IFN consensus sequence binding protein potentiates STAT1-dependent activation of IFNγ-responsive promoters in macrophages

Contursi, Cristina; Wang, I-Ming; Gabriele, Lucia; Gadina, Massimo; O'Shea, John; Morse, Herbert C.; Ozato, Keiko

doi:10.1073/pnas.97.1.91

Cited by 72Cytokine Signaling Pathways and Interactionsinterferon and immune responsesGenomics and Chromatin Dynamics

IFN consensus sequence binding protein potentiates STAT1-dependent activation of IFNγ-responsive promoters in macrophages

Open access

Contursi, Cristina, Wang, I-Ming, Gabriele, Lucia, Gadina, Massimo, O'Shea, John, Morse, Herbert C., Ozato, Keiko·2000·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.97.1.91PMC PMC26621

Open this paper in CoChat — free account

Abstract

IFNγ, once called the macrophage-activating factor, stimulates many genes in macrophages, ultimately leading to the elicitation of innate immunity. IFNγ's functions depend on the activation of STAT1, which stimulates transcription of IFNγ-inducible genes through the GAS element. The IFN consensus sequence binding protein ( icsb γ or IFN regulatory factor 8), encoding a transcription factor of the IFN regulatory factor family, is one of such IFNγ-inducible genes in macrophages. We found that macrophages from ICSBP−/− mice were defective in inducing some IFNγ-responsive genes, even though they were capable of activating STAT1 in response to IFNγ. Accordingly, IFNγ activation of luciferase reporters fused to the GAS element was severely impaired in ICSBP−/− macrophages, but transfection of ICSBP resulted in marked stimulation of these reporters. Consistent with its role in activating IFNγ-responsive promoters, ICSBP stimulated reporter activity in a GAS-specific manner, even in the absence of IFNγ treatment, and in STAT1 negative cells. Indicative of a mechanism for this stimulation, DNA affinity binding assays revealed that endogenous ICSBP was recruited to a multiprotein complex that bound to GAS. These results suggest that ICSBP, when induced by IFNγ through STAT1, in turn generates a second wave of transcription from GAS-containing promoters, thereby contributing to the elicitation of IFNγ's unique activities in immune cells.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1073/pnas.97.1.91

