The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Desferrioxamine induces erythropoietin gene expression and hypoxia- inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction
Open accessAbstract
Erythropoietin (EPO) gene transcription is activated in kidney cells in vivo and in Hep3B cells exposed to hypoxia or cobalt chloride. Hypoxia- inducible factor 1 (HIF-1) is a nuclear factor that binds to the hypoxia-inducible enhancer of the EPO gene at a site that is required for transcriptional activation. HIF-1 DNA-binding activity is induced by hypoxia or cobalt chloride treatment of Hep3B cells. We report that treatment of Hep3B cells with desferrioxamine (DFX) induced HIF-1 activity and EPO RNA expression with kinetics similar to the induction of HIF-1 by hypoxia or cobalt chloride. Induction by each of these stimuli was inhibited by cycloheximide, indicating a requirement for de novo protein synthesis. DFX appears to induce HIF-1 by chelating iron as induction was inhibited by coadministration of ferrous ammonium sulfate. DFX administration to mice transiently increased EPO RNA levels in the kidney. As previously shown for hypoxia and cobalt treatment, DFX also induced HIF-1 activity in non-EPO-producing cells, suggesting the existence of a common hypoxia signal-transduction pathway leading to HIF-1 induction in different cell types.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“HIF stabilization can be induced by iron chelators including desferrioxamine and bacterial siderophores [62, 63].”
From Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function (2013) · cites this paper as [62]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
Semenza, G. L., & Wang, G. L. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.12.5447 · Cited by 2,617
Self-citationGeneral involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.
Wang, G. L., & Semenza, G. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.9.4304 · Cited by 1,468
Self-citationErythropoietin: structure, control of production, and function
JELKMANN, W. E. B. (1992) · Physiological Reviews · doi:10.1152/physrev.1992.72.2.449 · Cited by 1,167
Regulation of the Erythropoietin Gene: Evidence That the Oxygen Sensor Is a Heme Protein
Goldberg, M. A., Dunning, S. P., & Bunn, H. F. (1988) · Science · doi:10.1126/science.2849206 · Cited by 1,032
Semenza, G. L., Nejfelt, M. K., Chi, S. M., & Antonarakis, S. E. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.13.5680 · Cited by 990
Self-citationCharacterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia.
Wang, G. L., & Semenza, G. L. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80571-7 · Cited by 863
Self-citationA haemoprotein with kinase activity encoded by the oxygen sensor of Rhizobium meliloti
Gilles‐Gonzalez, M., Ditta, G. S., & Helinski, D. R. (1991) · Nature · doi:10.1038/350170a0 · Cited by 477
Localization of erythropoietin synthesizing cells in murine kidneys by in situ hybridization
Koury, S., Bondurant, M. C., & Koury, M. (1988) · Blood · doi:10.1182/blood.v71.2.524.524 · Cited by 469
Peritubular cells are the site of erythropoietin synthesis in the murine hypoxic kidney.
Lacombe, C., Silva, J. L. D., Bruneval, P., Fournier, J. G., Wendling, F., Casadevall, N., Camilleri, J.-P., Bariety, J., Varet, B. R., & Tambourin, P. E. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113363 · Cited by 437
Cited by
Sorted by citations
Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
Forsythe, J. A., Jiang, B.-H., Iyer, N. V., Agani, F., Leung, S. W., Koos, R. D., & Semenza, G. L. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4604 · Cited by 3,981
Self-citationHuang, L. E., Gu, J., Schau, M., & Bunn, H. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.7987 · Cited by 2,113
Purification and Characterization of Hypoxia-inducible Factor 1
Wang, G. L., & Semenza, G. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.3.1230 · Cited by 2,094
Self-citationChandel, N. S., McClintock, D. S., Feliciano, C. E., Wood, T. M., Melendez, J. A., Rodriguez, A. M., & Schumacker, P. T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001914200 · Cited by 2,000
Regulation of Mammalian O 2 Homeostasis by Hypoxia-Inducible Factor 1
Semenza, G. L. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.551 · Cited by 1,914
Self-citationTranscriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.
