Cited by 766Erythropoietin and Anemia TreatmentCancer, Hypoxia, and MetabolismHemoglobin structure and function

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Desferrioxamine induces erythropoietin gene expression and hypoxia- inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction

Open access

Wang, GL, Semenza, GL·1993·Blood

Open this paper in CoChat — free account Open PDF

Abstract

Erythropoietin (EPO) gene transcription is activated in kidney cells in vivo and in Hep3B cells exposed to hypoxia or cobalt chloride. Hypoxia- inducible factor 1 (HIF-1) is a nuclear factor that binds to the hypoxia-inducible enhancer of the EPO gene at a site that is required for transcriptional activation. HIF-1 DNA-binding activity is induced by hypoxia or cobalt chloride treatment of Hep3B cells. We report that treatment of Hep3B cells with desferrioxamine (DFX) induced HIF-1 activity and EPO RNA expression with kinetics similar to the induction of HIF-1 by hypoxia or cobalt chloride. Induction by each of these stimuli was inhibited by cycloheximide, indicating a requirement for de novo protein synthesis. DFX appears to induce HIF-1 by chelating iron as induction was inhibited by coadministration of ferrous ammonium sulfate. DFX administration to mice transiently increased EPO RNA levels in the kidney. As previously shown for hypoxia and cobalt treatment, DFX also induced HIF-1 activity in non-EPO-producing cells, suggesting the existence of a common hypoxia signal-transduction pathway leading to HIF-1 induction in different cell types.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1182/blood.v82.12.3610.3610

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
Semenza, G. L., & Wang, G. L. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.12.5447 · Cited by 2,617
Self-citation
General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.
Wang, G. L., & Semenza, G. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.9.4304 · Cited by 1,468
Self-citation
Erythropoietin: structure, control of production, and function
JELKMANN, W. E. B. (1992) · Physiological Reviews · doi:10.1152/physrev.1992.72.2.449 · Cited by 1,167
Regulation of the Erythropoietin Gene: Evidence That the Oxygen Sensor Is a Heme Protein
Goldberg, M. A., Dunning, S. P., & Bunn, H. F. (1988) · Science · doi:10.1126/science.2849206 · Cited by 1,032
Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene.
Semenza, G. L., Nejfelt, M. K., Chi, S. M., & Antonarakis, S. E. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.13.5680 · Cited by 990
Self-citation
Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia.
Wang, G. L., & Semenza, G. L. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80571-7 · Cited by 863
Self-citation
A haemoprotein with kinase activity encoded by the oxygen sensor of Rhizobium meliloti
Gilles‐Gonzalez, M., Ditta, G. S., & Helinski, D. R. (1991) · Nature · doi:10.1038/350170a0 · Cited by 477
Localization of erythropoietin synthesizing cells in murine kidneys by in situ hybridization
Koury, S., Bondurant, M. C., & Koury, M. (1988) · Blood · doi:10.1182/blood.v71.2.524.524 · Cited by 469
Peritubular cells are the site of erythropoietin synthesis in the murine hypoxic kidney.
Lacombe, C., Silva, J. L. D., Bruneval, P., Fournier, J. G., Wendling, F., Casadevall, N., Camilleri, J.-P., Bariety, J., Varet, B. R., & Tambourin, P. E. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113363 · Cited by 437

Show all 33 references

Sorted by citations

Items 301–400 of 761

Identification of Chemical Compounds that Induce HIF-1α Activity
Xia, M., Huang, R., Sun, Y., Semenza, G. L., Aldred, S. F., Witt, K. L., Inglese, J., Tice, R. R., & Austin, C. P. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfp123 · Cited by 59
Self-citation
High-Iron Consumption Impairs Growth and Causes Copper-Deficiency Anemia in Weanling Sprague-Dawley Rats
Ha, J., Doğuer, Ç., Wang, X., Flores, S. R., & Collins, J. F. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161033 · Cited by 57
Generation of a Dominant-negative Mutant of Endothelial PAS Domain Protein 1 by Deletion of a Potent C-terminal Transactivation Domain
Maemura, K., Hsieh, C.-M., Jain, M. K., Fukumoto, S., Layne, M. D., Liu, Y., Kourembanas, S., Yet, S., Perrella, M. A., & Lee, M.-E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.44.31565 · Cited by 57
iNOS Expression Inhibits Hypoxia-Inducible Factor-1 Activity
Yin, J., Yang, D., Ku, G., & Hsu, C. Y. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3896 · Cited by 57
Importance of the HIF pathway in cobalt nanoparticle-induced cytotoxicity and inflammation in human macrophages
Nyga, A., Hart, A. J., & Tetley, T. D. (2015) · Nanotoxicology · doi:10.3109/17435390.2014.991430 · Cited by 56
Induction of hypoxia inducible factor‐1 attenuates metabolic insults induced by 3‐nitropropionic acid in rat C6 glioma cells
Yang, Y., Ju, T., & Yang, D. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03032.x · Cited by 56
The molecular response of mammalian cells to hypoxia and the potential for exploitation in cancer therapy.
