Hypoxia-regulated target genes implicated in tumor metastasis

Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin

Aziz, J., Shezali, H., Radzi, Z., Yahya, N. A., Abu Kassim, N. H., Czernuszka, J., & Rahman, M. T. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000447017 · Cited by 7,323

Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients

Locatelli, F., Fishbane, S. N., Block, G. A., & Macdougall, I. C. (2017) · American Journal of Nephrology · doi:10.1159/000455166 · Cited by 4,836

Cancer Metastasis: Building a Framework

Gupta, G. P., & Massagué, J. (2006) · Cell · doi:10.1016/j.cell.2006.11.001 · Cited by 4,333

Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?

Peinado, H., Olmeda, D., & Cano, A. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2131 · Cited by 3,121

Hypoxia-inducible factors and the response to hypoxic stress

Majmundar, A. J., Wong, W. J., & Simon, M. C. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.022 · Cited by 2,380

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

Keith, B., Johnson, R. S., & Simon, M. C. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3183 · Cited by 1,693

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

Semenza, G. L. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.01.005 · Cited by 1,514

The impact of O2 availability on human cancer

Bertout, J. A., Patel, S. A., & Simon, M. C. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2540 · Cited by 1,365

Direct regulation of TWIST by HIF-1α promotes metastasis

Yang, M.-H., Wu, M.-Z., Chiou, S.-H., Chen, P.-M., Chang, S.-Y., Liu, C.-J., Teng, S.-C., & Wu, K.-J. (2008) · Nature Cell Biology · doi:10.1038/ncb1691 · Cited by 1,345

Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche

Erler, J. T., Bennewith, K. L., Cox, T. R., Lang, G., Bird, D., Koong, A., Le, Q.-T., & Giaccia, A. J. (2009) · Cancer Cell · doi:10.1016/j.ccr.2008.11.012 · Cited by 1,231

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

Wise, D. R., Ward, P. S., Shay, J. E. S., Cross, J. R., Gruber, J. J., Sachdeva, U. M., Platt, J. M., DeMatteo, R. G., Simon, M. C., & Thompson, C. B. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117773108 · Cited by 975

Chemokine receptor CXCR4 downregulated by von Hippel–Lindau tumour suppressor pVHL

Staller, P., Sulitkova, J., Lisztwan, J., Moch, H., Oakeley, E. J., & Krek, W. (2003) · Nature · doi:10.1038/nature01874 · Cited by 870

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Notch signaling mediates hypoxia-induced tumor cell migration and invasion

Sahlgren, C., Gustafsson, M. V., Jin, S., Poellinger, L., & Lendahl, U. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802047105 · Cited by 823

Hypoxia and hypoxia-inducible factors: master regulators of metastasis

Lu, X., & Kang, Y. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-1360 · Cited by 723

Hypoxia-Inducible mir-210 Regulates Normoxic Gene Expression Involved in Tumor Initiation

Huang, X., Ding, L., Bennewith, K. L., Tong, R. T., Welford, S. M., Ang, K. K., Story, M. D., Le, Q., & Giaccia, A. J. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.006 · Cited by 634

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Pericyte Depletion Results in Hypoxia-Associated Epithelial-to-Mesenchymal Transition and Metastasis Mediated by Met Signaling Pathway

Cooke, V. G., LeBleu, V. S., Keskin, D., Khan, Z., O'Connell, J. T., Teng, Y., Duncan, M. B., Xie, L., Maeda, G., Vong, S., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2011.11.024 · Cited by 530

An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia

Benita, Y., Kikuchi, H., Smith, A. D., Zhang, M. Q., Chung, D. C., & Xavier, R. J. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp425 · Cited by 486

A molecular role for lysyl oxidase‐like 2 enzyme in Snail regulation and tumor progression

Peinado, H., la Cruz, M. D. C. I., Olmeda, D., Csiszár, K., Fong, K. S. K., Vega, S., Nieto, M. A., Cano, A., & Portillo, F. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600781 · Cited by 444

Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation

Wong, C. C.-L., Gilkes, D. M., Zhang, H., Chen, J., Wei, H., Chaturvedi, P., Fraley, S. I., Wong, C.-M., Khoo, U.-S., Ng, I. O.-L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113483108 · Cited by 437

P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis

Yamakuchi, M., Lotterman, C., Bao, C., Hruban, R. H., Karim, B. O., Mendell, J. T., Huso, D. L., & Lowenstein, C. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911082107 · Cited by 433

Hypoxia-Inducible Factor-1-Dependent Repression of E-cadherin in von Hippel-Lindau Tumor Suppressor–Null Renal Cell Carcinoma Mediated by TCF3, ZFHX1A, and ZFHX1B

Krishnamachary, B., Zagzag, D., Nagasawa, H., Rainey, K., Okuyama, H., Baek, J. H., & Semenza, G. L. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3719 · Cited by 415

ERβ Impedes Prostate Cancer EMT by Destabilizing HIF-1α and Inhibiting VEGF-Mediated Snail Nuclear Localization: Implications for Gleason Grading

Mak, P., Leav, I., Pursell, B. M., Bae, D., Yang, X., Taglienti, C. A., Gouvin, L. M., Sharma, V. M., & Mercurio, A. M. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.02.030 · Cited by 380

MiR-210 – micromanager of the hypoxia pathway

Huang, X., Le, Q., & Giaccia, A. J. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.03.004 · Cited by 376

Hypoxia-Inducible Factor-1-Dependent Repression of E-cadherin in von Hippel-Lindau Tumor Suppressor—Null Renal Cell Carcinoma Mediated by TCF3, ZFHX1A, and ZFHX1B

Gordon, M. S. (2007) · Yearbook of Oncology · doi:10.1016/s1040-1741(08)70352-x · Cited by 343

Glucose transporter glut-1 expression correlates with tumor hypoxia and predicts metastasis-free survival in advanced carcinoma of the cervix.

Airley, R. E., Loncaster, J. A., Davidson, S. E., Bromley, M., Roberts, S. K., Patterson, A. V., Hunter, R. D., Stratford, I. J., & West, C. (2001) · PubMed · Cited by 320

Differential Gene Up-Regulation by Hypoxia-Inducible Factor-1α and Hypoxia-Inducible Factor-2α in HEK293T Cells

Wang, V., Davis, D. A., Haque, M., Huang, E. L., & Yarchoan, R. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4130 · Cited by 317

TWIST activation by hypoxia inducible factor-1 (HIF-1): Implications in metastasis and development

Yang, M., & Wu, K.-J. (2008) · Cell Cycle · doi:10.4161/cc.7.14.6324 · Cited by 306

miR-103/107 Promote Metastasis of Colorectal Cancer by Targeting the Metastasis Suppressors DAPK and KLF4

Chen, H., Lin, Y., Chung, H.-C., Lang, Y., Lin, C., Huang, J. C., Wang, W.-C., Lin, F.-M., Chen, Z., Huang, H., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0667 · Cited by 304

Identification of Hypoxia-inducible Factor 1 Ancillary Sequence and Its Function in Vascular Endothelial Growth Factor Gene Induction by Hypoxia and Nitric Oxide

Kimura, H., Weisz, A., Ogura, T., Hitomi, Y., Kurashima, Y., Hashimoto, K., D’Acquisto, F., Makuuchi, M., & Esumi, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008398200 · Cited by 259

VHL Promotes E2 Box-Dependent E-Cadherin Transcription by HIF-Mediated Regulation of SIP1 and Snail

Evans, A. J., Russell, R. C., Roche, O., Burry, T. N., Fish, J. E., Chow, V. W. K., Kim, W. Y., Saravanan, A., Maynard, M. A., Gervais, M. L., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00892-06 · Cited by 255

Role of HIF-1α in the regulation ACE and ACE2 expression in hypoxic human pulmonary artery smooth muscle cells

Zhang, R., Wu, Y., Zhao, M. L., Liu, C., Zhou, L., Shen, S.-M., Liao, S., Yang, K., Li, Q. Y., & Wan, H. (2009) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.90415.2008 · Cited by 236

Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression

Luo, W., Chang, R., Zhong, J., Pandey, A., & Semenza, G. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217394109 · Cited by 228

Molecular mechanisms mediating metastasis of hypoxic breast cancer cells

Semenza, G. L. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.08.001 · Cited by 225

Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2α in von Hippel–Lindau renal cell carcinoma

Petrella, B. L., Lohi, J., & Brinckerhoff, C. (2004) · Oncogene · doi:10.1038/sj.onc.1208305 · Cited by 195

Activation of β-Catenin by Hypoxia in Hepatocellular Carcinoma Contributes to Enhanced Metastatic Potential and Poor Prognosis

Liu, L., Zhu, X., Wang, W., Shen, Y., Qin, Y., Ren, Z., Sun, H., & Tang, Z. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-2610 · Cited by 187

Hypoxia-Induced Down-Regulation of microRNA-34a Promotes EMT by Targeting the Notch Signaling Pathway in Tubular Epithelial Cells

Du, R., Sun, W., Xia, L., Zhao, A., Yu, Y., Zhao, L., Wang, H., Huang, C., & Sun, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030771 · Cited by 176

Hypoxia-inducible MicroRNA-210 augments the metastatic potential of tumor cells by targeting vacuole membrane protein 1 in hepatocellular carcinoma

Qiao, Y., Liang, L., Guo, W., Zha, R., Tian, Q., Huang, S., Yao, J., Ding, J., Bao, M., Ge, C., et al. (2010) · Hepatology · doi:10.1002/hep.24614 · Cited by 175

Hypoxia inducible factor-1 mediates expression of galectin-1: the potential role in migration/invasion of colorectal cancer cells

Zhao, X.-Y., Chen, T., Li, X., Guo, M., Xu, Y., Yue, F., Jiang, Y., Chen, G., & Zhao, K.-W. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq116 · Cited by 150

Hypoxia-induced mixed-lineage leukemia 1 regulates glioma stem cell tumorigenic potential

Heddleston, J. M., Wu, Q., Rivera, M., Minhas, S., Lathia, J. D., Sloan, A. E., Iliopoulos, O., Hjelmeland, A. B., & Rich, J. N. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.109 · Cited by 142

Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor–mediated upregulation of caveolin-1

Wang, Y., Roche, O., Xu, C., Moriyama, E. H., Heir, P., Chung, J., Roos, F. C., Chen, Y., Finak, G., Milosevic, M., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112129109 · Cited by 139

Hypoxia can induce c‐Met expression in glioma cells and enhance SF/HGF‐induced cell migration

Eckerich, C., Zapf, S., Fillbrandt, R., Loges, S., Westphal, M., & Lamszus, K. (2007) · International Journal of Cancer · doi:10.1002/ijc.22679 · Cited by 138

Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs

Voellenkle, C., van Rooij, J., Guffanti, A., Brini, E., Fasanaro, P., Isaia, E., Croft, L., David, M., Capogrossi, M. C., Moles, A., et al. (2012) · RNA · doi:10.1261/rna.027615.111 · Cited by 130

CD24 Is an Effector of HIF-1–Driven Primary Tumor Growth and Metastasis

Thomas, S., Harding, M. A., Smith, S. C., Overdevest, J. B., Nitz, M. D., Frierson, H. F., Tomlins, S. A., Kristiansen, G., & Theodorescu, D. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3666 · Cited by 128

Induction of ID2 Expression by Hypoxia-inducible Factor-1

Löfstedt, T., Jögi, A., Sigvardsson, M., Gradin, K., Poellinger, L., Påhlman, S., & Axelson, H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402904200 · Cited by 126

Hypoxia upregulates CD147 through a combined effect of HIF-1α and Sp1 to promote glycolysis and tumor progression in epithelial solid tumors

Ke, X., Fei, F., Chen, Y., Xu, L., Zhang, Z., Huang, Q., Zhang, H., Yang, H., Chen, Z., & Xing, J. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs196 · Cited by 124