Cites

41 of 42 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

ICSBP/IRF-8 is an IFN-γ-inducible transcription factor of the IRF family that regulates transcription through multiple target DNA elements, including ISRE, EICE, and GAS.
“Interferon (IFN) consensus sequence binding protein (ICSBP)/IFN regulatory factor (IRF)-8 is an IFN g -inducible transcription factor of the IRF family and regulates transcription through multiple target DNA elements, such as IFN-stimulated response element (ISRE), Ets/IRF composite element, and IFNg activation site (GAS).”
From Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells (2002) · cites this paper as [34]
ICSBP can act on a wide range of target elements beyond the IRS, such as the Ets site in the IL-12 p40 promoter and the IFN-γ activation site (GAS).
“Recent studies indicate that ICSBP can act on a wide range of target elements even beyond the IRS, such as the Ets site in IL-12 p40 promoter and the IFNg activation site (GAS). (15,34)”
From Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells (2002) · cites this paper as [34]
ICSBP-/- mice have defects in macrophage function, including the ability to induce IL-12 p40 and some IFN-γ-responsible genes.
“They have defects in the macrophage function, including the ability to induce interleukin-12 (IL-12) p40 and some IFNg -responsible genes.”
From Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells (2002) · cites this paper as [34]
ICSBP potentiates activation of GAS in macrophages, and ICSBP-/- macrophages are defective in inducing some IFN-γ-responsive genes such as FcγRI and iNOS but are capable of activating Stat1 in response to IFN-γ.
“A recent study suggests that ICSBP potentiates activation of GAS in macrophages. (34)”
From Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells (2002) · cites this paper as [34]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins
Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080 · see citing works
STATs and Gene Regulation
Darnell, J. E. (1997) · Science · doi:10.1126/science.277.5332.1630 · Cited by 3,979 · see citing works
HOW CELLS RESPOND TO INTERFERONS
Stark, G. R., Kerr, I. M., Williams, B. R. G., Silverman, R. H., & Schreiber, R. D. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.227 · Cited by 3,932 · see citing works
CELLULAR RESPONSES TO INTERFERON-γ
Boehm, U., Klamp, T., Groot, M., & Howard, J. C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.749 · Cited by 2,890 · see citing works
Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.
Ding, A. H., Nathan, C., & Stuehr, D. J. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.141.7.2407 · Cited by 2,840 · see citing works
Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation
Wen, Z., Zhong, Z., & Darnell, J. E. (1995) · Cell · doi:10.1016/0092-8674(95)90311-9 · Cited by 1,974 · see citing works
Jaks and STATs: biological implications.
Leonard, W., & O'Shea, J. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.293 · Cited by 1,939 · see citing works
Self-citation
Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway
Meraz, M. A., White, J. M., Sheehan, K. C. F., Bach, E. A., Rodig, S. J., Dighe, A. S., Kaplan, D. H., Riley, J. K., Greenlund, A. C., Campbell, D., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81288-x · Cited by 1,656 · see citing works
Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease
Durbin, J. E., Hackenmiller, R., Simon, M. C., & Levy, D. E. (1996) · Cell · doi:10.1016/s0092-8674(00)81289-1 · Cited by 1,522 · see citing works
Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice
Kaplan, D. H., Shankaran, V., Dighe, A. S., Stockert, E., Aguet, M., Old, L. J., & Schreiber, R. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7556 · Cited by 1,465 · see citing works
The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction
Müller, M., Briscoe, J., Laxton, C., Guschin, D., Ziemiecki, A., Silvennoinen, O., Harpur, A., Barbieri, G., Witthuhn, B., Schindler, C., et al. (1993) · Nature · doi:10.1038/366129a0 · Cited by 680 · see citing works
Immunodeficiency and Chronic Myelogenous Leukemia-like Syndrome in Mice with a Targeted Mutation of the ICSBP Gene
Holtschke, T., Löhler, J., Kanno, Y., Fehr, T., Giese, N., Rosenbauer, F., Lou, J., Knobeloch, K.-P., Gabriele, L., Waring, J. F., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81348-3 · Cited by 644 · see citing works
Self-citation
Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme.
Lowenstein, C. J., Glatt, C. S., Bredt, D. S., & Snyder, S. H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.15.6711 · Cited by 605 · see citing works
Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-& gamma; signal transduction pathway
Watling, D., Guschin, D. Y., Müller, M. M., Silvennoinen, O., Witthuhn, B. A., Quelle, F. W., Rogers, N. C., Schindler, C., Stark, G. R., Ihle, J. N., et al. (1993) · Nature · doi:10.1038/366166a0 · Cited by 533 · see citing works
REGULATION OF MHC CLASS II GENES: Lessons from a Disease
Mach, B., Steimle, V., Martínez-Soria, E., & Reith, W. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.301 · Cited by 487 · see citing works
The growing family of interferon regulatory factors
Nguyen, H., Hiscott, J., & Pitha, P. M. (1997) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(97)00019-1 · Cited by 480 · see citing works
GAS Elements: A Few Nucleotides with a Major Impact on Cytokine-Induced Gene Expression
DECKER, T., KOVARIK, P., & MEINKE, A. (1997) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1997.17.121 · Cited by 437 · see citing works
Interferon-γ: Biology and Role in Pathogenesis
Billiau, A. (1996) · Advances in immunology · doi:10.1016/s0065-2776(08)60428-9 · Cited by 417 · see citing works
Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon‐alpha and ‐gamma signal transduction pathways.
Müller, M., Laxton, C., Briscoe, J., Schindler, C., Improta, T., Darnell, J. E., Stark, G. R., & Kerr, I. M. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06106.x · Cited by 411 · see citing works
Regulation of Interferon-γ-Activated STAT1 by the Ubiquitin-Proteasome Pathway
Kim, T. K., & Maniatis, T. (1996) · Science · doi:10.1126/science.273.5282.1717 · Cited by 410 · see citing works
Absence of the type I IFN system in EC cells: Transcriptional activator (IRF-1) and repressor (IRF-2) genes are developmentally regulated
Harada, H., Willison, K. R., Sakakibara, J., Miyamoto, M., Fujita, T., & Taniguchi, T. (1990) · Cell · doi:10.1016/0092-8674(90)90163-9 · Cited by 368 · see citing works
Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF‐1 promoter to mediate induction by IFN alpha and IFN gamma, and is likely to autoregulate the p91 gene.
