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Desferrioxamine induces erythropoietin gene expression and hypoxia- inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction
Open accessAbstract
Erythropoietin (EPO) gene transcription is activated in kidney cells in vivo and in Hep3B cells exposed to hypoxia or cobalt chloride. Hypoxia- inducible factor 1 (HIF-1) is a nuclear factor that binds to the hypoxia-inducible enhancer of the EPO gene at a site that is required for transcriptional activation. HIF-1 DNA-binding activity is induced by hypoxia or cobalt chloride treatment of Hep3B cells. We report that treatment of Hep3B cells with desferrioxamine (DFX) induced HIF-1 activity and EPO RNA expression with kinetics similar to the induction of HIF-1 by hypoxia or cobalt chloride. Induction by each of these stimuli was inhibited by cycloheximide, indicating a requirement for de novo protein synthesis. DFX appears to induce HIF-1 by chelating iron as induction was inhibited by coadministration of ferrous ammonium sulfate. DFX administration to mice transiently increased EPO RNA levels in the kidney. As previously shown for hypoxia and cobalt treatment, DFX also induced HIF-1 activity in non-EPO-producing cells, suggesting the existence of a common hypoxia signal-transduction pathway leading to HIF-1 induction in different cell types.
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“HIF stabilization can be induced by iron chelators including desferrioxamine and bacterial siderophores [62, 63].”
From Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function (2013) · cites this paper as [62]
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Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
Semenza, G. L., & Wang, G. L. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.12.5447 · Cited by 2,617
Self-citationGeneral involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.
Wang, G. L., & Semenza, G. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.9.4304 · Cited by 1,468
Self-citationErythropoietin: structure, control of production, and function
JELKMANN, W. E. B. (1992) · Physiological Reviews · doi:10.1152/physrev.1992.72.2.449 · Cited by 1,167
Regulation of the Erythropoietin Gene: Evidence That the Oxygen Sensor Is a Heme Protein
Goldberg, M. A., Dunning, S. P., & Bunn, H. F. (1988) · Science · doi:10.1126/science.2849206 · Cited by 1,032
Semenza, G. L., Nejfelt, M. K., Chi, S. M., & Antonarakis, S. E. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.13.5680 · Cited by 990
Self-citationCharacterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia.
Wang, G. L., & Semenza, G. L. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80571-7 · Cited by 863
Self-citationA haemoprotein with kinase activity encoded by the oxygen sensor of Rhizobium meliloti
Gilles‐Gonzalez, M., Ditta, G. S., & Helinski, D. R. (1991) · Nature · doi:10.1038/350170a0 · Cited by 477
Localization of erythropoietin synthesizing cells in murine kidneys by in situ hybridization
Koury, S., Bondurant, M. C., & Koury, M. (1988) · Blood · doi:10.1182/blood.v71.2.524.524 · Cited by 469
Peritubular cells are the site of erythropoietin synthesis in the murine hypoxic kidney.
