Cited by 300Ruminant Nutrition and Digestive PhysiologyFatty Acid Research and HealthMeat and Animal Product Quality

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Toxicity of unsaturated fatty acids to the biohydrogenating ruminal bacterium, Butyrivibrio fibrisolvens

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Maia, Margarida RG, Chaudhary, Lal C, Bestwick, Charles S, Richardson, Anthony J, McKain, Nest, Larson, Tony R, Graham, Ian A, Wallace, Robert J·2010·BMC Microbiology

DOI 10.1186/1471-2180-10-52PMC PMC2836310

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Abstract

BACKGROUND: Health-promoting polyunsaturated fatty acids (PUFA) are abundant in forages grazed by ruminants and in vegetable and fish oils used as dietary supplements, but only a small proportion of PUFA finds its way into meat and milk, because of biohydrogenation in the rumen. Butyrivibrio fibrisolvens plays a major role in this activity. The aim of this study was to investigate the mechanisms by which PUFA affect the growth of B. fibrisolvens, how PUFA are metabolized and the metabolic response to growth in the presence of PUFA. RESULTS: Linoleic acid (LA; cis-9, cis-12-18:2) and alpha-linolenic acid (LNA; cis-9, cis-12, cis-15-18:3) increased the lag phase of B. fibrisolvens JW11, LNA having the greater effect. Growth was initiated only when the PUFA had been converted to vaccenic acid (VA; trans-11-18:1). The major fish oil fatty acids, eicosapentaenoic acid (EPA; 20:5(n-3)) and docosahexaenoic acid (DHA; 22:6(n-3)), were not metabolized and prevented growth. Cellular integrity, as determined fluorimetrically by propidium iodide (PI) ingression, was affected as much by 18:1 fatty acids, including VA, as 18:2 fatty acids. The methyl esters of LNA, LA, EPA and DHA had no effect on growth or other measurements. The ATP pool decreased by 2/3 when LA was added to growing bacteria, whereas most acyl CoA pools decreased by >96%. CONCLUSIONS: It was concluded that biohydrogenation occurs to enable B. fibrisolvens to survive the bacteriostatic effects of PUFA, and that the toxicity of PUFA is probably mediated via a metabolic effect rather than disruption of membrane integrity.

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Figure 1 Concentration of fatty acids in the medium following inoculation of B. fibrisolvens JW11 into M2 medium containing 50 μg ml-1 linoleic acid (LA; cis-9, cis-12-18:2). Growth (open circle, OD650), LA (square), cis-9, trans-11-18:2 (black circle), trans-11-18:1 (triangle). Results are means and SD from three cultures.CC BY · PubMed Central

Figure 2 Concentration of fatty acids in the medium following inoculation of B. fibrisolvens JW11 into M2 medium containing 50 μg ml-1 α-linolenic acid (LNA; cis-9, cis-12, cis-15-18:3). Growth (open circle, OD650), LNA (black circle), cis-9, trans-11, cis-15-18:3 (open square), trans-9, trans-11, cis-15-18:3 (black square), trans-11, cis-15-18:2 (open triangle), cis-9, trans-11-18:2 (black triangle), trans-11-18:1 (diamond). Results are means and SD from three cultures.CC BY · PubMed Central

Figure 3 Influence of different fatty acids and fatty acid methyl esters on cell integrity of B. fibrisolvens JW11. Loss of cell integrity was determined fluorimetrically by propidium iodide fluorescence. LNA, cis-9, cis-12, cis-15-18:3; γLNA, cis-6, cis-9, cis-12-18:3; LA, cis-9, cis-12-18:2; CLA, a mixture of cis-9, trans-11-18:2 and trans-10, cis-12-18:2; VA, trans-11-18:1; OA, cis-9-18:1; SA, 18:0. In order of increasing shading density: 50 μg fatty acid ml-1, 200 μg fatty acid ml-1, 50 μg fatty acid methyl ester ml-1, 200 μg fatty acid methyl ester ml-1. Results are means and SD from three determinations.CC BY · PubMed Central

Figure 4 Influence of different fatty acids on PI fluorescence of B. fibrisolvens JW11 by flow cytometry. Black - live cells; green - heat-killed cells; pink - 50 μg ml-1 LA; turquoise - 50 μg ml-1 LNA; orange - 50 μg ml-1 CLA; blue - 50 μg ml-1 VA; yellow - 50 μg ml-1 SA.CC BY · PubMed Central