Dachs, G. U., & Stratford, I. J. (1996) · Europe PMC (PubMed Central) · Cited by 56
Promotion of airway anastomotic microvascular regeneration and alleviation of airway ischemia by deferoxamine nanoparticles
Jiang, X., Malkovskiy, A. V., Tian, W., Sung, Y. K., Sun, W., Hsu, J. L., Manickam, S., Wagh, D. A., Joubert, L., Semenza, G. L., et al. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.09.092 · Cited by 56
Self-citation
Heme oxygenase/carbon monoxide signaling path-ways: Regulation and functional significance
Ryter, S. W., Otterbein, L. E., Morse, D., & Choi, A. M. K. (2002) · Springer eBooks · doi:10.1007/978-1-4615-1087-1_29 · Cited by 55
Activation of hypoxia-inducible factor-1 regulates human histidine decarboxylase expression
Jeong, H., Moon, P., Kim, S. J., Seo, J.-U., Kang, T. H., Kim, J., Kang, I., Um, J., Kim, H. M., & Hong, S. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-9001-1 · Cited by 54
Mitochondrial Ferritin Is a Hypoxia-Inducible Factor 1α-Inducible Gene That Protects from Hypoxia-Induced Cell Death in Brain
Wu, Q., Wu, W.-S., Su, L., Zheng, X., Wu, W., Santambrogio, P., Gou, Y.-J., Qian, H., Wang, P.-N., Li, Y.-R., et al. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7063 · Cited by 54
Desferoxamine and ethyl-3,4-dihydroxybenzoate protect myocardium by activating NOS and generating mitochondrial ROS
Philipp, S., Cui, L., Ludolph, B., Kelm, M., Schulz, R., Cohen, M. V., & Downey, J. M. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00472.2005 · Cited by 54
Engineering of Macrophages to Produce IFN-γ in Response to Hypoxia
Carta, L., Pastorino, S., Melillo, G., Bosco, M. C., Massazza, S., & Varesio, L. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.9.5374 · Cited by 54
Oxygen-dependent expression of hypoxia-inducible factor-1α in renal medullary cells of rats
Zou, A.-P., Yang, Z.-Z., Li, P., & Cowley, A. W. (2001) · Physiological Genomics · doi:10.1152/physiolgenomics.2001.6.3.159 · Cited by 54
From Erythropoietin to Oxygen: Hypoxia-Inducible Factor Hydroxylases and the Hypoxia Signal Pathway
Ratcliffe, P. J. (2002) · Blood Purification · doi:10.1159/000065201 · Cited by 54
Multiple pathways of neuroprotection against oxidative stress and excitotoxic injury in immature primary hippocampal neurons
Almli, L. M., Hamrick, S. E. G., Koshy, A. A., Täuber, M. G., & Ferriero, D. M. (2001) · Developmental Brain Research · doi:10.1016/s0165-3806(01)00302-9 · Cited by 53
The flavonoid quercetin induces hypoxia-inducible factor-1α (HIF-1α) and inhibits cell proliferation by depleting intracellular iron
Triantafyllou, A., Liakos, P., Tsakalof, A. K., Chachami, G., Paraskeva, E., Molyvdas, P.-A., Georgatsou, E., Simos, G., & Bonanou, S. (2006) · Free Radical Research · doi:10.1080/10715760601055324 · Cited by 54
Erythropoietin
Wenger, R. H., & Kurtz, A. (2011) · Comprehensive physiology · doi:10.1002/cphy.c100075 · Cited by 55
Cellular differentiation determines the expression of the hypoxia-inducible protein NDRG1 in pancreatic cancer
Angst, E., Sibold, S., Tiffon, C., Weimann, R., Gloor, B., Candinas, D., & Stroka, D. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603256 · Cited by 54
IL-1β upregulates Muc5ac expression via NF-κB-induced HIF-1α in asthma
Wu, S., Li, H., Yu, L., Wang, N., Li, X., & Chen, W. (2017) · Immunology Letters · doi:10.1016/j.imlet.2017.10.006 · Cited by 52
Hypoxia triggers neuroprotective alterations in hippocampal gene expression via a heme-containing sensor
Gage, A. T., & Stanton, P. K. (1996) · Brain Research · doi:10.1016/0006-8993(96)00092-3 · Cited by 52