Lacombe, C., Silva, J. L. D., Bruneval, P., Fournier, J. G., Wendling, F., Casadevall, N., Camilleri, J.-P., Bariety, J., Varet, B. R., & Tambourin, P. E. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113363 · Cited by 437
Cited by
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Liu, X., Deng, H., Tang, J., Wang, Z., Zhu, C., Cai, X., Rong, F., Chen, X., Sun, X., Jia, S., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05008-z · Cited by 35
Application of Deferoxamine in Tissue Regeneration Attributed to Promoted Angiogenesis
Shen, H., Ma, Y., Qiao, Y., Zhang, C., Chen, J., & Zhang, R. (2024) · Molecules · doi:10.3390/molecules29092050 · Cited by 34
Drynda, A., Drynda, S., Kekow, J., Lohmann, C. H., & Bertrand, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103034 · Cited by 34
Kupershmidt, L., & Youdim, M. B. H. (2023) · Cells · doi:10.3390/cells12050763 · Cited by 36
Klettner, A., Koinzer, S., Waetzig, V., Herdegen, T., & Roider, J. B. (2010) · Cutaneous and Ocular Toxicology · doi:10.3109/15569521003745685 · Cited by 34
Stabilization of hepatocyte growth factor mRNA by hypoxia-inducible factor 1
Chu, S., Feng, D., Ma, Y., Zhu, Z.-A., Zhang, H., & Qiu, J. (2008) · Molecular Biology Reports · doi:10.1007/s11033-008-9406-1 · Cited by 34
Potier, E., Ferreira, E., Dennler, S., Mauviel, A., Oudina, K., Logeart‐Avramoglou, D., & Petite, H. (2008) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.92 · Cited by 34
Yang, D., Chen, S., Yang, Y., Ju, T., Xu, J., & Hsu, C. Y. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705687 · Cited by 34
Zhao, Y., Zheng, Y., Luo, Q., Yan, T., Liu, X. X., Han, L., & Zou, L. (2014) · Placenta · doi:10.1016/j.placenta.2014.04.002 · Cited by 33
Brewitz, L., Tumber, A., Pfeffer, I., McDonough, M. A., & Schofield, C. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-65123-9 · Cited by 33
Beck, K., Wu, B. J., Ni, J., Santiago, F. S., Malabanan, K. P., Li, C., Wang, Y., Khachigian, L. M., & Stocker, R. (2010) · Circulation Research · doi:10.1161/circresaha.110.231985 · Cited by 33
Niu, N., Li, Z., Zhu, M., Sun, H., Yang, J., Xu, S., Zhao, W., & Song, R. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.9839 · Cited by 33
Gale, D. P., & Maxwell, P. H. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.10.012 · Cited by 32
The Role of Angiogenesis and Arteriogenesis in Myocardial Infarction and Coronary Revascularization
Spadaccio, C., Nenna, A., Rose, D., Piccirillo, F., Nusca, A., Grigioni, F., Chello, M., & Vlahakes, G. J. (2022) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-022-10241-0 · Cited by 32
Gultice, A. D., Kulkarni-Datar, K. S., & Brown, T. L. (2008) · Biology of Reproduction · doi:10.1095/biolreprod.107.067488 · Cited by 32
Tchetina, E. V., Markova, G. A., Poole, A. R., Zukor, D. J., Antoniou, J., Makarov, S. A., & Kuzin, A. N. (2016) · International Journal of Rheumatology · doi:10.1155/2016/6432867 · Cited by 32
Kietzmann, T., Porwol, T., Zierold, K., Jungermann, K. A., & Acker, H. (1998) · Biochemical Journal · doi:10.1042/bj3350425 · Cited by 32
Mitoxantrone Inhibits HIF-1α Expression in a Topoisomerase II–Independent Pathway
Toh, Y.-M., & Li, T.-K. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0235 · Cited by 32
Gap-junction-mediated Communication in Human Periodontal Ligament Cells
Kato, R., Ishihara, Y., Kawanabe, N., Sumiyoshi, K., Yoshikawa, Y., Nakamura, M., Imai, Y., Yanagita, T., Fukushima, H., Kamioka, H., et al. (2013) · Journal of Dental Research · doi:10.1177/0022034513489992 · Cited by 31
Lee, S., Yahng, S., Cho, B., Eom, K., Kim, Y., Lee, S., Min, C., Kim, H., Cho, S., Kim, D., et al. (2012) · Acta Haematologica · doi:10.1159/000342772 · Cited by 31
Freudenthaler, S. M., Schreeb, K. H., WIESE, A., PILZ, J., & Gleiter, C. H. (2002) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2002.00946.x · Cited by 31
Oxygen Sensing in the Circulation: "Cross Talk" Between Red Blood Cells and the Vasculature
