Tumor interactions with soluble factors and the nervous system
Open accessAbstract
In the genomic era of cancer research, the development of metastases has been attributed to mutations in the tumor that enable the cells to migrate. However, gene analyses revealed that primary tumors and metastases were in some cases genetically identical and the question was raised whether metastasis formation might be an inherent feature of certain tumor cells. In contradiction to this view, the last decade of cancer research has brought to light, that tumor cell migration, similar to leukocyte and fibroblast migration, is a highly regulated process. The nervous system plays an important role in this regulation, at least in two respects: firstly, neurotransmitters are known to regulate the migratory activity of tumor cells, and secondly, nerve fibers are used as routes for perineural invasion. We also summarize here the current knowledge on the innervation of tumors. Such a process might establish a neuro-neoplastic synapse, with the close interaction of tumor cells and nerve cells supporting metastasis formation.
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Stress promotes the development of cancer.
“Measures to reduce stress appear to be extremely important, as many studies have shown that stress promotes the development of cancer [62,63,64,65,66].”
From The Effect of Vinyasa Yoga Practice on the Well-Being of Breast-Cancer Patients during COVID-19 Pandemic (2023) · cites this paper as [66]
The Catecholamines section (page not provided) says chronic stress has been implicated in tumor progression and that epidemiological and animal studies support this view. That supports a link with progression, but the cited paper does not establish the broader, unqualified claim that stress promotes the development of cancer. (LLM, conf=0.84)
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- Authors
- Voss, M. J., & Entschladen, F.
- Affiliations
- Witten/Herdecke University (DE)
- Corresponding author
- Entschladen, Frank
- Venue
- Cell Communication and Signaling
- Published
- 2010-09-07
- Volume
- 8
- Issue
- 1
- Pages
- 21-21
- ISSN
- 1478-811X (ISSN-L)
- PMC
- PMC2942890
- OpenAlex
- W2144573847
- Cited by
- 25
- References
- 78
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 1 · 2020: 1 · 2019: 1 · 2018: 3 · 2016: 3 · 2015: 4 · 2013: 5 · 2012: 1
- FWCI
- 1.75
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Communication and Signaling (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Fritz-Bender-Stiftung
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Keywords
- tumor cell migration, metastasis, neurotransmitters, nervous system, perineural invasion, tumor innervation, soluble factors
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