Pine, R., Canova, A., & Schindler, C. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06245.x · Cited by 347 · see citing works
The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase.
Haspel, R. L., Salditt‐Georgieff, M., & Darnell, J. E. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01016.x · Cited by 312 · see citing works
An Interferon-γ-activated Site (GAS) Is Necessary for Full Expression of the Mouse iNOS Gene in Response to Interferon-γ and Lipopolysaccharide
Gao, J., Morrison, D. C., Parmely, T. J., Russell, S. W., & Murphy, W. J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.2.1226 · Cited by 303 · see citing works
Identification and sequence of an accessory factor required for activation of the human interferon γ receptor
Soh, J., DONNELLY, R. J., Kotenko, S. V., Mariano, T. M., Cook, J. R., Wang, N., Emanuel, S. L., Schwartz, B., Miki, T., & Pestka, S. (1994) · Cell · doi:10.1016/0092-8674(94)90354-9 · Cited by 262 · see citing works
Interferon Consensus Sequence Binding Protein–deficient Mice Display Impaired Resistance to Intracellular Infection Due to a Primary Defect in Interleukin 12 p40 Induction
Scharton-Kersten, T., Contursi, C., Masumi, A., Sher, A., & Ozato, K. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.9.1523 · Cited by 217 · see citing works
Self-citation
Interferon consensus sequence-binding protein, a member of the interferon regulatory factor family, suppresses interferon-induced gene transcription.
Nelson, N., Marks, M. S., Driggers, P. H., & Ozato, K. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.1.588 · Cited by 192 · see citing works
Self-citation
Interferon Consensus sequence-Binding Protein, a Member of the Interferon Regulatory Factor Family, Suppresses Interferon-Induced Gene Transcription
Nelson, N., Marks, M. S., Driggers, P. H., & Ozato, K. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.1.588-599.1993 · Cited by 192 · see citing works
Self-citation
The genomic structure of the murine ICSBP gene reveals the presence of the gamma interferon-responsive element, to which an ISGF3 alpha subunit (or similar) molecule binds
Kanno, Y., Kozak, C. A., Schindler, C., Driggers, P., Ennist, D. L., Gleason, S., Darnell, J. E., & Ozato, K. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.7.3951-3963.1993 · Cited by 185 · see citing works
Self-citation
The genomic structure of the murine ICSBP gene reveals the presence of the gamma interferon-responsive element, to which an ISGF3 alpha subunit (or similar) molecule binds.
Kanno, Y., Kozak, C. A., Schindler, C., Driggers, P. H., Ennist, D. L., Gleason, S. L., Darnell, J. E., & Ozato, K. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.7.3951 · Cited by 180 · see citing works
Self-citation
Interferon gamma-induced transcription of the high-affinity Fc receptor for IgG requires assembly of a complex that includes the 91-kDa subunit of transcription factor ISGF3.
Pearse, R. N., Feinman, R., Shuai, K., Darnell, J. E., Jr., & Ravetch, J. V. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.9.4314 · Cited by 179 · see citing works
The interferon gamma (IFN-γ) receptor: a paradigm for the multichain cytokine receptor
Pestka, S., Kotenko, S. V., Muthukumaran, G., Izotova, L. S., Cook, J. R., & Garotta, G. (1997) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(97)00009-9 · Cited by 172 · see citing works
Crucial Role of Interferon Consensus Sequence Binding Protein, but neither of Interferon Regulatory Factor 1 nor of Nitric Oxide Synthesis for Protection Against Murine Listeriosis
Fehr, T., Schoedon, G., Odermatt, B., Holtschke, T., Schneemann, M., Bachmann, M. F., Mak, T. W., Horak, I., & Zinkernagel, R. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.5.921 · Cited by 162 · see citing works
Interferon (IFN) Consensus Sequence-binding Protein, a Transcription Factor of the IFN Regulatory Factor Family, Regulates Immune Responses In Vivo through Control of Interleukin 12 Expression
Giese, N. A., Gabriele, L., Doherty, T. M., Klinman, D. M., Tadesse-Heath, L., Contursi, C., Epstein, S. L., & Morse, H. C. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.9.1535 · Cited by 160 · see citing works
Self-citation
The Histone Acetylase PCAF Is a Phorbol-Ester-Inducible Coactivator of the IRF Family That Confers Enhanced Interferon Responsiveness
Masumi, A., Wang, I.-M., Lefebvre, B., Yang, X.-J., Nakatani, Y., & Ozato, K. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.3.1810 · Cited by 124 · see citing works
Self-citation
Expression of IFN regulatory factor family proteins in lymphocytes. Induction of Stat-1 and IFN consensus sequence binding protein expression by T cell activation
Nelson, N., Kanno, Y., Hong, C., Contursi, C., Fujita, T., Fowlkes, B. J., O’Connell, E., Hu-Li, J., Paul, W. E., Jankovic, D., et al. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.10.3711 · Cited by 110 · see citing works
Self-citation
Molecular cloning and expression of the mouse high affinity Fc receptor for IgG.
Sears, D. W., Osman, N., Tate, B., McKenzie, I. F. C., & Hogarth, P. M. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.1.371 · Cited by 84 · see citing works
Interferon Regulatory Factors and TFIIB Cooperatively Regulate Interferon-Responsive Promoter Activity In Vivo and In Vitro
Wang, I.-M., Blanco, J. C. G., Tsai, S. Y., Tsai, M.-J., & Ozato, K. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.11.6313 · Cited by 64 · see citing works
Self-citation
Regulation of IFN-gamma-induced nuclear expression of IFN consensus sequence binding protein in murine peritoneal macrophages.
Politis, A. D., Ozato, K., Coligan, J. E., & Vogel, S. N. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.5.2270 · Cited by 61 · see citing works
Self-citation
IFN consenus sequence binding protein (ICSBP) is a conditional repressor of IFN inducible promoters
Welsz, A., Kirchhoff, S., & Levi, B.-Z. (1994) · International Immunology · doi:10.1093/intimm/6.8.1125 · Cited by 50 · see citing works
Differential requirement of IFN consensus sequence binding protein for the production of IL-12 and induction of Th1-type cells in response to IFN-gamma.
Wu, C. Y., Maeda, H., Contursi, C., Ozato, K., & Seder, R. A. (1999) · PubMed · Cited by 38 · see citing works
Self-citation
Differential Requirement of IFN Consensus Sequence Binding Protein for the Production of IL-12 and Induction of Th1-Type Cells in Response to IFN-γ
Wu, C.-Y., Maeda, H., Contursi, C., Ozato, K., & Seder, R. A. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.2.807 · Cited by 31 · see citing works
Self-citation

