Cited by 264interferon and immune responsesImmune Response and InflammationImmunotherapy and Immune Responses

The IRF family of transcription factors: Inception, impact and implications in oncogenesis

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Yanai, Hideyuki, Negishi, Hideo, Taniguchi, Tadatsugu·2012·OncoImmunology

Abstract

Members of the interferon-regulatory factor (IRF) proteins family were originally identified as transcriptional regulators of the Type I interferon system. Thanks to consistent advances made in our understanding of the immunobiology of innate receptors, it is now clear that several IRFs are critical for the elicitation of innate pattern recognition receptors, and-as a consequence-for adaptive immunity. In addition, IRFs have attracted great attentions as they modulate cellular responses that are involved in tumorigenesis. The regulation of oncogenesis by IRFs has important implications for understanding the host susceptibility to several Types of cancers, their progression, as well as the potential for therapeutic interventions.

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Crossref · 10.4161/onci.22475

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  • Borzoi correctly predicts upregulation of SHTN1 expression owing to the creation of a CEBP binding motif.

    “Borzoi correctly predicts the upregulation of SHTN1 expression owing to the creation of a CEBP binding motif69–72 (see Supplementary Fig. 9a and Extended Data Fig. 6a,b for additional examples).”

    From Predicting RNA-seq coverage from DNA sequence as a unifying model of gene regulation (2025) · cites this paper as [71]

    The retrieved passages from the References section concern interferon regulatory factors, not Borzoi or SHTN1. Searches for the claim’s wording, SHTN1 and CEBP, and Borzoi found no passage in our copy addressing the predicted upregulation or its proposed motif mechanism. (LLM, conf=0.77)

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Authors
Yanai, H., Negishi, H., & Taniguchi, T.
Affiliations
Japan Science and Technology Agency (JP)
Corresponding author
Taniguchi, Tadatsugu
Venue
OncoImmunology
Published
2012-11
Volume
1
Issue
8
Pages
1376-1386
ISSN
  • 2162-4011 (ISSN-L)
  • 2162-402X
OpenAlex
W2031904443
Cited by
261
References
140
Citations by year
2026: 15 · 2025: 18 · 2024: 24 · 2023: 22 · 2022: 32 · 2021: 29 · 2020: 25 · 2019: 26 · 2018: 21 · 2017: 14 · 2016: 8 · 2015: 9 · 2014: 12 · 2013: 6
FWCI
3.78
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • OncoImmunology (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
Core Research for Evolutional Science and Technology
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords
interferon regulatory factors, transcription factors, type I interferon, innate immunity, pattern recognition receptors, adaptive immunity, carcinogenesis, cancer susceptibility, tumor progression, cancer therapy

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