Molecular regulation of the PAI‐1 gene by hypoxia: contributions of Egr‐1, HIF‐1 α, and C/EBPα

Liao, H., Hyman, M. C., Lawrence, D. A., & Pinsky, D. J. (2006) · The FASEB Journal · doi:10.1096/fj.06-6285com · Cited by 121

MUC1, a New Hypoxia Inducible Factor Target Gene, Is an Actor in Clear Renal Cell Carcinoma Tumor Progression

Aubert, S., Fauquette, V., Hémon, B., Lepoivre, R., Briez, N., Bernard, D., SEUNINGEN, I. V., Leroy, X., & Perrais, M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4905 · Cited by 121

Hypoxia-Inducible Factor 1α Mediates Anoikis Resistance via Suppression of α5 Integrin

Rohwer, N., Welzel, M., Daskalow, K., Pfander, D., Wiedenmann, B., Detjen, K. M., & Cramer, T. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1839 · Cited by 111

Hypoxia and RAS-signaling pathways converge on, and cooperatively downregulate, the RECK tumor-suppressor protein through microRNAs

Loayza‐Puch, F., Yoshida, Y., Matsuzaki, T., Takahashi, C., Kitayama, H., & Noda, M. (2010) · Oncogene · doi:10.1038/onc.2010.23 · Cited by 97

HIF-1α downregulates miR-17/20a directly targeting p21 and STAT3: a role in myeloid leukemic cell differentiation

He, M., Wang, Q.-Y., Yin, Q.-Q., Tang, J., Lu, Y., Zhou, C.-X., Duan, C.-W., Hong, D.-L., Tanaka, T. T., Chen, G.-Q., et al. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.130 · Cited by 94

Expression of a Truncated Active Form of VDAC1 in Lung Cancer Associates with Hypoxic Cell Survival and Correlates with Progression to Chemotherapy Resistance

Brahimi-Horn, M. C., Ben-Hail, D., Ilié, M., Gounon, P., Rouleau, M., Hofman, V., Doyen, J., Mari, B. P., Shoshan‐Barmatz, V., Hofman, P. M., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3940 · Cited by 86

HIF-1α-induced histone demethylase JMJD2B contributes to the malignant phenotype of colorectal cancer cells via an epigenetic mechanism

Fu, L., Chen, L., Yang, J., Ye, T., Chen, Y., & Fang, J. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs217 · Cited by 86

Hypoxia-inducible Factor-1-mediated Regulation of Semaphorin 4D Affects Tumor Growth and Vascularity

Sun, Q., Zhou, H., Binmadi, N. O., & Basile, J. R. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.057166 · Cited by 83

ADAMTS1 Is a Unique Hypoxic Early Response Gene Expressed by Endothelial Cells

Hatipoğlu, Ö. F., Hirohata, S., Cilek, M. Z., Ogawa, H., Miyoshi, T., Obika, M., Demircan, K., Shinohata, R., Kusachi, S., & Ninomiya, Y. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.001313 · Cited by 77

Hypoxia Modulates EWS-FLI1 Transcriptional Signature and Enhances the Malignant Properties of Ewing's Sarcoma Cells In vitro

Aryee, D. N. T., Niedan, S., Kauer, M. O., Schwentner, R., Bennani-Baı̈ti, I. M., Ban, J., Muehlbacher, K., Kreppel, M., Walker, R. L., Meltzer, P. S., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-4333 · Cited by 76

Transcriptional Regulation of Urokinase-type Plasminogen Activator Receptor by Hypoxia-Inducible Factor 1 Is Crucial for Invasion of Pancreatic and Liver Cancer

Büchler, P., Reber, H. A., Tomlinson, J. S., Hankinson, O., Kallifatidis, G., Frieß, H., Herr, I., & Hines, O. J. (2009) · Neoplasia · doi:10.1593/neo.08734 · Cited by 75

Androgen-Dependent Gene Expression of Prostate-Specific Antigen Is Enhanced Synergistically by Hypoxia in Human Prostate Cancer Cells

