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Adipose Tissue as a Dedicated Reservoir of Functional Mast Cell Progenitors

Poglio, Sandrine, De Toni-Costes, Fabienne, Arnaud, Emmanuelle, Laharrague, Patrick, Espinosa, Eric, Casteilla, Louis, Cousin, Béatrice·2010·Stem Cells
DOI 10.1002/stem.523
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Abstract

White adipose tissue (WAT) is a heterogeneous tissue, found in various locations throughout the body, containing mature adipocytes and the stroma-vascular fraction (SVF). The SVF includes a large proportion of immune hematopoietic cells, among which, mast cells that contribute to diet-induced obesity. In this study, we asked whether mast cells present in mice adipose tissue could derive from hematopoietic stem/progenitor cells (HSPC) identified in the tissue. We therefore performed both in vitro and in vivo experiments dedicated to monitoring the progeny of WAT-derived HSPC. The entire study was conducted in parallel with bone marrow-derived cells, considered the gold standard for hematopoietic-lineage studies. Here, we demonstrate that adipose-derived HSPC contain a precursor-cell population committed to the mast cell lineage, and able to efficiently home to peripheral organs such as intestine and skin, where it acquires properties of functional tissue mast cells. Additionally, WAT contains a significant mast cell progenitor population, suggesting that the entire mast cell lineage process take place in WAT. Considering the quantitative importance of WAT in the adult organism and the increasing roles recently assigned to mast cells in physiopathology, WAT may represent an important source of mast cells in physiological and pathological situations.

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Research works printed but not linked: 30