Buehler, P. W., & Alayash, A. I. (2004) · Antioxidants and Redox Signaling · doi:10.1089/ars.2004.6.1000 · Cited by 32
Erythropoietin production: evidence for multiple oxygen sensing pathways
Daghman, N. A., Elder, G. E., Savage, G. A., Winter, P. C., Lappin, T. R. J., & Maxwell, A. P. (1999) · Annals of Hematology · doi:10.1007/s002770050514 · Cited by 31
Chung, Y. J., Swietach, P., Curtis, M. K., Ball, V., Robbins, P. A., & Lakhal‐Littleton, S. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.616920 · Cited by 31
Iron Deficiency and Renal Development in the Newborn Rat
Drake, K. A., Sauerbry, M. J., Blohowiak, S. E., Repyak, K. S., & Kling, P. J. (2009) · Pediatric Research · doi:10.1203/pdr.0b013e3181be79c2 · Cited by 30
Kasper, A. C., Moon, E. J., Hu, X., Park, Y., Wooten, C. M., Kim, H., Yang, W., Dewhirst, M. W., & Hong, J. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.04.071 · Cited by 30
STAT1 represses hypoxia-inducible factor-1-mediated transcription
Hiroi, M., Mori, K., Sakaeda, Y., Shimada, J., & Ohmori, Y. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.07.138 · Cited by 31
Iron, oxygen, and the pulmonary circulation
Frise, M. C., & Robbins, P. A. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00179.2015 · Cited by 31
Effects of desferrioxamine therapy on chronic disease anemia associated with rheumatoid arthritis
Salvarani, C., Baricchi, R., Lasagni, D., Boiardi, L., Piccinini, R., Brunati, C. C. M., Macchioni, P. L., & Portioli, I. (1996) · Rheumatology International · doi:10.1007/bf01816434 · Cited by 30
A novel iron chelator that does not induce HIF-1 activity
Creighton-Gutteridge, M., & Tyrrell, R. M. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00884-5 · Cited by 30
Willam, C., Nicholls, L. G., Ratcliffe, P. J., Pugh, C. W., & Maxwell, P. H. (2004) · Advances in Enzyme Regulation · doi:10.1016/j.advenzreg.2003.11.017 · Cited by 31
Regulation of the Erythropoietin Gene
Ebert, B. L., & Bunn, H. F. (1999) · Blood · doi:10.1182/blood.v94.6.1864.418k37_1864_1877 · Cited by 30
Reversing oncogenic transformation with iron chelation
Abdelaal, G., & Veuger, S. J. (2021) · Oncotarget · doi:10.18632/oncotarget.27866 · Cited by 30
Nouri, F., Salehinejad, P., Nematollahi‐Mahani, S. N., Kamarul, T., Zarrindast, M., & Sharifi, A. M. (2015) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0249-8 · Cited by 29
Baby, S. M., Roy, A., Mokashi, A., & Lahiri, S. (2003) · Histochemistry and Cell Biology · doi:10.1007/s00418-003-0588-2 · Cited by 29
The hypoxia-mimetic agent CoCl2 induces chemotherapy resistance in LOVO colorectal cancer cells
YANG, G., XU, S., PENG, L., Li, H., Zhao, Y., & Hu, Y. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.4836 · Cited by 29
Elevation of iron storage in humans attenuates the pulmonary vascular response to hypoxia
Bart, N., Curtis, M. K., Cheng, H., Hungerford, S. L., McLaren, R., Petousi, N., Dorrington, K. L., & Robbins, P. A. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00032.2016 · Cited by 30
Nestin expression in mesenchymal stromal cells: regulation by hypoxia and osteogenesis
Wong, A., Ghassemi, E., & Yellowley, C. E. (2014) · BMC Veterinary Research · doi:10.1186/s12917-014-0173-z · Cited by 30
Youdim, M. B. H., & Oh, Y. J. (2013) · Experimental Neurobiology · doi:10.5607/en.2013.22.3.167 · Cited by 28
Acute BMP2 upregulation following induction of ischemic osteonecrosis in immature femoral head
Kamiya, N., Shafer, S., Oxendine, I., Mortlock, D. P., Chandler, R. L., Oxburgh, L. H., & Kim, H. K. W. (2012) · Bone · doi:10.1016/j.bone.2012.11.023 · Cited by 28
HIF prolyl hydroxylase inhibition augments dopamine release in the rat brain in vivo
Witten, L. M., Sager, T. N., Thirstrup, K., Johansen, J. L., Larsen, D. B., Montezinho, L. P., & Mørk, A. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.21988 · Cited by 28
Desferrioxamine regulates HIF-1 alpha expression in neonatal rat brain after hypoxia-ischemia.
