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Cited by 134

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Neural respiratory drive and breathlessness in COPD

Jolley, Caroline J., Luo, Yuanming M., Steier, Joerg, Rafferty, Gerrard F., Polkey, Michael I., Moxham, John·2015·European Respiratory Journal
DOI 10.1183/09031936.00063014
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Abstract

The aim of this study was to test the hypothesis that neural respiratory drive, measured using diaphragm electromyogram (EMG di ) activity expressed as a percentage of maximum (EMG di%max ), is closely related to breathlessness in chronic obstructive pulmonary disease. We also investigated whether neuroventilatory uncoupling contributes significantly to breathlessness intensity over an awareness of levels of neural respiratory drive alone. EMGdi and ventilation were measured continuously during incremental cycle and treadmill exercise in 12 chronic obstructive pulmonary disease patients (forced expiratory volume in 1 s± sd was 38.7±14.5 % pred). EMG di was expressed both as EMG di%max and relative to tidal volume expressed as a percentage of predicted vital capacity to quantify neuroventilatory uncoupling. EMG di%max was closely related to Borg breathlessness in both cycle (r=0.98, p=0.0001) and treadmill exercise (r=0.94, p=0.005), this relationship being similar to that between neuroventilatory uncoupling and breathlessness (cycling r=0.94, p=0.005; treadmill r=0.91, p=0.01). The relationship between breathlessness and ventilation was poor when expansion of tidal volume became limited. In chronic obstructive pulmonary disease the intensity of exertional breathlessness is closely related to EMG di%max . These data suggest that breathlessness in chronic obstructive pulmonary disease can be largely explained by an awareness of levels of neural respiratory drive, rather than the degree of neuroventilatory uncoupling. EMG di%max could provide a useful physiological biomarker for breathlessness in chronic obstructive pulmonary disease.

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  1. 10.1513/pats.200611-159CC · DOI
  2. 10.1183/09059180.00000809 · DOI
  3. 10.1172/JCI103383 · DOI
  4. Evanich, 1973, Force output of the diaphragm as a function of phrenic nerve firing rate and lung volume, J Appl Physiol, 35, 208, 10.1152/jappl.1973.35.2.208 · DOI
  5. 10.1016/j.rmed.2010.02.019 · DOI
  6. 10.1164/ajrccm.155.1.9001298 · DOI
  7. 10.1152/japplphysiol.01470.2005 · DOI · Paper page
  8. 10.1164/ajrccm.160.5.9809068 · DOI
  9. 10.1183/09031936.00093408 · DOI
  10. Luo, 2010, Neural respiratory drive in patients with COPD during exercise tests, Respiration, 81, 294, 10.1159/000317136 · DOI
  11. 10.1136/thx.2010.142646 · DOI
  12. Sinderby, 1998, Voluntary activation of the human diaphragm in health and disease, J Appl Physiol, 85, 2146, 10.1152/jappl.1998.85.6.2146 · DOI
  13. 10.1097/CCM.0b013e3181cb0d7b · DOI
  14. 10.1007/s00134-011-2376-0 · DOI
  15. 10.1249/00005768-198205000-00012 · DOI · Paper page
  16. 10.1016/j.resp.2004.12.014 · DOI
  17. 10.1016/j.resp.2009.04.018 · DOI
  18. 10.1007/s00134-013-2910-3 · DOI
  19. 10.1152/japplphysiol.00950.2013 · DOI
  20. 10.1113/expphysiol.2013.074880 · DOI
  21. 10.1152/japplphysiol.00898.2006 · DOI · Paper page
  22. 10.1152/japplphysiol.00079.2008 · DOI
  23. 10.1113/jphysiol.2008.158154 · DOI
  24. Campbell, 1963, The sensation of breathlessness, Br Med Bull, 19, 36, 10.1093/oxfordjournals.bmb.a070002 · DOI
  25. 10.1016/j.resp.2012.05.018 · DOI
  26. 10.1016/j.resp.2004.04.003 · DOI
  27. Burdon, 1982, The perception of breathlessness in asthma, Am Rev Respir Dis, 126, 825
  28. 10.1056/NEJM199712183372503 · DOI · Paper page
  29. 10.1113/jphysiol.1954.sp005099 · DOI
  30. Mead, 1982, Analysis of volume displacement and length changes of the diaphragm during breathing, J Appl Physiol Respir Environ Exerc Physiol, 53, 750
  31. Ward, 1988, Respiratory sensation and pattern of respiratory muscle activation during diaphragm fatigue, J Appl Physiol, 65, 2181, 10.1152/jappl.1988.65.5.2181 · DOI
  32. 10.1378/chest.98.2.298 · DOI
  33. 10.1136/thx.2010.151332 · DOI
  34. 10.1378/chest.116.6.1593 · DOI
  35. Sinderby, 1997, Enhancement of signal quality in esophageal recordings of diaphragm EMG, J Appl Physiol, 82, 1370, 10.1152/jappl.1997.82.4.1370 · DOI
  36. 10.1016/j.resp.2014.03.004 · DOI
  37. Agostoni, 1960, Electromyography of the diaphragm in man and transdiaphragmatic pressure, J Appl Physiol, 15, 1093, 10.1152/jappl.1960.15.6.1093 · DOI
  38. Petit, 1960, Role of the diaphragm in breathing in conscious normal man: an electromyographic study, J Appl Physiol, 15, 1101, 10.1152/jappl.1960.15.6.1101 · DOI
  39. 10.1164/ajrccm.160.5.9904023 · DOI
  40. 10.1113/expphysiol.2012.071415 · DOI
  41. Decramer, 1984, Respiratory changes in parasternal intercostal length, J Appl Physiol Respir Environ Exerc Physiol, 57, 1254
  42. Decramer, 1986, Relationship between diaphragm length and abdominal dimensions, J Appl Physiol, 61, 1815, 10.1152/jappl.1986.61.5.1815 · DOI
  43. Gauthier, 1994, Three-dimensional reconstruction of the in vivo human diaphragm shape at different lung volumes, J App Physiol, 76, 495, 10.1152/jappl.1994.76.2.495 · DOI
  44. 10.1164/ajrccm.150.1.8025770 · DOI
  45. 10.1183/09031936.00092613 · DOI · Paper page

Cited by

Metadata

Authors
Jolley, C. J., Luo, Y. M., Steier, J., Rafferty, G. F., Polkey, M. I., & Moxham, J.
Venue
European Respiratory Journal
Publisher
European Respiratory Society (ERS)
Published
2014-10-16
Volume
45
Issue
2
Pages
355-364
ISSN
  • 0903-1936
  • 1399-3003
DOI
10.1183/09031936.00063014
Cited by
134
References
5
Language
en

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