The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Serum microRNAs as non-invasive biomarkers for cancer
Open accessAbstract
Human serum and other body fluids are rich resources for the identification of novel biomarkers, which can be measured in routine clinical diagnosis. microRNAs are small non-coding RNA molecules, which have an important function in regulating RNA stability and gene expression. The deregulation of microRNAs has been linked to cancer development and tumor progression. Recently, it has been reported that serum and other body fluids contain sufficiently stable microRNA signatures. Thus, the profiles of circulating microRNAs have been explored in a variety of studies aiming at the identification of novel non-invasive biomarkers. In this review, we discuss recent findings indicating that circulating microRNAs are useful as non-invasive biomarkers for different tumor types. Additionally, we summarize the knowledge about the mechanism of microRNA release and the putative functional roles of circulating microRNAs. Although several challenges remain to be addressed, circulating microRNAs have the potential to be useful for the diagnosis and prognosis of cancer diseases.
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Cites
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Age-related changes in microRNA levels in serum
Hooten, N. N., Fitzpatrick, M., Wood, W. H., De, S., Ejiogu, N., Zhang, Y., Mattison, J. A., Becker, K. G., Zonderman, A. B., & Evans, M. K. (2013) · Aging · doi:10.18632/aging.100603 · Cited by 329
A comprehensive, cell specific microRNA catalogue of human peripheral blood.
Juzenas, S., Venkatesh, G., Hübenthal, M., Hoeppner, M. P., Du, Z. G., Paulsen, M., Rosenstiel, P., Senger, P., Hofmann-Apitius, M., Keller, A., et al. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx706 · Cited by 181
Biomarkers for early diagnosis of pancreatic cancer
Jenkinson, C., Earl, J., Ghaneh, P., Halloran, C., Carrato, A., Greenhalf, W., Neoptolemos, J., & Costello, E. (2015) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2015.965145 · Cited by 42
Osaki, M., Kosaka, N., Okada, F., & Ochiya, T. (2014) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-013-0065-0 · Cited by 13
Metadata
- Authors
- Brase, J. C., Wuttig, D., Kuner, R., & Sültmann, H.
- Venue
- Molecular Cancer
- Published
- 2010
- Volume
- 9
- Issue
- 1
- Pages
- 306
- ISSN
- 1476-4598 (ISSN-L)
- OpenAlex
- W2105632406
- Cited by
- 421
- References
- 8
- FWCI
- 12.83
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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