The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
The use of the dilute Russell viper venom time for the diagnosis of lupus anticoagulants
Abstract
We describe here a test for lupus anticoagulants based on a modified Russell viper venom time (RVVT), using limiting amounts of phospholipid and venom. We have studied 29 patients with a prolonged dilute RVVT. Five of the 29 had a normal activated partial thromboplastin time and three of 14 tested by the tissue thromboplastin inhibition test were normal. In 17 of 19 patients tested, the dilute RVVT was completely normal when ionophore-treated platelets were substituted for phospholipid; the remaining two patients, both with very long phospholipid-dependent dilute RVVT's, were nearly completely normalized. The dilute RVVT is not prolonged in the presence of antibodies to factors VIII, IX, or XI. Thus, the dilute RVVT appears to be a simple, reproducible, sensitive, and relatively specific method for the detection of lupus anticoagulants.
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Polyspecific monoclonal lupus autoantibodies reactive with both polynucleotides and phospholipids.
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Cited by
Guidelines on the investigation and management of antiphospholipid syndrome
Keeling, D., Mackie, I., Moore, G. W., Greer, I. A., Greaves, M., & British Committee for Standards in Haematology (2012) · British Journal of Haematology · doi:10.1111/j.1365-2141.2012.09037.x · Cited by 740
Baglin, T., Luddington, R., Brown, K., & Baglin, C. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14111-6 · Cited by 694
Immunology and clinical importance of antiphospholipid antibodies
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Finazzi, G., Brancaccio, V., Moia, M., Ciavarella, N., Mazzucconi, M. G., Schinco, P., Ruggeri, M., Pogliani, E. M., Gamba, G., Rossi, E., et al. (1996) · The American Journal of Medicine · doi:10.1016/s0002-9343(96)00060-5 · Cited by 427
Urbanus, R. T., Siegerink, B., Roest, M., Rosendaal, F. R., de Groot, P. G., & Algra, A. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70239-x · Cited by 429
Metadata
- Authors
- Thiagarajan, P., Pengo, V, & Shapiro, S.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1986-10-01
- Volume
- 68
- Issue
- 4
- Pages
- 869-874
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W93524816
- Cited by
- 422
- References
- 34
- FWCI
- 11.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- Thiagarajan, P., Pengo, V, & Shapiro, S. (1986). The use of the dilute Russell viper venom time for the diagnosis of lupus anticoagulants. Blood. https://doi.org/10.1182/blood.v68.4.869.869
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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