The DOI matches its Crossref record; 223 of the 223 references it cites were found in a registry or an index.
A systematic review and meta-analysis of the effects of antibiotic consumption on antibiotic resistance
Open accessAbstract
BACKGROUND: Greater use of antibiotics during the past 50 years has exerted selective pressure on susceptible bacteria and may have favoured the survival of resistant strains. Existing information on antibiotic resistance patterns from pathogens circulating among community-based patients is substantially less than from hospitalized patients on whom guidelines are often based. We therefore chose to assess the relationship between the antibiotic resistance pattern of bacteria circulating in the community and the consumption of antibiotics in the community. METHODS: Both gray literature and published scientific literature in English and other European languages was examined. Multiple regression analysis was used to analyse whether studies found a positive relationship between antibiotic consumption and resistance. A subsequent meta-analysis and meta-regression was conducted for studies for which a common effect size measure (odds ratio) could be calculated. RESULTS: Electronic searches identified 974 studies but only 243 studies were considered eligible for inclusion by the two independent reviewers who extracted the data. A binomial test revealed a positive relationship between antibiotic consumption and resistance (p < .001) but multiple regression modelling did not produce any significant predictors of study outcome. The meta-analysis generated a significant pooled odds ratio of 2.3 (95% confidence interval 2.2 to 2.5) with a meta-regression producing several significant predictors (F(10,77) = 5.82, p < .01). Countries in southern Europe produced a stronger link between consumption and resistance than other regions. CONCLUSIONS: Using a large set of studies we found that antibiotic consumption is associated with the development of antibiotic resistance. A subsequent meta-analysis, with a subsample of the studies, generated several significant predictors. Countries in southern Europe produced a stronger link between consumption and resistance than other regions so efforts at reducing antibiotic consumption may need to be strengthened in this area. Increased consumption of antibiotics may not only produce greater resistance at the individual patient level but may also produce greater resistance at the community, country, and regional levels, which can harm individual patients.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“and a fast de-escalation was shown to be associated with a decreased risk [26, 27].”
From Lab efficiency and improvements in the management of bloodstream infections: a before and after study (2025) · cites this paper as [26]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Antibiotic resistance being correlated with antibiotic use, in terms of antimicrobial stewardship, it is crucial that antibiotics are only used when indicated”
From Lab efficiency and improvements in the management of bloodstream infections: a before and after study (2025) · cites this paper as [26]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
(2000) · Cited by 9,198
Outpatient antibiotic use in Europe and association with resistance: a cross-national database study
Goossens, H., Ferech, M., Vander Stichele, R., & Elseviers, M. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17907-0 · Cited by 3,359
