The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
Hypoxia-regulated target genes implicated in tumor metastasis
Open accessAbstract
Hypoxia is an important microenvironmental factor that induces cancer metastasis. Hypoxia/hypoxia-inducible factor-1α (HIF-1α) regulates many important steps of the metastatic processes, especially epithelial-mesenchymal transition (EMT) that is one of the crucial mechanisms to cause early stage of tumor metastasis. To have a better understanding of the mechanism of hypoxia-regulated metastasis, various hypoxia/HIF-1α-regulated target genes are categorized into different classes including transcription factors, histone modifiers, enzymes, receptors, kinases, small GTPases, transporters, adhesion molecules, surface molecules, membrane proteins, and microRNAs. Different roles of these target genes are described with regards to their relationship to hypoxia-induced metastasis. We hope that this review will provide a framework for further exploration of hypoxia/HIF-1α-regulated target genes and a comprehensive view of the metastatic picture induced by hypoxia.
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“In addition, iron regulates the activity of the transcription factors NF-κB and HIF-1α [58], which promote the expression of genes involved in the survival and metastasis of cancer cells [59, 60].”
From The utility of iron chelators in the management of inflammatory disorders (2015) · cites this paper as [60]
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2 retracted
Lysyl oxidase is essential for hypoxia-induced metastasis
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RetractedZhang, H., Wong, C. C. L., Wei, H., Gilkes, D. M., Korangath, P., Chaturvedi, P., Schito, L., Chen, J., Krishnamachary, B., Winnard, P. T., et al. (2012) · Oncogene · doi:10.1038/onc.2011.365 · Cited by 326
RetractedMolecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
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Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients
Locatelli, F., Fishbane, S. N., Block, G. A., & Macdougall, I. C. (2017) · American Journal of Nephrology · doi:10.1159/000455166 · Cited by 4,836
Cancer Metastasis: Building a Framework
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Metadata
- Authors
- Tsai, Y.-P., & Wu, K.-J.
- Affiliations
- National Yang Ming University (TW)
- Corresponding author
- Wu, Kou-Juey
- ORCID
- Wu, Kou-Juey
- Venue
- Journal of Biomedical Science
- Published
- 2012
- Volume
- 19
- Issue
- 1
- Pages
- 102
- ISSN
- 1021-7770 (ISSN-L)
- 1423-0127
- PMC
- PMC3541338
- OpenAlex
- W2120227239
- Cited by
- 190
- References
- 85
- Citations by year
- 2025: 7 · 2024: 5 · 2023: 9 · 2022: 9 · 2021: 15 · 2020: 13 · 2019: 11 · 2018: 16 · 2017: 22 · 2016: 19 · 2015: 24 · 2014: 24 · 2013: 16
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Journal of Biomedical Science (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Science Council (DOH101-TD-C-111-007)
- National Health Research Institutes (NHRI-EX101-9931BI)
- National Research Program for Biopharmaceuticals (NSC101-2325-B-010-004)
- Taichung Veterans General Hospital
- Taipei Veterans General Hospital (DOH101-TD-C-111-007)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- tumor hypoxia, HIF-1α, metastasis, epithelial-mesenchymal transition, transcription factors, histone modifiers, microRNA, small GTPases, adhesion molecules, kinases, receptors, tumor microenvironment
- MeSH terms
- Humans, Neoplasm Metastasis, Neoplasms, Transcription Factors, Transcription, Genetic, Signal Transduction, Cell Hypoxia, MicroRNAs, Hypoxia-Inducible Factor 1, alpha Subunit, Epithelial-Mesenchymal Transition
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