The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
The prevalence of quadriceps weakness in COPD and the relationship with disease severity
Abstract
Quadriceps strength relates to exercise capacity and prognosis in chronic obstructive pulmonary disease (COPD). We wanted to quantify the prevalence of quadriceps weakness in COPD and hypothesised that it would not be restricted to patients with severe airflow obstruction or dyspnoea. Predicted quadriceps strength was calculated using a regression equation (incorporating age, sex, height and fat-free mass), based on measurements from 212 healthy subjects. The prevalence of weakness (defined as observed values 1.645 standardised residuals below predicted) was related to Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage and Medical Research Council (MRC) dyspnoea score in two cohorts of stable COPD outpatients recruited from the UK (n = 240) and the Netherlands (n = 351). 32% and 33% of UK and Dutch COPD patients had quadriceps weakness. A significant proportion of patients in GOLD stages 1 and 2, or with an MRC dyspnoea score of 1 or 2, had quadriceps weakness (28 and 26%, respectively). These values rose to 38% in GOLD stage 4, and 43% in patients with an MRC Score of 4 or 5. Quadriceps weakness was demonstrable in one-third of COPD patients attending hospital respiratory outpatient services. Quadriceps weakness exists in the absence of severe airflow obstruction or breathlessness.
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“Previous studies in GOLD 1 COPD have also shown that perceived leg discomfort is often the main sensory locus of exercise limitation although the underlying mechanisms are not fully understood [12,13,35,41].”
From Mechanisms of exertional dyspnoea in symptomatic smokers without COPD (2016) · cites this paper as [41]
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Cited by
Spruit, M. A., Singh, S. J., Garvey, C., ZuWallack, R., Nici, L., Rochester, C., Hill, K., Holland, A. E., Lareau, S. C., Man, W. D.-C., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201309-1634st · Cited by 3,938
Self-citationAcute skeletal muscle wasting in critical illness
Puthucheary, Z. A., Rawal, J., McPhail, M., Connolly, B., Ratnayake, G., Chan, P., Hopkinson, N. S., Padhke, R., Dew, T., Sidhu, P. S., et al. (2013) · JAMA · doi:10.1001/jama.2013.278481 · Cited by 2,103
Self-citationQuadriceps wasting and physical inactivity in patients with COPD
Shrikrishna, D., Patel, M., Tanner, R. J., Seymour, J. M., Connolly, B. A., Puthucheary, Z. A., Walsh, S. L. F., Bloch, S. A., Sidhu, P. S., Hart, N., et al. (2012) · European Respiratory Journal · doi:10.1183/09031936.00170111 · Cited by 331
Self-citationMechanisms of exertional dyspnoea in symptomatic smokers without COPD
Elbehairy, A. F., Guenette, J. A., Faisal, A., Ciavaglia, C. E., Webb, K. A., Jensen, D., Ramsook, A. H., Neder, J. A., & O'Donnell, D. E. (2016) · European Respiratory Journal · doi:10.1183/13993003.00077-2016 · Cited by 99
Vignaud, J., Loiseau, C., Hérault, J., Mayer, C., Côme, M., Martin, I., & Ulmann, L. (2023) · Antioxidants · doi:10.3390/antiox12051050 · Cited by 72
Metadata
- Authors
- Seymour, J. M., Spruit, M. A., Hopkinson, N. S., Natanek, S. A., Man, W. D.-C., Jackson, A., Gosker, H. R., Schols, A. M. W. J., Moxham, J., Polkey, M. I., & Wouters, E. F. M.
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2009-11-06
- Volume
- 36
- Issue
- 1
- Pages
- 81-88
- ISSN
- 0903-1936
- 1399-3003
- Cited by
- 411
- References
- 7
- Language
- en
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- Seymour, J. M., Spruit, M. A., Hopkinson, N. S., Natanek, S. A., Man, W. D.-C., Jackson, A., Gosker, H. R., Schols, A. M. W. J., Moxham, J., Polkey, M. I., & Wouters, E. F. M. (2010). The prevalence of quadriceps weakness in COPD and the relationship with disease severity. European Respiratory Journal. https://doi.org/10.1183/09031936.00104909
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