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Deciphering the differentiation trajectory from hematopoietic stem cells to mast cells

Grootens, Jennine, Ungerstedt, Johanna S., Nilsson, Gunnar, Dahlin, Joakim S.·2018·Blood Advances
DOI 10.1182/bloodadvances.2018019539
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Abstract

Hematopoietic stem cells differentiate into all types of blood cells, including peripheral tissue-resident mast cells. The early mast cell differentiation takes place in the bone marrow, after which the progenitor cells enter the circulation and mature once reaching their target organ. Early results from single-cell culture experiments and colony-forming assays have produced the classic hierarchical tree model of hematopoiesis. The introduction of high-throughput, single-cell RNA sequencing is now revolutionizing our understanding of the differentiation process, questioning the classic tree-based models. By integrating the results from early cell culture experiments with single-cell transcriptomics, we present a differentiation landscape model of hematopoiesis and discuss it with focus on mast cells. The review also describes how the hematologic neoplasm systemic mastocytosis can be used to model human hematopoiesis using naturally occurring cell barcoding by means of the common KIT D816V mutation.

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Metadata

Authors
Grootens, J., Ungerstedt, J. S., Nilsson, G., & Dahlin, J. S.
Affiliations
  • 1Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
  • 3Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden
ORCID
Dahlin, Joakim S.
Venue
Blood Advances
Publisher
American Society of Hematology
Published
2018-09-11
Volume
2
Issue
17
Pages
2273-2281
ISSN
  • 2473-9529
  • 2473-9537
DOI
10.1182/bloodadvances.2018019539
Cited by
62
References
6
Language
en

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Grootens, J., Ungerstedt, J. S., Nilsson, G., & Dahlin, J. S. (2018). Deciphering the differentiation trajectory from hematopoietic stem cells to mast cells. Blood Advances. https://doi.org/10.1182/bloodadvances.2018019539