Li, L., Yin, X., Ma, N., Lin, F. H., Kong, X., Chi, J., & Feng, Z. (2014) · PubMed Central · Cited by 27
Ιωάννου, Μ., Pyrpasopoulou, A., Simos, G., Paraskeva, E., Nikolaidou, C. C., Venizelos, I., Koukoulis, G., Aslanidis, S., & Douma, S. (2012) · Modern Rheumatology · doi:10.1007/s10165-012-0787-6 · Cited by 27
Increased HIF‐1 alpha immunostaining in psoriasis compared to psoriasiform dermatitides
Ιωάννου, Μ., Sourli, F., Mylonis, I., Barbanis, S., Papamichali, R., Kouvaras, E., Zafiriou, E., Siomou, P., Klimi, E., Simos, G., et al. (2009) · Journal of Cutaneous Pathology · doi:10.1111/j.1600-0560.2009.01264.x · Cited by 27
Hypoxia impairs cell fusion and differentiation process in human cytotrophoblast, in vitro
Alsat, E., Wyplosz, P., Malassiné, A., Guibourdenche, J., Porquet, D., Nessmann, C., & Evain‐Brion, D. (1996) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199608)168:2 · Cited by 182
Carnosine as a potential therapeutic for the management of peripheral vascular disease
Feehan, J., Hariharan, R., Buckenham, T. M., Handley, C., Bhatnagar, A., Baba, S. P., & de Courten, B. V. (2022) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2022.07.006 · Cited by 26
Hypoxic preconditioning facilitates acclimatization to hypobaric hypoxia in rat heart
Singh, M., Shukla, D., Thomas, P., Saxena, S., & Bansal, A. (2010) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.2010.01163.x · Cited by 26
Osteopontin Upregulates the Expression of Glucose Transporters in Osteosarcoma Cells
Hsieh, I., Yang, R., & Fu, W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109550 · Cited by 26
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Zeigler, B. M., Vajdos, J., Qin, W., Loverro, L., & Niß, K. (2010) · Disease Models & Mechanisms · doi:10.1242/dmm.004788 · Cited by 28
Fábián, Z., Taylor, C. T., & Nguyen, L. K. (2016) · Journal of Molecular Medicine · doi:10.1007/s00109-016-1383-6 · Cited by 28
Amperometric sensing of HIF1α expressed in cancer cells and the effect of hypoxic mimicking agents
Hussain, K. K., Gurudatt, N. G., Mir, T. A., & Shim, Y. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.04.068 · Cited by 26
Sala, M. A., Chen, C., Zhang, Q., Do-Umehara, H. C., Wu, W., Misharin, A. V., Waypa, G. B., Fang, D., Budinger, G. R. S., Liu, S., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.000440 · Cited by 26
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Boakye, A. A., Zhang, D., Guo, L., Zheng, Y., Hoetker, D., Zhao, J., Posa, D. K., Ng, C. K., Zheng, H., Kumar, A., et al. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00751 · Cited by 26
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Cortezon‐Tamarit, F., Sarpaki, S., Calatayud, D. G., Mirabello, V., & Pascu, S. I. (2016) · The Chemical Record · doi:10.1002/tcr.201500292 · Cited by 26
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Melillo, G., Bosco, M. C., Musso, T., & Varesio, L. (1996) · Advances in experimental medicine and biology · doi:10.1007/978-1-4613-0381-7_22 · Cited by 26
Hypoxia in the intestine or solid tumors: A beneficial or deleterious alarm signal?
Shehade, H., Oldenhove, G., & Moser, M. (2014) · European Journal of Immunology · doi:10.1002/eji.201444719 · Cited by 26
Kimura, M., Takabuchi, S., Tanaka, T., Murata, M., Nishi, K., Oda, S., Oda, T., Kanai, M., Fukuda, K., Kizaka‐Kondoh, S., et al. (2008) · Biochemical Journal · doi:10.1042/bj20070824 · Cited by 25
Self-citationBorcar, A., Menze, M. A., Toner, M., & Hand, S. C. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1517-2 · Cited by 25
Hurst, J. H. (2016) · Journal of Clinical Investigation · doi:10.1172/jci90055 · Cited by 27
Kikuchi, S., Ninomiya, T., Kohno, T., Kojima, T., & Tatsumi, H. (2017) · Cell Biology and Toxicology · doi:10.1007/s10565-017-9402-0 · Cited by 25
Höfer, T., Pohjanvirta, R., Spielmann, P., Viluksela, M., Buchmann, D. P., Wenger, R. H., & Gassmann, M. (2004) · Biological Chemistry · doi:10.1515/bc.2004.024 · Cited by 25
Harned, J., Ferrell, J., Nagar, S., Goralska, M., Fleisher, L. N., & McGahan, M. C. (2012) · Experimental Eye Research · doi:10.1016/j.exer.2012.02.001 · Cited by 25
Iron chelators may help prevent photoaging
Kitazawa, M., Iwasaki, K., & Sakamoto, K. (2006) · Journal of Cosmetic Dermatology · doi:10.1111/j.1473-2165.2006.00218.x · Cited by 25
Kitamuro, T., Takahashi, K., Totsune, K., Nakayama, M., Murakami, O., Hida, W., Shirato, K., & Shibahara, S. (2001) · Peptides · doi:10.1016/s0196-9781(01)00520-4 · Cited by 25
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Chen, L., Wu, H., Ren, C., Liu, G., Zhang, W., Liu, W., & Lu, P. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.11877 · Cited by 24
Bloomer, R. J., Martin, K. R., & Pence, J. C. (2022) · Journal of Clinical and Translational Research · doi:10.18053/jctres.08.202202.005 · Cited by 24
Fatemian, M., Herigstad, M., Croft, Q. P. P., Formenti, F., Cardenas, R., Wheeler, C., Smith, T. G., Friedmannova, M., Dorrington, K. L., & Robbins, P. A. (2015) · The Journal of Physiology · doi:10.1113/jp270061 · Cited by 26
Dulak, J., Zagórska, A., Wegiel, B., Łoboda, A., & Józkowicz, A. (2006) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:44:1:031 · Cited by 24
Engineering vascularized tissues using natural and synthetic small molecules
Sefcik, L. S., Aronin, C. E. P., & Botchwey, E. A. (2008) · Organogenesis · doi:10.4161/org.4.4.6963 · Cited by 24
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Lee, K. H., Choi, E., Chun, Y., Myung-Suk, K. I. M., & Park, J. (2005) · Biochimie · doi:10.1016/j.biochi.2005.07.011 · Cited by 24
Wang, X., Yang, H., Yanagisawa, D., Bellier, J., Morino, K., Zhao, S., Liu, P., Vigers, P. N., & Tooyama, I. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.07.025 · Cited by 24
Activation of HIF-1α mRNA by hypoxia and iron chelator in isolated rat carotid body
Roy, A., Volgin, D. V., Baby, S. M., Mokashi, A., Kubin, L. K., & Lahiri, S. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.03.073 · Cited by 24
Abe, K., Ikeda, S., Nara, M., Kitadate, A., Tagawa, H., & Takahashi, N. (2023) · Cancer Medicine · doi:10.1002/cam4.5679 · Cited by 24
Generation and Characterization of Novel Local and Metastatic Human Neuroblastoma Variants
Nevo, I., Sagi‐Assif, O., Edry‐Botzer, L., Amar, D., Maman, S., Kariv, N., Leider–Trejo, L., Savelyeva, L., Schwab, M., Yron, I., et al. (2008) · Neoplasia · doi:10.1593/neo.08402 · Cited by 23
Iacobazzi, D., Garaeva, I., Albertario, A., Cherif, M., Angelini, G. D., Caputo, M., & Ghorbel, M. T. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000430257 · Cited by 23