Semenza, G., Roth, P. H., Fang, H. M., & Wang, G. L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31580-6 · Cited by 1,892
Self-citationHIF-1: mediator of physiological and pathophysiological responses to hypoxia
Semenza, G. L. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.4.1474 · Cited by 1,822
Self-citationSemenza, G. L., Jiang, B.-H., Leung, S. W., Passantino, R., Concordet, J.-P., Maire, P., & Giallongo, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.51.32529 · Cited by 1,752
Self-citationHypoxia-Inducible Factor-1 (HIF-1)
Ke, Q., & Costa, M. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.027029 · Cited by 1,690
Iron and cancer: more ore to be mined
Torti, S. V., & Torti, F. M. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3495 · Cited by 1,621
Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions
Chen, Z., Han, F., Du, Y., Shi, H., & Zhou, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01332-8 · Cited by 1,612
Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells
Li, Z., Bao, S., Wu, Q., Wang, H., Eyler, C., Sathornsumetee, S., Shi, Q., Cao, Y., Lathia, J., McLendon, R. E., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.03.018 · Cited by 1,354
A Red carpet for iron metabolism
Muckenthaler, M. U., Rivella, S., Hentze, M. W., & Galy, B. (2017) · Cell · doi:10.1016/j.cell.2016.12.034 · Cited by 1,319
Hypoxia-inducible expression of tumor-associated carbonic anhydrases.
Wykoff, C. C., Beasley, N. J. P., Watson, P. H., Turner, K., Pastorek, J., Sibtain, A., Wilson, G. D., Turley, H., Talks, K., Maxwell, P. H., et al. (2000) · PubMed · Cited by 1,260
Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia
Carreau, A., Hafny‐Rahbi, B. E., Matejuk, A., Grillon, C., & Kieda, C. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01258.x · Cited by 1,246
Hypoxia-Induced Angiogenesis: Good and Evil
Krock, B. L., Skuli, N., & Simon, M. C. (2011) · Genes & Cancer · doi:10.1177/1947601911423654 · Cited by 1,236
Dimerization, DNA Binding, and Transactivation Properties of Hypoxia-inducible Factor 1
Jiang, B.-H., Rue, E., Wang, G. L., Roe, R., & Semenza, G. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.17771 · Cited by 1,106
Self-citationHypoxia-inducible factor 1: master regulator of O2 homeostasis
Semenza, G. L. (1998) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(98)80016-6 · Cited by 1,092
Self-citationIntegration of Oxygen Signaling at the Consensus HRE
Wenger, R. H., Stiehl, D. P., & Camenisch, G. (2005) · Science's STKE · doi:10.1126/stke.3062005re12 · Cited by 1,032
The PAS Superfamily: Sensors of Environmental and Developmental Signals
Gu, Y.-Z., Hogenesch, J. B., & Bradfield, C. A. (2000) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.40.1.519 · Cited by 1,044
Regulation of glycolysis by the hypoxia-inducible factor (HIF): Implications for cellular physiology
Kierans, S. J., & Taylor, C. T. (2021) · The Journal of Physiology · doi:10.1113/jp280572 · Cited by 1,015
Iron Metabolism in Ferroptosis
Chen, X., Yu, C., Kang, R., & Tang, D. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.590226 · Cited by 1,001
HIF-1 and human disease: one highly involved factor
Semenza, G. L. (2000) · Genes & Development · doi:10.1101/gad.14.16.1983 · Cited by 909
Self-citationHydroxylation of HIF-1: Oxygen Sensing at the Molecular Level
Semenza, G. L. (2004) · Physiology · doi:10.1152/physiol.00001.2004 · Cited by 926
Self-citationHypoxia and Adipose Tissue Function and Dysfunction in Obesity
Trayhurn, P. (2013) · Physiological Reviews · doi:10.1152/physrev.00017.2012 · Cited by 932
Regulation of the Chemokine Receptor CXCR4 by Hypoxia
Schioppa, T., Uranchimeg, B., Saccani, A., Biswas, S. K., Doni, A., Rapisarda, A., Bernasconi, S., Saccani, S., Nebuloni, M., Vago, L., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030267 · Cited by 841