Figure 5 Influence of sodium lactate (70 mM) on the loss of cell integrity of B. fibrisolvens JW11 following incubation with LA (50 μg ml-1). Loss of cell integrity was determined by fluorescence in the presence of propidium iodide. Sodium lactate + LA (open bar), LA alone (black bar). Results are means and SD from three cultures, each of which was subject to 8 replicate measurements (n = 24).CC BY · PubMed Central

Figure 6 Influence of LA on ATP pools of B. fibrisolvens JW11 after 50% inoculation into fresh medium. LA (black circle), no LA (open circle). Results are means and SD from three separate cultures.CC BY · PubMed Central

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'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data
Nicholson, J. K., Lindon, J. C., & Holmes, E. C. (1999) · Xenobiotica · doi:10.1080/004982599238047 · Cited by 3,991
The Rumen Microbial Ecosystem
Hobson, P. N., & Stewart, C. S. (1997) · Springer eBooks · doi:10.1007/978-94-009-1453-7 · Cited by 2,159
Acidosis in cattle: a review.
Owens, F. N., Secrist, D. S., Hill, W. J., & Gill, D. R. (1998) · Journal of Animal Science · doi:10.2527/1998.761275x · Cited by 1,385
The rumen bacteria
Stewart, C. S., Flint, H. J., & Bryant, M. P. (1997) · The Rumen Microbial Ecosystem · doi:10.1007/978-94-009-1453-7_2 · Cited by 772
Keilin's Respiratory Chain Concept and Its Chemiosmotic Consequences
Mitchell, P. (1979) · Science · doi:10.1126/science.388618 · Cited by 738
Lipid metabolism in the rumen
Harfoot, C. G. (1978) · Progress in Lipid Research · doi:10.1016/0079-6832(78)90004-6 · Cited by 710
Intermediates and Products of the Biohydrogenation of Linoleic Acid by Butyrivibrio fibrisolvens
Kepler, C. R., Hirons, K. P., McNeill, J. J., & Tove, S. B. (1966) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)96781-5 · Cited by 693
Metabolism of polyunsaturated fatty acids and their toxicity to the microflora of the rumen
Maia, M. R. G., Chaudhary, L. C., Figueres, L., & Wallace, R. J. (2006) · Antonie van Leeuwenhoek · doi:10.1007/s10482-006-9118-2 · Cited by 530
Self-citation
Manipulating the fatty acid composition of muscle and adipose tissue in beef cattle
Scollan, N. D., Choi, N., Kurt, E., Fisher, A. V., Enser, M., & Wood, J. D. (2001) · British Journal Of Nutrition · doi:10.1079/bjn2000223 · Cited by 473
Effect of dietary fish oil on biohydrogenation of fatty acids and milk fatty acid content in cows
Shingfield, K. J., Ahvenjärvi, S. A., Toivonen, V., Ärölä, A., Nurmela, K., Huhtanen, P. J., & Griinari, J. M. (2003) · Animal Science · doi:10.1017/s1357729800053765 · Cited by 409

Show all 50 references

Research works printed but not linked: 3

Hungate RE: A roll tube method for cultivation of strict anaerobes. Methods in Microbiology. Edited by: Norris JR, Ribbons DW. 1969, London: Academic Press, 3B: 117-132. full_text.
Hobson PN: Rumen bacteria. Methods in Microbiology. Edited by: Norris JR, Ribbons DW. 1969, London: Academic Press, 3B: 133-139. full_text.
Herbert D, Phipps PJ, Strange RE: Chemical analysis of microbial cells. Methods in Microbiology. Edited by: Norris JR, Ribbons DW. 1971, London: Academic Press, 5B: 209-344. full_text.

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Fontes de ácidos graxos insaturados na alimentação de vacas leiteiras no período seco
Bettero, V. P. (2015) · Americanae (AECID Library)
Development of Methodology and Characterization of Ruminal Lipase-Producing Bacteria In Vitro
Edwards, H. D. (2012) · OakTrust (Texas A&M University Libraries)
Effects of rumen bacterial lipases on ruminal lipid metabolism
Williams, C. L., Tweed, J., Vallin, H., Davies, L., Scollan, N., & Huws, S. (2014) · doi:10.13140/2.1.1944.6085
Recovery of normal ruminal biohydrogenation and de novo fatty acid synthesis following induction of milk fat depression in dairy cows
Navarrete, D. E. R. (2013)
Longitudinal gene networks, canonical pathways and functional analysis of microarray data from Longissimus thoracis et lumborum muscle samples of early-weaned Angus steers
Moisá, S. J. (2012) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
Quitosana associada a grão de soja integral na alimentação de vacas leiteiras: I. Digestão, metabolismo e desempenho produtivo; II. Avaliação de metodologias para estimativas da digestibilidade aparente total e produção microbiana ruminal
Zanferari, F. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.10.2017.tde-22062017-143018
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Carrera, T. C. (2014) · Buleria (Universidad de León) · doi:10.18002/10612/4250
Síntesis endógena de ácidos grasos en la glándula mamaria y síndrome de baja grasa en la leche en ovejas = Endogenous synthesis of fatty acids in the mammary gland and milk fat depression in dairy ewes = Sintesi endogena di acidi grassi nella ghiandola mammaria e sindrome di scarso grasso nel latte di pecora
Forteguerri, E. B. R. (2015) · doi:10.18002/10612/5576
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Valle, T. A. D. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.10.2019.tde-23112018-100236
Effects of soybean meal versus processed whole soybean diets on the performance of young bulls and the fatty acid composition of intramuscular fat
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Bell, A. N. W., & Moran, C. A. (2020) · Advances in Bioscience and Biotechnology · doi:10.4236/abb.2020.1112033
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Widayati, W., Muktiani, A., & Widiyanto, W. (2021) · IOP Conference Series Earth and Environmental Science · doi:10.1088/1755-1315/803/1/012009
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Cediel-Devia, D. C., Silva, R. R., da Silva, F. F., Santos, L. V., da Silva, A. P. G., Santos, M. D. C., Dueñez, W. Y. S., Melgar, O. R. A., Paixão, T. R., Silva, J. W. D., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1454995/v1
Peer Review #1 of "DHA content in milk and biohydrogenation pathway in rumen: a review (v0.1)"
(2020) · PeerJ · doi:10.7287/peerj.10230v0.1/reviews/1
Peer Review #2 of "DHA content in milk and biohydrogenation pathway in rumen: a review (v0.1)"
(2020) · PeerJ · doi:10.7287/peerj.10230v0.1/reviews/2
Sphingolipid Metabolism and Insulin Resistance in Dairy Cattle
Navarrete, J. E. R. (2016) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.7335
Suplementación de la dieta de ovejas lecheras con aceite de girasol y lípidos marinos para modificar la composición de la grasa de la leche: efecto sobre el rendimiento productivo de los animales, la microbiota y las características de la fermentación ruminal y el perfil de ácidos grasos de la leche y la digesta = Supplementation of the diet of dairy ewes with sunflower oil and marine lipids to modulate milk fat composition: effect on animal performance, rumen microbiota and fermentation characteristics, and milk and digesta fatty acid profiles
Toral, P. G. (2010) · doi:10.18002/10612/982
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Holschuch, S. G. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.11.2022.tde-07112022-181153
Milk quality of ruminants fed with tannin-based diets
Muniz, A. J. C., Neto, S. G., Fernandes, B. D. O., dos Santos, F. S., Costa, R. G., Saraiva, C. A. S., de Souza, C. G., & Ribeiro, N. L. (2024) · Food Science and Technology · doi:10.5327/fst.00111
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Gu, Q., Lin, B., Wan, D., Tang, Q., Qi, Y., Ding, H., Zou, C., & Qin, G. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4822318
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REDDY, P. B., Chaturvedi, V. B., Chaudhary, L. C., & Kala, A. (2024) · The Indian Journal of Animal Sciences · doi:10.56093/ijans.v94i11.145876
Self-citation
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Pulter, C. C., Gonzáles-Viera, O., Perell, B., Deane, E., & Mete, A. (2025) · Veterinary and Animal Science · doi:10.1016/j.vas.2025.100438
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Dietary supplementation of calcium salts of palm oil or an encapsulated fat on nutrient digestibility, performance, and milk fatty acid profile in dairy cows
de Freitas, A. C., Grigoletto, N. T. S., Chesini, R. G., Sbaralho, O. P., Ribeiro, J. N., da Silva, G. G., Takiya, C. S., & Rennó, F. P. (2025) · Archives of Animal Nutrition · doi:10.1080/1745039x.2025.2542145
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Martinez, A., & St‐Pierre, B. (2025) · Microorganisms · doi:10.3390/microorganisms13112617
Functional native herbage (Capparis spinosa L.) modulates rumen fermentation and antioxidant capacity in grazing sheep by optimizing rumen microbial composition
Wang, X., Ran, L., & Hou, F. (2025) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2025.116589
Comparative effects of fatty acid supplement form and profile on nutrient digestibility and milk production in dairy cows
Bales, A. M., de Souza, J., & Lock, A. L. (2025) · Journal of Dairy Science · doi:10.3168/jds.2025-26807
Effects of dietary additives identified as potential methane mitigators on production characteristics, wool quality and yield and tissue fatty acid composition of sheep
Meale, S. J. (2014) · UPT. Syiah Kuala University Library (Syiah Kuala University)
Additional file 1 of Towards an understanding of oleate hydratases and their application in industrial processes
Prem, S., Helmer, C. P. O., Dimos, N., Himpich, S., Brück, T., Garbe, D., & Loll, B. (2022) · Figshare · doi:10.6084/m9.figshare.19568725
Additional file 1 of Microbiome-driven breeding strategy potentially improves beef fatty acid profile benefiting human health and reduces methane emissions
Martínez-Álvaro, M., Mattock, J., Auffret, M. D., Weng, Z., Duthie, C.-A., Dewhurst, R. J., Cleveland, M. A., Watson, M., & Roehe, R. (2022) · Figshare · doi:10.6084/m9.figshare.21285704
Evaluation des effets de l’utilisation de la graine de lin extrudée en élevages bovins laitiers
Meignan, T. (2018) · theses.fr (ABES) · doi:10.70675/31c49d28z5721z437ezb7f5z2561dd0c63a4
Prédiction de la production et de la composition de la matière grasse du lait par modélisation : rôle des flux de nutriments absorbés.
Prado, L. D. O. A. (2018) · theses.fr (ABES) · doi:10.70675/6317d1bcz51fdz4b1ezb417zf95e2953b19d
Can we predict the requirements for essential fatty acids and the associated supply in dairy cows by a quantitative modelling approach?
Denis, P. (2023) · theses.fr (ABES) · doi:10.70675/688e3684zef66z46e9zb27fz006ed291d13d
Effects of extruded linseed on ruminal fermentation, rumen microbiota, and enteric methane emissions in lactating dairy cows fed corn- or grass-silage-based diets
van Mullem, J., Jeyanathan, J., Ampe, B., Peiren, N., Fievez, V., & Vandaele, L. (2026) · Journal of Dairy Science · doi:10.3168/jds.2025-27946
Short-term milk production responses differ when balancing dietary 18-carbon fatty acids using high-oleic soybeans or a commercially available stearic acid-enriched supplement
Seelenbinder, B., Parales-Girón, J., Bales, A. M., & Lock, A. L. (2026) · JDS Communications · doi:10.3168/jdsc.2026-1022
Ruminal biohydrogenation and microbial lipids in dairy cows supplemented with fractionated palm oil or Hermetia illucens oil
Toral, P. G., Rastello, L., Hervás, G., Gasco, L., Coppa, M., Lussiana, C., Gerbelle, M., Galli, A., Alves, S. P., Trespeuch, C., et al. (2026) · Journal of Animal Science · doi:10.1093/jas/skag177
Bioenrichment of conjugated linoleic acid in oil-in-water (O/W) emulsion by Niubie as a natural biocatalyst
Wu, Y., 杨小碧, Liu, N., Chen, Y., Gu, J., Qin, L., & Miao, S. (2026) · Food Bioscience · doi:10.1016/j.fbio.2026.109239
Dietary Artemisia ordosica Krasch Supplementation Alters n-3 Polyunsaturated Fatty Acid Deposition and Lipid Metabolism in Cashmere Goat Meat
Liu, J., Yu, H., Dong, S., Zhang, S., Akonyani, Z. P., Zhang, Q., Guo, Y. H., Guo, X., Shi, B., Zhao, Y., et al. (2026) · Animals · doi:10.3390/ani16131982
Integrated multi-omics analysis reveals the co-adaptive mechanisms between ruminal microbiota and host epithelium in water buffaloes under chronic heat stress
Wu, Y.-Z., Jin-chi, Y., Li, J., Yang, C., & Sheng-yong, M. A. O. (2026) · Journal of Dairy Science · doi:10.3168/jds.2026-28742
Effects of dietary Schizochytrium spp. alone or combined with Nannochloropsis gaditana on milk fatty acid profile and oxidative status in lactating ewes
Mavrommatis, A., Correddu, F., Kyriakaki, P., Satolias, F. F., Nudda, A., & Tsiplakou, E. (2026) · Journal of Animal Science · doi:10.1093/jas/skag256
Rapeseed cake or oil use in a mixed forage and concentrate diet for growing cattle: manure biomethane yield, digestibility, nitrogen balance, and rumen/faecal microbiota
Folliard, N. T., Waters, S. M., Scully, S., O’Flaherty, V., & Kenny, D. A. (2026) · animal · doi:10.1016/j.animal.2026.101976
Sunflower seed processing affects nutrient utilization and performance in feedlot ewe lambs fed high-concentrate diets with or without chitosan
Nunes, F. D. S., Dias, B. B. P. D. A., Júnior, J. E. D. F., Rodrigues, H. P., Ferreira, J., da Silva, A. V., SANTANA, J. P. S., Souza, L. L., Santos, S. A., de Carvalho, G. G. P., et al. (2026) · Frontiers in Animal Science · doi:10.3389/fanim.2026.1903800
Supplementation with sunflower or soybean oil: ruminal parameters and fatty acid profile in a Rusitec system
Daniel, G. C., Britos, A., Vieitez, I., Cajarville, C., & Carro, S. (2026) · Brazilian Journal of Veterinary Medicine/Revista Brasileira de Medicina Veterinária · doi:10.29374/2527-2179.bjvm009026

Authors: Maia, M. R., Chaudhary, L. C., Bestwick, C. S., Richardson, A. J., McKain, N., Larson, T. R., Graham, I. A., & Wallace, R. J.
Affiliations: University of Aberdeen (GB)
University of York (GB)
Corresponding author: Wallace, Robert J
ORCID: Maia, Margarida RG
Chaudhary, Lal C
Bestwick, Charles S
Larson, Tony R
Graham, Ian A
Venue: BMC Microbiology
Publisher: Springer Science and Business Media LLC
Published: 2010-02-18
Volume: 10
Issue: 1
Pages: 52-52
ISSN: 1471-2180 (ISSN-L)
DOI: 10.1186/1471-2180-10-52
PMC: PMC2836310
OpenAlex: W2162688963
Cited by: 298
References: 50
Citations by year: 2026: 16 · 2025: 16 · 2024: 16 · 2023: 25 · 2022: 21 · 2021: 25 · 2020: 22 · 2019: 21 · 2018: 20 · 2017: 18 · 2016: 21 · 2015: 20 · 2014: 22 · 2013: 11 · 2012: 13
FWCI: 23.75
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: BMC Microbiology (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Aberdeen University Research Archive (Aberdeen University) (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Scottish Government
Fundação para a Ciência e a Tecnologia
Topics: Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Ruminant Nutrition and Digestive Physiology
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Meat and Animal Product Quality
Keywords: polyunsaturated fatty acids, Butyrivibrio fibrisolvens, biohydrogenation, rumen bacteria, linoleic acid, alpha-linolenic acid, vaccenic acid, eicosapentaenoic acid, docosahexaenoic acid, fish oil, bacterial growth inhibition, membrane integrity, ATP depletion, fatty acid metabolism
MeSH terms: Acyl Coenzyme A, Adenosine Triphosphate, Animals, Cell Membrane, Culture Media, Fatty Acids, Unsaturated, Flow Cytometry, Hydrogenation, Sheep, Sodium Lactate, Linoleic Acid, Butyrivibrio, Lipid Metabolism

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Toxicity of unsaturated fatty acids to the biohydrogenating ruminal bacterium, Butyrivibrio fibrisolvens

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