Flagged first, then by citations

Research works printed but not linked: 6

[15]Nelson N, Kanno Y, Hong C, Contursi C, Fujita T, Fowlkes B J, O'Connell E, Hu-Li J, Paul W E, Jankovic D, et al. J Immunol. 1996;156:3711–3720. [PubMed] [Google Scholar]
[16]Politis A D, Ozato K, Coligan J E, Vogel S N. J Immunol. 1994;152:2270–2278. [PubMed] [Google Scholar]
[28]Sears D W, Osman N, Tate B, McKenzie I F, Hogarth P M. J Immunol. 1990;144:371–378. [PubMed] [Google Scholar]
[29]Ding A H, Nathan C F, Stuehr D J. J Immunol. 1988;141:2407–2412. [PubMed] [Google Scholar]
[36]Haspel R L, Salditt-Georgieff M, Darnell J E., Jr EMBO J. 1996;15:6262–6268. [PMC free article] [PubMed] [Google Scholar]
[37]Wu C-Y, Maeda H, Contursi C, Ozato K, Seder R A. J Immunol. 1999;162:807–812. [PubMed] [Google Scholar]

Sorted by citations

The JAK/STAT signaling pathway: from bench to clinic
Hu, X., li, J., Fu, M., Zhao, X., & Wang, W. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00791-1 · Cited by 2,633 · see citing works
IRF Family of Transcription Factors as Regulators of Host Defense
Taniguchi, T., Ogasawara, K., Takaoka, A., & Tanaka, N. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.623 · Cited by 1,658 · see citing works
The IRF Family Transcription Factors in Immunity and Oncogenesis
Tamura, T., Yanai, H., Savitsky, D., & Taniguchi, T. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090400 · Cited by 1,259 · see citing works
Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion
Gangoso, E., Southgate, B., Bradley, L., Lehr, S., Gálvez‐Cancino, F., McGivern, N., Güç, E., Kapourani, C.-A., Byron, A., Ferguson, K. M., et al. (2021) · Cell · doi:10.1016/j.cell.2021.03.023 · Cited by 363 · see citing works
ICSBP Directs Bipotential Myeloid Progenitor Cells to Differentiate into Mature Macrophages
Tamura, T., Nagamura-Inoue, T., Shmeltzer, Z., Kuwata, T., & Ozato, K. (2000) · Immunity · doi:10.1016/s1074-7613(00)00016-9 · Cited by 305 · see citing works
Self-citation
Regulation of interferon and Toll‐like receptor signaling during macrophage activation by opposing feedforward and feedback inhibition mechanisms
Hu, X., Chakravarty, S. D., & Ivashkiv, L. B. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00707.x · Cited by 303 · see citing works
CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lung
Nieuwenhuis, E. E. S., Matsumoto, T., Exley, M. A., Schleipman, R. A., Glickman, J. N., Bailey, D. T., Corazza, N., Colgan, S. P., Onderdonk, A. B., & Blumberg, R. S. (2002) · Nature Medicine · doi:10.1038/nm0602-588 · Cited by 303 · see citing works
Regulatory Networks Involving STATs, IRFs, and NFκB in Inflammation
Platanitis, E., & Decker, T. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02542 · Cited by 251 · see citing works
Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein
Lee, C. H., Melchers, M., Wang, H., Torrey, T. A., Slota, R., Qi, C., Kim, J. Y., Lugar, P., Kong, H. J., Farrington, L. A., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051450 · Cited by 186 · see citing works
Self-citation
An IFN-γ-Inducible Transcription Factor, IFN Consensus Sequence Binding Protein (ICSBP), Stimulates IL-12 p40 Expression in Macrophages
Wang, I.-M., Contursi, C., Masumi, A., Ma, X., Trinchieri, G., & Ozato, K. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.1.271 · Cited by 187 · see citing works
Self-citation
Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells
Tamura, T., & Ozato, K. (2002) · Journal of Interferon & Cytokine Research · doi:10.1089/107999002753452755 · Cited by 183 · see citing works
Self-citation
ERK1 and ERK2 Activate CCAAAT/Enhancer-binding Protein-β-dependent Gene Transcription in Response to Interferon-γ
Hu, J., Roy, S. K., Shapiro, P. S., Rodig, S. J., Reddy, S. P., Platanias, L. C., Schreiber, R. D., & Kalvakolanu, D. V. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m004885200 · Cited by 153 · see citing works
A review of the clinical phenotype of 254 patients with genetically confirmed pachyonychia congenita
Eliason, M. J., Leachman, S. A., Feng, B., Schwartz, M. E., & Hansen, C. D. (2012) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2011.12.009 · Cited by 148 · see citing works
IFN-γ-Induced TNF-α Expression Is Regulated by Interferon Regulatory Factors 1 and 8 in Mouse Macrophages
Sol, V. V., Punzón, C., & Fresno, M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.7.4461 · Cited by 141 · see citing works
Interferon Regulatory Factor (Irf)-1 and Irf-2 Regulate Interferon γ–Dependent Cyclooxygenase 2 Expression
Blanco, J. C. G., Contursi, C., Salkowski, C. A., DeWitt, D. L., Ozato, K., & Vogel, S. N. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.12.2131 · Cited by 137 · see citing works
Self-citation
Interferon-γ activates transcription of NADPH oxidase 1 gene and upregulates production of superoxide anion by human large intestinal epithelial cells
Kuwano, Y., Kawahara, T., Yamamoto, H., Teshima-Kondo, S., Tominaga, K., Masuda, K., Kishi, K., Morita, K., & Rokutan, K. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00135.2005 · Cited by 130 · see citing works
Immune cell-specific amplification of interferon signaling by the IRF-4/8-PU. 1 complex
Kanno, Y., Levi, B.-Z., Tamura, T., & Ozato, K. (2005) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2005.25.770 · Cited by 128 · see citing works
Self-citation
IFN-γ Inhibits Gastric Carcinogenesis by Inducing Epithelial Cell Autophagy and T-Cell Apoptosis
Tu, S. P., Quante, M., Bhagat, G., Takaishi, S., Cui, G., Yang, X. D., Muthuplani, S., Shibata, W., Fox, J. G., Pritchard, D. M., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-4009 · Cited by 121 · see citing works
ICSBP/IRF-8 retrovirus transduction rescues dendritic cell development in vitro
Tsujimura, H., Tamura, T., Gongora, C., Aliberti, J., Sousa, C. R. E., Sher, A., & Ozato, K. (2003) · Blood · doi:10.1182/blood-2002-05-1327 · Cited by 114 · see citing works
Self-citation
PU.1 and Multiple IFN Regulatory Factor Proteins Synergize to Mediate Transcriptional Activation of the Human IL-1β Gene
Marecki, S., Riendeau, C. J., Liang, M. D., & Fenton, M. J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.11.6829 · Cited by 111 · see citing works
Alternate interferon signaling pathways
Kalvakolanu, D. V. (2003) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(03)00070-6 · Cited by 106 · see citing works
MEKK1 plays a critical role in activating the transcription factor C/EBP-β-dependent gene expression in response to IFN-γ
Roy, S. K., Hu, J., Meng, Q., Xia, Y., Shapiro, P. S., Reddy, S. P., Platanias, L. C., Lindner, D. J., Johnson, P. F., Pritchard, C. A., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122075799 · Cited by 100 · see citing works
NADPH Oxidases in the Gastrointestinal Tract: A Potential Role of Nox1 in Innate Immune Response and Carcinogenesis