Feidantsis, K. G., Anestis, A., & Michaelidis, B. (2013) · Cryobiology · doi:10.1016/j.cryobiol.2013.06.009 · Cited by 23
Indovina, P., Collini, M., Chirico, G. G., & Santini, M. T. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.01.040 · Cited by 23
Wang, Z., Zhang, Z., Wu, Y., Chen, L., Luo, Q., Zhang, J., Chen, J., Luo, Z., Huang, X., & Cheng, Y. (2012) · Experimental & Molecular Medicine · doi:10.3858/emm.2012.44.10.070 · Cited by 23
Donneys, A., Nelson, N. S., Perosky, J. E., Polyatskaya, Y., Rodriguez, J. J., Figueredo, C., Vasseli, C. A., Ratliff, H. C., Deshpande, S. S., Kozloff, K. M., et al. (2015) · Bone · doi:10.1016/j.bone.2015.12.051 · Cited by 23
Hwang, S., Ham, S., Lee, S. E., Lee, Y., & Lee, G. H. (2017) · NeuroToxicology · doi:10.1016/j.neuro.2017.10.006 · Cited by 24
Nowak, J. Z., Jóźwiak-Bębenista, M., & Bednarek, K. (2007) · Peptides · doi:10.1016/j.peptides.2007.04.007 · Cited by 23
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Kerendi, F., Kirshbom, P. M., Halkos, M. E., Wang, N.-P., Kin, H., Jiang, R., Zhao, Z., Kanter, K. R., Guyton, R. A., & Vinten‐Johansen, J. (2006) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2006.01.059 · Cited by 23
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Smollich, M., Götte, M., Kersting, C., Fischgräbe, J., Kiesel, L., & Wülfing, P. (2007) · Breast Cancer Research and Treatment · doi:10.1007/s10549-007-9589-5 · Cited by 23
Nguyen, M. V. C., Pouvreau, S., Hajjaji, F. Z. E., Denavit‐Saubié, M., & Péquignot, J.-M. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21202 · Cited by 23
Takano, H., Yamaguchi, J.-I., Kato, S., Hamada, M., Tada, M., & Endo, H. (2020) · Drug Metabolism and Disposition · doi:10.1124/dmd.120.000124 · Cited by 24
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Ex vivo expansion of circulating tumour cells (CTCs)
Mohamed, B. M., Ward, M. P., Bates, M., Spillane, C. D., Kelly, T. E., Martin, C. M., Gallagher, M. F., Heffernan, S., Norris, L., Kennedy, J., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-30733-6 · Cited by 22
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Metadata
- Authors
- Wang, G., & Semenza, G.
- Affiliations
- Johns Hopkins University (US)
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1993-12-15
- Volume
- 82
- Issue
- 12
- Pages
- 3610-3615
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1545825939
- Cited by
- 766
- References
- 33
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 12 · 2023: 24 · 2022: 18 · 2021: 26 · 2020: 24 · 2019: 18 · 2018: 19 · 2017: 17 · 2016: 34 · 2015: 24 · 2014: 26 · 2013: 26 · 2012: 32
- FWCI
- 5.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01dk039869-16)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 39869)
- Topics
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
- Keywords
- deferoxamine, erythropoietin gene expression, HIF-1, iron chelation, cobalt chloride, Hep3B cells, ferrous ammonium sulfate, cycloheximide, de novo protein synthesis
- MeSH terms
- Base Sequence, Cell Line, Cell Nucleus, Cobalt, Deferoxamine, DNA-Binding Proteins, Erythropoietin, Humans, Liver Neoplasms, Molecular Sequence Data, Nuclear Proteins, RNA, Neoplasm, Transcription Factors, Tumor Cells, Cultured, Oligonucleotide Probes, Signal Transduction, Cell Hypoxia, Gene Expression, Hepatoblastoma, Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor 1, alpha Subunit
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