 · Cited by 768
Self-citation
The application of Ferroptosis in diseases
Qiu, Y., Cao, Y., Cao, W., Jia, Y., & Lu, N. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104919 · Cited by 415
Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology
Morioka, S., Maueröder, C., & Ravichandran, K. S. (2019) · Immunity · doi:10.1016/j.immuni.2019.04.018 · Cited by 391
Interaction between macrophages and ferroptosis
Yang, Y., Wang, Y., Guo, L., Gao, W., Tang, T.-L., & Yan, M. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04775-z · Cited by 401
Iron in infection and immunity
Nairz, M., & Weiss, G. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100864 · Cited by 359
Ironing out the role of ferroptosis in immunity
Bell, H. N., Stockwell, B. R., & Zou, W. (2024) · Immunity · doi:10.1016/j.immuni.2024.03.019 · Cited by 238
Self-citation
Programmed death of macrophages in atherosclerosis: mechanisms and therapeutic targets
Meyer, G. R. Y. D., Zurek, M., Puylaert, P., & Martinet, W. (2024) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00957-0 · Cited by 221
In defence of ferroptosis
Alves, F. M., Lane, D. J. R., Nguyen, T. P. M., Bush, A. I., & Ayton, S. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02088-5 · Cited by 212
Ferroptosis: regulation by competition between NRF2 and BACH1 and propagation of the death signal
Nishizawa, H., Yamanaka, M., & Igarashi, K. (2022) · FEBS Journal · doi:10.1111/febs.16382 · Cited by 164
Challenges and advances in the management of inflammation in atherosclerosis
Xing, Y., & Lin, X. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.06.016 · Cited by 147
Erythroid lineage Jak2V617F expression promotes atherosclerosis through erythrophagocytosis and macrophage ferroptosis
Liu, W., Östberg, N. K., Yalçınkaya, M., Dou, H., Endo‐Umeda, K., Tang, Y., Hou, X., Xiao, T., Fidler, T. P., Abramowicz, S., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci155724 · Cited by 130
Zinc transporter ZIP7 is a novel determinant of ferroptosis
Chen, P., Wu, J., Xu, Y., Ding, C. C., Mestre, A. A., Lin, C., Yang, W., & Chi, J. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03482-5 · Cited by 128
Emerging roles of ferroptosis in the tumor immune landscape: from danger signals to anti‐tumor immunity
Shi, L., Liu, Y., Li, M., & Luo, Z. Y. (2021) · FEBS Journal · doi:10.1111/febs.16034 · Cited by 127
Ferroptosis: an emerging player in immune cells
Xu, S., Min, J., & Wang, F. (2021) · 中国科学通报：英文版 · doi:10.1016/j.scib.2021.02.026 · Cited by 118
Red blood cells as an organ? How deep omics characterization of the most abundant cell in the human body highlights other systemic metabolic functions beyond oxygen transport
Nemkov, T. G., Reisz, J. A., Xia, Y., Zimring, J. C., & D’Alessandro, A. (2018) · Expert Review of Proteomics · doi:10.1080/14789450.2018.1531710 · Cited by 117
The Role of Macrophage Iron Overload and Ferroptosis in Atherosclerosis
Ma, J., Zhang, H., Chen, Y., Liu, X., Tian, J., & Shen, W. (2022) · Biomolecules · doi:10.3390/biom12111702 · Cited by 119
Embryonal erythropoiesis and aging exploit ferroptosis
Zheng, H., Jiang, L., Tsuduki, T., Conrad, M., & Toyokuni, S. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102175 · Cited by 109
Dysregulation of iron metabolism in cancer stem cells
Recalcati, S., Gammella, E., & Cairo, G. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.07.015 · Cited by 111
Regulated Necrosis in Atherosclerosis
Puylaert, P., Zurek, M., Rayner, K. J., Meyer, G. R. Y. D., & Martinet, W. (2022) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.122.318177 · Cited by 111
Emerging Mechanisms and Disease Implications of Ferroptosis: Potential Applications of Natural Products
Ge, C., Zhang, S., Mu, H., Shaojun, Z., Tan, Z., Huang, X., Chen, X., Zou, J., Zhu, Y., Dong, F., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.774957 · Cited by 80
Programmed Death of Microglia in Alzheimer's Disease: Autophagy, Ferroptosis, and Pyroptosis
Qiu, Z., Zhang, H., Xia, M., Gu, J., Guo, K., Wang, H., & Miao, C. (2023) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2023.3 · Cited by 77
Iron and iron-dependent reactive oxygen species in the regulation of macrophages and fibroblasts in non-healing chronic wounds
Wlaschek, M., Singh, K., Sindrilaru, A., Crisan, D., & Scharffetter-Kochanek, K. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.09.036 · Cited by 76
“damaged red blood cells by macrophages [69], direct release of iron from macrophages [70], oxidative damage or neutrophil elastase activity damaging ferritin molecules [14], and of lipofuscin [71] may contribute to a non-physiologic accumulation of iron, thus, sustaining the hostile microenvironment [56] which prevent…”
Background
Macrophages and Iron: A Special Relationship
Recalcati, S., & Cairo, G. (2021) · Biomedicines · doi:10.3390/biomedicines9111585 · Cited by 81
T lymphocyte-derived extracellular vesicles aggravate abdominal aortic aneurysm by promoting macrophage lipid peroxidation and migration via pyruvate kinase muscle isozyme 2
Dang, G., Li, T., Yang, D., Yang, G., Du, X., Yang, J., Miao, Y., Han, L., Ma, X., Song, Y., et al. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102257 · Cited by 75
Iron Metabolism in the Tumor Microenvironment: Contributions of Innate Immune Cells
Liang, W. P., & Ferrara, N. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.626812 · Cited by 75
Escherichia coli induced ferroptosis in red blood cells of grass carp (Ctenopharyngodon idella)
Yang, M., Lu, Z., Li, F., Shi, F., Zhan, F., Zhao, L., Li, Y., Li, J., Lin, L., & Qin, Z. (2020) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2020.09.036 · Cited by 72
Redox signaling in innate immunity and inflammation: focus on macrophages and neutrophils
Braunstein, I., Motohashi, H., Dallenga, T. K., Schaible, U. E., & Benhar, M. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.06.006 · Cited by 75
Cytoprotective Role of Heme Oxygenase-1 in Cancer Chemoresistance: Focus on Antioxidant, Antiapoptotic, and Pro-Autophagy Properties
Wang, H., Cheng, Q., Bao, L., Li, M., Chang, K., & Yi, X. (2023) · Antioxidants · doi:10.3390/antiox12061217 · Cited by 69
The Multiple Facets of Iron Recycling
Slusarczyk, P., & Mleczko‐Sanecka, K. (2021) · Genes · doi:10.3390/genes12091364 · Cited by 64
Ferroptosis in tumor immunity and therapy
Gong, C., Ji, Q., Wu, M., Tu, Z., Lei, K., Luo, M., Liu, J., Lin, L., Li, K., Li, J., et al. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17529 · Cited by 56
Stressed erythrophagocytosis induces immunosuppression during sepsis through heme-mediated STAT1 dysregulation
Olonisakin, T. F., Suber, T. L., Gonzalez-Ferrer, S., Xiong, Z., Peñaloza, H. F., van der Geest, R., Xiong, Y., Osei-Hwedieh, D. O., Tejero, J., Rosengart, M. R., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci137468 · Cited by 54
Self-citation
Erastin‑induced ferroptosis causes physiological and pathological changes in healthy tissues of mice
Zhao, J., Xu, B., Xiong, Q., Feng, Y., & Du, H. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12352 · Cited by 58
Ferroptosis: A Critical Moderator in the Life Cycle of Immune Cells
Wang, P., & Lu, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.877634 · Cited by 57
Type I interferon is induced by hemolysis and drives antibody-mediated erythrophagocytosis in sickle cell disease
Liu, Y., Pal, M., Bao, W., Shi, P. A., Lobo, C. A., An, X., Manwani, D. G., Zhong, H., & Yazdanbakhsh, K. (2021) · Blood · doi:10.1182/blood.2021011629 · Cited by 52
Link of sorafenib resistance with the tumor microenvironment in hepatocellular carcinoma: Mechanistic insights
Tian, X., Yan, T., Liu, F., Liu, Q., Zhao, J., Xiong, H., & Jiang, S. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.991052 · Cited by 53
The Intersection of DNA Damage Response and Ferroptosis—A Rationale for Combination Therapeutics
Chen, P., Tseng, W. H.-S., & Chi, J. (2020) · Biology · doi:10.3390/biology9080187 · Cited by 51
Modulation of Iron Metabolism in Response to Infection: Twists for All Tastes
Gomes, A. C., Moreira, A. C., Mesquita, G., & Gomes, M. S. (2018) · Pharmaceuticals · doi:10.3390/ph11030084 · Cited by 52
Patrolling monocytes scavenge endothelial-adherent sickle RBCs: a novel mechanism of inhibition of vaso-occlusion in SCD
Liu, Y., Zhong, H., Bao, W., Mendelson, A., An, X., Shi, P. A., Chou, S. T., Manwani, D. G., & Yazdanbakhsh, K. (2019) · Blood · doi:10.1182/blood.2019000172 · Cited by 51
Macrophage‐fibroblast circuits in the spleen
Bellomo, A., Gentek, R., Golub, R., & Bajénoff, M. (2021) · Immunological Reviews · doi:10.1111/imr.12979 · Cited by 45
Effect of erythrophagocytosis-induced ferroptosis during angiogenesis in atherosclerotic plaques
Puylaert, P., Roth, L., Praet, M. V., Pintelon, I., Dumitrascu, C., van Nuijs, A. L. N., Klejborowska, G., Guns, P., Berghe, T. V., Augustyns, K., et al. (2023) · Angiogenesis · doi:10.1007/s10456-023-09877-6 · Cited by 46
Metformin induces ferroptosis through the Nrf2/HO-1 signaling in lung cancer
Deng, C., Xiong, L., Chen, Y., Wu, K., & Wu, J. (2023) · BMC Pulmonary Medicine · doi:10.1186/s12890-023-02655-6 · Cited by 46
Impaired iron recycling from erythrocytes is an early hallmark of aging
Slusarczyk, P., Mandal, P. K., Zurawska, G., Niklewicz, M., Chouhan, K., Mahadeva, R., Jończy, A., Macias, M., Szybińska, A., Cybulska, M., et al. (2023) · eLife · doi:10.7554/elife.79196 · Cited by 40
Ferroptosis, novel therapeutics in asthma
Lv, X., Dong, M., Tang, W., Qin, J., Wang, W., Li, M., Teng, F., Yi, L., Dong, J., & Wei, Y. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113516 · Cited by 43
Targeting ferroptosis in neuroimmune and neurodegenerative disorders for the development of novel therapeutics
Li, Z., Zhang, Y. Z., Ji, M., Wu, C., Zhang, Y., & Ji, S.-L. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116777 · Cited by 42
Metabolic Consequences of Efferocytosis and Its Impact on Atherosclerosis
Yurdagul, A. (2021) · Immunometabolism · doi:10.20900/immunometab20210017 · Cited by 41
The role of ROS-induced pyroptosis in CVD
Tian, K.-J., Yu, Y., Zhou, K., Deng, N.-H., Tian, Z., Wu, Z.-F., Liu, X., Zhang, F., & Jiang, Z. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1116509 · Cited by 39
Resident macrophages of the lung and liver: The guardians of our tissues
Kulle, A., Thanabalasuriar, A., Cohen, T. S., & Szydlowska, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1029085 · Cited by 43
The Intrinsic Biological Identities of Iron Oxide Nanoparticles and Their Coatings: Unexplored Territory for Combinatorial Therapies
Mulens‐Arias, V., Rojas, J. M., & Barber, D. F. (2020) · Nanomaterials · doi:10.3390/nano10050837 · Cited by 39
The Chemical Basis of Intracerebral Hemorrhage and Cell Toxicity With Contributions From Eryptosis and Ferroptosis
Derry, P. J., Vo, A. T. T., Gnanasekaran, A., Mitra, J., Liopo, A. V., Hegde, M. L., Tsai, A., Tour, J. M., & Kent, T. A. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.603043 · Cited by 42
