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Cited by 37Muscle metabolism and nutritionSports Performance and TrainingBiochemical effects in animals

The effects of creatine pyruvate and creatine citrate on performance during high intensity exercise

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Jäger, Ralf, Metzger, Jan, Lautmann, Karin, Shushakov, Vladimir, Purpura, Martin, Geiss, Kurt-Reiner, Maassen, Norbert·2008·Journal of the International Society of Sports Nutrition
DOI 10.1186/1550-2783-5-4PMC PMC2276184
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Abstract

BACKGROUND: A double-blind, placebo-controlled, randomized study was performed to evaluate the effect of oral creatine pyruvate (Cr-Pyr) and creatine citrate (Cr-Cit) supplementation on exercise performance in healthy young athletes. METHODS: Performance during intermittent handgrip exercise of maximal intensity was evaluated before (pretest) and after (posttest) 28 days of Cr-Pyr (5 g/d, n = 16), Cr-Cit (5 g/d, n = 16) or placebo (pla, 5 g/d, n = 17) intake. Subjects performed ten 15-sec exercise intervals, each followed by 45 sec rest periods. RESULTS: Cr-Pyr (p < 0.001) and Cr-Cit (p < 0.01) significantly increased mean power over all intervals. Cr-Cit increased force during the first and second interval (p < 0.01) compared to placebo. The effect of Cr-Cit on force decreased over time and the improvement was not significant at the sixth and ninth interval, whereas Cr-Pyr significantly increased force during all intervals (p < 0.001). Cr-Pyr (p < 0.001) and Cr-Cit (p < 0.01) resulted in an increase in contraction velocity, whereas only Cr-Pyr intake significantly (p < 0.01) increased relaxation velocity. Oxygen consumption measured during rest periods significantly increased with Cr-Pyr (p < 0.05), whereas Cr-Cit and placebo intake did not result in significant improvements. CONCLUSION: It is concluded that four weeks of Cr-Pyr and Cr-Cit intake significantly improves performance during intermittent handgrip exercise of maximal intensity and that Cr-Pyr might benefit endurance, due to enhanced activity of the aerobic metabolism.

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  • 4 weeks of supplementation with creatine salts significantly improved performance during intermittent handgrip exercise of maximal intensity, and CPY might benefit endurance due to enhanced aerobic metabolism.

    “It was concluded that 4 weeks of supplementation with creatine salts significantly improved performance during intermittent handgrip exercise of maximal intensity and that CPY might benefit endurance, due to enhanced aerobic metabolism.”

    From Analysis of the efficacy, safety, and regulatory status of novel forms of creatine (2011) · cites this paper as Jäger et al. 2008b

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Authors
Jäger, R., Metzger, J., Lautmann, K., Shushakov, V., Purpura, M., Geiss, K.-R., & Maassen, N.
Affiliations
  • Increnovo LLC (United States) (US)
  • Medizinische Hochschule Hannover (DE)
  • Institut Stadt I Mobilität I Energie (Germany) (DE)
Corresponding author
Jäger, Ralf
ORCID
Venue
Journal of the International Society of Sports Nutrition
Publisher
Informa UK Limited
Published
2008-01-03
Volume
5
Issue
1
Pages
4-4
ISSN
1550-2783 (ISSN-L)
DOI
10.1186/1550-2783-5-4
PMC
PMC2276184
OpenAlex
W2091806194
Cited by
37
References
6
Citations by year
2025: 3 · 2024: 1 · 2023: 2 · 2022: 6 · 2021: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 5
FWCI
1.22
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of the International Society of Sports Nutrition (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
University of Oklahoma
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
  • Health Sciences › Medicine › Physiology › Biochemical effects in animals
Keywords
creatine supplementation, high-intensity exercise, exercise performance, muscle force, contraction velocity, relaxation velocity, oxygen consumption, endurance

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