Cited by 766Erythropoietin and Anemia TreatmentCancer, Hypoxia, and MetabolismHemoglobin structure and function

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Desferrioxamine induces erythropoietin gene expression and hypoxia- inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction

Open access

Wang, GL, Semenza, GL·1993·Blood

Open this paper in CoChat — free account Open PDF

Abstract

Erythropoietin (EPO) gene transcription is activated in kidney cells in vivo and in Hep3B cells exposed to hypoxia or cobalt chloride. Hypoxia- inducible factor 1 (HIF-1) is a nuclear factor that binds to the hypoxia-inducible enhancer of the EPO gene at a site that is required for transcriptional activation. HIF-1 DNA-binding activity is induced by hypoxia or cobalt chloride treatment of Hep3B cells. We report that treatment of Hep3B cells with desferrioxamine (DFX) induced HIF-1 activity and EPO RNA expression with kinetics similar to the induction of HIF-1 by hypoxia or cobalt chloride. Induction by each of these stimuli was inhibited by cycloheximide, indicating a requirement for de novo protein synthesis. DFX appears to induce HIF-1 by chelating iron as induction was inhibited by coadministration of ferrous ammonium sulfate. DFX administration to mice transiently increased EPO RNA levels in the kidney. As previously shown for hypoxia and cobalt treatment, DFX also induced HIF-1 activity in non-EPO-producing cells, suggesting the existence of a common hypoxia signal-transduction pathway leading to HIF-1 induction in different cell types.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1182/blood.v82.12.3610.3610

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
Semenza, G. L., & Wang, G. L. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.12.5447 · Cited by 2,617
Self-citation
General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.
Wang, G. L., & Semenza, G. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.9.4304 · Cited by 1,468
Self-citation
Erythropoietin: structure, control of production, and function
JELKMANN, W. E. B. (1992) · Physiological Reviews · doi:10.1152/physrev.1992.72.2.449 · Cited by 1,167
Regulation of the Erythropoietin Gene: Evidence That the Oxygen Sensor Is a Heme Protein
Goldberg, M. A., Dunning, S. P., & Bunn, H. F. (1988) · Science · doi:10.1126/science.2849206 · Cited by 1,032
Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene.
Semenza, G. L., Nejfelt, M. K., Chi, S. M., & Antonarakis, S. E. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.13.5680 · Cited by 990
Self-citation
Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia.
Wang, G. L., & Semenza, G. L. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80571-7 · Cited by 863
Self-citation
A haemoprotein with kinase activity encoded by the oxygen sensor of Rhizobium meliloti
Gilles‐Gonzalez, M., Ditta, G. S., & Helinski, D. R. (1991) · Nature · doi:10.1038/350170a0 · Cited by 477
Localization of erythropoietin synthesizing cells in murine kidneys by in situ hybridization
Koury, S., Bondurant, M. C., & Koury, M. (1988) · Blood · doi:10.1182/blood.v71.2.524.524 · Cited by 469
Peritubular cells are the site of erythropoietin synthesis in the murine hypoxic kidney.
Lacombe, C., Silva, J. L. D., Bruneval, P., Fournier, J. G., Wendling, F., Casadevall, N., Camilleri, J.-P., Bariety, J., Varet, B. R., & Tambourin, P. E. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113363 · Cited by 437

Show all 33 references

Sorted by citations

Items 101–200 of 761

Functional Requirement of the Hypoxia-responsive Element in the Activation of the Inducible Nitric Oxide Synthase Promoter by the Iron Chelator Desferrioxamine
Melillo, G., Taylor, L. S., Brooks, A., Musso, T., Cox, G. W., & Varesio, L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.18.12236 · Cited by 201
Proliferation and differentiation of bone marrow stromal cells under hypoxic conditions
Ren, H., Cao, Y., Zhao, Q., Li, J., Zhou, C.-X., Liao, L., Jia, M., Zhao, Q., Cai, H., Han, Z., et al. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.05.169 · Cited by 201
Regulation of gene expression by oxygen: NF-κB and HIF-1, two extremes
Michiels, C., Minet, E., Mottet, D., & Raes, M. J. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01045-6 · Cited by 202
Cancer Drug Discovery and Development
Humphrey, J. S., Price, K., Gupta, E., Baxter, A. R. W., Bird, J., Sonnichsen, D. S., & Naglich, J. G. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-325-5_21 · Cited by 195
Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system
Zhou, Y.-D., Barnard, M., Tian, H., Li, X., Ring, H. Z., Francke, U., Shelton, J. M., Richardson, J. A., Russell, D. W., & McKnight, S. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.2.713 · Cited by 195
HIF-1: the knowns and unknowns of hypoxia sensing.
