The DOI matches its Crossref record; 116 of the 116 references it cites were found in a registry or an index.
Identification and manipulation of tumor associated macrophages in human cancers
Open accessAbstract
Evading immune destruction and tumor promoting inflammation are important hallmarks in the development of cancer. Macrophages are present in most human tumors and are often associated with bad prognosis. Tumor associated macrophages come in many functional flavors ranging from what is known as classically activated macrophages (M1) associated with acute inflammation and T-cell immunity to immune suppressive macrophages (M2) associated with the promotion of tumor growth. The role of these functionally different myeloid cells is extensively studied in mice tumor models but dissimilarities in markers and receptors make the direct translation to human cancer difficult. This review focuses on recent reports discriminating the type of infiltrating macrophages in human tumors and the environmental cues present that steer their differentiation. Finally, immunotherapeutic approaches to interfere in this process are discussed.
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Cites
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Cited by
Lin, Y., Xu, J., & Lan, H. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0760-3 · Cited by 1,398
Macrophage Regulation of Tumor Responses to Anticancer Therapies
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Romano, E., Kusio-Kobialka, M., Foukas, P. G., Baumgaertner, P., Meyer, C., Ballabeni, P., Michielin, O., Weide, B., Romero, P., & Speiser, D. E. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1417320112 · Cited by 601
Tumor-Associated Macrophages: Implications in Cancer Immunotherapy
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Self-citation
Metadata
- Authors
- Heusinkveld, M., & van der Burg, S. H.
- Venue
- Journal of Translational Medicine
- Published
- 2011-12
- Volume
- 9
- Issue
- 1
- Pages
- 216-216
- ISSN
- 1479-5876 (ISSN-L)
- OpenAlex
- W2101195992
- Cited by
- 435
- References
- 116
- FWCI
- 12.15
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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