  1. Ailhaud, 2006, Adipose tissue as a secretory organ: From adipogenesis to the metabolic syndrome, C R Biol, 329, 570, 10.1016/j.crvi.2005.12.012 · DOI
  2. Cousin, 2003, Reconstitution of lethally irradiated mice by cells isolated from adipose tissue, Biochem Biophys Res Commun, 301, 1016, 10.1016/S0006-291X(03)00061-5 · DOI
  3. Han, 2010, Adipose tissue is an extramedullary reservoir for functional hematopoietic stem and progenitor cells, Blood, 115, 957, 10.1182/blood-2009-05-219923 · DOI
  4. Bouloumie, 2008, Adipose tissue lymphocytes and macrophages in obesity and insulin resistance: Makers or markers, and which comes first?, Arterioscler Thromb Vasc Biol, 28, 1211, 10.1161/ATVBAHA.108.168229 · DOI · Paper page
  5. Nishimura, 2009, CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity, Nat Med, 15, 914, 10.1038/nm.1964 · DOI · Paper page
  6. Nakano, 1985, Fate of bone marrow-derived cultured mast cells after intracutaneous, intraperitoneal, and intravenous transfer into genetically mast cell-deficient W/Wv mice. Evidence that cultured mast cells can give rise to both connective tissue type and mucosal mast cells, J Exp Med, 162, 1025, 10.1084/jem.162.3.1025 · DOI · Paper page
  7. Marshall, 2004, Mast-cell responses to pathogens, Nat Rev Immunol, 4, 787, 10.1038/nri1460 · DOI
  8. Rao, 2008, Mast cells: Multifaceted immune cells with diverse roles in health and disease, Ann N Y Acad Sci, 1143, 83, 10.1196/annals.1443.023 · DOI
  9. Gaudenzio, 2009, Cell-cell cooperation at the T helper cell/mast cell immunological synapse, Blood, 114, 4979, 10.1182/blood-2009-02-202648 · DOI
  10. Enerback, 1966, Mast cells in rat gastrointestinal mucosa. 3. Reactivity towards compound 48/80, Acta Pathol Microbiol Scand, 66, 313, 10.1111/apm.1966.66.3.313 · DOI
  11. Irani, 1989, Detection of MCT and MCTC types of human mast cells by immunohistochemistry using new monoclonal anti-tryptase and anti-chymase antibodies, J Histochem Cytochem, 37, 1509, 10.1177/37.10.2674273 · DOI
  12. Tsai, 1991, Induction of mast cell proliferation, maturation, and heparin synthesis by the rat c-kit ligand, stem cell factor, Proc Natl Acad Sci USA, 88, 6382, 10.1073/pnas.88.14.6382 · DOI
  13. Bachelet, 2006, Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): A novel interface in the allergic process, J Biol Chem, 281, 27190, 10.1074/jbc.M602359200 · DOI
  14. Malbec, 2007, Peritoneal cell-derived mast cells: An in vitro model of mature serosal-type mouse mast cells, J Immunol, 178, 6465, 10.4049/jimmunol.178.10.6465 · DOI
  15. Miller, 2008, Characterization of mouse hematopoietic stem and progenitor cells, Curr Protoc Immunol, 10.1002/0471142735.im22b02s80 · DOI
  16. Pereira, 2007, Hematopoietic colony-forming cell assays, Methods Mol Biol, 407, 177, 10.1007/978-1-59745-536-7_14 · DOI
  17. Coulombel, 2004, Identification of hematopoietic stem/progenitor cells: Strength and drawbacks of functional assays, Oncogene, 23, 7210, 10.1038/sj.onc.1207941 · DOI
  18. Gurish, 2006, Mast cells: Ontogeny, homing, and recruitment of a unique innate effector cell, J Allergy Clin Immunol, 117, 1285, 10.1016/j.jaci.2006.04.017 · DOI
  19. Stechschulte, 1987, Effect of the mi allele on mast cells, basophils, natural killer cells, and osteoclasts in C57Bl/6J mice, J Cell Physiol, 132, 565, 10.1002/jcp.1041320321 · DOI
  20. Tsai, 1997, Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation, Blood, 89, 3636, 10.1182/blood.V89.10.3636 · DOI
  21. Arinobu, 2005, Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis, Proc Natl Acad Sci USA, 102, 18105, 10.1073/pnas.0509148102 · DOI · Paper page
  22. Chen, 2005, Identification of mast cell progenitors in adult mice, Proc Natl Acad Sci USA, 102, 11408, 10.1073/pnas.0504197102 · DOI · Paper page
  23. Arinobu, 2009, Origin of basophils and mast cells, Allergol Int, 58, 21, 10.2332/allergolint.08-RAI-0067 · DOI
  24. Crapper, 1983, Frequency of mast cell precursors in normal tissues determined by an in vitro assay: Antigen induces parallel increases in the frequency of P cell precursors and mast cells, J Immunol, 131, 923, 10.4049/jimmunol.131.2.923 · DOI
  25. Kasugai, 1995, Infection with Nippostrongylus brasiliensis induces invasion of mast cell precursors from peripheral blood to small intestine, Blood, 85, 1334, 10.1182/blood.V85.5.1334.bloodjournal8551334 · DOI
  26. Kitamura, 1977, Development of mast cells from grafted bone marrow cells in irradiated mice, Nature, 268, 442, 10.1038/268442a0 · DOI
  27. Takano, 2008, Establishment of the culture model system that reflects the process of terminal differentiation of connective tissue-type mast cells, FEBS Lett, 582, 1444, 10.1016/j.febslet.2008.03.033 · DOI
  28. Chaldakov, 2001, NGF, BDNF, leptin, and mast cells in human coronary atherosclerosis and metabolic syndrome, Arch Physiol Biochem, 109, 357, 10.1076/apab.109.4.357.4249 · DOI
  29. Taildeman, 2009, Human mast cells express leptin and leptin receptors, Histochem Cell Biol, 131, 703, 10.1007/s00418-009-0575-3 · DOI
  30. Hatanaka, 1986, Effects of degranulation of mast cells on proliferation of mesenchymal cells in the mesentery of mice, Cell Tissue Res, 246, 53, 10.1007/BF00218998 · DOI

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Metadata

Authors
Poglio, S., De Toni-Costes, F., Arnaud, E., Laharrague, P., Espinosa, E., Casteilla, L., & Cousin, B.
Affiliations
  • CNRS, UMR 5241 Métabolisme, Plasticité et Mitochondrie andToulouse, France
  • Institut National de la Santé et de la Recherche Médicale (INSERM), U563 andCentre de Physiopathologie de Toulouse-Purpan, Toulouse, France
Venue
Stem Cells
Publisher
Oxford University Press (OUP)
Published
2010-11-01
Volume
28
Issue
11
Pages
2065-2072
ISSN
  • 1066-5099
  • 1549-4918
DOI
10.1002/stem.523
Cited by
111
References
5
Language
en
Licence
academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Funders
  • ANR (≪Floradip≫ANR-08-BLAN-0324-04)
  • French “Ministère de la Recherche et de la Technologie.”

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CoChat. (2026). Citation check: Adipose Tissue as a Dedicated Reservoir of Functional Mast Cell Progenitors. https://app.cochat.ai/papers/10.1002/stem.523
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Poglio, S., De Toni-Costes, F., Arnaud, E., Laharrague, P., Espinosa, E., Casteilla, L., & Cousin, B. (2010). Adipose Tissue as a Dedicated Reservoir of Functional Mast Cell Progenitors. Stem Cells. https://doi.org/10.1002/stem.523