Zagórska, A., & Dulak, J. (2004) · Acta Biochimica Polonica · doi:10.18388/abp.2004_3545 · Cited by 194
Effects of Iron Supplementation and Depletion on Hypoxic Pulmonary Hypertension
Smith, T. G., Talbot, N. P., Privat, C., Rivera, M. C., Nickol, A. H., Ratcliffe, P. J., Dorrington, K. L., Lèon‐Velarde, F., & Robbins, P. A. (2009) · JAMA · doi:10.1001/jama.2009.1404 · Cited by 195
Hypoxia-inducible factor induction by tumour necrosis factor in normoxic cells requires receptor-interacting protein-dependent nuclear factor kappaB activation
Jung, Y., Isaacs, J. S., Lee, S., Trepel, J. B., Liu, Z.-G., & Neckers, L. (2003) · Biochemical Journal · doi:10.1042/bj20021279 · Cited by 193
Oxygen-Regulated Gene Expression in Bovine Blastocysts1
Harvey, A. J., Kind, K. L., Pantaleon, M., Armstrong, D. T., & Thompson, J. G. (2004) · Biology of Reproduction · doi:10.1095/biolreprod.104.028639 · Cited by 189
Heme Oxygenase-1: Molecular Mechanisms of Gene Expression in Oxygen-Related Stress
Ryter, S. W., & Choi, A. M. K. (2002) · Antioxidants and Redox Signaling · doi:10.1089/15230860260220120 · Cited by 189
Transcriptional Activation of the Human Leptin Gene in Response to Hypoxia
Ambrosini, G., Nath, A. K., Sierra-Honigmann, M. R., & Flores-Riveros, J. R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205172200 · Cited by 188
Hypoxia-inducible factors link iron homeostasis and erythropoiesis
Shah, Y. M., & Xie, L. (2014) · Gastroenterology · doi:10.1053/j.gastro.2013.12.031 · Cited by 187
Erythropoietin: a Model System for Studying Oxygen-Dependent Gene Regulation
Bunn, H. F., Gu, J., Huang, L. E., Park, J., & Zhu, H. (1998) · Journal of Experimental Biology · doi:10.1242/jeb.201.8.1197 · Cited by 187
Redox regulation of the hypoxia-inducible factor
Pouysségur, J., & Mechta-Grigoriou, F. (2006) · Biological Chemistry · doi:10.1515/bc.2006.167 · Cited by 186
Desferrioxamine Induces Delayed Tolerance against Cerebral Ischemia in Vivo and in Vitro
Prass, K., Ruscher, K., Karsch, M., Исаев, Н. К., Megow, D., Priller, J., Scharff, A., Dirnagl, U., & Meisel, A. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200205000-00003 · Cited by 185
HIFs and tumors—causes and consequences
Höpfl, G., Ogunshola, O. O., & Gassmann, M. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00538.2003 · Cited by 186
Hypoxia Stimulates Urokinase Receptor Expression Through a Heme Protein-Dependent Pathway
Graham, C. H., Fitzpatrick, T. E., & McCrae, K. R. (1998) · Blood · doi:10.1182/blood.v91.9.3300 · Cited by 184
Regulation of hypoxia-inducible factor 1α and induction of vascular endothelial growth factor in a rat neonatal stroke model
Mu, D., Jiang, X., Sheldon, R. A., Fox, C. K., Hamrick, S. E. G., Vexler, Z. S., & Ferriero, D. M. (2003) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.08.020 · Cited by 178
Sustained expression of Hif‐1α in the diabetic environment promotes angiogenesis and cutaneous wound repair
Mace, K. A., Yu, D. H., Paydar, K. Z., Boudreau, N. J., & Young, D. M. (2007) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2007.00278.x · Cited by 182
Expression, Ontogeny, and Regulation of Hypoxia-Inducible Transcription Factors in the Human Placenta1
Rajakumar, A., & Conrad, K. P. (2000) · Biology of Reproduction · doi:10.1095/biolreprod63.2.559 · Cited by 177
Hypoxia death stimulus induces translocation of p53 protein to mitochondria
Sansome, C., Zaika, A., Marchenko, N. D., & Moll, U. M. (2001) · FEBS Letters · doi:10.1016/s0014-5793(00)02368-1 · Cited by 180
HIF Hydroxylase Pathways in Cardiovascular Physiology and Medicine