Rokutan, K., Kawahara, T., Kuwano, Y., Tominaga, K., Sekiyama, A., & Teshima-Kondo, S. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1573 · Cited by 99 · see citing works
LXRα Regulates Macrophage Arginase 1 Through PU.1 and Interferon Regulatory Factor 8
Pourcet, B., Feig, J. E., Vengrenyuk, Y., Hobbs, A. J., Kepka-Lenhart, D., Garabedian, M. J., Morris, S. M., Fisher, E. A., & Pineda-Torra, I. (2011) · Circulation Research · doi:10.1161/circresaha.111.241810 · Cited by 97 · see citing works
Transcription factors that regulate growth and differentiation of myeloid cells.
Nagamura-Inoue, T., Tamura, T., & Ozato, K. (2001) · International Reviews of Immunology · doi:10.3109/08830180109056724 · Cited by 94 · see citing works
Self-citation
IRF‐8/ICSBP and IRF‐1 cooperatively stimulate mouse IL‐12 promoter activity in macrophages
Masumi, A., Tamaoki, S., Wang, I., Ozato, K., & Komuro, K. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03556-1 · Cited by 87 · see citing works
Self-citation
Transcriptional regulation of macrophage arginase 1 expression and its role in atherosclerosis
Pourcet, B., & Pineda‐Torra, I. (2013) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2012.10.003 · Cited by 82 · see citing works
PU.1/Interferon Regulatory Factor Interactions; Mechanisms of Transcriptional Regulation
Marecki, S., & Fenton, M. J. (2000) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:33:2:127 · Cited by 74 · see citing works
Interferon regulatory factor 8/interferon consensus sequence binding protein is a critical transcription factor for the physiological phenotype of microglia
Horiuchi, M., Wakayama, K., Itoh, A., Kawai, K., Pleasure, D., Ozato, K., & Itoh, T. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-227 · Cited by 76 · see citing works
Self-citation
Acute SIV infection of the brain leads to upregulation of IL6 and interferon-regulated genes: expression patterns throughout disease progression and impact on neuroAIDS
Roberts, E., Burudi, E. M. E., Flynn, C. T., Madden, L. J., Roinick, K. L., Watry, D. D., Zandonatti, M. A., Taffe, M. A., & Fox, H. S. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.08.030 · Cited by 75 · see citing works
Macrophage-Stimulating Protein, the Ligand for the Stem Cell-Derived Tyrosine Kinase/RON Receptor Tyrosine Kinase, Inhibits IL-12 Production by Primary Peritoneal Macrophages Stimulated with IFN-γ and Lipopolysaccharide
Morrison, A. C., Wilson, C. B., Ray, M., & Correll, P. H. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.3.1825 · Cited by 73 · see citing works
Statins Downregulate K6a Promoter Activity: A Possible Therapeutic Avenue for Pachyonychia Congenita
Zhao, Y., Gärtner, U., Smith, F. J. D., & McLean, W. H. I. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.41 · Cited by 72 · see citing works
Review: ICSBP/IRF-8 Transactivation: A Tale of Protein-Protein Interaction
Levi, B.-Z., Hashmueli, S., Gleit-Kielmanowicz, M., Azriel, A., & Meraro, D. (2002) · Journal of Interferon & Cytokine Research · doi:10.1089/107999002753452764 · Cited by 70 · see citing works
Molecular Mechanisms for Synchronized Transcription of Three Complement C1q Subunit Genes in Dendritic Cells and Macrophages*
Chen, G.-B., Tan, C., Teh, B. K., & Lu, J.-H. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.286427 · Cited by 70 · see citing works
Review: The Role of IRF-4 in Transcriptional Regulation
Marecki, S., & Fenton, M. J. (2002) · Journal of Interferon & Cytokine Research · doi:10.1089/107999002753452737 · Cited by 67 · see citing works
DNA methylation protects against cisplatin-induced kidney injury by regulating specific genes, including interferon regulatory factor 8
Guo, C., Pei, L., Xiao, X., Wei, Q., Chen, J., Ding, H., Huang, S., Fan, G., Shi, H., & Dong, Z. (2017) · Kidney International · doi:10.1016/j.kint.2017.03.038 · Cited by 66 · see citing works
Complex Formation of the Interferon (IFN) Consensus Sequence-binding Protein with IRF-1 Is Essential for Murine Macrophage IFN-γ-induced iNOS Gene Expression
Xiong, H., Zhu, C. Y., Li, H., Chen, F., Mayer, L., Ozato, K., Unkeless, J. C., & Plevy, S. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209583200 · Cited by 64 · see citing works
Self-citation
ICSBP/IRF-8 inhibits mitogenic activity of p210 Bcr/Abl in differentiating myeloid progenitor cells
Tamura, T., Kong, H. J., Tunyaplin, C., Tsujimura, H., Calame, K. L., & Ozato, K. (2003) · Blood · doi:10.1182/blood-2003-01-0291 · Cited by 62 · see citing works
Self-citation
DNA Methylation Represses IFN-γ–Induced and Signal Transducer and Activator of Transcription 1–Mediated IFN Regulatory Factor 8 Activation in Colon Carcinoma Cells
McGough, J. M., Yang, D., Huang, S., Georgi, D. E., Hewitt, S. M., Röcken, C., Tänzer, M., Ebert, M. P., & Liu, K. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0280 · Cited by 59 · see citing works
Kinetic analysis of genomewide gene expression reveals molecule circuitries that control T cell activation and Th1/2 differentiation
Lu, B., Zagouras, P., Fischer, J. E., Lu, J. F., Li, B., & Flavell, R. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307743100 · Cited by 54 · see citing works
IFN Regulatory Factor 8 Mediates Apoptosis in Nonhemopoietic Tumor Cells via Regulation of Fas Expression
Yang, D., Thangaraju, M., Browning, D. D., Dong, Z., Korchin, B., Lev, D. C., Ganapathy, V., & Liu, K. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.7.4775 · Cited by 55 · see citing works
Expression of interferon consensus sequence binding protein induces potent immunity against BCR/ABL-induced leukemia
Deng, M., & Daley, G. Q. (2001) · Blood · doi:10.1182/blood.v97.11.3491 · Cited by 50 · see citing works
Induction of cyclooxygenase-2 by heat shock protein 60 in macrophages and endothelial cells
Billack, B., Heck, D. E., Mariano, T. M., Gardner, C. R., Sur, R., Laskin, D. L., & Laskin, J. D. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00609.2001 · Cited by 47 · see citing works
Leishmania majorInfection Activates NF-κB and Interferon Regulatory Factors 1 and 8 in Human Dendritic Cells
Jayakumar, A., Donovan, M. J., Tripathi, V., Ramalho-Ortigão, M., & McDowell, M. A. (2008) · Infection and Immunity · doi:10.1128/iai.01252-07 · Cited by 42 · see citing works
Genetic Determinants of Susceptibility to Mycobacterial Infections: IRF8, A New Kid on the Block
Salem, S., & Gros, P. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-6111-1_3 · Cited by 42 · see citing works
Microglia and Brain Macrophages as Drivers of Glioma Progression
Zheng, Y., & Graeber, M. B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415612 · Cited by 38 · see citing works
Generation of Human Dendritic Cells That Simultaneously Secrete IL-12 and Have Migratory Capacity by Adenoviral Gene Transfer of hCD40L in Combination With IFN-γ
