The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
The zebrafish lysozyme C promoter drives myeloid-specific expression in transgenic fish
Open accessAbstract
Background: How different immune cell compartments contribute to a successful immune response is central to fully understanding the mechanisms behind normal processes such as tissue repair and the pathology of inflammatory diseases. However, the ability to observe and characterize such interactions, in real-time, within a living vertebrate has proved elusive. Recently, the zebrafish has been exploited to model aspects of human disease and to study specific immune cell compartments using fluorescent reporter transgenic lines. A number of blood-specific lines have provided a means to exploit the exquisite optical clarity that this vertebrate system offers and provide a level of insight into dynamic inflammatory processes previously unavailable. Results: We used regulatory regions of the zebrafish lysozyme C (lysC) gene to drive enhanced green fluorescent protein (EGFP) and DsRED2 expression in a manner that completely recapitulated the endogenous expression profile of lysC. Labeled cells were shown by co-expression studies and FACS analysis to represent a subset of macrophages and likely also granulocytes. Functional assays within transgenic larvae proved that these marked cells possess hallmark traits of myelomonocytic cells, including the ability to migrate to inflammatory sources and phagocytose bacteria. Conclusion: These reporter lines will have utility in dissecting the genetic determinants of commitment to the myeloid lineage and in further defining how lysozyme-expressing cells participate during inflammation.
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Cites
Inflammatory cells during wound repair: the good, the bad and the ugly
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“These studies also support existing knowledge regarding the timing of arrival of the different leukocytic lineages during a robust inflammatory response [60].”
BackgroundResultInfluentialAbsence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL
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Cited by
A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish
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“Fish Lines—Wild-type AB, Tg(lyz:Dsred) (16), Tg(coro1a: eGFP)hkz04t, Tg(coro1a:eGFP)hkz05t, and runx1 fish strains were maintained as described (25).”
BackgroundMacrophages modulate adult zebrafish tail fin regeneration
Petrie, T. A., Strand, N. S., Tsung-Yang, C., Rabinowitz, J. S., & Moon, R. T. (2014) · Development · doi:10.1242/dev.098459 · Cited by 365
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Self-citationAdult Zebrafish as a Model System for Cutaneous Wound-Healing Research
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Emerging fungal pathogen Candida auris evades neutrophil attack
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Rac2 Regulates the Migration of T Lymphoid Progenitors to the Thymus during Zebrafish Embryogenesis
Lu, X., Zhang, Y., Liu, F., & Wang, L. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1901494 · Cited by 21
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Metadata
- Authors
- Hall, C., Flores, M. V., Storm, T., Crosier, K., & Crosier, P.
- Venue
- BMC Developmental Biology
- Published
- 2007-05-04
- Volume
- 7
- Issue
- 1
- Pages
- 42-42
- ISSN
- 1471-213X (ISSN-L)
- OpenAlex
- W2076970838
- Cited by
- 591
- References
- 7
- FWCI
- 6.69
- Type
- journal article
- Language
- en
- Open access
- hybrid
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