Hypoxia regulates the ferrous iron uptake and reactive oxygen species level via divalent metal transporter 1 (DMT1) Exon1B by hypoxia‐inducible factor‐1
Wang, D., Wang, L., Zhao, Y. C., Lu, Y., & Zhu, L. (2010) · IUBMB Life · doi:10.1002/iub.363 · Cited by 52
The role of hypoxia-induced genes in ovarian angiogenesis
Meidan, R., Klipper, E., Zalman, Y., & Yalu, R. (2012) · Reproduction Fertility and Development · doi:10.1071/rd12139 · Cited by 52
Hypoxia-Mediated Induction of the Polyamine System Provides Opportunities for Tumor Growth Inhibition by Combined Targeting of Vascular Endothelial Growth Factor and Ornithine Decarboxylase
Svensson, K. J., Welch, J. E., Kucharzewska, P., Bengtson, P., Bjurberg, M., Påhlman, S., ten Dam, G. B., Persson, L., & Belting, M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2340 · Cited by 51
Role of protein kinase Cδ in transmitting hypoxia signal to HSF and HIF‐1
Baek, S., Lee, U. Y., Park, E., Han, M., Lee, Y., & Park, Y. (2001) · Journal of Cellular Physiology · doi:10.1002/jcp.1117 · Cited by 51
Adenosine‐dependent activation of hypoxia‐inducible factor‐1 induces late preconditioning in liver cells†
Alchera, E., Tacchini, L., Imarisio, C., Ponte, C. D., Ponti, C. D., Gammella, E., Cairo, G., Albano, E., & Carini, R. (2008) · Hepatology · doi:10.1002/hep.22249 · Cited by 50
Transcriptional Regulation of SDHa Flavoprotein by Nuclear Respiratory Factor-1 Prevents Pseudo-hypoxia in Aerobic Cardiac Cells
Piantadosi, C. A., & Suliman, H. B. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709741200 · Cited by 50
Sodium-Glucose Cotransporter 2 Inhibitors in Patients with Non-Diabetic Chronic Kidney Disease
Mima, A. (2021) · Advances in Therapy · doi:10.1007/s12325-021-01735-5 · Cited by 49
Hypoxia induces changes in expression of isoforms of the divalent metal transporter (DMT1) in rat pheochromocytoma (PC12) cells
Lis, A., Paradkar, P. N., Singleton, S., Kuo, H.-C., Garrick, M. D., & Roth, J. A. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.03.023 · Cited by 49
Targeting Hypoxia-Inducible Factor-1 (HIF-1) Signaling in Therapeutics: Implications for the Treatment of Inflammatory Bowel Disease
Hirota, S. A., Beck, P. L., & MacDonald, J. A. (2009) · Recent Patents on Inflammation & Allergy Drug Discovery · doi:10.2174/187221309787158434 · Cited by 48
Ischemia-induced Copper Loss and Suppression of Angiogenesis in the Pathogenesis of Myocardial Infarction
He, W., & Kang, Y. J. (2012) · Cardiovascular Toxicology · doi:10.1007/s12012-012-9174-y · Cited by 48
HIF-1α is neuroprotective during the early phases of mild hypoxia in rat cortical neurons
López‐Hernández, B., Posadas, I., Podlesniy, P., Abad, M. A., Trullás, R., & Ceña, V. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.11.040 · Cited by 47
Hypoxia Inducible Factor-1α in Osteochondral Tissue Engineering
Taheem, D. K., Jell, G., & Gentleman, E. (2019) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2019.0283 · Cited by 47
Hypoxic Induction of Exosome Uptake through Proteoglycan-Dependent Endocytosis Fuels the Lipid Droplet Phenotype in Glioma
Cerezo-Magaña, M., Christianson, H. C., Kuppevelt, T. H. V., Forsberg‐Nilsson, K., & Belting, M. (2020) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-20-0560 · Cited by 47
Enhanced antitumor activity of xanthohumol, a diacylglycerol acyltransferase inhibitor, under hypoxia
Goto, K., Asai, T., Hara, S., Namatame, I., Tomoda, H., Ikemoto, M., & Oku, N. (2004) · Cancer Letters · doi:10.1016/j.canlet.2004.07.034 · Cited by 47
Altered gene expression during hypoxia and reoxygenation of the heart
