Experimental infection with equine herpesvirus type 1 (EHV-1) induces chorioretinal lesions.
Open accessAbstract
Equine herpesvirus myeloencephalitis (EHM) remains one of the most devastating manifestations of equine herpesvirus type 1 (EHV-1) infection but our understanding of its pathogenesis remains rudimentary, partly because of a lack of adequate experimental models. EHV-1 infection of the ocular vasculature may offer an alternative model as EHV-1-induced chorioretinopathy appears to occur in a significant number of horses, and the pathogenesis of EHM and ocular EHV-1 may be similar. To investigate the potential of ocular EHV-1 as a model for EHM, and to determine the frequency of ocular EHV-1, our goal was to study: (1) Dissemination of virus following acute infection, (2) Development and frequency of ocular lesions following infection, and (3) Utility of a GFP-expressing virus for localization of the virus in vivo. Viral antigen could be detected following acute infection in ocular tissues and the central nervous system (experiment 1). Furthermore, EHV-1 infection resulted in multifocal choroidal lesions in 90% (experiment 2) and 50% (experiment 3) of experimentally infected horses, however ocular lesions did not appear in vivo until between 3 weeks and 3 months post-infection. Taken together, the timing of the appearance of lesions and their ophthalmoscopic features suggest that their pathogenesis may involve ischemic injury to the chorioretina following viremic delivery of virus to the eye, mirroring the vascular events that result in EHM. In summary, we show that the frequency of ocular EHV-1 is 50-90% following experimental infection making this model attractive for testing future vaccines or therapeutics in an immunologically relevant age group.
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The frequency of EHV-1 ocular lesions varies between 50 and 90% in experimentally infected horses.
“The frequency of EHV-1 ocular lesions varies between 50 and 90% in experimentally infected horses (Hussey et al., 2013).”
From The Pathogenesis and Immune Evasive Mechanisms of Equine Herpesvirus Type 1 (2021) · cites this paper as Hussey et al., 2013
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- Authors
- Hussey, G., Goehring, L. S., Lunn, D. P., Hussey, S. B., Huang, T., Osterrieder, N., Powell, C., Hand, J., Holz, C., & Slater, J.
- Affiliations
- Michigan State University (US)
- Colorado State University (US)
- North Carolina State University (US)
- Freie Universität Berlin (DE)
- Royal Veterinary College (GB)
- Corresponding author
- Hussey, Gisela
- ORCID
- Venue
- Veterinary Research
- Published
- 2013
- Volume
- 44
- Issue
- 1
- Pages
- 118
- ISSN
- 0928-4249 (ISSN-L)
- 1297-9716
- PMC
- PMC4028784
- OpenAlex
- W2171324876
- Cited by
- 70
- References
- 33
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 6 · 2023: 7 · 2022: 12 · 2021: 7 · 2020: 6 · 2019: 7 · 2018: 2 · 2017: 6 · 2016: 5 · 2015: 5 · 2014: 1
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Veterinary Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by)
- RVC Research Online (Royal Veterinary College) (submittedVersion, cc-by)
- Refubium (Universitätsbibliothek der Freien Universität Berlin) (submittedVersion, cc-by)
- Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver (cc-by)
- Funders
- Horserace Betting Levy Board
- Topics
- Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
- Keywords
- equine herpesvirus 1, chorioretinopathy, choroidal lesions, viral dissemination, central nervous system infection, viremia
- MeSH terms
- Animals, Chorioretinitis, Encephalomyelitis, Herpesvirus 1, Equid, Fluorescein Angiography, Herpesviridae Infections, Horse Diseases, Horses, Neutralization Tests, Nose, Random Allocation, Viremia, Virus Shedding, Green Fluorescent Proteins
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