Knippertz, I., Hesse, A., Schunder, T., Kämpgen, E., Brenner, M. K., Schuler, G., Steinkasserer, A., & Nettelbeck, D. M. (2009) · Journal of Immunotherapy · doi:10.1097/cji.0b013e3181a28422 · Cited by 36 · see citing works
Cooperative contributions of Interferon regulatory factor 1 (IRF1) and IRF8 to interferon-γ-mediated cytotoxic effects on oligodendroglial progenitor cells
Horiuchi, M., Itoh, A., Pleasure, D., Ozato, K., & Itoh, T. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-8 · Cited by 31 · see citing works
Self-citation
Increased Expression of Interferon Signaling Genes in the Bone Marrow Microenvironment of Myelodysplastic Syndromes
Kim, M., Hwang, S., Park, K., Kim, S. Y., Lee, Y. K., & Lee, D. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120602 · Cited by 30 · see citing works
Analysis of the human kidney transcriptome and plasma proteome identifies markers of proximal tubule maladaptation to injury
Wen, Y., Su, E. Y., Xu, L., Menez, S. P., Moledina, D. G., Obeid, W., Palevsky, P. M., Mansour, S. G., Devarajan, P., Cantley, L. G., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.ade7287 · Cited by 28 · see citing works
Convergence of Interferon-γ and Progesterone Signaling Pathways in Human Endometrium: Role of PIASy (Protein Inhibitor of Activated Signal Transducer and Activator of Transcription-y)
Zoumpoulidou, G., Jones, M. C., de Mattos, S. F., Francis, J. M., Fusi, L., Lee, Y. S., Christian, M., Varshochi, R., Lam, E. W. ‐., & Brosens, J. J. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0467 · Cited by 26 · see citing works
Nc886, a Novel Suppressor of the Type I Interferon Response Upon Pathogen Intrusion
Lee, Y.-S., Bao, X., Lee, H.-H., Jang, J. J., Saruuldalai, E., Park, G., Im, W. R., Park, J., Kim, S., Shin, S., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042003 · Cited by 25 · see citing works
Cytokine-induced tumor suppressors: A GRIM story
Kalvakolanu, D. V., Nallar, S. C., & Kalakonda, S. (2010) · Cytokine · doi:10.1016/j.cyto.2010.03.009 · Cited by 25 · see citing works
Enhanced osteoclastogenesis in patients with MSMD due to impaired response to IFN-γ
Tsumura, M., Miki, M., Mizoguchi, Y., Hirata, O., Nishimura, S., Tamaura, M., Kagawa, R., Hayakawa, S., Kobayashi, M., & Okada, S. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.05.018 · Cited by 23 · see citing works
microRNA dysregulation in polyglutamine toxicity of TATA-box binding protein is mediated through STAT1 in mouse neuronal cells
Roshan, R., Choudhary, A., Bhambri, A., Bakshi, B., Ghosh, T., & Pillai, B. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0925-3 · Cited by 17 · see citing works
Inhibition of complement C3 prevents osteoarthritis progression in guinea pigs by blocking STAT1 activation
Xu, J. X., Xu, F. Z., Furbish, A. B., Braxton, A. M., Brumfield, B., Helke, K. L., & Peterson, Y. K. (2024) · Communications Biology · doi:10.1038/s42003-024-06051-6 · Cited by 18 · see citing works
A Novel Transactivating Factor That Regulates Interferon-γ-dependent Gene Expression
Hu, J., Meng, Q., Roy, S. K., Raha, A., Hu, J., Zhang, J., Hashimoto, K., & Kalvakolanu, D. V. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202679200 · Cited by 15 · see citing works
The Host-Protective Effect of Arabinosylated Lipoarabinomannan against Leishmania donovani Infection Is Associated with Restoration of IFN-γ Responsiveness
Chowdhury, B. P., Bandyopadhyay, S., Das, S., Majumder, S., Jha, M. K., Majumdar, S. B., Saha, B., & Subrata, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117247 · Cited by 12 · see citing works
IL-27 improves migrational and antiviral potential of CB dendritic cells
Birkholz, J., Doganci, A., Darstein, C., Gehring, S., Zepp, F., & Meyer, C. U. (2014) · Human Immunology · doi:10.1016/j.humimm.2014.02.004 · Cited by 10 · see citing works
The Role of the Placental Enzyme Indoleamine 2,3-Dioxygenase in Normal and Abnormal Human Pregnancy
Kudo, Y., & Sugimoto, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084577 · Cited by 9 · see citing works
A truncated IFN-regulatory factor-8\IFN consensus sequence-binding protein acts as dominant-negative, interferes with endogenous protein-protein interactions and leads to apoptosis of immune cells
Hashmueli, S. (2003) · International Immunology · doi:10.1093/intimm/dxg077 · Cited by 9 · see citing works
The Icsbp locus is a common proviral insertion site in mature B-cell lymphomas/plasmacytomas induced by exogenous murine leukemia virus
Ma, S. L., Sørensen, A. B., Kunder, S., Sørensen, K. D., Quintanilla‐Martínez, L., Morris, D. W., Schmidt, J., & Pedersen, F. S. (2006) · Virology · doi:10.1016/j.virol.2006.05.006 · Cited by 9 · see citing works
Tumor-Derived Cytokines Dysregulate Macrophage Interferon-γ Responsiveness and Interferon Regulatory Factor-8 Expression
Mullins, D. W., Martins, R. S., & Elgert, K. D. (2003) · Experimental Biology and Medicine · doi:10.1177/153537020322800305 · Cited by 8 · see citing works
Grass carp (Ctenopharyngodon idella) interferon regulatory factor 8 down-regulates interferon1 expression via interaction with interferon regulatory factor 2 in vitro
Chang, K., Han, K. S., Qiu, W., Hu, Z., Chen, X., Chen, X., Xie, X., Wang, S., Hu, C., & Mao, H. (2021) · Molecular Immunology · doi:10.1016/j.molimm.2021.04.020 · Cited by 6 · see citing works
Proteasome Composition in Cytokine-Treated Neurons and Astrocytes is Determined Mainly by Subunit Displacement
Shanley, K. L., Hu, C., & Bizzozero, O. A. (2020) · Neurochemical Research · doi:10.1007/s11064-020-02958-8 · Cited by 5 · see citing works
Transcription Factors That Regulate Macrophage Development and Function
Hume, D. A., & Himes, S. R. (2003) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-55742-2_2 · Cited by 4 · see citing works
Molecular characterization and functional analysis of interferon regulatory factor 8 in the sea cucumber Apostichopus japonicus during Vibrio splendidus challenge
Wang, Y., Wang, X., Jiang, J., Li, C., & Shao, Y. (2026) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2026.111292 · Cited by 3 · see citing works
Macrophage Immunity and Mycobacterium tuberculosis
MacMicking, J. D., & McKinney, J. D. (2003) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-55742-2_22 · Cited by 2 · see citing works
Interferon Regulatory Factors: Role in Transcriptional Regulation of Macrophage Plasticity and Activation
Eames, H. L., & Udalova, I. A. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1311-4_22 · Cited by 1 · see citing works
Mechanisms of Transcriptional Regulation
Marecki, S., & Fenton, M. J. (2000) · Cited by 2 · see citing works
TUMOR-BEARING HOST MACROPHAGE DYSFUNCTION: ROLE OF
Martins, R. S. (2001)
Tumor-Bearing Host Macrophage Dysfunction: Role of CD40/CD40L Interactions
Martins, R. S. (2001) · VTechWorks (Virginia Tech)