Horii, K., Suzuki, Y., Kondo, Y., Akimoto, M., Nishimura, T., Yamabe, Y., Sakaue, M., Sano, T., Kitagawa, T., Himeno, S., et al. (2007) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-06-0226 · Cited by 75

Invited review: decoding the microRNA response to hypoxia

Pocock, R. (2011) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-010-0910-5 · Cited by 72

Regulation of CD151 by Hypoxia Controls Cell Adhesion and Metastasis in Colorectal Cancer

Chien, C., Lin, S., Lai, Y.-Y., Lin, B.-W., Lin, S.-C., Lee, J., & Tsai, S. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1651 · Cited by 72

Transcriptional up-regulation of RhoE by hypoxia-inducible factor (HIF)-1 promotes epithelial to mesenchymal transition of gastric cancer cells during hypoxia

Zhou, J., Li, K., Gu, Y., Feng, B., Ren, G., Zhang, L., Yf, W., Nie, Y., & Fan, D. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.10.065 · Cited by 71

Pdcd4 repression of lysyl oxidase inhibits hypoxia-induced breast cancer cell invasion

Santhanam, A. N., Baker, A. R., Hegamyer, G., Kirschmann, D. A., & Colburn, N. H. (2010) · Oncogene · doi:10.1038/onc.2010.158 · Cited by 67

HIF1α regulated expression of XPA contributes to cisplatin resistance in lung cancer

Liu, Y., Bernauer, A. M., Yingling, C. M., & Belinsky, S. A. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs142 · Cited by 65

HSulf-1 Modulates FGF2- and Hypoxia-Mediated Migration and Invasion of Breast Cancer Cells

Khurana, A., Liu, P., Mellone, P., Lorenzon, L., Vincenzi, B., Datta, K., Yang, B., Linhardt, R. J., Lingle, W. L., CHIEN, J. R., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3059 · Cited by 65

Proteomics-based identification of two novel direct targets of hypoxia-inducible factor-1 and their potential roles in migration/invasion of cancer cells

Liao, S., Zhao, X., Han, Y., Zhang, J., Wang, L., Xia, L., Zhao, K., Zheng, Y., Guo, M., & Chen, G. (2009) · PROTEOMICS · doi:10.1002/pmic.200800922 · Cited by 64

Up-Regulation ofc-metProtooncogene Product Expression through Hypoxia-Inducible Factor-1α Is Involved in Trophoblast Invasion under Low-Oxygen Tension

Hayashi, M., Sakata, M., Takeda, T., Tahara, M., Yamamoto, T., Okamoto, Y., Minekawa, R., Isobe, A., Ohmichi, M., Tasaka, K., et al. (2005) · Endocrinology · doi:10.1210/en.2005-0416 · Cited by 56

Hypoxia‐inducible factor‐1α regulates matrix metalloproteinase‐1 activity in human bone marrow‐derived mesenchymal stem cells

Lin, J.-L., Wang, M. J., Lee, D., Liang, C.-C., & Lin, S. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.06.033 · Cited by 55

Human Enhancer of Filamentation 1 Is a Mediator of Hypoxia-Inducible Factor-1α–Mediated Migration in Colorectal Carcinoma Cells

Kim, S.-H., Xia, D., Kim, S.-W., Holla, V. R., Menter, D. G., & DuBois, R. N. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2110 · Cited by 54

Regulation of the Matricellular Proteins CYR61 (CCN1) and NOV (CCN3) by Hypoxia-Inducible Factor-1α and Transforming-Growth Factor-β3 in the Human Trophoblast

Wolf, N., Yang, W., Dunk, C. E., Gashaw, I., Lye, S. J., Ring, T., Schmidt, M., Winterhager, E., & Gellhaus, A. (2010) · Endocrinology · doi:10.1210/en.2009-1195 · Cited by 52

Hypoxia-Inducible Factor-1α Regulates Chemotactic Migration of Pancreatic Ductal Adenocarcinoma Cells through Directly Transactivating the CX3CR1 Gene