Self-citationMethicillin-Resistant S. aureus Infections among Patients in the Emergency Department
Moran, G. J., Krishnadasan, A., Gorwitz, R. J., Fosheim, G. E., McDougal, L. K., Carey, R. B., & Talan, D. A. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055356 · Cited by 2,285
Costelloe, C., Metcalfe, C., Lovering, A., Mant, D., & Hay, A. D. (2010) · BMJ · doi:10.1136/bmj.c2096 · Cited by 1,981
The Relationship between Antimicrobial Use and Antimicrobial Resistance in Europe
Bronzwaer, S. L. A. M., Cars, O., Buchholz, U., Mölstad, S., Goettsch, W., Veldhuijzen, I. K., Kool, J. L., Sprenger, M. J. W., Degener, J. E., & System, P. I. T. E. A. R. S. (2002) · Emerging infectious diseases · doi:10.3201/eid0803.010192 · Cited by 691
Bacterial Resistance: Origins, Epidemiology, and Impact
Livermore, D. M. (2003) · Clinical Infectious Diseases · doi:10.1086/344654 · Cited by 589
Low Dosage and Long Treatment Duration of β-Lactam
Guillemot, D., Carbon, C., Balkau, B., Geslin, P., Lecoeur, H., Vauzelle-Kervroedan, F., Bouvenot, G., & Eschwège, É. (1998) · JAMA · doi:10.1001/jama.279.5.365 · Cited by 545
Malhotra‐Kumar, S., Lammens, C., Coenen, S., Herck, K. V., & Goossens, H. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60235-9 · Cited by 541
Self-citationArason, V. A., Kristinsson, K. G., Sigurdsson, J. A., Stefansdottir, G., Mölstad, S., & Gudmundsson, S. (1996) · BMJ · doi:10.1136/bmj.313.7054.387 · Cited by 493
Antimicrobial Drug Use and Resistance in Europe
van de Sande-Bruinsma, N., Grundmann, H., Verloo, D., Tiemersma, E. W., Monen, J., Goossens, H., Ferech, M., & the European Antimicrobial Resistance Surveillance System and European Surveillance of Antimicrobial Consumption Project Groups (2008) · Emerging infectious diseases · doi:10.3201/eid1411.070467 · Cited by 481
Self-citation
Cited by
Sorted by citations
Understanding the mechanisms and drivers of antimicrobial resistance
Holmes, A. H., Moore, L. S. P., Sundsfjord, A., Steinbakk, M., Regmi, S., Karkey, A., Guerin, P. J., & Piddock, L. J. V. (2015) · The Lancet · doi:10.1016/s0140-6736(15)00473-0 · Cited by 2,877
Association of adverse events with antibiotic use in hospitalized patients.
Tamma, P. D., Avdic, E., Li, D. X., Dzintars, K., & Cosgrove, S. E. (2017) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2017.1938 · Cited by 800
Schuts, E. C., Hulscher, M., Mouton, J. W., Verduin, C. M., Stuart, J. W. T. C., Overdiek, H. W. P. M., van der Linden, P. D., Natsch, S., Hertogh, C. M. P. M., Wolfs, T. F. W., et al. (2016) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(16)00065-7 · Cited by 772
Collignon, P., Beggs, J. J., Walsh, T. R., Gandra, S., & Laxminarayan, R. (2018) · The Lancet Planetary Health · doi:10.1016/s2542-5196(18)30186-4 · Cited by 750
Global trends in antibiotic consumption during 2016–2023 and future projections through 2030
Klein, E. Y., Impalli, I., Poleon, S., Denoël, P., Cipriano, M., Boeckel, T. P. V., Pecetta, S., Bloom, D. E., & Nandi, A. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2411919121 · Cited by 481
Metal Resistance and Its Association With Antibiotic Resistance
Pal, C., Asiani, K., Arya, S., Rensing, C., Stekel, D. J., Larsson, D. G. J., & Hobman, J. L. (2017) · Advances in microbial physiology/Advances in Microbial Physiology · doi:10.1016/bs.ampbs.2017.02.001 · Cited by 444
Quantifying drivers of antibiotic resistance in humans: a systematic review
Chatterjee, A., Modarai, M., Naylor, N. R., Boyd, S. E., Atun, R. A., Barlow, J. G., Holmes, A. H., Johnson, A. P., & Robotham, J. V. (2018) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(18)30296-2 · Cited by 388
Bell, G. (2017) · Annual Review of Ecology Evolution and Systematics · doi:10.1146/annurev-ecolsys-110316-023011 · Cited by 369
Nair, D. V. T., Venkitanarayanan, K., & Johny, A. K. (2018) · Foods · doi:10.3390/foods7100167 · Cited by 375
Biomaterials and Nanotherapeutics for Enhancing Skin Wound Healing
Das, S., & Baker, A. B. (2016) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2016.00082 · Cited by 336
Antibiotic strategies in the era of multidrug resistance
Karam, G. H., Chastre, J. E., Wilcox, M. H., & Vincent, J. (2016) · Critical Care · doi:10.1186/s13054-016-1320-7 · Cited by 310
Kadri, S. S., Lai, Y. L., Warner, S., Strich, J. R., Babiker, A., Ricotta, E., Demirkale, C. Y., Dekker, J. P., Palmore, T. N., Rhee, C., et al. (2020) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(20)30477-1 · Cited by 284
An international cross-sectional survey of antimicrobial stewardship programmes in hospitals
Howard, P., Pulcini, C., Hara, G. L., West, R. M., Gould, I. M., Harbarth, S., & Nathwani, D. (2014) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dku497 · Cited by 277
Rationalizing antimicrobial therapy in the ICU: a narrative review
Timsit, J., Bassetti, M., Cremer, O. L., Daikos, G. L., Waele, J. J. D., Kalil, A. C., Kipnis, É., Kollef, M. H., Laupland, K. B., Paiva, J.-A., et al. (2019) · Intensive Care Medicine · doi:10.1007/s00134-019-05520-5 · Cited by 280
von Dach, E., Albrich, W. C., Brunel, A.-S., Prendki, V., Cuvelier, C., Flury, D., Gayet-Ageron, A., Huttner, B., Kohler, P., Lemmenmeier, E., et al. (2020) · JAMA · doi:10.1001/jama.2020.6348 · Cited by 259
Mammari, N., Lamouroux, E., Boudier, A., & Duval, R. E. (2022) · Microorganisms · doi:10.3390/microorganisms10020437 · Cited by 262
Septimus, E. J. (2018) · Medical Clinics of North America · doi:10.1016/j.mcna.2018.04.005 · Cited by 247
MacGowan, A. P., & MacNaughton, E. (2017) · Medicine · doi:10.1016/j.mpmed.2017.07.006 · Cited by 246
Allel, K., Day, L., Hamilton, A., Lin, L. K., Furuya‐Kanamori, L., Moore, C. E., Boeckel, T. P. V., Laxminarayan, R., & Yakob, L. (2023) · The Lancet Planetary Health · doi:10.1016/s2542-5196(23)00026-8 · Cited by 253
A conceptual framework for the environmental surveillance of antibiotics and antibiotic resistance
Huijbers, P. M. C., Flach, C.-F., & Larsson, D. G. J. (2019) · Environment International · doi:10.1016/j.envint.2019.05.074 · Cited by 236
Antibiotic resistance in urban aquatic environments: can it be controlled?
Manaia, C. M., Macedo, G., Fatta‐Kassinos, D., & Nunes, O. C. (2015) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-015-7202-0 · Cited by 235
The distribution of antibiotic use and its association with antibiotic resistance
Olesen, S. W., Barnett, M. L., MacFadden, D. R., Brownstein, J. S., Hernández–Dı́az, S., Lipsitch, M., & Grad, Y. H. (2018) · eLife · doi:10.7554/elife.39435 · Cited by 227
Nandi, A., Pecetta, S., & Bloom, D. E. (2023) · EClinicalMedicine · doi:10.1016/j.eclinm.2023.101848 · Cited by 238
Systematic Review of Factors Associated with Antibiotic Prescribing for Respiratory Tract Infections
McKay, R., Mah, A., Law, M. R., McGrail, K. M., & Patrick, D. M. (2016) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00209-16 · Cited by 237