An IFN-γ-Inducible Transcription Factor, IFN Consensus Sequence Binding Protein (ICSBP), Stimulates IL-12 p40 Expression in Macrophages
Wang, I.-M., Contursi, C., Masumi, A., Ma, X., Trinchieri, G., & Ozato, K. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.1.271 · Cited by 187 · see citing works
Self-citation
Regulation of IFN Consensus Sequence Binding Protein Expression in Murine Macrophages
Kantakamalakul, W., Politis, A. D., Marecki, S., Sullivan, T., Ozato, K., Fenton, M. J., & Vogel, S. N. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.12.7417 · Cited by 61 · see citing works
Self-citation
Modulation of interferon consensus sequence binding protein mRNA in murine peritoneal macrophages. Induction by IFN-gamma and down-regulation by IFN-alpha, dexamethasone, and protein kinase inhibitors
Politis, A. D., Sivo, J., Driggers, P. H., Ozato, K., & Vogel, S. N. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.3.801 · Cited by 68 · see citing works
Self-citation
Regulation of IFN-gamma-induced nuclear expression of IFN consensus sequence binding protein in murine peritoneal macrophages.
Politis, A. D., Ozato, K., Coligan, J. E., & Vogel, S. N. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.5.2270 · Cited by 61 · see citing works
Self-citation
IFN-γ Up-Regulates IL-18 Gene Expression Via IFN Consensus Sequence-Binding Protein and Activator Protein-1 Elements in Macrophages
Kim, Y.-M., Im, J. Y., Han, S. H., Kang, H. S., & Choi, I. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.6.3198 · Cited by 77 · see citing works

