Cited by 192Cancer, Hypoxia, and MetabolismMechanisms of cancer metastasisCancer Cells and Metastasis

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Hypoxia-regulated target genes implicated in tumor metastasis

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Tsai, Ya-Ping, Wu, Kou-Juey·2012·Journal of Biomedical Science

DOI 10.1186/1423-0127-19-102PMC PMC3541338

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Abstract

Hypoxia is an important microenvironmental factor that induces cancer metastasis. Hypoxia/hypoxia-inducible factor-1α (HIF-1α) regulates many important steps of the metastatic processes, especially epithelial-mesenchymal transition (EMT) that is one of the crucial mechanisms to cause early stage of tumor metastasis. To have a better understanding of the mechanism of hypoxia-regulated metastasis, various hypoxia/HIF-1α-regulated target genes are categorized into different classes including transcription factors, histone modifiers, enzymes, receptors, kinases, small GTPases, transporters, adhesion molecules, surface molecules, membrane proteins, and microRNAs. Different roles of these target genes are described with regards to their relationship to hypoxia-induced metastasis. We hope that this review will provide a framework for further exploration of hypoxia/HIF-1α-regulated target genes and a comprehensive view of the metastatic picture induced by hypoxia.

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2 retracted

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Retracted
RETRACTED ARTICLE: HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs
Zhang, H., Wong, C. C. L., Wei, H., Gilkes, D. M., Korangath, P., Chaturvedi, P., Schito, L., Chen, J., Krishnamachary, B., Winnard, P. T., et al. (2012) · Oncogene · doi:10.1038/onc.2011.365 · Cited by 326
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Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
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Authors: Tsai, Y.-P., & Wu, K.-J.
Affiliations: National Yang Ming University (TW)
Corresponding author: Wu, Kou-Juey
ORCID: Wu, Kou-Juey
Venue: Journal of Biomedical Science
Publisher: Springer Science and Business Media LLC
Published: 2012
Volume: 19
Issue: 1
Pages: 102
ISSN: 1021-7770 (ISSN-L)
1423-0127
DOI: 10.1186/1423-0127-19-102
PMC: PMC3541338
OpenAlex: W2120227239
Cited by: 190
References: 85
Citations by year: 2025: 7 · 2024: 5 · 2023: 9 · 2022: 9 · 2021: 15 · 2020: 13 · 2019: 11 · 2018: 16 · 2017: 22 · 2016: 19 · 2015: 24 · 2014: 24 · 2013: 16
FWCI: 1.53
Type: journal article
Language: en
Open access: diamond
doi.org
Licence: cc-by
Locations: Journal of Biomedical Science (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: National Science Council (DOH101-TD-C-111-007)
National Health Research Institutes (NHRI-EX101-9931BI)
National Research Program for Biopharmaceuticals (NSC101-2325-B-010-004)
Taichung Veterans General Hospital
Taipei Veterans General Hospital (DOH101-TD-C-111-007)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords: tumor hypoxia, HIF-1α, metastasis, epithelial-mesenchymal transition, transcription factors, histone modifiers, microRNA, small GTPases, adhesion molecules, kinases, receptors, tumor microenvironment
MeSH terms: Humans, Neoplasm Metastasis, Neoplasms, Transcription Factors, Transcription, Genetic, Signal Transduction, Cell Hypoxia, MicroRNAs, Hypoxia-Inducible Factor 1, alpha Subunit, Epithelial-Mesenchymal Transition

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