Piacentini, L., & Karliner, J. S. (1999) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(99)00010-8 · Cited by 47
Contribution of hypoxia‐inducible factor‐1α to transcriptional regulation of vascular endothelial growth factor in bovine developing luteal cells
Zhang, Z., Yin, D., & Wang, Z. (2011) · Animal Science Journal · doi:10.1111/j.1740-0929.2010.00832.x · Cited by 46
Cobalt chloride, a chemical inducer of hypoxia-inducible factor-1α in U251 human glioblastoma cell line
Okail, M. S. A. (2010) · Journal of Saudi Chemical Society · doi:10.1016/j.jscs.2010.02.005 · Cited by 46
Intermediary Metabolite Precursor Dimethyl-2-Ketoglutarate Stabilizes Hypoxia-Inducible Factor-1α by Inhibiting Prolyl-4-Hydroxylase PHD2
Hou, P., Kuo, C., Cheng, C.-T., Liou, J., Ann, D. K., & Chen, Q. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113865 · Cited by 46
Sensorineural hearing loss and ischemic injury: Development of animal models to assess vascular and oxidative effects
Olivetto, E., Simoni, E., Guaran, V., Astolfi, L., & Martini, A. (2015) · Hearing Research · doi:10.1016/j.heares.2015.05.004 · Cited by 46
Phosphorylation and activation of STAT proteins by hypoxia in breast cancer cells
Lee, M. Y., Joung, Y. H., Lim, E. J., Park, J., Ye, S., Park, T., Zhang, Z., Park, D. K., Lee, K. J., & Yang, Y. M. (2005) · The Breast · doi:10.1016/j.breast.2005.05.005 · Cited by 48
Oxygen tension regulates preosteocyte maturation and mineralization
Zahm, A. M., Bucaro, M. A., Srinivas, V., Shapiro, I. M., & Adams, C. S. (2008) · Bone · doi:10.1016/j.bone.2008.03.010 · Cited by 46
Ironing-Out Mechanisms of Neuronal Injury under Hypoxic–Ischemic Conditions and Potential Role of Iron Chelators as Neuroprotective Agents
Sorond, F. A., & Ratan, R. R. (2000) · Antioxidants and Redox Signaling · doi:10.1089/15230860050192206 · Cited by 46
Loss of PINK1 Attenuates HIF-1α Induction by Preventing 4E-BP1-Dependent Switch in Protein Translation under Hypoxia
Lin, W., Wadlington, N. L., Chen, L., Zhuang, X., Brorson, J. R., & Kang, U. J. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2286-13.2014 · Cited by 47
EFFECTS OF DEFEROXAMINE-ACTIVATED HYPOXIA-INDUCIBLE FACTOR-1 ON THE BRAINSTEM AFTER SUBARACHNOID HEMORRHAGE IN RATS
Hishikawa, T., Ono, S., Ogawa, T., Tokunaga, K., Sugiu, K., & Date, I. (2008) · Neurosurgery · doi:10.1227/01.neu.0000311082.88766.33 · Cited by 45
The microenvironment for erythropoiesis is regulated by HIF-2α through VCAM-1 in endothelial cells
Yamashita, T., Ohneda, O., Sakiyama, A., Iwata, F., Ohneda, K., & Fujii-Kuriyama, Y. (2008) · Blood · doi:10.1182/blood-2007-11-122648 · Cited by 44
Landmark advances in the development of erythropoietin
Fisher, J. W. (2010) · Experimental Biology and Medicine · doi:10.1258/ebm.2010.010137 · Cited by 44
Hypoxia-inducible factor 1 and related gene products in anaesthetic-induced preconditioning
Hieber, S., Huhn, R., Hollmann, M. W., Weber, N. C., & Preckel, B. (2009) · European Journal of Anaesthesiology · doi:10.1097/eja.0b013e3283212cbb · Cited by 44
Involvement of Hif-1 in desferrioxamine-induced invasion of glioblastoma cells
Elstner, A., Holtkamp, N., & von Deimling, A. (2007) · Clinical & Experimental Metastasis · doi:10.1007/s10585-007-9057-y · Cited by 46
Copper promotion of angiogenesis in isolated rat aortic ring: role of vascular endothelial growth factor
Li, Q., Ding, X., & Kang, Y. J. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.08.013 · Cited by 44
Things get broken: the hypoxia-inducible factor prolyl hydroxylases in ischemic heart disease
Schreiber, T., Salhöfer, L., Quinting, T., & Fandrey, J. (2019) · Basic Research in Cardiology · doi:10.1007/s00395-019-0725-2 · Cited by 43