Authors: Contursi, C., Wang, I.-M., Gabriele, L., Gadina, M., O'Shea, J., Morse, H. C., & Ozato, K.
Affiliations: National Institutes of Health (US)
Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, and Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal Diseases, National Institutes of Health, Bethesda, MD 20892
ORCID: Wang, I-Ming
Gabriele, Lucia
Gadina, Massimo
Morse, Herbert C.
Ozato, Keiko
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2000-01-04
Volume: 97
Issue: 1
Pages: 91-96
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.97.1.91
PMC: PMC26621
OpenAlex: W2034779553
Cited by: 72
References: 40
Citations by year: 2026: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 5 · 2020: 1 · 2018: 1 · 2017: 2 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 2
FWCI: 4.12
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: IRF8, STAT1, interferon-gamma, macrophages, transcriptional activation, innate immunity, transcriptional regulation
MeSH terms: Interferon Regulatory Factor-8, Animals, Cell Line, DNA-Binding Proteins, Humans, Interferon-gamma, Macrophages, Promoter Regions, Genetic, Repressor Proteins, Transfection, Transcriptional Activation, Trans-Activators, Genes, Reporter, Mice, Knockout, Reverse Transcriptase Polymerase Chain Reaction, STAT1 Transcription Factor, Interferon Regulatory Factors, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

IFN consensus sequence binding protein potentiates STAT1-dependent activation of IFNγ-responsive promoters in macrophages

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks