The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index; none of the 46 sources its claims cite is checked for support yet.
Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review
Open accessAbstract
BACKGROUND: Insomnia is common in primary care, can persist after co-morbid conditions are treated, and may require long-term medication treatment. A potential alternative to medications is cognitive behavioral therapy for insomnia (CBT-I). METHODS: In accordance with PRISMA guidelines, we systematically reviewed MEDLINE, EMBASE, the Cochrane Central Register, and PsycINFO for randomized controlled trials (RCTs) comparing CBT-I to any prescription or non-prescription medication in patients with primary or comorbid insomnia. Trials had to report quantitative sleep outcomes (e.g. sleep latency) in order to be included in the analysis. Extracted results included quantitative sleep outcomes, as well as psychological outcomes and adverse effects when available. Evidence base quality was assessed using GRADE. RESULTS: Five studies met criteria for analysis. Low to moderate grade evidence suggests CBT-I has superior effectiveness to benzodiazepine and non-benzodiazepine drugs in the long term, while very low grade evidence suggests benzodiazepines are more effective in the short term. Very low grade evidence supports use of CBT-I to improve psychological outcomes. CONCLUSIONS: CBT-I is effective for treating insomnia when compared with medications, and its effects may be more durable than medications. Primary care providers should consider CBT-I as a first-line treatment option for insomnia.
Overview
AI snapshot
Written from the paper’s full text.
TL;DR
This systematic review found that CBT-I is at least as effective as sleep medications for chronic insomnia and may produce more durable long-term benefits. The evidence base was limited to five RCTs, all in primary insomnia, and was too small and heterogeneous for meta-analysis.
Key findings
- Five RCTs met inclusion criteria, all in patients with primary insomnia; comparators were zopiclone, zolpidem, temazepam, and triazolam. One trial in comorbid insomnia was excluded because it used nefazodone, now withdrawn.
- Low- to moderate-grade evidence suggested CBT-I was superior to benzodiazepine and non-benzodiazepine drugs in the long term, while very low-grade evidence suggested benzodiazepines were more effective in the short term. Moderate-grade evidence favored CBT-I over non-benzodiazepines in the short term.
- Long-term CBT-I generally improved sleep latency by 30–45 minutes, total sleep time by 30–60 minutes, and sleep efficiency by 8–16%; drug effects declined over time. In Morin 1999 at 24 months, CBT-I increased total sleep time by 65.2 minutes and sleep efficiency by 16.4%, versus 11.5 minutes and 2.9% for temazepam, with all temazepam measurements significantly worsening from end of treatment to follow-up.
- Psychological outcomes favored CBT-I in one trial: at 6 months, State-Trait Anxiety Index scores improved for CBT-I versus zopiclone (state: –5.11 vs. +1.61, p < 0.05; trait: –4.47 vs. +1.97, p < 0.01). Sleep Impairment Index declined 10 points with CBT-I versus 4 with temazepam at 24 months (p = 0.01), and PSQI improved 1.2 points with CBT-I versus worsened 0.8 points with temazepam at 8 months (p < 0.01).
Methods
- PRISMA-guided systematic review of MEDLINE, EMBASE, Cochrane Central Register, and PsycINFO through September 2011, plus review of published systematic reviews for missed RCTs.
- Included published RCTs of adults aged 18+ with chronic insomnia per DSM-IV, comparing individual or group CBT-I delivered by a professional to FDA-approved prescription or non-prescription insomnia medications; studies had to report at least one quantitative sleep outcome. Studies with fewer than 10 patients per group, self-help programs, and comparisons of CBT-I components were excluded.
- Five RCTs were included; evidence was too small and heterogeneous for meta-analysis. Quality was assessed with a nine-point Jadad/Chalmers-based scale, and overall evidence strength was rated using GRADE. Sleep diary and automated measures (polysomnography/actigraphy) were analyzed separately.
Limitations
- Stated: all included trials focused on primary insomnia and may not represent the majority of patients with comorbid medical or psychiatric disorders; only one comorbid-insomnia trial was found and was excluded because the drug was withdrawn. No trials compared CBT-I with antihistamines or antidepressants, adverse-event reporting was limited, long-term data versus non-benzodiazepines were sparse, short-term CBT-I versus benzodiazepine data were inconsistent, and double-blinding was not possible.
- Stated: the evidence base was too small and heterogeneous for meta-analysis, and three of five included studies were in older adults.
- Evident from the text: only five RCTs were available, outcome measures and demographic composition were diverse, and the review could not draw conclusions about relative safety.
Model-written summary. Check it against the paper before relying on it.
Integrity signals
Registry
Cites
Statistics
Figures
Verification
Claims the paper makes
26 Not checked yet · 26 Own result · 14 Own interpretation · 10 No basis given · 4 Own method
In the paper
“Only one trial compared CBT-I to drug therapy in patients with comorbid insomnia [34]: the drug used was nefazodone (now withdrawn from the market), so the study was excluded from further analysis.”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Results
What the sources say
- Not checked yetcites [34] Thase ME, Rush AJ, Manber R, Kornstein SG, Klein DN, Markowitz JC, Ninan PT, Friedman ES, Dunner DL, Schatzberg AF, Borian FE, Trivedi MH, Keller MB: Differential effects of nefazodone and cognitive behavioral analysis system of psychotherapy on insomnia associated with chronic forms of major depression. J Clin Psychiatry. 2002, 63: 493-500. 10.4088/JCP.v63n0605. source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Very low grade evidence supports use of CBT-I to improve psychological outcomes.”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Abstract > Results
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“very low grade evidence suggests benzodiazepines are more effective in the short term”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Abstract > Results
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Low to moderate grade evidence suggests CBT-I has superior effectiveness to benzodiazepine and non-benzodiazepine drugs in the long term”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Abstract > Results
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Five studies met criteria for analysis.”
- Also stated in: § Results · plain
“Our search found a total of five RCTs that met the inclusion criteria and compared CBT-I to medications.”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Abstract > Results
plainn = 5- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Also stated in: § Results · plain
None of the sources cited for this claim have been checked yet.
In the paper
“The trials compared CBT-I to zopiclone [29], zolpidem [30], temazepam [31,32], and triazolam [33].”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Results
What the sources say
- Not checked yetcites [29] Sivertsen B, Omvik S, Pallesen S, Bjorvatn B, Havik OE, Kvale G, Nielsen GH, Nordhus IH: Cognitive behavioral therapy vs zopiclone for treatment of chronic primary insomnia in older adults: a randomized controlled trial. JAMA. 2006, 295: 2851-2858. 10.1001/jama.295.24.2851. source
- Not checked yetcites [30] Jacobs GD, Pace-Schott EF, Stickgold R, Otto MW: Cognitive behavior therapy and pharmacotherapy for insomnia: a randomized controlled trial and direct comparison. Arch Intern Med. 2004, 164: 1888-1896. 10.1001/archinte.164.17.1888. source
- Not checked yetcites [31] Morin CM, Colecchi C, Stone J, Sood R, Brink D: Behavioral and pharmacological therapies for late-life insomnia: a randomized controlled trial. JAMA. 1999, 281: 991-999. 10.1001/jama.281.11.991. source
- Not checked yetcites [32] Wu R, Bao J, Zhang C, Deng J, Long C: Comparison of sleep condition and sleep-related psychological activity after cognitive-behavior and pharmacological therapy for chronic insomnia. Psychother Psychosom. 2006, 75: 220-228. 10.1159/000092892. source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Our search found a total of five RCTs that met the inclusion criteria and compared CBT-I to medications.”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Results
plainn = 5- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“The five trials all involved patients with primary insomnia.”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Results
plainn = 5- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“There have only been a handful of studies that have included both cognitive behavioral and pharmacotherapy treatment arms for inclusion in this systematic review.”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Discussion
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“We found no trials comparing CBT-I to antihistamines or antidepressants.”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Results > Adverse effects of treatment
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- It may state two separate claims as one. 12
- Probably not a substantial claim. 14
- The quote only partly states this claim. 2
In the paper
“Wu et al [32] surveyed patients using the Pittsburgh Sleep Quality Index: after 8 months this measure improved an average of 1.2 points in patients treated with CBT-I, while it worsened 0.8 points in patients given tamezepam (p < 0.01).”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Results > Patients’ subjective evaluation of sleep
What the sources say
- Not checked yetcites [32] Wu R, Bao J, Zhang C, Deng J, Long C: Comparison of sleep condition and sleep-related psychological activity after cognitive-behavior and pharmacological therapy for chronic insomnia. Psychother Psychosom. 2006, 75: 220-228. 10.1159/000092892. source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Some studies reported intermediate time points as well, which were consistent with the initial and final results.”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Results > Quantitative sleep outcomes
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In terms of demographic composition, three of the five studies we included were in older adults.”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Discussion
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“The studies also were diverse in terms of sleep-related outcome measures (subjective versus objective) and demographic composition.”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Discussion
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“All trials asked patients to complete sleep diaries.”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Results > Quantitative sleep outcomes
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“CBT-I vs. non-benzodiazepines | Short term | Improved more with CBT-I”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Results > Quantitative sleep outcomes
What the sources say
- Not checked yetcites [26] Atkins D, Best D, Briss PA, Eccles M, Falck-Ytter Y, Flottorp S, Guyatt GH, Harbour RT, Haugh MC, Henry D, Hill S, Jaeschke R, Leng G, Liberati A, Magrini N, Mason J, Middleton P, Mrukowicz J, O'Connell D, Oxman AD, Phillips B, Schunemann HJ, Edejer TT, Varonen H, Vist GE, Williams JW, Zaza S, GRADE Working Group: Grading quality of evidence and strength of recommendations. BMJ. 2004, 328: 1490-1497. source
- Not checked yetcites [27] Guyatt GH, Oxman AD, Kunz R, Falck-Ytter Y, Vist GE, Liberati A, Schunemann HJ, GRADE Working Group: Going from evidence to recommendations. BMJ. 2008, 336: 1049-1051. 10.1136/bmj.39493.646875.AE. source
- Not checked yetcites [28] Guyatt GH, Oxman AD, Kunz R, Vist GE, Falck-Ytter Y, Schunemann HJ, GRADE Working Group: What is “quality of evidence” and why is it important to clinicians?. BMJ. 2008, 336: 995-998. 10.1136/bmj.39490.551019.BE. source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one. The quote only partly states this claim.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Reported sleep measures included sleep latency, TST, and total time spent awake during the night.”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Results > Quantitative sleep outcomes
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Trends towards improved results with CBT-I were observed in the Penn State Worry Questionnaire and the Worry Domains Questionnaire, but the differences between groups were not statistically significant.”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Results > Quality of life and daytime outcomes
What the sources say
- Not checked yetcites [35] Omvik S, Sivertsen B, Pallesen S, Bjorvatn B, Havik OE, Nordhus IH: Daytime functioning in older patients suffering from chronic insomnia: treatment outcome in a randomized controlled trial comparing CBT with zopiclone. Behav Res Ther. 2008, 46: 623-641. 10.1016/j.brat.2008.02.013. source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“CBT-I vs. benzodiazepines | Short term | Improved less with CBT-I”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Results > Quantitative sleep outcomes
What the sources say
- Not checked yetcites [26] Atkins D, Best D, Briss PA, Eccles M, Falck-Ytter Y, Flottorp S, Guyatt GH, Harbour RT, Haugh MC, Henry D, Hill S, Jaeschke R, Leng G, Liberati A, Magrini N, Mason J, Middleton P, Mrukowicz J, O'Connell D, Oxman AD, Phillips B, Schunemann HJ, Edejer TT, Varonen H, Vist GE, Williams JW, Zaza S, GRADE Working Group: Grading quality of evidence and strength of recommendations. BMJ. 2004, 328: 1490-1497. source
- Not checked yetcites [27] Guyatt GH, Oxman AD, Kunz R, Falck-Ytter Y, Vist GE, Liberati A, Schunemann HJ, GRADE Working Group: Going from evidence to recommendations. BMJ. 2008, 336: 1049-1051. 10.1136/bmj.39493.646875.AE. source
- Not checked yetcites [28] Guyatt GH, Oxman AD, Kunz R, Vist GE, Falck-Ytter Y, Schunemann HJ, GRADE Working Group: What is “quality of evidence” and why is it important to clinicians?. BMJ. 2008, 336: 995-998. 10.1136/bmj.39490.551019.BE. source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one. The quote only partly states this claim.
None of the sources cited for this claim have been checked yet.
In the paper
“The overall quality of the evidence base for each comparison was rated using the GRADE approach [26-28].”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Methods > Data abstraction and analysis
What the sources say
- Not checked yetcites [26] Atkins D, Best D, Briss PA, Eccles M, Falck-Ytter Y, Flottorp S, Guyatt GH, Harbour RT, Haugh MC, Henry D, Hill S, Jaeschke R, Leng G, Liberati A, Magrini N, Mason J, Middleton P, Mrukowicz J, O'Connell D, Oxman AD, Phillips B, Schunemann HJ, Edejer TT, Varonen H, Vist GE, Williams JW, Zaza S, GRADE Working Group: Grading quality of evidence and strength of recommendations. BMJ. 2004, 328: 1490-1497. source
- Not checked yetcites [27] Guyatt GH, Oxman AD, Kunz R, Falck-Ytter Y, Vist GE, Liberati A, Schunemann HJ, GRADE Working Group: Going from evidence to recommendations. BMJ. 2008, 336: 1049-1051. 10.1136/bmj.39493.646875.AE. source
- Not checked yetcites [28] Guyatt GH, Oxman AD, Kunz R, Vist GE, Falck-Ytter Y, Schunemann HJ, GRADE Working Group: What is “quality of evidence” and why is it important to clinicians?. BMJ. 2008, 336: 995-998. 10.1136/bmj.39490.551019.BE. source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Measures from patients’ sleep diaries and measures from automated means (polysomnography and actigraphy) were analyzed separately because of known unreliability in patients’ perceptions of sleep.”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Methods > Inclusion criteria
boosteddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
- Rests on an assumption: There can be substantial differences between automated measures of sleep time and patients' self-reports on sleep diaries.
None of the sources cited for this claim have been checked yet.
In the paper
“Assessment of RCT quality was done using a nine-point scale (Additional file 1: Table S6) based on scales by Jadad [24] and Chalmers [25].”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Methods > Data abstraction and analysis
What the sources say
- Not checked yetcites [24] Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, McQuay HJ: Assessing the quality of reports of randomized clinical trials: is blinding necessary?. Control Clin Trials. 1996, 17: 1-12. 10.1016/0197-2456(95)00134-4. source
- Not checked yetcites [25] Chalmers TC, Smith H, Blackburn B, Silverman B, Schroeder B, Reitman D, Ambroz A: A method for assessing the quality of a randomized control trial. Control Clin Trials. 1981, 2: 31-49. 10.1016/0197-2456(81)90056-8. source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“But this review does not tell us whether CBT-I is as effective as sleep medications.”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Background
What the sources say
- Not checked yetcites [21] Okajima I, Komada Y, Inoue Y: A meta-analysis on the treatment effectiveness of cognitive behavioral therapy for primary insomnia. Sleep Biol Rhythms. 2011, 9: 24-34. source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
In the paper
“Inclusion criteria were defined in advance of data abstraction using the PICO framework below [22].”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Methods > Inclusion criteria
What the sources say
- Not checked yetcites [22] Richardson WS, Wilson MC, Nishikawa J, Hayward RS: The well-built clinical question: A key to evidence-based decisions. ACP J Club. 1995, 3: A12-A13. source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“A new systematic review [21] meta-analyzes evidence from 14 randomized trials comparing groups of patients given CBT-I to control groups.”
- Also stated in: § Background · plain
“The meta-analysis found that CBT-I had a medium to large effect in reducing insomnia, and that the effects were maintained even after conclusion of the treatment period.”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Background
What the sources say
- Not checked yetcites [21] Okajima I, Komada Y, Inoue Y: A meta-analysis on the treatment effectiveness of cognitive behavioral therapy for primary insomnia. Sleep Biol Rhythms. 2011, 9: 24-34. source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Also stated in: § Background · plain
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Data synthesis methods followed the practice of the Cochrane Collaboration.”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Methods > Data abstraction and analysis
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“The AHRQ Evidence-based Practice review [20] addressed that question, but it was published in 2005 and lacks evidence published since September 2004.”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Background
What the sources say
- Not checked yetcites [20] Buscemi N, Vandermeer B, Friesen C, Bialy L, Tubman M, Ospina M, Klassen TP, Witmans M: Manifestations and Management of Chronic Insomnia in Adults. Evidence Report/ Technology Assessment No. 125. AHRQ Publication No. 05-E021-2. 2005, Rockville: Agency for Healthcare Research and Quality
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“There is now evidence to suggest that insomnia often persists following resolution of these ‘primary’ conditions, and that it generally does not spontaneously resolve over time if left untreated [5].”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Background
What the sources say
- Not checked yetcites [5] Morin CM, Belanger L, LeBlanc M, Ivers H, Savard J, Espie CA, Merette C, Baillargeon L, Gregoire JP: The natural history of insomnia: a population-based 3-year longitudinal study. Arch Intern Med. 2009, 169: 447-453. 10.1001/archinternmed.2008.610. source
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Two research analysts (MDM, BL) reviewed full text of each retrieved article to determine whether it met the stated inclusion criteria. Disagreements were resolved by a third reviewer (PG).”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Methods > Literature searches and study inclusion/exclusion
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Lastly, all studies in this field suffer an unavoidable risk of bias because double-blinding is not possible.”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Discussion
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Second, CBT-I may have advantages when compared to medications, most notably more durable treatment gains that reduce or eliminate the need for long-term pharmacologic treatment.”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Discussion
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Despite the evidence supporting the effectiveness of CBT-I, many providers may not be aware of its existence or know how to refer patients for treatment [39].”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Discussion
What the sources say
- Not checked yetcites [39] Wetzler RG, Winslow DH: New solutions for treating chronic insomnia: an introduction to behavioral sleep medicine. J Ky Med Assoc. 2006, 104: 502-512.
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“CBT-I is an effective treatment for insomnia that can produce durable results in a relatively brief number of visits.”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Conclusion
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Data on long-term outcomes of CBT-I compared to non-benzodiazepines is still sparse, and inconsistencies in the data comparing CBT-I to benzodiazepines in the short term need to be resolved.”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Discussion
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
The paper relies on this without support.
Medications are usually not curative, leading to long-term treatment over many years despite a lack of safety and efficacy data for their long-term use beyond 1–2 years.
“Perhaps the most important disadvantage is that medications are usually not curative, leading to long-term treatment over many years despite a lack of safety and efficacy data for their long-term use beyond 1–2 years.”
The paper relies on this without support.
CBT-I has fewer known side effects than medication.
“Treating insomnia with CBT-I, as opposed to medication, has a number of potential advantages, including fewer known side effects”
The paper relies on this without support.
There can be substantial differences between automated measures of sleep time and patients' self-reports on sleep diaries.
“There can also be substantial differences between automated measures of sleep time and patients’ self-reports on sleep diaries.”
The paper relies on this without support.
Insomnia RCTs generally find larger effects of treatment on subjective measures such as questionnaires than on objective measures of actigraphy and polysomnography.
“In terms of outcome measures, insomnia RCTs generally find larger effects of treatment on subjective measures such as questionnaires than on objective measures of actigraphy and polysomnography.”
The paper relies on this without support.
The diagnosis of insomnia relies on patient report and not on a diagnostic laboratory test.
“the diagnosis of insomnia relies on patient report and not on a diagnostic laboratory test.”
The paper relies on this without support.
Many patients presenting with insomnia to primary care practices will have secondary or co-morbid insomnia.
“many patients presenting with insomnia to primary care practices will have secondary or co-morbid insomnia”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The recommended first-line treatment, Cognitive Behavioral Therapy for Insomnia (CBTI) does not carry these risks and is therefore preferable for reasons beyond demonstrated efficacy(244-248), efficacy relative to medications(249-253), and effectiveness(254).”
From Sleep: important considerations for the prevention of cardiovascular disease (2016) · cites this paper as [248]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Results
“| Wu 2006 [31] | CBT-I: 19 | –32.8 min | +30.3 min | Not reported | +10.2% | | p values based on post-intervention differences |”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Results
“| Wu 2006 [32] | RCT | 77 patients | Individual CBT-I 2 per week, 8 weeks | Temazepam, see comment | Sleep diaries, polysomnography | Dose 7.5 mg→30 mg→15 mg over 8 week period |”
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Results > Patients’ subjective evaluation of sleep
“Both reported that patients were significantly more satisfied with CBT-I than with zopiclone, but they did so using different measures.”
§ Comparative effectiveness of cognitive behavioral therapy for insomnia: a systematic review > Results > Patients’ subjective evaluation of sleep
“In Morin’s study [31] the Sleep Impairment Index declined 10 points after 24 months for patients treated with CBT-I, but only 4 points for patients given tamezepam (p = 0.01).”
Citations
Cites
Assessing the quality of reports of randomized clinical trials: Is blinding necessary?
Jadad, A. R., Moore, R. A., Carroll, D., Jenkinson, C., Reynolds, D. J. M., Gavaghan, D. J., & McQuay, H. J. (1996) · Controlled Clinical Trials · doi:10.1016/0197-2456(95)00134-4 · Cited by 17,582 · cited 2×
“Assessment of RCT quality was done using a nine-point scale (Additional file 1: Table S6) based on scales by Jadad [24] and Chalmers [25].”
MethodGrading quality of evidence and strength of recommendations
(2004) · BMJ · doi:10.1136/bmj.328.7454.1490 · Cited by 8,477 · cited 6×
“The overall quality of the evidence base for each comparison was rated using the GRADE approach [26-28].”
MethodInfluentialEpidemiology of insomnia: what we know and what we still need to learn
Ohayon, M. M. (2002) · Sleep Medicine Reviews · doi:10.1053/smrv.2002.0186 · Cited by 3,743 · cited 1×
“The prevalence of insomnia in primary care patients is as high as 69% [1,2] compared to 33% in the general population [3].”
BackgroundWhat is ‘quality of evidence’ and why is it important to clinicians?
Guyatt, G. H., Oxman, A. D., Kunz, R., Vist, G. E., Falck-Ytter, Y., & Schünemann, H. J. (2008) · BMJ · doi:10.1136/bmj.39490.551019.be · Cited by 3,250 · cited 6×
“The overall quality of the evidence base for each comparison was rated using the GRADE approach [26-28].”
MethodInfluentialThe well-built clinical question: A key to evidence-based decisions
(1995) · ACP Journal Club · doi:10.7326/acpjc-1995-123-3-a12 · Cited by 2,931 · cited 1×
“Inclusion criteria were defined in advance of data abstraction using the PICO framework below [22].”
MethodBaglioni, C., Battagliese, G., Feige, B., Spiegelhalder, K., Nissen, C., Voderholzer, U., Lombardo, C., & Riemann, D. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.01.011 · Cited by 2,779
Epidemiologic study of sleep disturbances and psychiatric disorders. An opportunity for prevention?
Ford, D. E. (1989) · JAMA · doi:10.1001/jama.262.11.1479 · Cited by 2,440
Epidemiologic Study of Sleep Disturbances and Psychiatric Disorders: An Opportunity for Prevention?
Ford, D. E. (1989) · JAMA · doi:10.1001/jama.1989.03430110069030 · Cited by 2,252
Clinical Guideline for the Evaluation and Management of Chronic Insomnia in Adults
Schutte-Rodin, S., Broch, L., Buysse, D., Dorsey, C., & Sateia, M. (2008) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.27286 · Cited by 1,943 · cited 3×
“Some patients also prefer non-medication treatments [12,16,17].”
BackgroundGoing from evidence to recommendations
Guyatt, G. H., Oxman, A. D., Kunz, R., Falck-Ytter, Y., Vist, G. E., Liberati, A., & Schünemann, H. J. (2008) · BMJ · doi:10.1136/bmj.39493.646875.ae · Cited by 1,810
Research works printed but not linked: 1
- NIH state-of-the-science conference statement on manifestations and management of chronic insomnia in adults. NIH Consens Sci Statements. 2005, 22: 1-30.
Cited by
Sorted by citations
Items 201–300 of 620
Mournet, A. M., & Kleiman, E. M. (2024) · Journal of Sleep Research · doi:10.1111/jsr.14133 · Cited by 17
Effect of acupuncture on insomnia following stroke: study protocol for a randomized controlled trial
Cao, Y., Yin, X., Soto-Aguilar, F., Liu, Y., Yin, P., Wu, J., Zhu, B.-C., Li, W., Lao, L., & Xu, S. (2016) · Trials · doi:10.1186/s13063-016-1670-0 · Cited by 15
“However, CBT often causes an acute reduction in total sleep time (TST) during the first few weeks of treatment, which means that SD improvements with CBT require long-term implementation [9].”
BackgroundCost‐effectiveness of telephone cognitive behavioral therapy for osteoarthritis‐related insomnia
Yeung, K., Zhu, W., McCurry, S. M., Korff, M. V., Wellman, R., Morin, C. M., & Vitiello, M. V. (2021) · Journal of the American Geriatrics Society · doi:10.1111/jgs.17469 · Cited by 15
CBT-I Cannot Rest Until the Sleepy Teen Can
Gradisar, M., & Richardson, C. E. (2015) · SLEEP · doi:10.5665/sleep.5220 · Cited by 18
Cognitive-Behavioral Therapy for Insomnia in Older Adults
Cassidy‐Eagle, E. L., Siebern, A. T., Chen, H., Kim, H., & Palesh, O. G. (2021) · Cognitive and Behavioral Practice · doi:10.1016/j.cbpra.2021.04.002 · Cited by 15
Effectiveness of an App-Based Short Intervention to Improve Sleep: Randomized Controlled Trial
Vollert, B., Müller, L. K., Jacobi, C., Trockel, M., & Beintner, I. (2022) · JMIR Mental Health · doi:10.2196/39052 · Cited by 13
“It is considered more suitable than a (pure) pharmacological treatment, especially given the limited evidence for long-term effects of the latter [29].”
Sleep disruption in older surgical patients and its important implications
Butris, N., Tang, E., He, D., Wang, D., & Chung, F. F. (2023) · International Anesthesiology Clinics · doi:10.1097/aia.0000000000000391 · Cited by 15
“CBT-I has been shown to be more effective in improving sleep disturbance than benzodiazepine and non-benzodiazepines; with the effect being sustained beyond 6 to 12 months.(104) CBT-I improves both sleep and pain, with a probability of 81% and 71% of having better sleep after CBT-I at posttreatment and follow-up of up…”
BackgroundCurry, G., Cheung, T. C. C., Zhang, S., Logue, S., McAnena, L. B., Price, R. K., & Sittlington, J. (2024) · Brain stimulation · doi:10.1016/j.brs.2024.05.010 · Cited by 16
“Cognitive behavioural therapy for insomnia (CBT-I) is the first approach in most western countries as it is effective with minimal side-effects [1,20,22 – 24, 28, 29 The vestibular system detects changes in both head motion and position and is critical for balance and spatial orientation.”
BackgroundVeterans’ experiences with and perspectives on insomnia treatment: A qualitative study.