Stabilization of wild-type p53 by hypoxia-inducible factor 1α
An, W. G., Kanekal, M., Simon, M. C., Maltepe, E., Blagosklonny, M. V., & Neckers, L. Μ. (1998) · Nature · doi:10.1038/32925 · Cited by 834
Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
Bruick, R. K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.16.9082 · Cited by 767
Erythropoietin: Physiology and Pharmacology Update
Fisher, J. W. (2003) · Experimental Biology and Medicine · doi:10.1177/153537020322800101 · Cited by 707
Early Expression of Angiogenesis Factors in Acute Myocardial Ischemia and Infarction
Lee, S. H., Wolf, P. L., Escudero, R., Deutsch, R., Jamieson, S. W., & Thistlethwaite, P. A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003023420904 · Cited by 693
Hypoxia, Clonal Selection, and the Role of HIF-1 in Tumor Progression
Semenza, G. L. (2000) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230091169186 · Cited by 657
Self-citationTransactivation and Inhibitory Domains of Hypoxia-inducible Factor 1α
Jiang, B.-H., Zheng, J. Z., Leung, S. W., Roe, R., & Semenza, G. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.31.19253 · Cited by 629
Self-citationWiesener, M. S., Turley, H., Allen, W. E., Willam, C., Eckardt, K., Talks, K., Wood, S. M., Gatter, K. C., Harris, A. L., Pugh, C. W., et al. (1998) · Blood · doi:10.1182/blood.v92.7.2260 · Cited by 629
Zimna, A., & Kurpisz, M. (2015) · BioMed Research International · doi:10.1155/2015/549412 · Cited by 604
HIF1 and oxygen sensing in the brain
Sharp, F. R., & Bernaudin, M. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1408 · Cited by 579
Ebert, B. L., Firth, J. D., & Ratcliffe, P. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.49.29083 · Cited by 569
Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling
Rey, S., & Semenza, G. L. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq045 · Cited by 555
Self-citationTreins, C., Giorgetti‐Peraldi, S., Murdaca, J., Semenza, G. L., & OBBERGHEN, E. V. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204152200 · Cited by 554
Self-citationActivation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit
Pugh, C. W., O'Rourke, J. F., Nagao, M., Gleadle, J., & Ratcliffe, P. J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.17.11205 · Cited by 526
Expression of hypoxia-inducible factor 1: mechanisms and consequences
Semenza, G. L. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00292-0 · Cited by 517
Self-citationHeme oxygenase/carbon monoxide signaling pathways: Regulation and functional significance
Ryter, S. W., Otterbein, L. E., Morse, D., & Choi, A. M. K. (2002) · Molecular and Cellular Biochemistry · doi:10.1023/a:1015957026924 · Cited by 497
Marsboom, G., Tóth, P. T., Ryan, J. J., Hong, Z., Wu, X., Fang, Y.-H., Thenappan, T., Piao, L. H., Zhang, H. J., Pogoriler, J. E., et al. (2012) · Circulation Research · doi:10.1161/circresaha.111.263848 · Cited by 476
Mammalian Oxygen Sensing, Signalling and Gene Regulation
Wenger, R. H. (2000) · Journal of Experimental Biology · doi:10.1242/jeb.203.8.1253 · Cited by 444
Familial Alzheimer's disease: Site of mutation influences clinical phenotype
Lippa, C. F., Swearer, J. M., Kane, K., Nochlin, D., Bird, T. D., Ghetti, B. F., Nee, L. E., George‐Hyslop, P. S., Pollen, D. A., & Drachman, D. A. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200009)48:3 · Cited by 67
Self-citationSelective iron chelation in Friedreich ataxia: biologic and clinical implications
Boddaert, N., Le Quan Sang, K. H., Rötig, A., Leroy-Willig, A., Gallet, S., Brunelle, F., Sidi, D., Thalabard, J.-C., Munnich, A., & Cabantchik, Z. I. (2007) · Blood · doi:10.1182/blood-2006-12-065433 · Cited by 409
Cellular oxygen sensing by mitochondria: old questions, new insight
Chandel, N. S., & Schumacker, P. T. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.5.1880 · Cited by 389
Singhal, R., & Shah, Y. M. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.011188 · Cited by 401
Oxygen Sensing, Hypoxia-Inducible Factor-1 and the Regulation of Mammalian Gene Expression
Ratcliffe, P. J., O’rourke, J. F., Maxwell, P. H., & Pugh, C. W. (1998) · Journal of Experimental Biology · doi:10.1242/jeb.201.8.1153 · Cited by 368
Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases
Eltzschig, H. K., Bratton, D. L., & Colgan, S. P. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4422 · Cited by 364
Down-Regulation of Rad51 and Decreased Homologous Recombination in Hypoxic Cancer Cells
Bindra, R. S., Schaffer, P. J., Meng, A. X., Woo, J. M. P., Måseide, K., Roth, M. E., Lizardi, P. M., Hedley, D. W., Bristow, R. G., & Glazer, P. M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.19.8504-8518.2004 · Cited by 368
Mammalian Per-Arnt-Sim Proteins in Environmental Adaptation
McIntosh, B. E., Hogenesch, J. B., & Bradfield, C. A. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135922 · Cited by 352
Martin, F., Linden, T., Katschinski, D. M., Oehme, F., Flamme, I., Mukhopadhyay, C. K., Eckhardt, K., Tröger, J., Barth, S., Camenisch, G., et al. (2005) · Blood · doi:10.1182/blood-2004-10-3980 · Cited by 350
Marchesi, F., Monti, P., Leone, B. E., Zerbi, A., Vecchi, A., Piemonti, L., Mantovani, A., & Allavena, P. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1343 · Cited by 342
Regulation of the Erythropoietin Gene
Ebert, B. L., & Bunn, H. F. (1999) · Blood · doi:10.1182/blood.v94.6.1864 · Cited by 338
McMahon, S., Charbonneau, M., Grandmont, S., Richard, D. E., & Dubois, C. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604507200 · Cited by 335
Oxygen sensors and angiogenesis
Maxwell, P. H., & Ratcliffe, P. J. (2002) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.2001.0287 · Cited by 333
Le, N. T. V., & Richardson, D. R. (2004) · Blood · doi:10.1182/blood-2004-05-1866 · Cited by 321
Zaman, K., Ryu, H., Hall, D. H., O’Donovan, K., Lin, K., Miller, M. P., Marquis, J. C., Baraban, J. M., Semenza, G. L., & Ratan, R. R. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-22-09821.1999 · Cited by 319
Self-citationVincent, K. A., Shyu, K., Luo, Y., Magner, M., Tio, R. A., Jiang, C., Goldberg, M. A., Akita, G. Y., Gregory, R. J., & Isner, J. M. (2000) · Circulation · doi:10.1161/01.cir.102.18.2255 · Cited by 314
Anaemia in kidney disease: harnessing hypoxia responses for therapy
Koury, M. J., & Haase, V. H. (2015) · Nature Reviews Nephrology · doi:10.1038/nrneph.2015.82 · Cited by 313
Lahiri, S., Roy, A., Baby, S. M., Hoshi, T., Semenza, G. L., & Prabhakar, N. R. (2006) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2005.07.001 · Cited by 312
Self-citationCopper Regulation of Hypoxia-Inducible Factor-1 Activity
Feng, W., Ye, F., Xue, W., Zhou, Z., & Kang, Y. J. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.051516 · Cited by 309
Topoisomerase I-Mediated Inhibition of Hypoxia-Inducible Factor 1
Rapisarda, A., Uranchimeg, B., Sordet, O., Pommier, Y., Shoemaker, R. H., & Melillo, G. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3139 · Cited by 301
Regulation of the Erythropoietin Gene
Imagawa, S., Goldberg, M. A., & Bunn, H. F. (1989) · Advances in experimental medicine and biology · doi:10.1007/978-1-4613-0623-8_9 · Cited by 298
104 candidate genes for the hypoxic tumor phenotype
Koong, A. C., Denko, N. C., Schindler, C., Le, Q., Terris, D. T., Ibrahim, H. Z., Goffinet, D. R., & Giaccia, A. J. (1999) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(99)90122-0 · Cited by 290
Wood, S. M., Gleadle, J., Pugh, C. W., Hankinson, O., & Ratcliffe, P. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.25.15117 · Cited by 289
Inhibition of Hypoxia-inducible Factor 1 Activation by Carbon Monoxide and Nitric Oxide
Huang, E. L., Willmore, W. G., Gu, J., Goldberg, M. A., & Bunn, H. F. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.13.9038 · Cited by 288
Reuß, B., Hertel, M., Werner, S., & Unsicker, K. (2000) · Glia · doi:10.1002/(sici)1098-1136(200005)30:3 · Cited by 52
Hypoxia-Inducible Factor 1: Control of Oxygen Homeostasis in Health and Disease
Semenza, G. L. (2001) · Pediatric Research · doi:10.1203/00006450-200105000-00002 · Cited by 281
Self-citationHypoxic induction of Ctgf is directly mediated by Hif-1
Higgins, D. F., Biju, M. P., Akai, Y., Wutz, A., Johnson, R. S., & Haase, V. H. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00245.2004 · Cited by 284
Decreased Expression of the DNA Mismatch Repair Gene Mlh1 under Hypoxic Stress in Mammalian Cells
Mihaylova, V. T., Bindra, R. S., Yuan, J., Hegan, D. C., Narayanan, L., Jensen, R. B., Giordano, F. J., Johnson, R. S., Rockwell, S., & Glazer, P. M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.9.3265-3273.2003 · Cited by 281
Obach, M., Navarro‐Sabaté, À., Caro, J., Kong, X., Duran, J., Gómez, M., Perales, J. C., Ventura, F., Rosa, J. L., & Bartrons, R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406096200 · Cited by 274
The human side of hypoxia‐inducible factor
Smith, T. G., Robbins, P. A., & Ratcliffe, P. J. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07029.x · Cited by 270
Piret, J., Mottet, D., Raes, M. J., & Michiels, C. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04680.x · Cited by 258
Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing
Webb, J. D., Coleman, M. L., & Pugh, C. W. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0147-7 · Cited by 261
The hypoxia-inducible factors: key transcriptional regulators of hypoxic responses
Bracken, C. P., Whitelaw, M. L., & Peet, D. J. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-2370-y · Cited by 259
Hu, J. Y., Discher, D. J., Bishopric, N. H., & Webster, K. A. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8543 · Cited by 254
Hypoxia induces lytic replication of Kaposi sarcoma–associated herpesvirus
Davis, D. A., Rinderknecht, A. S., Zoeteweij, J. P., Aoki, Y., Read-Connole, E., Tosato, G., Blauvelt, A., & Yarchoan, R. (2001) · Blood · doi:10.1182/blood.v97.10.3244 · Cited by 254
Bunn, H. F. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a011619 · Cited by 234
Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials
Yeh, T., Leissing, T. M., Abboud, M. I., Thinnes, C. C., Atasoylu, O., Holt‐Martyn, J. P., Zhang, D., Tumber, A., Lippl, K., Lohans, C. T., et al. (2017) · Chemical Science · doi:10.1039/c7sc02103h · Cited by 247
Frost, J., Galdeano, C., Soares, P., Gadd, M. S., Grzes, K. M., Ellis, L. C. J., Epemolu, O., Shimamura, S., Bantscheff, M., Grandi, P., et al. (2016) · Nature Communications · doi:10.1038/ncomms13312 · Cited by 246
O'Rourke, J. F., Tian, Y.-M., Ratcliffe, P. J., & Pugh, C. W. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.4.2060 · Cited by 242
Inflammation and Hypoxia: HIF and PHD Isoform Selectivity
Watts, E., & Walmsley, S. R. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.10.006 · Cited by 248
McNamee, E. N., Korns Johnson, D., Homann, D., & Clambey, E. T. (2013) · Immunologic Research · doi:10.1007/s12026-012-8349-8 · Cited by 234
Álvarez-Tejado, M., Naranjo‐Suarez, S., Jiménez, C., Carrera, A. C., Landázuri, M. O., & del Peso, L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011688200 · Cited by 234
Regulating cellular oxygen sensing by hydroxylation
Fandrey, J., Gorr, T. A., & Gassmann, M. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.05.005 · Cited by 234
Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo
Yambire, K. F., Rostosky, C. M., Watanabe, T., Pacheu‐Grau, D., Torres-Odio, S., Sanchez-Guerrero, A., Senderovich, O., Meyron‐Holtz, E. G., Milošević, I., Frahm, J., et al. (2019) · eLife · doi:10.7554/elife.51031 · Cited by 232
Effects of hypoxia on the expression of proangiogenic factors in differentiated 3T3-F442A adipocytes
Lolmède, K., Durand de Saint Front, V, Galitzky, J., Lafontan, M., & Bouloumié, A. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802407 · Cited by 224
Chau, W. K., Ip, C. K. M., Mak, A. S. C., Lai, H.-C., & Wong, A. S. T. (2012) · Oncogene · doi:10.1038/onc.2012.290 · Cited by 222
Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway
Hirsilä, M., Koivunen, P., Xu, L., Seeley, T. W., Kivirikko, K. I., & Myllyharju, J. (2005) · The FASEB Journal · doi:10.1096/fj.04-3399fje · Cited by 224
HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O2 levels
Masson, N., & Ratcliffe, P. J. (2003) · Journal of Cell Science · doi:10.1242/jcs.00655 · Cited by 221
Kvietikova, I., Wenger, R. H., Marti, H. H., & Gassmann, M. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.22.4542 · Cited by 213
Shen, X., Wan, C., Ramaswamy, G., Mavalli, M. D., Wang, Y., Duvall, C. L., Deng, L. F., Guldberg, R. E., Eberhart, A., Clemens, T. L., et al. (2009) · Journal of Orthopaedic Research® · doi:10.1002/jor.20886 · Cited by 215
Hypoxic Regulation of Angiopoietin-2 Expression in Endothelial Cells
Pichiule, P., Chavez, J. C., & LaManna, J. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m305146200 · Cited by 217
Chang, E. I., Loh, S. A., Ceradini, D. J., Chang, E. I., Lin, S.-E., Bastidas, N., Aarabi, S., Chan, D. A., Freedman, M. L., Giaccia, A. J., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.715847 · Cited by 206
Büchler, P., Reber, H. A., Büchler, M. C., Shrinkante, S., Büchler, M. W., Frieß, H., Semenza, G. L., & Hines, O. J. (2003) · Pancreas · doi:10.1097/00006676-200301000-00010 · Cited by 208
Self-citationCoulet, F., Nadaud, S., Agrapart, M., & Soubrier, F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305420200 · Cited by 209
Hypoxia-inducible factor 1 and the molecular physiology of oxygen homeostasis
Semenza, G. L. (1998) · Journal of Laboratory and Clinical Medicine · doi:10.1016/s0022-2143(98)90091-9 · Cited by 207
Self-citation
Metadata
- Authors
- Wang, G., & Semenza, G.
- Affiliations
- Johns Hopkins University (US)
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1993-12-15
- Volume
- 82
- Issue
- 12
- Pages
- 3610-3615
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1545825939
- Cited by
- 766
- References
- 33
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 12 · 2023: 24 · 2022: 18 · 2021: 26 · 2020: 24 · 2019: 18 · 2018: 19 · 2017: 17 · 2016: 34 · 2015: 24 · 2014: 26 · 2013: 26 · 2012: 32
- FWCI
- 5.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01dk039869-16)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 39869)
- Topics
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
- Keywords
- deferoxamine, erythropoietin gene expression, HIF-1, iron chelation, cobalt chloride, Hep3B cells, ferrous ammonium sulfate, cycloheximide, de novo protein synthesis
- MeSH terms
- Base Sequence, Cell Line, Cell Nucleus, Cobalt, Deferoxamine, DNA-Binding Proteins, Erythropoietin, Humans, Liver Neoplasms, Molecular Sequence Data, Nuclear Proteins, RNA, Neoplasm, Transcription Factors, Tumor Cells, Cultured, Oligonucleotide Probes, Signal Transduction, Cell Hypoxia, Gene Expression, Hepatoblastoma, Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor 1, alpha Subunit
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
