The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Increased erythrophagocytosis induces ferroptosis in red pulp macrophages in a mouse model of transfusion
Open accessAbstract
monocytes, suggests that, following RPM depletion induced by robust erythrophagocytosis, there is a coordinated effort to restore homeostasis of the RPM population by local self-maintenance and contributions from circulating monocytes. In conclusion, these findings may be clinically relevant to pathological conditions that can arise as a result of increased erythrophagocytosis, such as transfusion-related immunomodulation and impaired host immunity.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Under conditions such as immune-driven RBC damage, sickle cell disease or acute hemolysis, the pool of RPM in the spleen is dramatically reduced, presumably through a combination of programmed (apoptosis) and iron-induced, ROS-mediated cell death (ferroptosis) (Youssef et al., 2018).”
From Iron in infection and immunity (2020) · cites this paper as Youssef et al., 2018
Citations
Cites
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691
Self-citationRegulation of Ferroptotic Cancer Cell Death by GPX4
Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713
Self-citationInactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732
Self-citationFerroptosis: process and function
Xie, Y., Hou, W., Song, X., Yu, Y., Huang, J., Sun, X., Kang, R., & Tang, D. (2016) · Cell Death & Differentiation · doi:10.1038/cdd.2015.158 · Cited by 3,727
Monocyte recruitment during infection and inflammation
Shi, C., & Pamer, E. G. (2011) · Nature Reviews Immunology · doi:10.1038/nri3070 · Cited by 3,015
The ferritins: molecular properties, iron storage function and cellular regulation
Harrison, P. M., & Arosio, P. (1996) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(96)00022-9 · Cited by 2,667
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578
The role of iron and reactive oxygen species in cell death
Dixon, S. J., & Stockwell, B. R. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1416 · Cited by 2,381
Self-citationHashimoto, D., Chow, A., Noizat, C., Teo, P., Beasley, M. B., Leboeuf, M., Becker, C. D., See, P., Price, J., Lucas, D., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.004 · Cited by 2,311
Glutaminolysis and transferrin regulate ferroptosis
Gao, M., Monian, P., Quadri, N., Ramasamy, R., & Jiang, X. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.06.011 · Cited by 2,069
Yang, W. S., & Stockwell, B. R. (2008) · Chemistry & Biology · doi:10.1016/j.chembiol.2008.02.010 · Cited by 1,876
Self-citationMeasuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations
Kalyanaraman, B., Darley-Usmar, V. M., Davies, K. J. A., Dennery, P. A., Forman, H. J., Grisham, M. B., Mann, G. E., Moore, K. P., Roberts, L. J., & Ischiropoulos, H. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.09.030 · Cited by 1,842
Tsou, C.-L., Peters, W., Si, Y., Slaymaker, S., Aslanian, A. M., Weisberg, S. P., Mack, M., & Charo, I. F. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29919 · Cited by 1,152
Self-citationFerrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models
Skouta, R., Dixon, S. J., Wang, J., Dunn, D. E., Orman, M., Shimada, K., Rosenberg, P. A., Lo, D. C., Weinberg, J. M., Linkermann, A., et al. (2014) · Journal of the American Chemical Society · doi:10.1021/ja411006a · Cited by 1,146
Self-citationSynchronized renal tubular cell death involves ferroptosis
Linkermann, A., Skouta, R., Himmerkus, N., Mulay, S. R., Dewitz, C., De Zen, F., Prokai, A., Zuchtriegel, G., Krombach, F., Welz, P.-S., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415518111 · Cited by 1,126
Self-citationBoring, L., Gosling, J., Chensue, S. W., Kunkel, S. L., Farese, R. V., Broxmeyer, H. E., & Charo, I. F. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119798 · Cited by 1,096
T cell lipid peroxidation induces ferroptosis and prevents immunity to infection
Matsushita, M., Freigang, S., Schneider, C., Conrad, M., Bornkamm, G. W., & Kopf, M. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20140857 · Cited by 672
Health Care–Associated Infection After Red Blood Cell Transfusion
Rohde, J. M., Dimcheff, D. E., Blumberg, N., Saint, S. K., Langa, K. M., Kuhn, L. E., Hickner, A., & Rogers, M. A. M. (2014) · JAMA · doi:10.1001/jama.2014.2726 · Cited by 610
Clinical consequences of red cell storage in the critically ill
Tinmouth, A. T., Fergusson, D. A., Yee, I. C., Hébert, P. C., & ABLE Investigators and the Canadian Critical Care Trials Group (2006) · Transfusion · doi:10.1111/j.1537-2995.2006.01026.x · Cited by 572
Age of transfused blood is an independent risk factor for postinjury multiple organ failure
Zallen, G. S., Offner, P. J., Moore, E. E., Blackwell, J., Ciesla, D. J., Gabriel, J., Denny, C., & Silliman, C. C. (1999) · The American Journal of Surgery · doi:10.1016/s0002-9610(99)00239-1 · Cited by 515
Chen, L., Hambright, W. S., Na, R., & Ran, Q. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.680090 · Cited by 498
Hod, E. A., Zhang, N., Sokol, S. A., Wojczyk, B. S., Francis, R. O., Ansaldi, D., Francis, K. P., Della-Latta, P., Whittier, S., Sheth, S., et al. (2010) · Blood · doi:10.1182/blood-2009-10-245001 · Cited by 485
Self-citationRole for Spi-C in the development of red pulp macrophages and splenic iron homeostasis
Kohyama, M., Ise, W., Edelson, B. T., Wilker, P. R., Hildner, K., Mejia, C., Frazier, W. A., Murphy, T. L., & Murphy, K. M. (2009) · Nature · doi:10.1038/nature07472 · Cited by 479
Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages
Haldar, M., Kohyama, M., So, A. Y.-L., KC, W., Wu, X., Briseño, C. G., Satpathy, A. T., Kretzer, N. M., Arase, H., Rajasekaran, N. S., et al. (2014) · Cell · doi:10.1016/j.cell.2014.01.069 · Cited by 431
On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver
Theurl, I., Hilgendorf, I., Nairz, M., Tymoszuk, P., Haschka, D., Asshoff, M., He, S., Gerhardt, L. M. S., Holderried, T. A. W., Seifert, M., et al. (2016) · Nature Medicine · doi:10.1038/nm.4146 · Cited by 412
Glucose-6-Phosphate Dehydrogenase Deficiency
Luzzatto, L., Nannelli, C., & Notaro, R. (2016) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2015.11.006 · Cited by 408
Macrophages and Iron Metabolism
Soares, M. P., & Hamza, I. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.016 · Cited by 401
Influence of Storage on Red Blood Cell Rheological Properties
Berezina, T. L., Zaets, S. B., Morgan, C., Spillert, C. R., Kamiyama, M., Spolarics, Z., Deitch, E. A., & Machiedo, G. W. (2002) · Journal of Surgical Research · doi:10.1006/jsre.2001.6306 · Cited by 382
Carson, J. L., Brooks, M. M., Abbott, J. D., CHAITMAN, B. R., Kelsey, S. F., Triulzi, D. J., SRINIVAS, V. S., Menegus, M. A., Marroquin, O. C., Rao, S. V., et al. (2013) · American Heart Journal · doi:10.1016/j.ahj.2013.03.001 · Cited by 379
Association of mortality with age of blood transfused in septic ICU patients
Purdy, F. R., Tweeddale, M., & Merrick, P. M. (1997) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/bf03012772 · Cited by 358
Increased Rate of Infection Associated With Transfusion of Old Blood After Severe Injury
Offner, P. J. (2002) · Archives of Surgery · doi:10.1001/archsurg.137.6.711 · Cited by 324
Conditional macrophage ablation in transgenic mice expressing a Fas-based suicide gene
Burnett, S. H., Kershen, E. J., Zhang, J., Zeng, L., Straley, S. C., Kaplan, A. M., & Cohen, D. A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0903442 · Cited by 307
Red cell changes during storage
Hess, J. R. (2010) · Transfusion and Apheresis Science · doi:10.1016/j.transci.2010.05.009 · Cited by 290
Storage lesion: role of red blood cell breakdown
Kim‐Shapiro, D. B., Lee, J. S., & Gladwin, M. T. (2011) · Transfusion · doi:10.1111/j.1537-2995.2011.03100.x · Cited by 273
Kovtunovych, G., Eckhaus, M., Ghosh, M. C., Ollivierre, H., & Rouault, T. A. (2010) · Blood · doi:10.1182/blood-2010-03-272138 · Cited by 273
Jia, T., Serbina, N. V., Brandl, K., Zhong, M., Leiner, I. M., Charo, I. F., & Pamer, E. G. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.10.6846 · Cited by 272
Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production
Fortes, G. B., Alves, L. S., de Oliveira, R., Dutra, F. F., Rodrigues, D., Fernandez, P. L., Souto-Padron, T., De Rosa, M. J., Kelliher, M., Golenbock, D., et al. (2012) · Blood · doi:10.1182/blood-2011-08-375303 · Cited by 246
Cunnington, A. J., de Souza, J. B., Walther, M., & Riley, E. M. (2012) · Nature Medicine · doi:10.1038/nm.2601 · Cited by 231
Changes in Physical Properties of Stored Erthrocytes
Hradin, A. R., Weed, R. I., & Reed, C. F. (1969) · Transfusion · doi:10.1111/j.1537-2995.1969.tb04929.x · Cited by 204
Coupling Heme and Iron Metabolism via Ferritin H Chain
Gozzelino, R., & Soares, M. P. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5666 · Cited by 151
Hemolytic Transfusion Reactions
Strobel, E. (2008) · Transfusion Medicine and Hemotherapy · doi:10.1159/000154811 · Cited by 151
Larraufie, M., Yang, W. S., Jiang, E., Thomas, A. G., Slusher, B. S., & Stockwell, B. R. (2015) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2015.07.018 · Cited by 135
Self-citationTransfusion-related immunomodulation: a reappraisal
Youssef, L. A., & Spitalnik, S. L. (2017) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000376 · Cited by 123
Self-citationA novel mouse model of red blood cell storage and posttransfusion in vivo survival
Gilson, C. R., Kraus, T. S., Hod, E. A., Hendrickson, J. E., Spitalnik, S. L., Hillyer, C. D., Shaz, B. H., & Zimring, J. C. (2009) · Transfusion · doi:10.1111/j.1537-2995.2009.02173.x · Cited by 121
Self-citationCallan, M. B., Patel, R. T., Rux, A. H., Bandyopadhyay, S., Sireci, A. N., O’Donnell, P. A., Ruane, T., Sikora, T. U., Marryott, K., Sachais, B. S., et al. (2013) · Vox Sanguinis · doi:10.1111/vox.12058 · Cited by 77
Self-citationAutoimmune hemolytic anemia: From lab to bedside
Chaudhary, R., & Das, S. (2014) · Asian Journal of Transfusion Science · doi:10.4103/0973-6247.126681 · Cited by 72
Vandromme, M. J., McGwin, G., Marques, M. B., Kerby, J. D., Rue, L. W., & Weinberg, J. A. (2009) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0b013e3181a5a8f9 · Cited by 54
Human and murine splenic neutrophils are potent phagocytes of IgG-opsonized red blood cells
Meinderts, S. M., Oldenborg, P., Beuger, B. M., Klei, T. R. L., Johansson, J., Kuijpers, T. W., Matozaki, T., Huisman, E. J., de Haas, M., van den Berg, T. K., et al. (2017) · Blood Advances · doi:10.1182/bloodadvances.2017004671 · Cited by 48
Murine malaria: blood clearance and organ sequestration of Plasmodium yoelii-infected erythrocytes
Smith, L., Hunter, K. W., Oldfield, E. C., & Strickland, G. T. (1982) · Infection and Immunity · doi:10.1128/iai.38.1.162-167.1982 · Cited by 28
Wójczyk, B. S., Kim, N., Bandyopadhyay, S., Francis, R. O., Zimring, J. C., Hod, E. A., & Spitalnik, S. L. (2014) · Transfusion · doi:10.1111/trf.12755 · Cited by 26
Self-citationRb, J., Sl, N., & Ag, S. (1975) · PubMed · Cited by 13
Cited by
Sorted by citations
Ferroptosis in infection, inflammation, and immunity
Chen, X., Kang, R., Kroemer, G., & Tang, D. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20210518 · Cited by 844
Unsolved mysteries: How does lipid peroxidation cause ferroptosis?
Feng, H., & Stockwell, B. R. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2006203 · Cited by 768
Self-citationThe application of Ferroptosis in diseases
Qiu, Y., Cao, Y., Cao, W., Jia, Y., & Lu, N. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104919 · Cited by 415
Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology
Morioka, S., Maueröder, C., & Ravichandran, K. S. (2019) · Immunity · doi:10.1016/j.immuni.2019.04.018 · Cited by 391
Interaction between macrophages and ferroptosis
Yang, Y., Wang, Y., Guo, L., Gao, W., Tang, T.-L., & Yan, M. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04775-z · Cited by 401
Metadata
- Authors
- Youssef, L. A., Rebbaa, A., Pampou, S., Weisberg, S. P., Stockwell, B. R., Hod, E. A., & Spitalnik, S. L.
- Affiliations
- Department of Microbiology and Immunology,
- Department of Pathology and Cell Biology,
- J. P. Sulzberger Columbia Genome Center,
- Department of Biological Sciences (RU)
- ORCID
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2018-06-07
- Volume
- 131
- Issue
- 23
- Pages
- 2581-2593
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- PMC
- PMC5992863
- OpenAlex
- W2801527259
- Cited by
- 186
- References
- 51
- Citations by year
- 2026: 22 · 2025: 24 · 2024: 25 · 2023: 33 · 2022: 31 · 2021: 21 · 2020: 15 · 2019: 9 · 2018: 6
- FWCI
- 5.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Blood (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1s10od020056-01)
- National Heart, Lung, and Blood Institute (R01HL121275, R01HL115557, R01HL133049, F31HL134284)
- National Cancer Institute (R35CA209896, P01CA087497)
- National Institute of Allergy and Infectious Diseases (T32AI106711)
- National Center for Research Resources (S10RR027050)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Hematology › Blood transfusion and management
- Keywords
- erythrophagocytosis, ferroptosis, red pulp macrophages, blood transfusion, monocytes, macrophage homeostasis, transfusion-related immunomodulation, host immunity
- MeSH terms
- Animals, Cell Division, Disease Models, Animal, Erythrocytes, Macrophages, Mice, Inbred C57BL, Monocytes, Phagocytosis, Lipid Peroxidation, Cell Death, Erythrocyte Transfusion, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review