Targeting reactive oxygen species and fat acid oxidation for the modulation of tumor-associated macrophages: a narrative review
Teng, Y., Xu, L., Li, W., Liu, P., Tian, L., & Liu, M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1224443 · Cited by 38
Heme-stress activated NRF2 skews fate trajectories of bone marrow cells from dendritic cells towards red pulp-like macrophages in hemolytic anemia
Vallelian, F., Buzzi, R. M., Pfefferlé, M., Yalamanoglu, A., Dubach, I. L., Wassmer, A., Gentinetta, T., Hansen, K., Humar, R., Schulthess, N., et al. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-00932-1 · Cited by 33
Red Blood Cell Storage: From Genome to Exposome Towards Personalized Transfusion Medicine
D’Alessandro, A., & Hod, E. A. (2023) · Transfusion Medicine Reviews · doi:10.1016/j.tmrv.2023.150750 · Cited by 35
Self-citation
Erythrophagocytosis by Microglia/Macrophage in Intracerebral Hemorrhage: From Mechanisms to Translation
Liu, J., Zhu, Z., & Leung, G. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.818602 · Cited by 35
Understanding the mechanistic roles of microplastics combined with heavy metals in regulating ferroptosis: Adding new paradigms regarding the links with diseases
Chen, Q., Liu, Y., Bi, L., Jin, L., & Peng, R. (2023) · Environmental Research · doi:10.1016/j.envres.2023.117732 · Cited by 35
Reticulocytes in donor blood units enhance red blood cell alloimmunization
Thomas, T. A., Qiu, A., Kim, C. Y., Gordy, D. E., Miller, A., Tredicine, M., Dzieciątkowska, M., Zotti, F. D., Hod, E. A., D’Alessandro, A., et al. (2023) · Haematologica · doi:10.3324/haematol.2023.282815 · Cited by 33
Self-citation
The dance of macrophage death: the interplay between the inevitable and the microenvironment
Makuch, M., Stepanechko, M., & Bzowska, M. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1330461 · Cited by 35
Thymosin β4 Is an Endogenous Iron Chelator and Molecular Switcher of Ferroptosis
Lachowicz, J. I., Pichiri, G., Piludu, M., Fais, S., Orrù, G., Congiu, T., Piras, M., Faa, G., Fanni, D., Torre, G. D., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23010551 · Cited by 32
Red Blood Cell Omics and Machine Learning in Transfusion Medicine: Singularity Is Near
D’Alessandro, A. (2023) · Transfusion Medicine and Hemotherapy · doi:10.1159/000529744 · Cited by 31
Immune cells dying from ferroptosis: mechanisms and therapeutic opportunities
Liu, J., Dong, R., Yuan, B., Xie, Y., Feng, Z., Zhou, S., Luan, F., & Chen, Y. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08204-9 · Cited by 32
Interaction between macrophages and ferroptosis: Metabolism, function, and diseases
Jiang, Q., Wan, R., Jiang, J., Li, T., Li, Y., Yu, S., Zhao, B., & Li, Y. (2024) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003189 · Cited by 31
Transcriptomic reveals the ferroptosis features of host response in a mouse model of Zika virus infection
Yan, Q., Zheng, W., Jiang, Y., Zhou, P., Lai, Y., Liu, C., Wu, P., Zhuang, H., Huang, H.-T., Li, G., et al. (2022) · Journal of Medical Virology · doi:10.1002/jmv.28386 · Cited by 32
The crosslinks between ferroptosis and autophagy in asthma
Lv, X., Tang, W., Qin, J., Wang, W., Dong, J., & Wei, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1140791 · Cited by 33
Too much iron: A masked foe for leukemias
Brissot, É., Bernard, D. G., Loréal, O., Brissot, P., & Troadec, M. (2019) · Blood Reviews · doi:10.1016/j.blre.2019.100617 · Cited by 29
Emerging insights into the role of ferroptosis in the pathogenesis of autoimmune diseases
Fan, J., Jiang, T., & He, D. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1120519 · Cited by 27
Metabolic Reprogramming of Mouse Bone Marrow Derived Macrophages Following Erythrophagocytosis
Catala, A., Youssef, L. A., Reisz, J. A., Dzieciątkowska, M., Powers, N. E., Marchetti, C., Karafin, M. S., Zimring, J. C., Hudson, K. E., Hansen, K. C., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00396 · Cited by 28
Self-citation
Ferroptosis: a potential target for the treatment of atherosclerosis
Li, C., Liu, R., Xiong, Z., Bao, X., Liang, S., Zeng, H., Wei, J. J., Gong, Q., Liu, L., & Guo, J. (2024) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2024016 · Cited by 25
A double-edged sword with a therapeutic target: iron and ferroptosis in immune regulation
Ni, S., Yuan, Y., Song, S., & Li, X. (2022) · Nutrition Reviews · doi:10.1093/nutrit/nuac071 · Cited by 24
Ferroptosis as an emerging target in sickle cell disease
Fortuna, V., Lima, J. C., Oliveira, G. F., de Oliveira, Y. S. C., Getachew, B., Nekhai, S. A., Aschner, M., & Tizabi, Y. (2024) · Current Research in Toxicology · doi:10.1016/j.crtox.2024.100181 · Cited by 25
The emerging role of ferroptosis in the pathological development and progression of sepsis
Zhou, H., Huang, J., Liu, Y., Wang, J., & Wang, J. (2025) · Military Medical Research · doi:10.1186/s40779-025-00665-5 · Cited by 29
Ferroptosis in periodontitis: mechanisms, impacts, and systemic connections
Guan, P., Ruan, Q., Li, J., Xi, M., Qi, W., Ko, K. I., & Ni, J. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02550-5 · Cited by 27
Ferroptosis of epithelial ovarian cancer: genetic determinants and therapeutic potential
Lin, C., & Chi, J. (2020) · Oncotarget · doi:10.18632/oncotarget.27749 · Cited by 24
HIF-1α/m6A/NF-κB/CCL3 axis-mediated immunosurveillance participates in low level benzene-related erythrohematopoietic development toxicity
Cong, X., Li, X., Xu, K., Yin, L., Liang, G., Sun, R., Pu, Y., & Zhang, J. (2024) · Environment International · doi:10.1016/j.envint.2024.108493 · Cited by 22
The m6A eraser FTO suppresses ferroptosis via mediating ACSL4 in LPS-induced macrophage inflammation
Zhao, Y., Ding, W., Cai, Y., Li, Q., Zhang, W., Bai, Y., Zhang, Y., Xu, Q., & Feng, Z. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167354 · Cited by 22
Myeloperoxidase as a Marker to Differentiate Mouse Monocyte/Macrophage Subsets
Gurski, C. J., & Dittel, B. N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158246 · Cited by 24
Inductively-Coupled Plasma Mass Spectrometry–Novel Insights From an Old Technology Into Stressed Red Blood Cell Physiology
Stephenson, D., Nemkov, T. G., Qadri, S. M., Sheffield, W. P., & D’Alessandro, A. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.828087 · Cited by 19
Crosstalk between ferroptosis and innate immune in diabetic kidney disease: mechanisms and therapeutic implications
Wang, J., Shi, H., Yang, Y. S., & Gong, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1505794 · Cited by 21
Novel concepts in red blood cell clearance
Neri, S., Swinkels, D. W., Matlung, H. L., & van Bruggen, R. (2021) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000679 · Cited by 18
Innate Lymphoid Cells and Adaptive Immune Cells Cross-Talk: A Secret Talk Revealed in Immune Homeostasis and Different Inflammatory Conditions
Kumar, V. (2021) · International Reviews of Immunology · doi:10.1080/08830185.2021.1895145 · Cited by 19
A new role for erythropoietin in the homeostasis of red blood cells
Arias, C. F., Valente-Leal, N., Bertocchini, F., Marques, S., Acosta, F. J., & Fernández-Arias, C. (2024) · Communications Biology · doi:10.1038/s42003-023-05758-2 · Cited by 18
Is ferroptosis immunogenic? The devil is in the details!
Kepp, O., & Kroemer, G. (2022) · OncoImmunology · doi:10.1080/2162402x.2022.2127273 · Cited by 17
Nrf2 sensitizes ferroptosis through L-2-hydroxyglutarate-mediated chromatin modifications in sickle cell disease
Xi, C., Pang, J., Zhi, W., Chang, C., Siddaramappa, U., Shi, H., Horuzsko, A., Pace, B. S., & Zhu, X. (2023) · Blood · doi:10.1182/blood.2022018159 · Cited by 16
When might transferrin, hemopexin or haptoglobin administration be of benefit following the transfusion of red blood cells?
Buehler, P. W., & Karnaukhova, E. (2018) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000458 · Cited by 16
TLR7 modulates extramedullary splenic erythropoiesis in P. yoelii NSM-infected mice through the regulation of iron metabolism of macrophages with IFN-γ
Li, J., Liu, L., Xing, J., Chen, D., Fang, C., Mo, F., Gong, Y., Tan, Z., Liang, G., Xiao, W. L., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1123074 · Cited by 15
Post-Transfusion Hemophagocytosis Without Hemophagocytic Lymphohistiocytosis
McGinnis, E., Medvedev, N., Richards, M. J., Chen, L. Y. C., & Wong, M. P. (2019) · Mayo Clinic Proceedings Innovations Quality & Outcomes · doi:10.1016/j.mayocpiqo.2019.07.001 · Cited by 15
Ferroptosis in Oral Cancer: Mechanistic Insights and Clinical Prospects
Lee, J., & Roh, J. (2025) · Cells · doi:10.3390/cells14211685 · Cited by 16
Disruption of monocyte-macrophage differentiation and trafficking by a heme analog during active inflammation
Schaefer, R. E. M., Callahan, R. C., Atif, S. M., Orlicky, D. J., Cartwright, I. M., Fontenot, A. P., Colgan, S. P., & Onyiah, J. C. (2021) · Mucosal Immunology · doi:10.1038/s41385-021-00474-8 · Cited by 14
Polysaccharide of Atractylodes macrocephala Koidz Alleviates Cyclophosphamide-Induced Thymus Ferroptosis in Gosling
Zhou, X., Cao, N., Xu, D., Tian, Y., Shen, X., Jiang, D., Huang, Y., Li, W., & Li, B. (2022) · Animals · doi:10.3390/ani12233394 · Cited by 14
Ferroptosis of Endothelial Cells Triggered by Erythrophagocytosis Contributes to Thrombogenesis in Uremia
Li, Z., Yan, M., Wang, Z., An, Y., Wei, X., Li, T., Xu, M., Xia, Y., Wang, L., & Gao, C. (2023) · Thrombosis and Haemostasis · doi:10.1055/a-2117-7890 · Cited by 14
Reprogramming of red blood cell metabolism in Zika virus–infected donors
Catala, A., Stone, M., Busch, M. P., & D’Alessandro, A. (2022) · Transfusion · doi:10.1111/trf.16851 · Cited by 14
IL-18 Binding Protein–Producing Cells Attenuate Anemia in Murine Macrophage Activation Syndrome
Harel, M., Fauteux‐Daniel, S., Rodriguez, E., Palmer, G., & Gabay, C. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2300065 · Cited by 12
Autoantibody-Mediated Erythrophagocytosis Increases Tuberculosis Susceptibility in HIV Patients
Dai, Y., Cai, Y., Wang, X., Zhu, J., Liu, X., Liu, H., Li, L., Zhang, Y., Liu, S., Wen, Z., et al. (2020) · mBio · doi:10.1128/mbio.03246-19 · Cited by 13
Metronomic capecitabine with rapamycin exerts an immunosuppressive effect by inducing ferroptosis of CD4+ T cells after liver transplantation in rat
Wang, H., Yang, R., Wang, Z.-L., Cao, L., Kong, D., Sun, Q., Yoshida, S., Ren, J., Chen, T., Duan, J., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110810 · Cited by 12
Ferroptosis contributes to immunosuppression
He, N., Yuan, D., Luo, M., Xu, Q., Wen, Z., Wang, Z., Zhao, J., & Liu, Y. (2024) · Frontiers of Medicine · doi:10.1007/s11684-024-1080-8 · Cited by 13
Bleed volume of experimental knee haemarthrosis correlates with the subsequent degree of haemophilic arthropathy
Vøls, K. K., Kjelgaard-Hansen, M. J., Ley, C. D., Hansen, A. K., & Petersen, M. (2019) · Haemophilia · doi:10.1111/hae.13672 · Cited by 12
Identification of hub genes and pathways of ferroptosis in Fusarium keratitis by bioinformatics methods
Teng, X., Xiong, X., Sha, X.-Y., Lei, Y., Diao, Y., Liu, J., Tian, Y., Liu, L., & Zhong, J. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1103471 · Cited by 12
Blocking the CD47-SIRPα interaction reverses the disease phenotype in a polycythemia vera mouse model
Lysenko, V., Schürch, P. M., Tuzlak, S., van Wijk, N. W.-V., Kovtonyuk, L. V., Becher, B., Manz, M. G., Kreutmair, S., & Theocharides, A. P. A. (2023) · Leukemia · doi:10.1038/s41375-023-01903-2 · Cited by 12
Disrupting the immune homeostasis: the emerging role of macrophage ferroptosis in autoimmune diseases
Liu, T., Huang, Y., Wang, Y., & Shen, H. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114745 · Cited by 13
Macrophage ferroptosis potentiates GCN2 deficiency induced pulmonary venous arterialization
Zhang, J., Mao, P., Zhou, T., Yue, B., Li, Y., Qiu, Y., Ying, K., Wang, F., Chen, J., & Yang, J. H. (2025) · Nature Communications · doi:10.1038/s41467-025-64035-4 · Cited by 11
Synthesis and Optimization of Nitroxide-Based Inhibitors of Ferroptotic Cell Death in Cancer Cells and Macrophages
Charaschanya, M., Maskrey, T. S., LaPorte, M. G., Janjic, J. M., & Wipf, P. (2022) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.1c00561 · Cited by 11

Authors: Youssef, L. A., Rebbaa, A., Pampou, S., Weisberg, S. P., Stockwell, B. R., Hod, E. A., & Spitalnik, S. L.
Affiliations: Department of Microbiology and Immunology,
Department of Pathology and Cell Biology,
J. P. Sulzberger Columbia Genome Center,
Department of Biological Sciences (RU)
ORCID: Youssef, Lyla A.
Rebbaa, Abdelhadi
Pampou, Sergey
Weisberg, Stuart P.
Stockwell, Brent R.
Hod, Eldad A.
Spitalnik, Steven L.
Venue: Blood
Publisher: American Society of Hematology
Published: 2018-06-07
Volume: 131
Issue: 23
Pages: 2581-2593
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood-2017-12-822619
PMC: PMC5992863
OpenAlex: W2801527259
Cited by: 186
References: 51
Citations by year: 2026: 22 · 2025: 24 · 2024: 25 · 2023: 33 · 2022: 31 · 2021: 21 · 2020: 15 · 2019: 9 · 2018: 6
FWCI: 5.47
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Blood (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (1s10od020056-01)
National Heart, Lung, and Blood Institute (R01HL121275, R01HL115557, R01HL133049, F31HL134284)
National Cancer Institute (R35CA209896, P01CA087497)
National Institute of Allergy and Infectious Diseases (T32AI106711)
National Center for Research Resources (S10RR027050)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Health Sciences › Medicine › Hematology › Blood transfusion and management
Keywords: erythrophagocytosis, ferroptosis, red pulp macrophages, blood transfusion, monocytes, macrophage homeostasis, transfusion-related immunomodulation, host immunity
MeSH terms: Animals, Cell Division, Disease Models, Animal, Erythrocytes, Macrophages, Mice, Inbred C57BL, Monocytes, Phagocytosis, Lipid Peroxidation, Cell Death, Erythrocyte Transfusion, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Increased erythrophagocytosis induces ferroptosis in red pulp macrophages in a mouse model of transfusion

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks