Cited by 50Chronic Myeloid Leukemia TreatmentsImmunotherapy and Immune ResponsesT-cell and Retrovirus Studies

Expression of interferon consensus sequence binding protein induces potent immunity against BCR/ABL-induced leukemia

Deng, Ming, Daley, George Q.·2001·Blood

Abstract

Mice deficient in the interferon consensus sequence binding protein (ICSBP) develop a disease resembling chronic myeloid leukemia (CML), which in humans is caused by the BCR/ABL oncoprotein. Interferon-α (IFN-α) induces ICSBP expression and is an effective therapy for CML. This study examined whether enforced expression of ICSBP might antagonize BCR/ABL-induced leukemia; results demonstrated that ICSBP-modified cells generated a protective CD8+ cytotoxic T-cell response against BCR/ABL-transformed BaF3 cells in a murine leukemia model. ICSBP expression represents a novel means of stimulating a host immune response to BCR/ABL+ leukemia cells and a potential strategy for immunotherapy of CML.

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Crossref · 10.1182/blood.v97.11.3491

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  • Forced expression of ICSBP induces potent immunity against Bcr-Abl-induced leukemia in mice, and in vivo leukemia caused by transformed BaF3 cells was completely inhibited by coexpression of ICSBP.

    “Furthermore, it was shown that forced expression of ICSBP induces potent immunity against Bcr-Abl-induced leukemia in mice. (53)”

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Authors
Deng, M., & Daley, G. Q.
Affiliations
Harvard University (US)
Venue
Blood
Published
2001-06-01
Volume
97
Issue
11
Pages
3491-3497
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
OpenAlex
W1994905417
Cited by
50
References
47
Citations by year
2025: 1 · 2022: 1 · 2021: 2 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 4 · 2013: 2 · 2012: 4
FWCI
2.07
Type
journal article
Language
en
Open access
closed
Locations
  • Blood (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r29ca076418-04)
  • National Cancer Institute (R01CA086991, CA 76418, CA86991)
Topics
  • Health Sciences › Medicine › Hematology › Chronic Myeloid Leukemia Treatments
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
Keywords
IRF8, BCR-ABL, chronic myeloid leukemia, interferon-alpha, CD8+ cytotoxic T lymphocytes, antitumor immunity, leukemia immunotherapy, Ba/F3 cells, gene therapy
MeSH terms
Interferon Regulatory Factor-8, Animals, Cell Transformation, Neoplastic, Female, Immunity, Immunization, Interferons, Leukemia, Mice, Inbred BALB C, Neoplasm Transplantation, Repressor Proteins, Spleen, Transfection, Gene Expression, Fusion Proteins, bcr-abl, Mice, SCID, Mice, Inbred NOD, CD8-Positive T-Lymphocytes, Reverse Transcriptase Polymerase Chain Reaction, Interferon Regulatory Factors, Mice

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