Evaluation of immune responses following infection of ponies with an EHV-1 ORF1/2 deletion mutant.

Hussey, Gisela Soboll; Hussey, Stephen B; Wagner, Bettina; Horohov, David W; Van de Walle, Gerlinde R; Osterrieder, Nikolaus; Goehring, Lutz S; Rao, Sangeeta; Lunn, David P

doi:10.1186/1297-9716-42-23

Cited by 73Herpesvirus Infections and TreatmentsAnimal Virus Infections StudiesViral-associated cancers and disorders

Evaluation of immune responses following infection of ponies with an EHV-1 ORF1/2 deletion mutant.

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Hussey, Gisela Soboll, Hussey, Stephen B, Wagner, Bettina, Horohov, David W, Van de Walle, Gerlinde R, Osterrieder, Nikolaus, Goehring, Lutz S, Rao, Sangeeta +1 more·2011·Veterinary Research

DOI 10.1186/1297-9716-42-23PMC PMC3045331

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Abstract

Equine herpesvirus-1 (EHV-1) infection remains a significant problem despite the widespread use of vaccines. The inability to generate a protective immune response to EHV-1 vaccination or infection is thought to be due to immunomodulatory properties of the virus, and the ORF1 and ORF2 gene products have been hypothesized as potential candidates with immunoregulatory properties. A pony infection study was performed to define immune responses to EHV-1, and to determine if an EHV-1 ORF1/2 deletion mutant (ΔORF1/2) would have different disease and immunoregulatory effects compared to wild type EHV-1 (WT). Infection with either virus led to cytokine responses that coincided with the course of clinical disease, particularly the biphasic pyrexia, which correlates with respiratory disease and viremia, respectively. Similarly, both viruses caused suppression of proliferative T-cell responses on day 7 post infection (pi). The ΔORF1/ORF2 virus caused significantly shorter primary pyrexia and significantly reduced nasal shedding, and an attenuated decrease in PBMC IL-8 as well as increased Tbet responses compared to WT-infected ponies. In conclusion, our findings are (i) that infection of ponies with EHV-1 leads to modulation of immune responses, which are correlated with disease pathogenesis, and (ii) that the ORF1/2 genes are of importance for disease outcome and modulation of cytokine responses.

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EHV-1 early protein pUL56 modulates cytokine responses both in vivo and in vitro.
“Besides, EHV-1 early protein pUL56 (encoded by EHV-1 ORF1) has also been shown to modulate the cytokine responses both in vivo and in vitro (Soboll Hussey et al., 2011; Hussey et al., 2014).”
From The Pathogenesis and Immune Evasive Mechanisms of Equine Herpesvirus Type 1 (2021) · cites this paper as Soboll Hussey et al., 2011
The Results and Discussion report altered IL-8 and Tbet responses in ponies infected with a virus lacking both ORF1 and ORF2, supporting an in vivo immunomodulatory role for those genes. The study does not isolate the effect of ORF1’s pUL56 protein, and its in vitro cytokine re-stimulation results found no significant difference between infection groups. Pages are not specified in our copy. (LLM, conf=0.88)
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Authors: Hussey, G. S., Hussey, S. B., Wagner, B., Horohov, D. W., Van de Walle, G. R., Osterrieder, N., Goehring, L. S., Rao, S., & Lunn, D. P.
Affiliations: Colorado State University (US)
Cornell University (US)
University of Kentucky (US)
Freie Universität Berlin (DE)
Corresponding author: Hussey, Gisela Soboll
ORCID: Hussey, Gisela Soboll
Wagner, Bettina
Osterrieder, Nikolaus
Goehring, Lutz S
Rao, Sangeeta
Lunn, David P
Venue: Veterinary Research
Publisher: Springer Science and Business Media LLC
Published: 2011-02-07
Volume: 42
Issue: 1
Pages: 23-23
ISSN: 0928-4249 (ISSN-L)
1297-9716
DOI: 10.1186/1297-9716-42-23
PMC: PMC3045331
OpenAlex: W2115244008
Cited by: 73
References: 39
Citations by year: 2025: 4 · 2024: 7 · 2023: 4 · 2022: 2 · 2021: 6 · 2020: 4 · 2019: 6 · 2018: 5 · 2017: 7 · 2016: 2 · 2015: 4 · 2014: 8 · 2013: 7 · 2012: 5
FWCI: 5.04
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Veterinary Research (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Ghent University Academic Bibliography (Ghent University) (submittedVersion, other-oa)
UKnowledge (University of Kentucky) (submittedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Refubium (Universitätsbibliothek der Freien Universität Berlin) (submittedVersion, cc-by)
Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver (cc-by)
Funders: U.S. Department of Agriculture
Grayson-Jockey Club Research Foundation
Topics: Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
Keywords: equine herpesvirus 1, immunomodulation, cytokine response, fever, nasal shedding, T cell proliferation, interleukin-8, T-bet, viremia, respiratory diseases, attenuated virus
MeSH terms: Animals, Antibodies, Viral, Enzyme-Linked Immunosorbent Assay, Herpesvirus 1, Equid, Female, Herpesviridae Infections, Horse Diseases, Horses, Immunity, Innate, Male, Nasal Mucosa, Random Allocation, RNA, Messenger, Viral Proteins, Viremia, Cytokines, Virus Shedding, Adaptive Immunity

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Evaluation of immune responses following infection of ponies with an EHV-1 ORF1/2 deletion mutant.

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