Iron chelation inhibits mTORC1 signaling involving activation of AMPK and REDD1/Bnip3 pathways
Shang, C., Zhou, H., Liu, W., Shen, T., Luo, Y., & Huang, S. (2020) · Oncogene · doi:10.1038/s41388-020-1366-5 · Cited by 43
Drug-Induced Reactivation of Apoptosis Abrogates HIV-1 Infection
Hanauske-Abel, H. M., Saxena, D., Palumbo, P. E., Hanauske, A.-R., Luchessi, A. D., Cambiaghi, T. D., Hoque, M., Spino, M., Gandolfi, D. D., Heller, D. S., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074414 · Cited by 43
Effects of CoCl2on multi-lineage differentiation of C3H/10T1/2 mesenchymal stem cells
Yoo, H., Moon, Y. H., & Kim, M. (2016) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2016.20.1.53 · Cited by 43
Expression of hypoxia-inducible factor 1α in mononuclear phagocytes infected with Leishmania amazonensis
Degrossoli, A., Bosetto, M. C., Lima, C. B. C., & Giorgio, S. (2007) · Immunology Letters · doi:10.1016/j.imlet.2007.09.009 · Cited by 44
Human apo-lactoferrin as a physiological mimetic of hypoxia stabilizes hypoxia-inducible factor-1 alpha
Zakharova, E. T., Kostevich, V. A., Av, S., & Vasilyev, V. B. (2012) · BioMetals · doi:10.1007/s10534-012-9586-y · Cited by 45
Retracted: Role of hypoxia‐inducible factors in the dexrazoxane‐mediated protection of cardiomyocytes from doxorubicin‐induced toxicity
Spagnuolo, R. D., Recalcati, S., Tacchini, L., & Cairo, G. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01208.x · Cited by 42
Retracted
Breathing at high altitude
Joseph, V., & Péquignot, J.-M. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0143-y · Cited by 42
Prolyl Hydroxylase Inhibitors Protect from the Bone Loss in Ovariectomy Rats by Increasing Bone Vascularity
Liu, X., Tu, Y., Zhang, L., Qi, J., Ma, T., & Deng, L. (2013) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-013-9780-8 · Cited by 43
Hypoxia-induced angiogenesis is increased by the controlled release of deferoxiamine from gelatin hydrogels
Saito, T., & Tabata, Y. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.04.021 · Cited by 42
Iron Chelators Inhibit VCAM-1 Expression in Human Dermal Microvascular Endothelial Cells
Koo, S., Casper, K. A., Otto, K. B., Gira, A. K., & Swerlick, R. A. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12144.x · Cited by 42
Dysregulation of ferroportin 1 interferes with spleen organogenesis in polycythaemia mice
Mok, H., Mendoza, M., Prchal, J. T., Balogh, P., & Schumacher, A. (2004) · Development · doi:10.1242/dev.01342 · Cited by 43
Mutual Regulation between Redox and Hypoxia-Inducible Factors in Cardiovascular and Renal Complications of Diabetes
Iacobini, C., Vitale, M., Haxhi, J., Pesce, C. M., Pugliese, G., & Menini, S. (2022) · Antioxidants · doi:10.3390/antiox11112183 · Cited by 43
Desferrioxamine Supports Metabolic Function in Primary Human Macrophages Infected With Mycobacterium tuberculosis
Phelan, J. J., McQuaid, K., Kenny, C., Gogan, K. M., Cox, D. J., Basdeo, S. A., O’Leary, S. M., Tazoll, S. C., Maoldomhnaigh, C. Ó., O’Sullivan, M. P., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00836 · Cited by 41
Unlocking mammalian regeneration through hypoxia inducible factor one alpha signaling
DeFrates, K. G., Franco, D., Heber‐Katz, E., & Messersmith, P. B. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2020.120646 · Cited by 43
Regulatory Effect of Hypoxia-Inducible Factor-1α on hCG-Stimulated Endothelin-2 Expression in Granulosa Cells from the PMSG-Treated Rat Ovary
Zhang, J., Zhang, Z., Wu, Y., Chen, L., Luo, Q., Chen, J., Huang, X., Cheng, Y., & Wang, Z. (2012) · Journal of Reproduction and Development · doi:10.1262/jrd.2012-089 · Cited by 41
Hypertonic induction of aquaporin-5: novel role of hypoxia-inducible factor-1α
Zhou, B., Ann, D. K., Li, X., Kim, K., Lin, H. H., Minoo, P., Crandall, E. D., & Borok, Z. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00070.2006 · Cited by 41
Design of homogeneous, monopegylated erythropoietin analogs with preserved in vitro bioactivity
Long, D. L., Doherty, D. H., Eisenberg, S. P., Smith, D. J., Rosendahl, M. S., Christensen, K. R., Edwards, D. P., Chlipala, E. A., & Cox, G. N. (2006) · Experimental Hematology · doi:10.1016/j.exphem.2006.02.011 · Cited by 41
Oxygen regulated gene expression: Erythropoietin as a model system
Ratcliffe, P. J., Ebert, B. L., Firth, J. D., Gleadle, J., Maxwell, P. H., Nagao, M., O'rourke, J. F., Pugh, C. W., & Wood, S. M. (1997) · Kidney International · doi:10.1038/ki.1997.72 · Cited by 41
Transferrin receptor 1 mRNA is downregulated in placenta of hepcidin transgenic embryos
Martin, M. E., Nicolas, G., Hetet, G., Vaulont, S., Grandchamp, B., & Beaumont, C. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.08.010 · Cited by 40
Promoting vascularization for tissue engineering constructs: current strategies focusing on HIF-regulating scaffolds
Esser, T. U., Roshanbinfar, K., & Engel, F. B. (2018) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2019.1561855 · Cited by 40
Identification and characterization of demethylase JMJD1A as a gene upregulated in the human cellular response to hypoxia
Sar, A., Ponjevic, D., Nguyen, M., Box, A. H., & Demetrick, D. J. (2009) · Cell and Tissue Research · doi:10.1007/s00441-009-0805-y · Cited by 40
Identification by phage display of single-domain antibody fragments specific for the ODD domain in hypoxia-inducible factor 1alpha
Groot, A. J., Verheesen, P., Westerlaken, E. J., Gort, E. H., van der Groep, P., Bovenschen, N., van der Wall, E., van Diest, P. J., & Shvarts, A. (2006) · Laboratory Investigation · doi:10.1038/labinvest.3700395 · Cited by 41
Lack of mitochondrial DNA impairs chemical hypoxia-induced autophagy in liver tumor cells through ROS-AMPK-ULK1 signaling dysregulation independently of HIF-1α
Marín, J. J. G., Lozano, E., & Perez, M. J. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.09.025 · Cited by 39
Hypoxia-inducible factors: roles in cardiovascular disease progression, prevention, and treatment
Semenza, G. L. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac089 · Cited by 43
Self-citation
Hypoxia‐Inducible Factor 1 Inhibitors
Melillo, G. (2007) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(07)35020-9 · Cited by 39
Anti-vascular agent Combretastatin A-4-P modulates Hypoxia Inducible Factor-1 and gene expression
Dachs, G. U., Steele, A. J., Coralli, C., Kanthou, C., Brooks, A. C., Gunningham, S. P., Currie, M. J., Watson, A. I., Robinson, B. A., & Tozer, G. M. (2006) · BMC Cancer · doi:10.1186/1471-2407-6-280 · Cited by 39
Iron-chelating agent desferrioxamine stimulates formation of neutrophil extracellular traps (NETs) in human blood-derived neutrophils
Völlger, L., Akong, K., Cox, L., Goldmann, O., Wang, Y., Schäfer, S. T., Naim, H. Y., Nizet, V., & von Köckritz‐Blickwede, M. (2016) · Bioscience Reports · doi:10.1042/bsr20160031 · Cited by 39
Hypoxia-Inducible Factor 2α Binds to Cobalt in Vitro
Yuan, Y., Beitner‐Johnson, D., & Millhorn, D. E. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5835 · Cited by 39
A mycobacterial iron chelator, desferri-exochelin, induces hypoxia-inducible factors 1 and 2, NIP3, and vascular endothelial growth factor in cancer cell lines.
Chong, T. W., Horwitz, L. D., Moore, J. W., Sowter, H., & Harris, A. L. (2002) · PubMed · Cited by 38
The effects of iron deficiency on estradiol-induced suppression of erythropoietin induction in rats: implications of pregnancy-related anemia
Horiguchi, H., Oguma, E., & Kayama, F. (2005) · Blood · doi:10.1182/blood-2004-06-2350 · Cited by 39
Hypoxia and panvascular diseases: exploring the role of hypoxia-inducible factors in vascular smooth muscle cells under panvascular pathologies
Hu, Y., Zhao, Y., Li, P., Lu, H., Li, H., & Ge, J. (2023) · 中国科学通报：英文版 · doi:10.1016/j.scib.2023.07.032 · Cited by 37
Hypoxia enhances MUC1 expression in a lung adenocarcinoma cell line
Mikami, Y., Hisatsune, A., Tashiro, T., Isohama, Y., & Katsuki, H. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.01.002 · Cited by 37
Hypoxia-Inducible Factor-1α Mediates Increased Sympathoexcitation via Glutamatergic N-Methyl- d -Aspartate Receptors in the Paraventricular Nucleus of Rats With Chronic Heart Failure
Sharma, N. M., Cunningham, C., Zheng, H., Liu, X., & Patel, K. P. (2016) · Circulation Heart Failure · doi:10.1161/circheartfailure.116.003423 · Cited by 37
Modulating Iron for Metabolic Support of TB Host Defense
Phelan, J. J., Basdeo, S. A., Tazoll, S. C., McGivern, S., Saborido, J. R., & Keane, J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02296 · Cited by 37
Effects of prolyl hydroxylase inhibitors on adipogenesis and hypoxia inducible factor 1 alpha levels under normoxic conditions
Floyd, Z. E., Kilroy, G. E., Wu, X., & Gimble, J. M. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21266 · Cited by 37
Hypoxia activates signal transducers and activators of transcription 5 (STAT5) and increases its binding activity to the GAS element in mammary epithelial cells
Joung, Y.-H., Park, J., Park, T., Lee, C., Kim, O. H., Ye, S., Yang, U. M., Lee, K. J., & Yang, Y. M. (2003) · Experimental & Molecular Medicine · doi:10.1038/emm.2003.46 · Cited by 37
The role of the bone marrow in allergy and asthma
Denburg, J. A., Inman, M. D., Leber, B. F., Sehmi, R., & O’Byrne, P. M. (1996) · Allergy · doi:10.1111/j.1398-9995.1996.tb04578.x · Cited by 37
Dibenzoylmethane, a natural dietary compound, induces HIF-1α and increases expression of VEGF
Mabjeesh, N. J., Willard, M. T., Harris, W. B., Sun, H.-Y., Wang, R., Zhong, H., Umbreit, J. N., & Simons, J. W. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00336-x · Cited by 37
Hypoxia-inducible factor-1 mediates pancreatic β-cell dysfunction by intermittent hypoxia
Wang, N., Shi, X., Khan, S. A., Wang, B. L., Semenza, G. L., Prabhakar, N. R., & Nanduri, J. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00309.2020 · Cited by 38
Self-citation
Lysyl Oxidase, A Critical Intra- and Extra-Cellular Target in the Lung for Cigarette Smoke Pathogenesis
Li, W., Zhou, J., Chen, L., Luo, Z., & Zhao, Y. (2011) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph8010161 · Cited by 36
Modulating the hypoxia-inducible factor signaling pathway as a therapeutic modality to regulate retinal angiogenesis
DeNiro, M., Alsmadi, O. A., & Al-Mohanna, F. A. (2009) · Experimental Eye Research · doi:10.1016/j.exer.2009.06.013 · Cited by 37
Hypoxia-driven cell motility reflects the interplay between JMY and HIF-1α
Coutts, A. S., Pires, I. M., Weston, L., Buffa, F. M., Milani, M., Li, J., Harris, A. L., Hammond, E. M., & Thangue, N. B. L. (2011) · Oncogene · doi:10.1038/onc.2011.188 · Cited by 37
UCN-01, a Protein Kinase C Inhibitor, Inhibits Endothelial Cell Proliferation and Angiogenic Hypoxic Response
Kruger, E. A., Blagosklonny, M. V., Dixon, S. C., & Figg, W. D. (2000) · Invasion and Metastasis · doi:10.1159/000024514 · Cited by 36
The hypoxic response and aging
Kaeberlein, M. R., & Kapahi, P. (2009) · Cell Cycle · doi:10.4161/cc.8.15.9126 · Cited by 36
Hypoxia-regulated retinal glial cell-specific promoter for potential gene therapy in disease
Prentice, H. M., Biswal, M. R., Dorey, C. K., & Blanks, J. C. (2011) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.10-6835 · Cited by 35
Endothelial differentiation of bone marrow mesenchyme stem cells applicable to hypoxia and increased migration through Akt and NFκB signals
Liu, C., Tsai, A.-L., Li, P.-C., Huang, C.-W., & Wu, C. (2017) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0470-0 · Cited by 35
Breakthrough science: hypoxia-inducible factors, oxygen sensing, and disorders of hematopoiesis
Semenza, G. L. (2021) · Blood · doi:10.1182/blood.2021011043 · Cited by 39
Self-citation
CoCl2-simulated hypoxia in skeletal muscle cell lines: Role of free radicals in gene up-regulation and induction of apoptosis
Ciafrè, S. A., Niola, F., Giorda, E., Farace, M. G., & Caporossi, D. (2006) · Free Radical Research · doi:10.1080/10715760601096799 · Cited by 35
Oxygen sensing and response to hypoxia by mammalian cells
Wang, G.-L., & Semenza, G. L. (1996) · Redox Report · doi:10.1080/13510002.1996.11747034 · Cited by 35
Self-citation

Authors: Wang, G., & Semenza, G.
Affiliations: Johns Hopkins University (US)
Venue: Blood
Publisher: American Society of Hematology
Published: 1993-12-15
Volume: 82
Issue: 12
Pages: 3610-3615
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood.v82.12.3610.3610
OpenAlex: W1545825939
Cited by: 766
References: 33
Citations by year: 2026: 4 · 2025: 9 · 2024: 12 · 2023: 24 · 2022: 18 · 2021: 26 · 2020: 24 · 2019: 18 · 2018: 19 · 2017: 17 · 2016: 34 · 2015: 24 · 2014: 26 · 2013: 26 · 2012: 32
FWCI: 5.23
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Blood (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01dk039869-16)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 39869)
Topics: Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
Keywords: deferoxamine, erythropoietin gene expression, HIF-1, iron chelation, cobalt chloride, Hep3B cells, ferrous ammonium sulfate, cycloheximide, de novo protein synthesis
MeSH terms: Base Sequence, Cell Line, Cell Nucleus, Cobalt, Deferoxamine, DNA-Binding Proteins, Erythropoietin, Humans, Liver Neoplasms, Molecular Sequence Data, Nuclear Proteins, RNA, Neoplasm, Transcription Factors, Tumor Cells, Cultured, Oligonucleotide Probes, Signal Transduction, Cell Hypoxia, Gene Expression, Hepatoblastoma, Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor 1, alpha Subunit

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Desferrioxamine induces erythropoietin gene expression and hypoxia- inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks