Transgenerational programming of maternal behaviour by prenatal stress
Open accessAbstract
Peripartum events hold the potential to have dramatic effects in the programming of physiology and behaviour of offspring and possibly subsequent generations. Here we have characterized transgenerational changes in rat maternal behaviour as a function of gestational and prenatal stress. Pregnant dams of the parental generation were exposed to stress from days 12-18 (F0-S). Their daughters and grand-daughters were either stressed (F1-SS, F2-SSS) or non-stressed (F1-SN, F2-SNN). Maternal antepartum behaviours were analyzed at a time when pregnant dams usually show a high frequency of tail chasing behaviours. F1-SS, F2-SNN and F2-SSS groups showed a significant reduction in tail chasing behaviours when compared with controls. The effects of multigenerational stress (SSS) slightly exceeded those of transgenerational stress (SNN) and resulted in absence of tail chasing behaviour. These findings suggest that antepartum maternal behaviour in rats is programmed by transgenerational inheritance of stress responses. Thus, altered antepartum maternal behaviour may serve as an indicator of an activated stress response during gestation.
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Maternal physiology, particularly stress and nutrition, can greatly impact the neural and behavioral development of offspring.
“This is in keeping with a large body of research showing that maternal physiology, particularly stress (85–87) and nutrition (88–90), can greatly impact the neural and behavioral development of offspring.”
From Oxytocin during Development: Possible Organizational Effects on Behavior (2015) · cites this paper as [85]
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The Human Toll of Collective Trauma: The Ravages of War and Persecution
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- Authors
- Ward, I. D., Zucchi, F. C., Robbins, J. C., Falkenberg, E. A., Olson, D. M., Benzies, K., & Metz, G. A.
- Affiliations
- University of Lethbridge (CA)
- University of Alberta (CA)
- University of Calgary (CA)
- Corresponding author
- Metz, Gerlinde A
- Venue
- BMC Pregnancy and Childbirth
- Published
- 2013-01
- Volume
- 13
- Issue
- S1
- Pages
- S9-S9
- ISSN
- 1471-2393 (ISSN-L)
- PMC
- PMC3561190
- OpenAlex
- W2097619644
- Cited by
- 73
- References
- 39
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 11 · 2019: 4 · 2018: 5 · 2017: 12 · 2016: 7 · 2015: 7 · 2014: 7 · 2013: 3
- FWCI
- 7.44
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- BMC Pregnancy and Childbirth (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Open ULeth Scholarship (OPUS) (University of Lethbridge) (submittedVersion, cc-by)
- Funders
- Alberta Innovates (200700595)
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Keywords
- prenatal stress, maternal behavior, stress response, rats, offspring behavior
- MeSH terms
- Analysis of Variance, Animals, Behavior, Animal, Female, Maternal Behavior, Pregnancy, Prenatal Exposure Delayed Effects, Stress, Psychological, Rats, Long-Evans, Models, Animal, Rats, Peripartum Period
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