Bishop, T., & Ratcliffe, P. J. (2015) · Circulation Research · doi:10.1161/circresaha.117.305109 · Cited by 172
Negative Regulation of Hypoxic Responses via Induced Reptin Methylation
Lee, J. S., Kim, Y.-H., Kim, I. S., Kim, B., Choi, H. J., Lee, J. M., Shin, H. R., Kim, J. H., Kim, J.-Y., Seo, S., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.008 · Cited by 172
Self-citation
Vascular Responses to Hypoxia and Ischemia
Semenza, G. L. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.181644 · Cited by 169
Self-citation
2-Methoxyestradiol Inhibits Hypoxia-Inducible Factor-1α and Suppresses Growth of Lesions in a Mouse Model of Endometriosis
Becker, C. M., Rohwer, N., Funakoshi, T., Cramer, T., Bernhardt, W., Birsner, A. E., Folkman, J., & D’Amato, R. J. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.061244 · Cited by 169
Cold ischemic injury of transplanted kidneys: new insights from experimental studies
Salahudeen, A. K. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00098.2004 · Cited by 166
The anaemia of cancer: death by a thousand cuts
Spivak, J. L. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1648 · Cited by 166
Oxygen sensing and signaling: impact on the regulation of physiologically important genes
Zhu, H., & Bunn, H. F. (1999) · Respiration Physiology · doi:10.1016/s0034-5687(99)00024-9 · Cited by 162
The increase in pulmonary arterial pressure caused by hypoxia depends on iron status
Smith, T. G., Balanos, G. M., Croft, Q. P. P., Talbot, N. P., Dorrington, K. L., Ratcliffe, P. J., & Robbins, P. A. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.160960 · Cited by 162
Hypoxia-inducible factors and diabetes
Gunton, J. E. (2020) · Journal of Clinical Investigation · doi:10.1172/jci137556 · Cited by 159
Regulation of hypoxia-inducible factor 1 and the loss of the cellular response to hypoxia in diabetes
Bento, C. F., & Pereira, P. (2011) · Diabetologia · doi:10.1007/s00125-011-2191-8 · Cited by 163
Interactions between nitric oxide and hypoxia-inducible factor signaling pathways in inflammatory disease
Olson, N. C., & van der Vliet, A. (2011) · Nitric Oxide · doi:10.1016/j.niox.2010.12.010 · Cited by 161
Oxidative Stress and Transcriptional Regulation in Alzheimer Disease
Shi, Q., & Gibson, G. E. (2007) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e31815721c3 · Cited by 158
Hypoxia-inducible Expression of a Natural cis-Antisense Transcript Inhibits Endothelial Nitric-oxide Synthase
Fish, J. E., Matouk, C. C., Yeboah, E., Bevan, S. C., Khan, M., Patil, K., Ohh, M., & Marsden, P. A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608318200 · Cited by 156
Adaptive Cellular Stress Pathways as Therapeutic Targets of Dietary Phytochemicals: Focus on the Nervous System
Lee, J., Jo, D., Park, D., Chung, H. Y., & Mattson, M. P. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.007757 · Cited by 155
Production of IL-1 receptor antagonist by hepatocytes is regulated as an acute-phase proteinin vivo
Gabay, C., Gigley, J. P., Sipe, J. D., Arend, W. P., & Fantuzzi, G. (2001) · European Journal of Immunology · doi:10.1002/1521-4141(200102)31:2 · Cited by 61
Translocation of iron from lysosomes into mitochondria is a key event during oxidative stress-induced hepatocellular injury
Uchiyama, A., Kim, J.-S., Kon, K., Jaeschke, H., Ikejima, K., Watanabe, S., & Lemasters, J. J. (2008) · Hepatology · doi:10.1002/hep.22498 · Cited by 154
Isoenzyme-specific regulation of genes involved in energy metabolism by hypoxia: similarities with the regulation of erythropoietin
Ebert, B. L., Gleadle, J., O'ROURKE, J. F., Bartlett, S. M., Poulton, J., & Ratcliffe, P. J. (1996) · Biochemical Journal · doi:10.1042/bj3130809 · Cited by 150
The HIF pathway as a therapeutic target
Hewitson, K. S., & Schofield, C. J. (2004) · Drug Discovery Today · doi:10.1016/s1359-6446(04)03202-7 · Cited by 148
Selective Overexpression of the Hypoxia-Inducible Transcription Factor, HIF-2α, in Placentas from Women with Preeclampsia1
Rajakumar, A., Whitelock, K. A., Weissfeld, L. A., Daftary, A. R., Marković, N., & Conrad, K. P. (2001) · Biology of Reproduction · doi:10.1093/biolreprod/64.2.499 · Cited by 152
Hypoxia Post-translationally Activates Iron-regulatory Protein 2
Hanson, E. S., Foot, L. M., & Leibold, E. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.8.5047 · Cited by 146
Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores
Hartmann, H., Eltzschig, H. K., Wurz, H., Hantke, K., Rakin, A., Yazdi, A. S., Matteoli, G., Bohn, E., Autenrieth, I. B., Karhausen, J., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.12.008 · Cited by 143
Interleukin-10 Deficiency Impairs Bone Marrow–Derived Endothelial Progenitor Cell Survival and Function in Ischemic Myocardium
Krishnamurthy, P., Thal, M. A., Verma, S. K., Hoxha, E., Lambers, E., Ramirez, V., Qin, G., Losordo, D. W., & Kishore, R. (2011) · Circulation Research · doi:10.1161/circresaha.111.248369 · Cited by 143
Synergistic effects of CoCl2 and ROCK inhibition on mesenchymal stem cell differentiation into neuron-like cells
Pacary, E., Legros, H., Valable, S., Duchatelle, P., Lecocq, M., Petit, E., Nicole, O., & Bernaudin, M. (2006) · Journal of Cell Science · doi:10.1242/jcs.03004 · Cited by 145
The Role of Hypoxia Inducible Factor 1 in Cobalt Chloride Induced Cell Death in Mouse Embryonic Fibroblasts
Vengellur, A. (2004) · Toxicological Sciences · doi:10.1093/toxsci/kfh278 · Cited by 142
Involvement of Drp1 in hypoxia-induced migration of human glioblastoma U251 cells
Wan, Y., Zhang, J., Yang, Z., Jiang, L., WEI, Y.-F., Lai, Q., WANG, J.-B., XIN, H.-B., & Han, X. (2014) · Oncology Reports · doi:10.3892/or.2014.3235 · Cited by 144
Oxygen‐dependent regulation of hypoxia‐inducible factors by prolyl and asparaginyl hydroxylation
Lando, D., Gorman, J. J., Whitelaw, M. L., & Peet, D. J. (2003) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2003.03445.x · Cited by 138
Hypoxia Up-regulates Expression of Peroxisome Proliferator-activated Receptor γ Angiopoietin-related Gene (PGAR) in Cardiomyocytes: Role of Hypoxia Inducible Factor 1α
Belanger, A. J., Lu, H., Date, T., Liu, L. X., Vincent, K. A., Akita, G. Y., Cheng, S. H., Gregory, R. J., & Jiang, C. (2002) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2002.2021 · Cited by 137
HIF-1
Maxwell, P. H. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000092792.97122.e0 · Cited by 134
Regulation of Erythropoietin Production: New Insights Into Molecular Mechanisms of Oxygen Homeostasis
Semenza, G. L. (1994) · Hematology/Oncology Clinics of North America · doi:10.1016/s0889-8588(18)30134-5 · Cited by 134
Self-citation
Role of HIF-1 and NF-κB Transcription Factors in the Modulation of Transferrin Receptor by Inflammatory and Anti-inflammatory Signals
Tacchini, L., Gammella, E., De Ponti, C., Recalcati, S., & Cairo, G. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800365200 · Cited by 132
Stabilization of Vascular Endothelial Growth Factor mRNA by Hypoxia-Inducible Factor 1
Liu, L. X., Lu, H., Luo, Y., Date, T., Belanger, A. J., Vincent, K. A., Akita, G. Y., Goldberg, M. A., Cheng, S. H., Gregory, R. J., et al. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6551 · Cited by 131
Candidate genes for the hypoxic tumor phenotype.
Koong, A. C., Denko, N. C., Hudson, K. M., Schindler, C., Swiersz, L. M., Koch, C., Evans, S. M., Ibrahim, H., Le, Q., Terris, D. J., et al. (2000) · PubMed · Cited by 130
Inhibition of prolyl hydroxylases by dimethyloxaloylglycine after stroke reduces ischemic brain injury and requires hypoxia inducible factor-1α
Ogle, M. E., Gu, X., Espinera, A. R., & Wei, L. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.10.020 · Cited by 130
Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intact
Doege, K., Heine, S., Jensen, I., Jelkmann, W., & Metzen, E. (2005) · Blood · doi:10.1182/blood-2005-03-1138 · Cited by 128
Cell functions impaired by frataxin deficiency are restored by drug-mediated iron relocation
Kakhlon, O., Manning, H., Breuer, W. V., Melamed‐Book, N., Lu, C., Cortopassi, G. A., Münnich, A., & Cabantchik, Z. I. (2008) · Blood · doi:10.1182/blood-2008-06-161919 · Cited by 131
Hypoxia-Inducible Factor 1
Semenza, G. L., Agani, F. H., Iyer, N. V., Jiang, B., Leung, S., Wiener, C., & Yu, A. Y. (1998) · CHEST Journal · doi:10.1378/chest.114.1_supplement.40s · Cited by 127
Self-citation
Neonatal Iron Deficiency Causes Abnormal Phosphate Metabolism by Elevating FGF23 in Normal and ADHR Mice
Clinkenbeard, E. L., Farrow, E., Summers, L. J., Cass, T. A., Roberts, J. L., Bayt, C. A., Lahm, T., Albrecht, M. E., Allen, M. R., Peacock, M., et al. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2049 · Cited by 126
Pharmacological targeting of the HIF hydroxylases – A new field in medicine development
Chan, M. C., Holt‐Martyn, J. P., Schofield, C. J., & Ratcliffe, P. J. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.01.001 · Cited by 128
Nitric oxide and superoxide: Interference with hypoxic signaling
Brüne, B., & ZHOU, J. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.03.005 · Cited by 128
Delayed administration of deferoxamine reduces brain damage and promotes functional recovery after transient focal cerebral ischemia in the rat
Fréret, T., Valable, S., Chazalviel, L., Saulnier, R., MacKenzie, E. T., Petit, E., Bernaudin, M., Boulouard, M., & Schumann‐Bard, P. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04699.x · Cited by 125
Hypoxia‐induced vascular endothelial growth factor expression in normal rat astrocyte cultures
Ijichi, A., Sakuma, S., & Tofilon, P. J. (1995) · Glia · doi:10.1002/glia.440140203 · Cited by 125
Cadmium Induces Anemia through Interdependent Progress of Hemolysis, Body Iron Accumulation, and Insufficient Erythropoietin Production in Rats
Horiguchi, H., Oguma, E., & Kayama, F. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr100 · Cited by 126
Oxygen Regulation of Gene Expression: A Study in Opposites
D’Angio, C. T., & Finkelstein, J. N. (2000) · Molecular Genetics and Metabolism · doi:10.1006/mgme.2000.3074 · Cited by 123
Hypoxia and the regulation of gene expression
Gleadle, J., & Ratcliffe, P. J. (1998) · Molecular Medicine Today · doi:10.1016/s1357-4310(97)01198-2 · Cited by 124
β2-Microglobulin Induces Epithelial to Mesenchymal Transition and Confers Cancer Lethality and Bone Metastasis in Human Cancer Cells
Josson, S., Nomura, T., Lin, J., Huang, W., Wu, D., Zhau, H. E., Zayzafoon, M., Weizmann, M. N., Gururajan, M., & Chung, L. W. K. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3382 · Cited by 122
Regulation of Iron Regulatory Protein 1 during Hypoxia and Hypoxia/Reoxygenation
Hanson, E. S., & Leibold, E. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.13.7588 · Cited by 122
HIF at the crossroads between ischemia and carcinogenesis
Paul, S., Simons, J. W., & Mabjeesh, N. J. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.10479 · Cited by 122
Hypoxia and sterile inflammation in cystic fibrosis airways: mechanisms and potential therapies
Montgomery, S., Mall, M. A., Kicic, A., & Stick, S. M. (2016) · European Respiratory Journal · doi:10.1183/13993003.00903-2016 · Cited by 130
Hypoxia induces class III beta-tubulin gene expression by HIF-1α binding to its 3' flanking region
Raspaglio, G., Filippetti, F., Prislei, S., Penci, R., Maria, I. D., Cicchillitti, L., Mozzetti, S., Scambia, G., & Ferlini, C. (2007) · Gene · doi:10.1016/j.gene.2007.11.015 · Cited by 119
Hsp27 Upregulation by HIF-1 Signaling Offers Protection against Retinal Ischemia in Rats
Whitlock, N. A., Agarwal, N. A., Ma, J., & Crosson, C. E. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-0043 · Cited by 119
Induction of T-type Calcium Channel Gene Expression by Chronic Hypoxia
Toro, R. D., Levitsky, K. L., López‐Barneo, J., & Chiara, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212576200 · Cited by 118
Lack of Evidence for the Involvement of the Phosphoinositide 3-Kinase/Akt Pathway in the Activation of Hypoxia-inducible Factors by Low Oxygen Tension
Álvarez-Tejado, M., Alfranca, A., Aragonés, J., Vara, A., Landázuri, M. O., & del Peso, L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200017200 · Cited by 118
Regulation of Hypoxia-Inducible Factor (HIF)-1 Activity and Expression of HIF Hydroxylases in Response to Insulin-Like Growth Factor I
Treins, C., Giorgetti‐Peraldi, S., Murdaca, J., Monthouel, M.-N., & OBBERGHEN, E. V. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0239 · Cited by 119
General applicability of chicken egg yolk antibodies: the performance of IgY immunoglobulins raised against the hypoxia‐inducible factor 1α
Camenisch, G., TINI, M., Chilov, D., Kvietikova, I., Srinivas, V., CARO, J., Spielmann, P., Wenger, R. H., & Gassmann, M. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.1.81 · Cited by 117
Iron: An Essential Element of Cancer Metabolism
Hsu, M. Y., Mina, E., Roetto, A., & Porporato, P. E. (2020) · Cells · doi:10.3390/cells9122591 · Cited by 119
Cobalt induces hypoxia-inducible factor-1α (HIF-1α) in HeLa cells by an iron-independent, but ROS-, PI-3K- and MAPK-dependent mechanism
Triantafyllou, A., Liakos, P., Tsakalof, A. K., Georgatsou, E., Simos, G., & Bonanou, S. (2006) · Free Radical Research · doi:10.1080/10715760600730810 · Cited by 122
Hypoxia-inducible factor 1–mediated characteristic features of cancer cells for tumor radioresistance
Harada, H. (2016) · Journal of Radiation Research · doi:10.1093/jrr/rrw012 · Cited by 116
Identification of Hypoxically Inducible mRNAs in HeLa Cells Using Differential‐Display PCR
O'rourke, J. F., Pugh, C. W., Bartlett, S. M., & Ratcliffe, P. J. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.00403.x · Cited by 113
Induction of heme oxygenase-1 by hypoxia and free radicals in human dermal fibroblasts
Panchenko, M. V., Farber, H. W., & Korn, J. H. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.278.1.c92 · Cited by 113
Genetic regulation of cell function in response to iron overload or chelation
Templeton, D. M., & Liu, Y. (2003) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00497-x · Cited by 112
Hypoxia-inducible factor 1α and erythropoietin upregulation with deferoxamine salvage after neonatal stroke
Mu, D., Chang, Y. S., Vexler, Z. S., & Ferriero, D. M. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.06.001 · Cited by 109
ATF4-dependent transcription is a key mechanism in VEGF up-regulation by oxidized phospholipids: critical role of oxidized sn-2 residues in activation of unfolded protein response
Oskolkova, O., Afonyushkin, T., Leitner, A., von Schlieffen, E., Gargalovic, P. S., Lusis, A. J., Binder, B. R., & Bochkov, V. N. (2008) · Blood · doi:10.1182/blood-2007-09-112870 · Cited by 114
Injectable deferoxamine nanoparticles loaded chitosan-hyaluronic acid coacervate hydrogel for therapeutic angiogenesis
Selvaprithiviraj, V., Sivashanmugam, A., Mohandas, A., Janarthanan, R., Iyer, S., Nair Shantikumar, V., & Jayakumar, R. (2017) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2017.10.033 · Cited by 107
Impaired Oxygen-dependent Reduction of HIF-1α and -2α Proteins in Pre-eclamptic Placentae
Rajakumar, A., Doty, K. D., Daftary, A., Harger, G. F., & Conrad, K. P. (2003) · Placenta · doi:10.1053/plac.2002.0893 · Cited by 108
Expression of Hypoxia-inducible Factor-1 and Vascular Endothelial Growth Factor in Response to Venous Hypertension
Zhu, Y., Lawton, M. T., Du, R., Shwe, Y., Chen, Y., Shen, F., Young, W. L., & Yang, G. (2006) · Neurosurgery · doi:10.1227/01.neu.0000228962.68204.cf · Cited by 106
A role for hypoxia-inducible factor-1α in desferoxamine neuroprotection
Hamrick, S. E. G., McQuillen, P. S., Jiang, X., Mu, D., Madan, A., & Ferriero, D. M. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2004.12.080 · Cited by 107
Expression of proinflammatory cytokines via HIF-1α and NF-κB activation on desferrioxamine-stimulated HMC-1 cells
Jeong, H., Chung, H., Lee, B., Kim, S.-J., Yoo, S., Hong, S., & Kim, H. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01073-8 · Cited by 107
Hypoxia-inducible factor in brain
Sharp, F. R., Bergeron, M., & Bernaudin, M. (2001) · Advances in experimental medicine and biology · doi:10.1007/978-1-4757-3401-0_18 · Cited by 105
Endothelial Cell-Derived Nitric Oxide Enhances Aerobic Glycolysis in Astrocytes via HIF-1 -Mediated Target Gene Activation
Brix, B., Mesters, J. R., Pellerin, L., & Jöhren, O. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0879-12.2012 · Cited by 103
Antiangiogenic activity of genistein in pancreatic carcinoma cells is mediated by the inhibition of hypoxia‐inducible factor‐1 and the down‐regulation of VEGF gene expression
Büchler, P., Reber, H. A., Büchler, M. W., Frieß, H., Lavey, R. S., & Hines, O. J. (2003) · Cancer · doi:10.1002/cncr.11873 · Cited by 104
Clinical iron deficiency disturbs normal human responses to hypoxia
Frise, M. C., Cheng, H., Nickol, A. H., Curtis, M. K., Pollard, K. A., Roberts, D. J., Ratcliffe, P. J., Dorrington, K. L., & Robbins, P. A. (2016) · Journal of Clinical Investigation · doi:10.1172/jci85715 · Cited by 106
The antimycotic ciclopirox olamine induces HIF‐1α stability, VEGF expression, and angiogenesis
Linden, T., Katschinski, D. M., Eckhardt, K., Scheid, A., Pagel, H., & Wenger, R. H. (2003) · The FASEB Journal · doi:10.1096/fj.02-0586fje · Cited by 102
Expression of the neurotrophin receptor TrkA down-regulates expression and function of angiogenic stimulators in SH-SY5Y neuroblastoma cells.
Eggert, A., Grotzer, M. A., Ikegaki, N., Liu, X. G., Evans, A. E., & Brodeur, G. M. (2002) · PubMed · Cited by 100
JNK1 Mediates Degradation HIF-1α by a VHL-Independent Mechanism that Involves the Chaperones Hsp90/Hsp70
Zhang, D., Li, J., Costa, M., Gao, J., & Huang, C. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-0448 · Cited by 99
New agents that stimulate erythropoiesis
Bunn, H. F. (2006) · Blood · doi:10.1182/blood-2006-08-019083 · Cited by 99
Iron Chelation by Deferoxamine Prevents Renal Interstitial Fibrosis in Mice with Unilateral Ureteral Obstruction
Ikeda, Y., Ozono, I., Tajima, S., Imao, M., Horinouchi, Y., Izawa-Ishizawa, Y., Kihira, Y., Miyamoto, L., Ishizawa, K., Tsuchiya, K., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089355 · Cited by 98
Inhibition of Prolyl Hydroxylase Protects against 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Neurotoxicity
Lee, D. W., Rajagopalan, S., Siddiq, A., Gwiazda, R. H., Yang, L., Beal, M. F., Ratan, R. R., & Andersen, J. K. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.000638 · Cited by 97
Iron-Sensing Proteins that Regulate Hepcidin and Enteric Iron Absorption
Knutson, M. D. (2010) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.012809.104801 · Cited by 96
Hypoxia and RAS-signaling pathways converge on, and cooperatively downregulate, the RECK tumor-suppressor protein through microRNAs
Loayza‐Puch, F., Yoshida, Y., Matsuzaki, T., Takahashi, C., Kitayama, H., & Noda, M. (2010) · Oncogene · doi:10.1038/onc.2010.23 · Cited by 97

Authors: Wang, G., & Semenza, G.
Affiliations: Johns Hopkins University (US)
Venue: Blood
Publisher: American Society of Hematology
Published: 1993-12-15
Volume: 82
Issue: 12
Pages: 3610-3615
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood.v82.12.3610.3610
OpenAlex: W1545825939
Cited by: 766
References: 33
Citations by year: 2026: 4 · 2025: 9 · 2024: 12 · 2023: 24 · 2022: 18 · 2021: 26 · 2020: 24 · 2019: 18 · 2018: 19 · 2017: 17 · 2016: 34 · 2015: 24 · 2014: 26 · 2013: 26 · 2012: 32
FWCI: 5.23
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Blood (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01dk039869-16)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 39869)
Topics: Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
Keywords: deferoxamine, erythropoietin gene expression, HIF-1, iron chelation, cobalt chloride, Hep3B cells, ferrous ammonium sulfate, cycloheximide, de novo protein synthesis
MeSH terms: Base Sequence, Cell Line, Cell Nucleus, Cobalt, Deferoxamine, DNA-Binding Proteins, Erythropoietin, Humans, Liver Neoplasms, Molecular Sequence Data, Nuclear Proteins, RNA, Neoplasm, Transcription Factors, Tumor Cells, Cultured, Oligonucleotide Probes, Signal Transduction, Cell Hypoxia, Gene Expression, Hepatoblastoma, Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor 1, alpha Subunit

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Desferrioxamine induces erythropoietin gene expression and hypoxia- inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks