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Cited by 317Ovarian function and disordersGestational Diabetes Research and ManagementPregnancy and preeclampsia studies

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

Obstetric complications in women with polycystic ovary syndrome: a systematic review and meta-analysis

Open access
Qin, Jun Z, Pang, Li H, Li, Mu J, Fan, Xiao J, Huang, Ru D, Chen, Hong Y·2013·Reproductive Biology and Endocrinology
DOI 10.1186/1477-7827-11-56PMC PMC3737012
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Abstract

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of childbearing age. The risk of pregnancy and neonatal complications in women with PCOS is debatable. In order to determine the risk of pregnancy and neonatal complications, evidence regarding these risks was examined. Methods: Literature searches were performed in the electronic databases MEDLINE, EMBASE, and CENTRAL based on the established strategy and eligible tries were included according to inclusion and exclusion criteria. A systematic literature review looking at rates of gestational diabetes mellitus (GDM), pregnancy-induced hypertension (PIH), preeclampsia, premature delivery, neonatal birth weight, caesarean section and admission to a neonatal intensive care unit (NICU) was conducted in women with PCOS. Pregnancy outcomes between women with PCOS versus controls were included. Sensitivity analyses were performed to determine the reliability of the available evidence and to validate the results. The study was performed with the approval of the ethics committee of the First Affiliated Hospital of Guangxi Medical University. Results: A total of 27studies, involving 4982 women with PCOS and 119692 controls were eligible for the meta-analysis. Women with PCOS demonstrated a significantly higher risk of developing GDM (OR3.43; 95% CI: 2.49–4.74), PIH (OR3.43; 95% CI: 2.49–4.74), preeclampsia (OR2.17; 95% CI: 1.91–2.46), preterm birth (OR1.93; 95%CI: 1.45–2.57), caesarean section (OR 1.74; 95% CI: 1.38–2.11) compared to controls. Their babies had a marginally significant lower birth weight (WMD −0.11g; 95%CI: -0.19 – -0.03), and higher risk of admission to NICU (OR 2.32; 95% CI: 1.40–3.85) compared to controls. Conclusions: Women with PCOS have increased risk of adverse pregnancy and neonatal complications. It is necessary to establish guidelines for supervision during pregnancy and parturition to prevent these complications.

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Crossref · 10.1186/1477-7827-11-56

Cites

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Figures

Figure 1 Flow diagram of included studies for this meta-analysis.
Figure 1 Flow diagram of included studies for this meta-analysis.CC BY · PubMed Central
Figure 2 OR for incidence of GDM in women with PCOS and controls. 01 Incidence of GDM all studies included. 02 borderline eligible studies excluded.
Figure 2 OR for incidence of GDM in women with PCOS and controls. 01 Incidence of GDM all studies included. 02 borderline eligible studies excluded.CC BY · PubMed Central
Figure 3 OR for incidence of PIH in women with PCOS and controls. 01 Incidence of PIH all studies included. 02 borderline eligible studies excluded.
Figure 3 OR for incidence of PIH in women with PCOS and controls. 01 Incidence of PIH all studies included. 02 borderline eligible studies excluded.CC BY · PubMed Central
Figure 4 OR for incidence of PE in women with PCOS and controls. 01 Incidence PE all studies included. 02 borderline eligible studies excluded.
Figure 4 OR for incidence of PE in women with PCOS and controls. 01 Incidence PE all studies included. 02 borderline eligible studies excluded.CC BY · PubMed Central
Figure 5 OR for incidence of preterm rate in women with PCOS and controls. 01 Preterm rate all studies included. 02 borderline eligible studies excluded.
Figure 5 OR for incidence of preterm rate in women with PCOS and controls. 01 Preterm rate all studies included. 02 borderline eligible studies excluded.CC BY · PubMed Central
Figure 6 WMD for birth weight in women with PCOS and controls. 01 Incidence of birth weight all studies included. 02 borderline eligible studies excluded.
Figure 6 WMD for birth weight in women with PCOS and controls. 01 Incidence of birth weight all studies included. 02 borderline eligible studies excluded.CC BY · PubMed Central
Figure 7 OR for incidence of caesarean section in women with PCOS and controls. 01 Incidence of caesarean section all studies included. 02 borderline eligible studies excluded.
Figure 7 OR for incidence of caesarean section in women with PCOS and controls. 01 Incidence of caesarean section all studies included. 02 borderline eligible studies excluded.CC BY · PubMed Central
Figure 8 OR for incidence of admission to an NICU in women with PCOS and controls.
Figure 8 OR for incidence of admission to an NICU in women with PCOS and controls.CC BY · PubMed Central

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Citations

Cites

Research works printed but not linked: 2

  1. Zawadzki JK, Dunaif A: Diagnostic criteria for polycystic ovary syndrome: towards a rational approach. Boston. 1992, 77-84.
  2. Cardenas M, Coulson CC, Legro RS: Abstract: American Society for Reproductive Medicine. Infertile PCOS women do not have an increased risk for gestational diabetes or macrosomia. 1996, Scientific Oral and Poster Sessions Programme Supplement, 85-

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Metadata

Authors
Qin, J. Z., Pang, L. H., Li, M. J., Fan, X. J., Huang, R. D., & Chen, H. Y.
Affiliations
First Affiliated Hospital of GuangXi Medical University (CN)
Corresponding author
  • Pang, Li H
  • Li, Mu J
Venue
Reproductive Biology and Endocrinology
Publisher
Springer Science and Business Media LLC
Published
2013-06-26
Volume
11
Issue
1
Pages
56-56
ISSN
1477-7827 (ISSN-L)
DOI
10.1186/1477-7827-11-56
PMC
PMC3737012
OpenAlex
W2143450042
Cited by
317
References
49
Citations by year
2026: 13 · 2025: 19 · 2024: 41 · 2023: 27 · 2022: 38 · 2021: 27 · 2020: 27 · 2019: 25 · 2018: 27 · 2017: 18 · 2016: 9 · 2015: 28 · 2014: 17
FWCI
2.91
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Reproductive Biology and Endocrinology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Keywords
polycystic ovary syndrome, pregnancy complications, gestational diabetes mellitus, gestational hypertension, preeclampsia, preterm birth, cesarean section, birth weight, neonatal intensive care admission, adverse pregnancy outcomes
MeSH terms
Female, Humans, Infant, Newborn, Polycystic Ovary Syndrome, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Risk Factors, Diabetes, Gestational, Risk Assessment, Hypertension, Pregnancy-Induced, Premature Birth

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