(EFSA), E. F. S. A., & European Medicines Agency (EMA) (2015) · EFSA Journal · doi:10.2903/j.efsa.2015.4006 · Cited by 223
Lewnard, J. A., Charani, E., Gleason, A., Hsu, L. Y., Khan, W. A., Karkey, A., Chandler, C. I. R., Mashe, T., Khan, E. A., Bulabula, A. N. H., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)00862-6 · Cited by 220
Samtiya, M., Matthews, K. R., Dhewa, T., & Puniya, A. K. (2022) · Foods · doi:10.3390/foods11192966 · Cited by 225
Fouz, N., Pangesti, K. N. A., Yasir, M., Al‐Malki, A. L., Azhar, E. I., Hill-Cawthorne, G. A., & Ghany, M. A. E. (2020) · Tropical Medicine and Infectious Disease · doi:10.3390/tropicalmed5010033 · Cited by 208
Recommendations for antibacterial therapy in adults with COVID-19 – an evidence based guideline
Sieswerda, E., de Boer, M. G. J., Bonten, M. J. M., Boersma, W. G., Jonkers, R. E., Aleva, R. M., Kullberg, B. J., Schouten, J. A., van de Garde, E. M. W., Verheij, T. J., et al. (2020) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2020.09.041 · Cited by 199
Cương, N. V., Padungtod, P., Thwaites, G. E., & Carrique-Mas, J. J. (2018) · Antibiotics · doi:10.3390/antibiotics7030075 · Cited by 187
Belachew, S. A., Hall, L., & Selvey, L. A. (2021) · Antimicrobial Resistance and Infection Control · doi:10.1186/s13756-020-00880-w · Cited by 187
Ranjalkar, J., & Chandy, S. J. (2019) · Journal of Family Medicine and Primary Care · doi:10.4103/jfmpc.jfmpc_275_19 · Cited by 184
Cambau, E., Saunderson, P. R., Matsuoka, M., Cole, S. T., Kai, M., Suffys, P. N., Rosa, P. S., Williams, D. L., Gupta, U. D., Lavania, M., et al. (2018) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2018.02.022 · Cited by 180
Gender differences in antibiotic prescribing in the community: a systematic review and meta-analysis
Schröder, W., Sommer, H., Gladstone, B. P., Foschi, F., Hellman, J., Evengård, B., & Tacconelli, E. (2016) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkw054 · Cited by 179
Species Sensitivity to Toxic Substances: Evolution, Ecology and Applications
Spurgeon, D. J., Lahive, E., Robinson, A., Short, S., & Kille, P. (2020) · Frontiers in Environmental Science · doi:10.3389/fenvs.2020.588380 · Cited by 196
Lipsky, B. A., Dryden, M., Gottrup, F., Nathwani, D., Seaton, R. A., & Stryja, J. (2016) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkw287 · Cited by 180
Li, L.-G., Huang, Q., Yin, X., & Zhang, T. (2020) · Water Research · doi:10.1016/j.watres.2020.116127 · Cited by 182
Risk assessment for antibiotic resistance in South East Asia
Chéreau, F., Opatowski, L., Tourdjman, M., & Vong, S. (2017) · BMJ · doi:10.1136/bmj.j3393 · Cited by 177
Zhang, Y., Cheng, D., Xie, J., Zhang, Y., Wan, Y., Zhang, Y., & Shi, X. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.134529 · Cited by 175
Godman, B., Haque, M., McKimm, J., Abu Bakar, M., Sneddon, J., Wale, J., Campbell, S., Martin, A. P., Hoxha, I., Abilova, V., et al. (2020) · Current Medical Research and Opinion · doi:10.1080/03007995.2019.1700947 · Cited by 171
Sakeena, M. H. F., Bennett, A. A., & McLachlan, A. J. (2018) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2018.09.022 · Cited by 157
Vallin, M., Polyzoi, M., Marrone, G., Rosales-Klintz, S., Wisell, K. T., & Lundborg, C. S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152160 · Cited by 149
O’Connor, R., O’Doherty, J., O’Regan, A., & Dunne, C. P. (2018) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-018-1774-5 · Cited by 143
How can we improve antibiotic prescribing in primary care?
Dyar, O. J., Beovič, B., Vlahović–Palčevski, V., Verheij, T. J., & Pulcini, C. (2016) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.2016.1151353 · Cited by 142
Childhood vaccines and antibiotic use in low- and middle-income countries
Lewnard, J. A., Lo, N. C., Arinaminpathy, N., Frost, I., & Laxminarayan, R. (2020) · Nature · doi:10.1038/s41586-020-2238-4 · Cited by 146
Adverse events in people taking macrolide antibiotics versus placebo for any indication
Hansen, M. P., Scott, A. M., McCullough, A. R., Thorning, S., Aronson, J. K., Beller, E., Glasziou, P., Hoffmann, T., Clark, J. M., & Mar, C. D. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011825.pub2 · Cited by 144
Dorado-García, A., Mevius, D. J., Jacobs, J. H., van Geijlswijk, I. M., Mouton, J. W., Wagenaar, J. A., & Heederik, D. J. J. (2016) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkw308 · Cited by 138
Treiber, F. M., & Beranek-Knauer, H. (2021) · Antibiotics · doi:10.3390/antibiotics10050534 · Cited by 138
Rodríguez-Villodres, Á., Martín‐Gandul, C., Peñalva, G., Guisado-Gil, A. B., Crespo‐Rivas, J. C., Pachón-Ibáñez, M. E., Lepe, J. A., & Cisneros, J. M. (2021) · Antibiotics · doi:10.3390/antibiotics10060680 · Cited by 132
Antimicrobial resistance in human populations: challenges and opportunities
Allcock, S. H., Young, E. H., Holmes, M. A., Gurdasani, D., Dougan, G., Sandhu, M. S., Solomon, L., & Török, M. E. (2017) · Global Health · doi:10.1017/gheg.2017.4 · Cited by 131
Outcomes of respiratory viral-bacterial co-infection in adult hospitalized patients
Liu, Y., Ling, L., Wong, S. H., Wang, M. H., Fitzgerald, J. R., Zou, X., Fang, S., Liu, X., Wang, X., Hu, W., et al. (2021) · EClinicalMedicine · doi:10.1016/j.eclinm.2021.100955 · Cited by 133
Antibiotic Use in Children – A Cross-National Analysis of 6 Countries
Youngster, I., Avorn, J., Belleudi, V., Cantarutti, A., Díez‐Domingo, J., Kirchmayer, U., Park, B., Peiró, S., Sanfélix‐Gimeno, G., Schröder, H., et al. (2016) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2016.11.027 · Cited by 129
Yang, P., Chen, Y., Jiang, S., Shen, P., Lu, X., & Xiao, Y. (2018) · Antimicrobial Resistance and Infection Control · doi:10.1186/s13756-018-0430-1 · Cited by 126
Katwyk, S. R. V., Grimshaw, J., Nkangu, M., Nagi, R., Mendelson, M., Taljaard, M., & Hoffman, S. J. (2019) · PLoS Medicine · doi:10.1371/journal.pmed.1002819 · Cited by 126
Stanton, I. C., Bethel, A. C., Leonard, A. F. C., Gaze, W. H., & Garside, R. (2022) · Environmental Evidence · doi:10.1186/s13750-022-00262-2 · Cited by 122
2D/2D Heterojunction systems for the removal of organic pollutants: A review
Qin, M.-Z., Fu, W.-X., Guo, H. Y., Niu, C., Huang, D., Liang, C., Yang, Y.-Y., Liu, H.-Y., Tang, N., & Fan, Q.-Q. (2021) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2021.102540 · Cited by 119
Improper disposal of unused antibiotics: an often overlooked driver of antimicrobial resistance
Anwar, M., Iqbal, Q., & Saleem, F. (2020) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2020.1754797 · Cited by 118
Antimicrobial Stewardship in Veterinary Medicine
Lloyd, D. H., & Page, S. W. (2018) · Microbiology Spectrum · doi:10.1128/microbiolspec.arba-0023-2017 · Cited by 122
Phage engineering and phage‐assisted CRISPR‐Cas delivery to combat multidrug‐resistant pathogens
Khambhati, K., Bhattacharjee, G., Gohil, N., Dhanoa, G. K., Sagona, A. P., Mani, I., Bui, N. L., Chu, D., Karapurkar, J. K., Jang, S. H., et al. (2022) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10381 · Cited by 115
Nanoparticle-drug conjugates treating bacterial infections
Jelínková, P., Mazumdar, A., Sur, V. P., Kočiová, S., Dolezelikova, K., Jimenez, A. M. J., Koudelková, Z., Mishra, P. K., Šmerková, K., Heger, Z., et al. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.06.013 · Cited by 113
Rodríguez‐Mañas, L. (2020) · Drugs in Context · doi:10.7573/dic.2020-4-13 · Cited by 113
Lewin‐Epstein, O., Baruch, S., Hadany, L., Stein, G. Y., & Obolski, U. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa1576 · Cited by 116
Sale of WHO AWaRe groups antibiotics without a prescription in Pakistan: a simulated client study
Saleem, Z., Hassali, M. A., Godman, B., Fatima, M., Ahmad, Z., Sajid, A., Rehman, I. U., Nadeem, M. U., Javaid, Z., Malik, M., et al. (2020) · Journal of Pharmaceutical Policy and Practice · doi:10.1186/s40545-020-00233-3 · Cited by 111
Maréchal, M. L., Tebano, G., Monnier, A. A., Adriaenssens, N., Gyssens, I. C., Huttner, B. D., Milanič, R., Schouten, J. A., Benić, M. S., Versporten, A., et al. (2018) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dky117 · Cited by 112
Billah, M. M., & Rahman, M. S. (2024) · Journal of Hazardous Materials Advances · doi:10.1016/j.hazadv.2024.100407 · Cited by 114
van Hecke, O., Wang, K., Lee, J. J., Roberts, N. W., & Butler, C. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix233 · Cited by 104
Antibiotic prescribing in primary healthcare: Dominant factors and trade-offs in decision-making
Lum, E., Page, K., Whitty, J. A., Doust, J. A., & Graves, N. (2018) · Infection Disease & Health · doi:10.1016/j.idh.2017.12.002 · Cited by 108
Alrasheedy, A. A., Alsalloum, M. A., Almuqbil, F. A., Almuzaini, M. A., Aba Alkhayl, B. S., Albishri, A. S., Alharbi, F. F., Alharbi, S. R., Alodhayb, A. K., Alfadl, A. A., et al. (2020) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2020.1705156 · Cited by 102
Prospects for the Use of New Technologies to Combat Multidrug-Resistant Bacteria
de Lima, R., Fiol, F. D. S. D., & Balcão, V. M. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00692 · Cited by 98
Kalungia, A. C., Mwambula, H., Munkombwe, D., Marshall, S., Schellack, N., May, C. B., Jones, A. S. C., & Godman, B. (2019) · Journal of Chemotherapy · doi:10.1080/1120009x.2019.1622293 · Cited by 97
Exploiting genomics to mitigate the public health impact of antimicrobial resistance
Waddington, C. S., Carey, M. E., Boinett, C. J., Higginson, E. E., Veeraraghavan, B., & Baker, S. G. (2022) · Genome Medicine · doi:10.1186/s13073-022-01020-2 · Cited by 99
Farooqui, H. H., Selvaraj, S., Mehta, A., & Heymann, D. L. (2018) · PLoS ONE · doi:10.1371/journal.pone.0204805 · Cited by 96
Reina, A. C., Martínez-Piernas, A. B., Bertakis, Y., Xekoukoulotakis, N. P., Agüera, A., & Pérez, J. A. S. (2019) · Water Research · doi:10.1016/j.watres.2019.115037 · Cited by 96
Horumpende, P. G., Said, S. H., Mazuguni, F. S., Antony, M. L., Kumburu, H. H., Sonda, T., Mwanziva, C. E., Mshana, S. E., Mmbaga, B. T., Kajeguka, D. C., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0206623 · Cited by 95
Irek, E. O., Amupitan, A. A., Obadare, T. O., & Aboderin, A. O. (2018) · African Journal of Laboratory Medicine · doi:10.4102/ajlm.v7i2.796 · Cited by 95
Antimicrobial Resistance Among Streptococcus pneumoniae
Cillóniz, C., García‐Vidal, C., Ceccato, A., & Torres, A. (2018) · Springer eBooks · doi:10.1007/978-3-319-78538-7_2 · Cited by 94
Sindato, C., Mboera, L. E. G., Katale, B. Z., Frumence, G., Kimera, S. I., Clark, T. G., Legido‐Quigley, H., Mshana, S. E., Rweyemamu, M. M., & Matee, M. I. (2020) · Antimicrobial Resistance and Infection Control · doi:10.1186/s13756-020-00862-y · Cited by 94
Groundwater resources as a global reservoir for antimicrobial-resistant bacteria
Andrade, L., Kelly, M., Hynds, P. D., Weatherill, J. J., Majury, A. L., & O’Dwyer, J. (2019) · Water Research · doi:10.1016/j.watres.2019.115360 · Cited by 99
The role of emerging organic contaminants in the development of antimicrobial resistance
Alderton, I., Palmer, B. R., Heinemann, J. A., Pattis, I., Weaver, L., Ginés, M. J. G., Horswell, J., & Tremblay, L. A. (2021) · Emerging contaminants · doi:10.1016/j.emcon.2021.07.001 · Cited by 96
Saleem, Z., Godman, B., Cook, A., Khan, M. A., Campbell, S., Seaton, R. A., Siachalinga, L., Haseeb, A., Amir, A., Kurdi, A. B., et al. (2022) · Antibiotics · doi:10.3390/antibiotics11121824 · Cited by 97
Socioeconomic Enablers for Contagion: Factors Impelling the Antimicrobial Resistance Epidemic
Collignon, P., & Beggs, J. J. (2019) · Antibiotics · doi:10.3390/antibiotics8030086 · Cited by 92
Wang, G., Wu, P., Tang, R., & Zhang, W. (2022) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkac170 · Cited by 92
Antibiotic Use and Resistance Pattern in Ethiopia: Systematic Review and Meta-Analysis
Muhie, O. A. (2019) · International Journal of Microbiology · doi:10.1155/2019/2489063 · Cited by 91
Afriyie, D. K., Sefah, I. A., Sneddon, J., Malcolm, W., McKinney, R., Cooper, L., Kurdi, A. B., Godman, B., & Seaton, R. A. (2020) · JAC-Antimicrobial Resistance · doi:10.1093/jacamr/dlaa001 · Cited by 89
Mixed strain pathogen populations accelerate the evolution of antibiotic resistance in patients
Caballero, J. D., Wheatley, R. M., Kapel, N., López-Causapé, C., van der Schalk, T. E., Quinn, A., Shaw, L. P., Ogunlana, L., Recanatini, C., Xavier, B. B., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39416-2 · Cited by 88
Behavioral Approach to Appropriate Antimicrobial Prescribing in Hospitals
Sikkens, J. J., van Agtmael, M. A., Peters, E. J. G., Lettinga, K. D., van der Kuip, M., Vandenbroucke‐Grauls, C. M. J. E., Wagner, C., & Kramer, M. H. H. (2017) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2017.0946 · Cited by 89
Point prevalence surveys of antimicrobial use: a systematic review and the implications
Saleem, Z., Hassali, M. A., Godman, B., Versporten, A., Hashmi, F. K., Saeed, H., Saleem, F., Salman, M., Rehman, I. U., & Khan, T. M. (2020) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2020.1767593 · Cited by 85
Schwartz, K. L., Langford, B. J., Daneman, N., Chen, B., Brown, K. A., McIsaac, W. J., Tu, K., Candido, E., Johnstone, J., Leung, V., et al. (2020) · CMAJ Open · doi:10.9778/cmajo.20190175 · Cited by 92
Wheatley, R. M., Caballero, J. D., Kapel, N., Winter, F. D., Jangir, P. K., Quinn, A., del Barrio-Tofiño, E., López-Causapé, C., Hedge, J., Torrens, G., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22814-9 · Cited by 83
Self-citationGirijan, S. K., Paul, R., Rejish Kumar, V. J., & Pillai, D. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.141538 · Cited by 83
Anestopoulos, I., Kiousi, D. E., Klavaris, A., Galanis, Α., Sałek, K., Euston, S. R., Pappa, A., & Panayiotidis, M. I. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12070688 · Cited by 82
Postma, M., Sjölund, M., Collineau, L., Loesken, S., Stärk, K. D. C., Dewulf, J., Andreasen, M., Backhans, A., Belloc, C., Collineau, L., et al. (2014) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dku347 · Cited by 80
Mwita, J. C., Ogunleye, O. O., Olalekan, A. O., Kalungia, A. C., Kurdi, A. B., Saleem, Z., Sneddon, J., & Godman, B. (2021) · International Journal of General Medicine · doi:10.2147/ijgm.s253216 · Cited by 80
Sijbom, M., Büchner, F. L., Saadah, N. H., Numans, M. E., & de Boer, M. G. J. (2023) · BMJ Open · doi:10.1136/bmjopen-2022-065006 · Cited by 76
Adverse events in patients taking macrolide antibiotics versus placebo for any indication
Hansen, M. P., Thorning, S., Aronson, J. K., Beller, E., Glasziou, P., Hoffmann, T., & Mar, C. D. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011825 · Cited by 75
Antimicrobial Nanomaterials Derived from Natural Products—A Review
Wang, J., & Vermerris, W. (2016) · Materials · doi:10.3390/ma9040255 · Cited by 75
Biliński, J., Grzesiowski, P., Muszyński, J., Wróblewska, M., Mądry, K., Robak, K., Dzieciątkowski, T., Wiktor-Jędrzejczak, W., & Basak, G. W. (2016) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-016-0387-9 · Cited by 74
Knowledge, attitude and practice of antibiotic use and misuse among adults in Riyadh, Saudi Arabia
Al‐Shibani, N., Hamed, A. E. S., Labban, N. Y., Al‐Kattan, R., Al-Otaibi, H. N., & Alfadda, S. A. (2017) · Saudi Medical Journal · doi:10.15537/smj.2017.10.19887 · Cited by 77
Zhang, A., Hobman, E. V., Barro, P. D., Young, A., Carter, D. J., & Byrne, M. K. (2021) · Antibiotics · doi:10.3390/antibiotics10030232 · Cited by 73
Surgical Antibiotic Prophylaxis and Risk for Postoperative Antibiotic-Resistant Infections
Cohen, M. E., Salmasian, H., Li, J., Liu, J., Zachariah, P., Wright, J. D., & Freedberg, D. E. (2017) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2017.08.010 · Cited by 74
Metadata
- Authors
- Bell, B. G., Schellevis, F., Stobberingh, E., Goossens, H., & Pringle, M.
- Affiliations
- University of Nottingham (GB)
- Maastricht University (NL)
- University of Antwerp (BE)
- Corresponding author
- Bell, Brian G
- Venue
- BMC Infectious Diseases
- Published
- 2014-01-09
- Volume
- 14
- Issue
- 1
- Pages
- 13-13
- ISSN
- 1471-2334 (ISSN-L)
- PMC
- PMC3897982
- OpenAlex
- W2064618548
- Cited by
- 1,262
- References
- 223
- Citations by year
- 2026: 56 · 2025: 91 · 2024: 151 · 2023: 151 · 2022: 149 · 2021: 156 · 2020: 158 · 2019: 105 · 2018: 93 · 2017: 60 · 2016: 50 · 2015: 27 · 2014: 13
- FWCI
- 7.04
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Infectious Diseases (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, cc-by)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- European Commission (223083)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antibiotic Use and Resistance
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
- Keywords
- antibiotic use, antibiotic resistance, community-acquired infections, antimicrobial resistance patterns, selection pressure, Southern Europe, regional variation in resistance
- MeSH terms
- Anti-Bacterial Agents, Drug Resistance, Microbial, Europe, Humans, Odds Ratio
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