Zhao, T., Gao, S., Wang, X., Liu, J., Duan, Y., Yuan, Z., Sheng, J., Li, S., Wang, F., Yu, M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043399 · Cited by 48

Adaptation of Human CD4+ T Cells to Pathophysiological Hypoxia: A Transcriptome Analysis

GABER, T., HÄUPL, T., SANDIG, G., TYKWINSKA, K., FANGRADT, M., TSCHIRSCHMANN, M., HAHNE, M., DZIURLA, R., EREKUL, K., LAUTENBACH, M., et al. (2009) · The Journal of Rheumatology · doi:10.3899/jrheum.090255 · Cited by 47

Hypoxia promotes metastasis in human gastric cancer by up‐regulating the 67‐kDa laminin receptor

Liu, L., Sun, L., Zhao, P., Yao, L., Jin, H., Liang, S., Wang, Y., Zhang, D., Pang, Y., Shi, Y., et al. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01592.x · Cited by 46

Hypoxia Regulates Insulin Receptor Substrate-2 Expression to Promote Breast Carcinoma Cell Survival and Invasion

Mardilovich, K., & Shaw, L. M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1152 · Cited by 45

Histone demethylase JMJD2B-mediated cell proliferation regulated by hypoxia and radiation in gastric cancer cell

Kim, J., Yi, J. M., Park, S., Kim, J., Son, T. G., Yang, K., Yoo, M., & Heo, K. (2012) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2012.10.001 · Cited by 43

Nitric oxide causes macrophage migration via the HIF-1-stimulated small GTPases Cdc42 and Rac1

Zhou, J., Dehne, N., & Brüne, B. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.06.006 · Cited by 40

Hypoxia increases CX3CR1 expression via HIF-1 and NF-κB in androgen-independent prostate cancer cells

Xiao, L., Chen, Y., Lin, P., ZOU, H.-F., LIN, F., Zhao, L., Li, D., GUO, L., Tang, J., Zheng, X., et al. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1610 · Cited by 37

Recepteur d'Origine Nantais Tyrosine Kinase Is a Direct Target of Hypoxia-inducible Factor-1α-mediated Invasion of Breast Carcinoma Cells

Thangasamy, A., Rogge, J., & Ammanamanchi, S. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809320200 · Cited by 35

Hypoxic Conversion of SMAD7 Function from an Inhibitor into a Promoter of Cell Invasion

Heikkinen, P. T., Nummela, M., Jokilehto, T., Grenman, R. A., Kähäri, V., & Jaakkola, P. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3777 · Cited by 31

Hypoxia-inducible factor-1 up-regulates the expression of Toll-like receptor 4 in pancreatic cancer cells under hypoxic conditions

Fan, P., Zhang, J., Wang, B., Wu, H.-Q., Zhou, S.-X., Wang, C., Zhang, J., Tian, Y., & Wu, H. (2012) · Pancreatology · doi:10.1016/j.pan.2012.02.015 · Cited by 23

Regulation of RON Tyrosine Kinase-mediated Invasion of Breast Cancer Cells

Thangasamy, A., Rogge, J., & Ammanamanchi, S. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706957200 · Cited by 23

Hypoxia-inducible factor-1α modulates the down-regulation of the homeodomain protein CDX2 in colorectal cancer

Sun (2010) · Oncology Reports · doi:10.3892/or_00000833 · Cited by 18

Liprin-α4 is a new hypoxia-inducible target gene required for maintenance of cell–cell contacts

Mattauch, S., Sachs, M., & Behrens, J. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.06.022 · Cited by 17

Anoikis molecular pathways and its role in cancer progression

Paoli, P., Giannoni, E., & Chiarugi, P. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.06.026 · Cited by 1,160

Defining normoxia, physoxia and hypoxia in tumours—implications for treatment response

McKeown, S. R. (2014) · The British Journal of Radiology · doi:10.1259/bjr.20130676 · Cited by 1,050

Regulation of pyruvate metabolism and human disease

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