Bramoweth, A. D., Rodriguez, K. L., Klima, G. J., Appelt, C. J., & Chinman, M. (2020) · Psychological Services · doi:10.1037/ser0000494 · Cited by 16
Tang, H.-Y. J., McCurry, S. M., Pike, K. C., Riegel, B. J., & Vitiello, M. V. (2021) · Sleep Medicine · doi:10.1016/j.sleep.2021.03.025 · Cited by 15
Impact of Pharmacotherapy on Insomnia in Patients with Alzheimer’s Disease
Roland, J. P., & Bliwise, D. L. (2021) · Drugs & Aging · doi:10.1007/s40266-021-00891-1 · Cited by 14
Benzodiazepine use risk: Understanding patient specific risk perceptions and medication beliefs
Sake, F., WONG, K. K. H., Bartlett, D. J., & Saini, B. (2018) · Research in Social and Administrative Pharmacy · doi:10.1016/j.sapharm.2018.12.007 · Cited by 14
Drug treatment strategies for insomnia in patients with post-traumatic stress disorder
Akinnusi, M. E., & Solh, A. A. E. (2019) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2019.1574745 · Cited by 15
“compared the efficacy of pharmacological and behavioral therapies for insomnia [100,101].”
BackgroundLinnet, K., Sigurdsson, J. A., Tómasdóttir, M. Ó., Sigurdsson, E. L., & Gudmundsson, L. S. (2019) · BMJ Open · doi:10.1136/bmjopen-2019-033545 · Cited by 14
Sleep disturbance and menopause
Carmona, N. E., Solomon, N., & Adams, K. E. (2025) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000001012 · Cited by 18
Hinrichsen, G. A., & Leipzig, R. M. (2022) · Clinical Gerontologist · doi:10.1080/07317115.2022.2104675 · Cited by 13
Cancer and Stress: Understanding the Connections and Interventions
D’Andre, S. D., Ellsworth, L. L., Kirsch, J. L., Montane, H. N., Kruger, M. B., Donovan, K. A., Bronars, C. A., Markovic, S. N., & Ehlers, S. L. (2024) · American Journal of Lifestyle Medicine · doi:10.1177/15598276241304373 · Cited by 14
Türkmen, C., Schneider, C. L., Viechtbauer, W., Bolstad, I., Chakravorty, S., Miller, M. B., Kallestad, H., Angenete, G. W., Johann, A. F., Feige, B., et al. (2025) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2025.102049 · Cited by 19
Trauma, Sleep and Mental Health Problems in Low-Income Young Adults
Fusco, R. A., Yuan, Y., Lee, H., & Newhill, C. E. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18031145 · Cited by 14
“Multiple randomized control trials have shown the effectiveness of CBT-I in reducing sleep latency, increasing total sleep time, and decreasing nighttime awakenings [56].”
BackgroundSelf-referral to group cognitive behavioural therapy: Is it effective for treating chronic insomnia?
Hartley, S., Dagneaux, S., Londe, V., Liane, M.-T., Aussert, F., Francs, C. C. D., & Royant‐Parola, S. (2016) · L Encéphale · doi:10.1016/j.encep.2016.08.013 · Cited by 13
Sleep and health in older adults
Li, J., & Gooneratne, N. S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815373-4.00004-6 · Cited by 19
Jacobsen, P. B., Prasad, R., Villani, J., Lee, C. M., Rochlin, D. H., Scheuter, C., Kaplan, R. M., Freedland, K. E., Manber, R., Kanaan, J., et al. (2019) · Health Psychology · doi:10.1037/hea0000774 · Cited by 13
Neville, H. L., Losier, M., Pitman, J., Gehrig, M., Isenor, J. E., Minard, L. V., Penny, E., & Bowles, S. K. (2020) · The Canadian Journal of Hospital Pharmacy · doi:10.4212/cjhp.v73i3.2997 · Cited by 12
Kutscher, S. J., & Juang, C. (2023) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000001283 · Cited by 13
Daniel, L. C., Wang, H., Brinkman, T. M., Ruble, K., Zhou, E. S., Palesh, O. G., Stremler, R., Howell, R. M., Mulrooney, D. A., Crabtree, V. M., et al. (2024) · JNCI Cancer Spectrum · doi:10.1093/jncics/pkae010 · Cited by 16
“…be offered, such as cognitive behavioral therapy for insomnia, which is the first line of treatment for chronic insomnia in adults (44), has been shown to be superior to sleep medications in a generally health population (45), and is efficacious for improving sleep in cancer survivors (46-48).”
Galgut, Y., Hoyos, C. M., Kempler, L., Aji, M., Grunstein, R. R., Gordon, C. J., & Bartlett, D. J. (2024) · Journal of Sleep Research · doi:10.1111/jsr.14442 · Cited by 14
“These outcomes remain robust and durable (van der Zweerde et al., 2019) across different delivery modalities including digital platforms (Simon et al., 2023; Zachariae et al., 2016) and across various adult populations (Mitchell et al., 2012; Wu et al., 2015).”
Sato, D., Sutoh, C., Seki, Y., Nagai, E., & Shimizu, E. (2019) · JMIR Formative Research · doi:10.2196/12635 · Cited by 12
“In their systematic review, Mitchell et al [5] stated that over the long term the effectiveness of CBT for insomnia is superior to the effectiveness of benzodiazepine and non-benzodiazepine drugs.”
Cognitive Behavioral Therapy for Insomnia in the Digital Age
Kang, S., & Kim, Y. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9721-0_30 · Cited by 11
Careful Prescribing of Benzodiazepines during COVID-19 Pandemic: A Review
Agrawal, R. (2020) · JOURNAL OF MENTAL HEALTH AND CLINICAL PSYCHOLOGY · doi:10.29245/2578-2959/2020/4.1214 · Cited by 12
Turkowitch, D., Ludwig, R. L., Nelson, E., Drerup, M. L., & Siengsukon, C. F. (2022) · Multiple Sclerosis International · doi:10.1155/2022/7110582 · Cited by 12
“CBT-I has been shown to be more effective and durable compared to pharmacological interventions, showing improved sleep outcomes persisting for up to 10 years post-CBT-I treatment [13, 14].”
BackgroundStenberg, J., Ritola, V., Joffe, G., Saarni, S. E., & Rosenström, T. H. (2022) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.10186 · Cited by 13
Reddy, A., Mansuri, Z., Vadukapuram, R., Shah, K. H., Thootkur, M., & Trivedi, C. G. (2023) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0000000000001613 · Cited by 15
“It does not have the side effects, including addiction potential and tolerance effects that come with pharmacological interventions (Mitchell et al., 2012).”
BackgroundCurrent Clinical Practice of Insomnia
Choi, H. Y., & Lim, W. (2013) · Ewha Medical Journal · doi:10.12771/emj.2013.36.2.84 · Cited by 12
Li, P. W. C., Yu, D. S. F., Chong, S. O. K., & Lin, R. S. Y. (2020) · The Journal of Cardiovascular Nursing · doi:10.1097/jcn.0000000000000662 · Cited by 12
Tadros, M., Li, S. H., Upton, E. L., Newby, J. M., & Werner‐Seidler, A. (2023) · JMIR Human Factors · doi:10.2196/44145 · Cited by 11
“Psychological interventions designed to improve sleep are effective in general adult populations [26-29], comparable to the pharmacological approaches typically used in primary care [30].”
BackgroundTussey, E. J., Pérez, G. R., & Lynch, S. M. (2024) · SLEEP Advances · doi:10.1093/sleepadvances/zpae012 · Cited by 14
“Researchers might consider adapting the gold standard treatment for insomnia, Cognitive Behavioral Therapy for Insomnia, to incarcerated populations [46].”
BackgroundExploring the Psychiatric Manifestations of Primary Sjögren’s Syndrome: A Narrative Review
Salehi, M., Zamiri, A., Kim, J., Texeira, C., Shah, K., & Gunturu, S. (2024) · International Journal of Rheumatology · doi:10.1155/2024/5520927 · Cited by 13
Kim, C. H., Lee, Y.-J., Kang, S., & Lee, S. H. (2025) · Journal of Medical Internet Research · doi:10.2196/67751 · Cited by 13
“The effect of CBT-I on QoL has shown varying results across studies, with some finding it effective and others not [22,49].”
Tratamento da Insônia em Atenção Primária à Saúde
Ribeiro, N. F. (2016) · Revista Brasileira de Medicina de Família e Comunidade · doi:10.5712/rbmfc11(38)1271 · Cited by 11
Gencarelli, A., Sorrell, A., Everhart, C. M., Zurlinden, T., & Everhart, D. E. (2021) · Sleep And Breathing · doi:10.1007/s11325-021-02329-9 · Cited by 11
Shareh, H., Hasheminik, M., & Jamalinik, M. (2022) · Behavioural and Cognitive Psychotherapy · doi:10.1017/s1352465822000364 · Cited by 12
Geagea, L., Ghanimé, P. M., Hayek, S. E., Kobeissy, F. H., Tamim, H., Elbejjani, M., & Talih, F. R. (2022) · Sleep Medicine · doi:10.1016/j.sleep.2022.09.017 · Cited by 11
Integrative Medicine for the Treatment of Persistent Pain
Hillinger, M. G., Wolever, R. Q., McKernan, L. C., & Elam, R. O. (2017) · Primary Care Clinics in Office Practice · doi:10.1016/j.pop.2017.02.008 · Cited by 11
“When compared with medications, CBT-I is as effective, and its effects may be more durable than medications.(68) It improves sleep habits and schedules, and focuses on correcting inaccurate perceptions and beliefs regarding sleep and insomnia that tend to worsen sleep difficulties.”
BackgroundBenzodiazepine usage and patient preference for alternative therapies: A descriptive study
Sake, F., WONG, K. K. H., Bartlett, D. J., & Saini, B. (2019) · Health Science Reports · doi:10.1002/hsr2.116 · Cited by 11
Lien, M., Bredeli, E., Sivertsen, B., Kallestad, H., Pallesen, S., Smith, O. R. F., Faaland, P. M., Ritterband, L. M., Thorndike, F. P., & Vedaa, Ø. (2019) · Chronobiology International · doi:10.1080/07420528.2019.1647435 · Cited by 11
“Cognitive-behavioral therapy for insomnia (CBTi) is the recommended first-line treatment for patients suffering from chronic insomnia (Mitchell et al. 2012; Qaseem et al. 2016).”
BackgroundGill, J., Lee, H., Baxter, T., Reddy, S. Y., Barr, T. L., Kim, H., Wang, D., & Mysliwiec, V. (2015) · Biological Research For Nursing · doi:10.1177/1099800415575343 · Cited by 13
Sleep disorders in chronic obstructive pulmonary disease
(2015) · Indian Journal of Sleep Medicine · doi:10.5005/ijsm-10-1-11 · Cited by 11
Treating insomnia in patients with comorbid psychiatric disorders: A focused review.
Garland, S. N., Vargas, I., Grandner, M. A., & Perlis, M. L. (2018) · Canadian Psychology/Psychologie canadienne · doi:10.1037/cap0000141 · Cited by 12
Self-citationPost traumatic stress and sleep disorders in long COVID: Patient management and treatment
Herring, T. E., Chopra, A., Friedly, J. L., Bender, J. A., Gentile, N. L., & Knowles, L. M. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123081 · Cited by 13
Specht, A., Betz, L. T., Riepenhausen, A., Jauch‐Chara, K., Jacob, G. A., Riemann, D. W., & Göder, R. (2024) · Journal of Sleep Research · doi:10.1111/jsr.14409 · Cited by 9
Pertab, J. L., Merkley, T. L., Winiarski, H. R., Cramond, K. M. J., & Cramond, A. J. (2025) · Journal of Personalized Medicine · doi:10.3390/jpm15010033 · Cited by 12
Buus, R. M., Genovese, S., & Jespersen, K. V. (2025) · Journal of Sleep Research · doi:10.1111/jsr.70006 · Cited by 12
van der Hoek, H., Peersmann, S. H. M., Maurice‐Stam, H., Kaspers, G. J. L., van den Bergh, E. M. M., Tissing, W. J. E., Kremer, L. C. M., Abbink, F. C. H., de Vries, A. C. H., Loonen, J. J., et al. (2025) · Cancer · doi:10.1002/cncr.35796 · Cited by 10
“23,24 However, the beneficial effect of CBT - i lasts longer 25 and is without the frequent negative side effects of sleep medication.”
Exploring Interventions for Sleep Disorders in Adolescent Cannabis Users
Furer, T., Nayak, K., & Shatkin, J. P. (2018) · Medical Sciences · doi:10.3390/medsci6010011 · Cited by 10
Ellett, L. M. K., Lim, R., Pratt, N. L., Kerr, M., Ramsay, E. N., LeBlanc, T. V., Barratt, J. D., & Roughead, E. E. (2018) · BMC Health Services Research · doi:10.1186/s12913-018-3443-9 · Cited by 9
Declining trend in use of medications for sleep disturbance in the United States from 2013 to 2018
Kaufmann, C. N., Spira, A. P., Wickwire, E. M., Mojtabai, R., Ancoli‐Israel, S., Fung, C. H., & Malhotra, A. (2022) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.10132 · Cited by 11
Cognitive Behavioral Therapy for Insomnia in School-Aged Children and Adolescents
Dewald‐Kaufmann, J., de Bruin, E. J., & Michael, G. (2022) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2022.06.003 · Cited by 12
Context-Aware Sleep Health Recommender Systems (CASHRS): A Narrative Review
Liang, Z. (2022) · Electronics · doi:10.3390/electronics11203384 · Cited by 10
“The meta-analysis of digital CBT-I has demonstrated significant improvements in sleep quality [37,38] and long-term benefits compared to pharmacotherapy [39].”
BackgroundSleep Disorders in the Elderly
Chokroverty, S. (2017) · Springer eBooks · doi:10.1007/978-1-4939-6578-6_51 · Cited by 10
Taouk, L. H., Farrow, V. A., & Schulkin, J. A. (2017) · Journal of Psychosomatic Obstetrics & Gynecology · doi:10.1080/0167482x.2017.1320985 · Cited by 10
“Additionally, cognitive behavioral therapy for insomnia (CBT-I) has shown efficacy and even superiority to medication in treating insomnia and other sleep disturbances [21,22]; this intervention may help combat the high prevalence of insomnia and poor sleep quality noted among physicians [23].”
BackgroundHollsten, I., Foldbo, B. M., Andersen, M. K. K., & Nexøe, J. (2020) · Scandinavian Journal of Primary Health Care · doi:10.1080/02813432.2020.1753382 · Cited by 10
“CBT-I is considered a safe and effective treatment for insomnia, possibly with even longer-lasting effects compared with sleep medication [26].”
BackgroundAndrogen Deprivation and Sleep Disturbance
Myers, J. S., Siengsukon, C. F., Sherman, J., Shen, X., Ptomey, L. T., Montgomery, R. N., Bock, K. J., Rice, A. M., Parker, W. P., & Maliski, S. L. (2022) · Cancer Nursing · doi:10.1097/ncc.0000000000001100 · Cited by 10
Integrating Modern Concepts of Insomnia and its Contemporary Treatment into Primary Care
Doghramji, P. P. (2014) · Postgraduate Medicine · doi:10.3810/pgm.2014.09.2802 · Cited by 12
Use of mHealth Technologies to Increase Sleep Quality among Older Adults: A Scoping Review
Grotto, G., Martinello, M., & Buja, A. (2024) · Clocks & Sleep · doi:10.3390/clockssleep6030034 · Cited by 10
Staiano, W., Callahan, C. E., Davis, M., Tanner, L., Coe, C. M., Kunkle, S., & Kirk, U. (2025) · JMIR mhealth and uhealth · doi:10.2196/68665 · Cited by 11
“Consequently, behavioral and psychological interventions, such as cognitive behavioral therapy for insomnia (CBT-I) [15] and mindfulness [16,17], have gained popularity for treating sleep disturbances and insomnia, with a robust body of literature supporting their efficacy [15-18].”
Cognitive-Behavioral Therapy for Insomnia (CBT-I)
Bennett, D. S. (2020) · Springer eBooks · doi:10.1007/978-3-030-44447-1_3 · Cited by 9
Complementary and Integrative Health Interventions for Insomnia in Veterans and Military Populations
Staples, J. K., Gibson, C., & Uddo, M. M. (2021) · Psychological Reports · doi:10.1177/00332941211048473 · Cited by 9
“Advantages of CBT-I include enduring change, a general absence of side effects, and gains that can be obtained in a relatively short period of time (6–8 weeks) (Mitchell et al., 2012).”
BackgroundPunamäki, R., Tammilehto, J., Flykt, M. S., Vänskä, M., Tiitinen, A. E., Poikkeus, P., & Lindblom, J. (2022) · Journal of Applied Developmental Psychology · doi:10.1016/j.appdev.2022.101420 · Cited by 10
Mason, A., Irving, J., Pritchard, M., Sanyal, J., Colling, C., Chandran, D., & Stewart, R. J. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-051873 · Cited by 9
“Monitoring CBTp receipt over time could decipher whether these initiatives are effective at increasing general access for those with psychosis, and specific access for different sociodemographic groups and those with additional depressive symptoms (who may benefit the most).”
Acupuncture for post-stroke insomnia
Xiang, J., Li, H., Xiong, J., Hua, F., Huang, S., Jiang, Y., Zhou, X., Liao, K., & Xu, L. (2020) · Medicine · doi:10.1097/md.0000000000021381 · Cited by 9
Nam, H., Chang, J., Trockel, M., Okajima, I., Yang, C., Chan, N. Y., Li, S. X., & Suh, S. A. (2022) · Sleep And Breathing · doi:10.1007/s11325-022-02609-y · Cited by 10
“CBT-I is effective for insomnia and has shown better long-term treatment outcomes than pharmacological interventions [5].”
BackgroundHoller, E., Campbell, N. L., Boustani, M. A., Dexter, P. R., Miled, Z. B., & Owora, A. H. (2023) · Sleep Health · doi:10.1016/j.sleh.2023.02.002 · Cited by 9
Low-intensity sleep intervention in a youth mental health service: A case series analysis
Rollinson, R., Price, I., Gee, B., Lyons, J., Carroll, B., Wilson, J., & Clarke, T. (2021) · Behavioural and Cognitive Psychotherapy · doi:10.1017/s135246582000051x · Cited by 8
“…is a strong evidence base regarding the effectiveness of cognitive behavioural therapy for insomnia (CBTi) in improving sleep quality for adults (Mitchell et al., 2012; Trauer et al., 2015), with CBTi being recommended as a first-line treatment for insomnia by NICE (National Institute of…”
BackgroundFretz, K. M. (2023) · Translational Behavioral Medicine · doi:10.1093/tbm/ibac104 · Cited by 14
Too Sour to be True? Tart Cherries (Prunus cerasus) and Sleep: a Systematic Review and Meta-analysis
Stretton, B., Eranki, A., Kovoor, J. G., Bacchi, S., Gupta, A. K., Maddern, G. J., & Boyd, M. A. (2023) · Current Sleep Medicine Reports · doi:10.1007/s40675-023-00261-w · Cited by 8
“One nutritional supplement that has shown early promise is Prunus cerasus (tart, sour, Montmorency cherry) [20, 24].”
BackgroundMariappan, V. A., & Mukhtar, F. (2025) · Journal of Clinical Psychology · doi:10.1002/jclp.23781 · Cited by 8
The Effect of Cognitive-Behavioral Therapy on Improving Sleep Quality in the Elderly
hedayat, S., & Arefi, M. (2015) · Knowledge & Research in Applied Psychology · Cited by 8
Longitudinal associations between insomnia, cannabis use and stress among US veterans
Davis, J. P., Prindle, J., Saba, S. K., Castro, C. A., Hummer, J. F., Canning, L. M., & Pedersen, E. R. (2023) · Journal of Sleep Research · doi:10.1111/jsr.13945 · Cited by 8
“Cognitive behavioural therapy for insomnia (CBT-I; Mitchell et al., 2012; Muppavarapu et al., 2020)”
MethodAlshehri, M. M., Alenazi, A. M., Hoover, J. C., Alothman, S., Phadnis, M. A., RUCKER, J. L., Befort, C. A., Miles, J. M., Kluding, P. M., & Siengsukon, C. F. (2019) · JMIR Research Protocols · doi:10.2196/14647 · Cited by 8
“CBT-I is superior to sleep medications in terms of cost and long-term benefits [55].”
Wang, W.-D., Li, G., Hong, L., Liu, Y., Zhao, Y., Lin, Y.-N., Wang, F., Li, T., Yan, X., & Huang, Y.-Y. (2014) · International Journal of Behavioral Medicine · doi:10.1007/s12529-014-9415-5 · Cited by 8
“CBT-I has been shown to be superior to medication treatment both in short-term and long-term management of insomnia in elder adults [11] and for patients with persistent insomnia [12].”
MethodKoffel, E., & Farrell‐Carnahan, L. (2014) · Military Medicine · doi:10.7205/milmed-d-13-00455 · Cited by 10
Cognitive Behavior Therapy for Insomnia: state of the science or a stated science?
Ellis, J. G., & Barclay, N. L. (2014) · Sleep Medicine · doi:10.1016/j.sleep.2014.04.008 · Cited by 8
Mapping the illness trajectories of insomnia: a biographical disruption?
Cheung, J. M. Y., Saini, B., Bartlett, D. J., Laba, T., & Mason, P. H. (2016) · Sociology of Health & Illness · doi:10.1111/1467-9566.12525 · Cited by 9
de Dhaem, O. B., Seng, E. K., & Minen, M. T. (2017) · Pain Medicine · doi:10.1093/pm/pnx161 · Cited by 8
Pruiksma, K. E., Fina, B. A., Dietch, J. R., Dondanville, K. A., Williams, J. M., Wright, E. C., Molino, A. T. C., Hall‐Clark, B. N., Nicholson, K. L., Peterson, A. L., et al. (2018) · Cognitive and Behavioral Practice · doi:10.1016/j.cbpra.2017.12.007 · Cited by 9
Zhu, Y., Stephenson, C., Moghimi, E., Jagayat, J., Nikjoo, N., Kumar, A., Shirazi, A., Patel, C., Omrani, M., & Alavi, N. (2023) · PLOS ONE · doi:10.1371/journal.pone.0285757 · Cited by 7
“Uptake of CBTi is also poor for several reasons, including high costs, long wait time, and inaccessibility to services [20].”
Berry, M. S., & Dunn, K. E. (2024) · Experimental and Clinical Psychopharmacology · doi:10.1037/pha0000723 · Cited by 8
Intimate Partner Violence and Sleep: An Overview of Sleep Disturbances and Interventions
Maharaj, P. E., Barclay, N. L., Descartes, C. H., & Breo, H. D. (2021) · Springer eBooks · doi:10.1007/978-3-319-89999-2_132 · Cited by 12
Himelfarb, M., & Shatkin, J. P. (2024) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2023.06.008 · Cited by 7
COMISA (Comorbid Insomnia and Sleep Apnea): a Practical Approach
Brock, M. S., Foster, S. N., Motamedi, V., & Mysliwiec, V. (2018) · Current Sleep Medicine Reports · doi:10.1007/s40675-018-0127-2 · Cited by 10
Cheong, M. J., Lee, G. E., Kang, H.-W., Kim, S.-I., Kim, H. K., Jo, H.-I., Kang, Y., Kim, J.-H., & Baek, H.-G. (2018) · Medicine · doi:10.1097/md.0000000000013499 · Cited by 6
Torrens, I., Esteva, M., Vicens, C., Pizá-Portell, M. R., Vidal-Thomàs, M. C., Vidal-Ribas, C., Lorente, P., & Torres-Solera, E. (2021) · BMC Family Practice · doi:10.1186/s12875-021-01429-5 · Cited by 8
“The results of recent systematic reviews showed that CBT-i provided by psychologists and psychiatrics is more effective than usual treatments [13] and medications, and it also lasts longer [14], even in patients with comorbidities [15].”
ResultKang, S., Waters, A. J., & Bryan, C. J. (2022) · Military Psychology · doi:10.1080/08995605.2022.2058301 · Cited by 9
“CBTi includes intervention strategies that target patients’ unhelpful attitudes about insomnia, and behavioral strategies such as stimulus control, sleep restriction, and relaxation to decrease or eliminate the perpetuating factors of insomnia (Mitchell et al., 2012).”
BackgroundClinical Spectrum and Trajectory of Innovative Therapeutic Interventions for Insomnia: A Perspective
Lo, Y.-J., Mishra, V. K., Lo, H.-Y., Dubey, N. K., & Lo, W. (2022) · Aging and Disease · doi:10.14336/ad.2022.1203 · Cited by 10
“In addition, compared to acupuncture therapy, CBT has been found as an effective candidate for primary care due to greater and long-term efficacy [274, 275].”
BackgroundTreacy, T., O'Meara, Y., Galligan, M. C., Henry, A. L., Lensen, S. F., Higgins, M. J., Hickey, M., & Brennan, D. J. (2023) · Contemporary Clinical Trials · doi:10.1016/j.cct.2023.107337 · Cited by 6
Doos Ali Vand, H., Gharraee, B., Asgharnejad Farid, A.-A., Ghaleh Bandi, M. F., & Habibi, M. (2018) · Iranian Journal of Psychiatry and Behavioral Sciences · doi:10.5812/ijpbs.14452 · Cited by 7
“Cognitive behavioral therapy for Insomnia (CBT-I) is the first therapeutic option for primary insomnia (18).”
BackgroundTreatment effect of cognitive-behavior therapy for insomnia combined with usual medication
Jan, Y.-W., Yang, C., Huang, S., & Lee, H. (2019) · Sleep and Biological Rhythms · doi:10.1007/s41105-019-00218-z · Cited by 7
Erickson, A. J., Rodrı́guez, J. C., Ravyts, S. G., Dzierzewski, J. M., Fung, C. H., Kelly, M. R., Ryden, A., Carlson, G. E., Josephson, K. R., Mitchell, M. N., et al. (2024) · Journal of the American Geriatrics Society · doi:10.1111/jgs.18910 · Cited by 6
Self-citationTadros, M., Li, S., Corkish, B., Upton, E. L., Newby, J. M., & Werner‐Seidler, A. (2024) · Behavioral Sleep Medicine · doi:10.1080/15402002.2024.2374258 · Cited by 10
Wang, P., Chen, Y., Zhang, A., Xie, C., & Wang, K. (2025) · Sleep Medicine · doi:10.1016/j.sleep.2025.106680 · Cited by 6
Metadata
- Authors
- Mitchell, M. D., Gehrman, P., Perlis, M., & Umscheid, C. A.
- Affiliations
- University of Pennsylvania Health System (US)
- University of Pennsylvania (US)
- Corresponding author
- Mitchell, Matthew D
- Venue
- BMC Family Practice
- Published
- 2012-05-25
- Volume
- 13
- Issue
- 1
- Pages
- 40-40
- ISSN
- 1471-2296 (ISSN-L)
- PMC
- PMC3481424
- OpenAlex
- W2026032799
- Semantic Scholar
- 21aa68d115e33399322c96f824a3fa2bf6eeab3e
- Cited by
- 617
- References
- 55
- Citations by year
- 2026: 33 · 2025: 59 · 2024: 43 · 2023: 55 · 2022: 59 · 2021: 101 · 2020: 45 · 2019: 43 · 2018: 38 · 2017: 32 · 2016: 33 · 2015: 30 · 2014: 32 · 2013: 9 · 2012: 5
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Family Practice (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- University of Pennsylvania
- Perelman School of Medicine, University of Pennsylvania
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
- Keywords
- cognitive behavioral therapy for insomnia, insomnia, benzodiazepines, non-benzodiazepine hypnotics, sleep medication, sleep latency, psychological outcomes, adverse effects, comorbid insomnia, primary care, long-term treatment effectiveness
- MeSH terms
- Humans, Sleep Initiation and Maintenance Disorders, Quality of Life, Cognitive Behavioral Therapy, Outcome Assessment, Health Care, Evidence-Based Medicine, Comparative Effectiveness Research
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
A language model drew the claims from the paper on 2026-10-10, under version 3 of the claim definition (model deepseek-v4.1-flash, prompt extract-v3).
A second model labelled each claim on 2026-10-10 (model jev-1.13-20260917, definition revision gold-guideline-v0.2).
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
