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A comparative review of cell culture systems for the study of microglial biology in Alzheimer’s disease
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Over the past two decades, it has become increasingly apparent that Alzheimer’s disease neuropathology is characterized by activated microglia (brain resident macrophages) as well as the classic features of amyloid plaques and neurofibrillary tangles. The intricacy of microglial biology has also become apparent, leading to a heightened research interest in this particular cell type. Over the years a number of different microglial cell culturing techniques have been developed to study either primary mammalian microglia, or immortalized cell lines. Each microglial system has advantages and disadvantages and should be selected for its appropriateness in a particular research context. This review summarizes several of the most common microglial cell culture systems currently being employed in Alzheimer’s research including primary microglia; BV2 and N9 retroviral immortalized microglia; human immortalized microglia (HMO6); and spontaneously immortalized rodent microglial lines (EOC lines and HAPI cells). Particularities of cell culture requirements and characteristics of microglial behavior, especially in response to applied inflammogen stimuli, are compared and discussed across these cell types.
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“However, several reports have indicated that differences between immortalized cell lines and primary murine microglia are not insignificant [83,84].”
From Lipoprotein Lipase Regulates Microglial Lipid Droplet Accumulation (2021) · cites this paper as [84]
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Cites
Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence
Bignami, A., Eng, L. F., Dahl, D. R., & Uyeda, C. T. (1972) · Brain Research · doi:10.1016/0006-8993(72)90398-8 · Cited by 1,456
Microglial Dysfunction and Defective β-Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice
Hickman, S. E., Allison, E. K., & El Khoury, J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0616-08.2008 · Cited by 1,329
Characterization of ameboid microglia isolated from developing mammalian brain
Giulian, D., & Baker, T. J. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-08-02163.1986 · Cited by 1,300
Immortalization of murine microglial cells by a v-raf / v-myc carrying retrovirus
Blasi, E., Barluzzi, R., Bocchini, V., Mazzolla, R., & Bistoni, F. (1990) · Journal of Neuroimmunology · doi:10.1016/0165-5728(90)90073-v · Cited by 1,076
Cytology & cellular pathology of the nervous system
Penfield, W. G. (1965) · Medical Entomology and Zoology · Cited by 1,035
Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death
Boje, K. M., & Arora, P. K. (1992) · Brain Research · doi:10.1016/0006-8993(92)91004-x · Cited by 944
Production of superoxide anions by a CNS macrophage, the microglia
Colton, C. A., & Gilbert, D. L. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)80305-8 · Cited by 614
Li, Y., Liu, L., Barger, S. W., & Griffin, W. S. T. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-05-01605.2003 · Cited by 563
Koenigsknecht-Talboo, J., & Landreth, G. E. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1808-05.2005 · Cited by 477
Research works printed but not linked: 1
- Castero J: Estudie del compotemento de la microglia cultivade on vetro. Datos concernientes a su histogenesis. Mem R Soc Cep Hist Nat 1930, 14:125–182.
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Khan, A. S., & Langmann, T. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01999-8 · Cited by 44
Kumar, A., Giri, S., & Kumar, A. (2016) · Cellular Microbiology · doi:10.1111/cmi.12625 · Cited by 44
Toledo, E. G., Tapia-Arellano, A., Célis, F., Sinai, T., Campos, M., Kogan, M. J., & Sintov, A. C. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119957 · Cited by 44
Ooi, Y. Y., Dheen, S. T., & Tay, S. S. W. (2014) · NeuroImmunoModulation · doi:10.1159/000365483 · Cited by 43
Hydroxytyrosol Decreases LPS- and α-Synuclein-Induced Microglial Activation In Vitro
Gallardo-Fernández, M., Ortega, R. H., Alonso-Bellido, I. M., Rodríguez‐Gómez, J. A., Troncoso, A. M., García-Parrilla, M. C., Venero, J. L., Espinosa‐Oliva, A. M., & de Pablos, R. M. (2019) · Antioxidants · doi:10.3390/antiox9010036 · Cited by 47
Supriady, H., Kamarudin, M. N. A., Chan, C. K., Goh, B. H., & Kadir, H. A. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.05.042 · Cited by 43
Bhat, S. A., Henry, R. J., Blanchard, A. C., Stoica, B. A., Loane, D. J., & Faden, A. I. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.14954 · Cited by 42
Payne, A., Taka, E., Adinew, G. M., & Soliman, K. F. A. (2023) · Brain Sciences · doi:10.3390/brainsci13040632 · Cited by 40
Neibert, K. D., Gosein, V., Sharma, A., Khan, M., Whitehead, M. A., Maysinger, D., & Kakkar, A. K. (2013) · Molecular Pharmaceutics · doi:10.1021/mp4000508 · Cited by 40
Suresh, S. N., Pandurangi, J., Murumalla, R. K., Vidyadhara, D. J., Garimella, L., Acharya, A., Rai, S., Paul, A., Yarreiphang, H., Pillai, M. S., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.10.036 · Cited by 40
Han, K., Sun, C., Jia, N., Li, R., Zhang, Z., & Zhong, Y. (2020) · Folia Neuropathologica · doi:10.5114/fn.2020.94002 · Cited by 40
Cocaine-mediated downregulation of microglial miR-124 expression involves promoter DNA methylation.
Guo, M.-L., Periyasamy, P., Liao, K., Kook, Y. H., Niu, F., Callen, S. E., & Buch, S. (2016) · Epigenetics · doi:10.1080/15592294.2016.1232233 · Cited by 41
In vitro models of microglia: a comparative study
Woolf, Z., Stevenson, T. J., Lee, K., Highet, B., Foliaki, J. M., Ratiu, R., Rustenhoven, J., Correia, J. A., Schweder, P. M., Heppner, P. A., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-99867-z · Cited by 40
Moniruzzaman, M., Bose, S., Kim, Y., Chin, Y., & Cho, J. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.01.023 · Cited by 39
Raha, S., Lee, H. J., Yumnam, S., Hong, G. E., Saralamma, V. V. G., Ha, Y. L., Kim, J. O., Kim, Y. S., Heo, J., Lee, S. J., et al. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.07.017 · Cited by 39
Orvedahl, A., McAllaster, M. R., Sansone, A., Dunlap, B. F., Desai, C., Wang, Y., Balce, D. R., Luke, C. J., Lee, S., Orchard, R. C., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1822157116 · Cited by 40
Yang, T., Zang, S., Wang, Y., Zhu, Y., Jiang, L., Chen, X., Zhang, X., Cheng, J., Gao, R., Xiao, H., et al. (2020) · Toxicology Letters · doi:10.1016/j.toxlet.2020.07.028 · Cited by 39
Fisetin Inhibits NLRP3 Inflammasome by Suppressing TLR4/MD2-Mediated Mitochondrial ROS Production
Molagoda, I. M. N., Athapaththu, A. M. G. K., Choi, Y. H., Park, C., Jin, C.-Y., Kang, C., Lee, M., & Kim, G. (2021) · Antioxidants · doi:10.3390/antiox10081215 · Cited by 39
Acute ACAT1/SOAT1 Blockade Increases MAM Cholesterol and Strengthens ER-Mitochondria Connectivity
Harned, T. C., Stan, R. V., Cao, Z., Chakrabarti, R., Higgs, H. N., Chang, C. C. Y., & Chang, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065525 · Cited by 41
Kim, S. M., McIlwraith, E. K., Chalmers, J. A., & Belsham, D. D. (2018) · Neuroendocrinology · doi:10.1159/000494759 · Cited by 37
Han, D., Moon, S., Kim, Y., Kim, J., Jin, J., & Kim, Y. (2013) · PROTEOMICS · doi:10.1002/pmic.201300091 · Cited by 37
Liu, F., Zhou, R., Yan, H., Yin, H., Wu, X., Tan, Y., & Li, L. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.09.034 · Cited by 37
Zhao, L., Li, J., Fu, Y., Zhang, M., Wang, B., Ouellette, J. N., Shahi, P. K., Pattnaik, B. R., Watters, J. J., Wong, W. T., et al. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0775-4 · Cited by 36
Dave, K. M., Ali, L., & Manickam, D. S. (2020) · PLoS ONE · doi:10.1371/journal.pone.0231597 · Cited by 37
Nurr1 performs its anti-inflammatory function by regulating RasGRP1 expression in neuro-inflammation
Oh, M., Kim, S., Gil, J.-E., Byun, J.-S., Cha, D.-W., Ku, B., Lee, W., Kim, W. K., Oh, K., Lee, E., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-67549-7 · Cited by 36
Avallone, R., Lucchi, C., Puja, G., Codeluppi, A., Filaferro, M., Vitale, G., Rustichelli, C., & Biagini, G. (2020) · Cells · doi:10.3390/cells9092091 · Cited by 36
Regulated Necrosis Orchestrates Microglial Cell Death in Manganese-Induced Toxicity
Alcon, S. P., Gorojod, R. M., & Kotler, M. L. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.10.006 · Cited by 35
A Novel Interaction of Translocator Protein 18 kDa (TSPO) with NADPH Oxidase in Microglia
Loth, M. K., Guariglia, S. R., Ré, D. B., Perez, J., de Paiva, V. N., McGlothan, J. L., Chambers, J. W., Azzam, D. J., & Guilarte, T. R. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02042-w · Cited by 35
Singh, V., Gera, R., Kushwaha, R., Sharma, A. K., Patnaik, S., & Ghosh, D. (2016) · Scientific Reports · doi:10.1038/srep30601 · Cited by 35
Wang, T., Yin, Y., Jiang, X., Ruan, Y., Xu, J., Hu, X., Li, T., Chu, L., & Li, L. (2023) · Scientific Reports · doi:10.1038/s41598-023-41101-9 · Cited by 34
Artificial intelligence for neurodegenerative experimental models
Marzi, S. J., Schilder, B. M., Nott, A., Frigerio, C. S., Willaime‐Morawek, S., Bucholc, M., Hanger, D. P., James, C. R., Lewis, P. A., Lourida, I., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13479 · Cited by 35
Li, W., Meng, X., Peng, K., Han, Y., Liu, H., Zhao, W., Wang, G., Deng, L., Liu, H., Li, Z., et al. (2023) · Advanced Science · doi:10.1002/advs.202305989 · Cited by 36
Goode, A. E., Carter, D. A. G., Motskin, M., Pienaar, I. S., Chen, S., Hu, S., Ruenraroengsak, P., Ryan, M. P., Shaffer, M. S. P., Dexter, D. T., et al. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.08.019 · Cited by 34
Song, X., Hu, J., Sun, M.-N., Li, Z., Zhu, Z., Song, L.-K., Yuan, Y., Liu, G., & Chen, N. (2014) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2014.05.002 · Cited by 34
Nutraceutical and therapeutic potential of Phycocyanobilin for treating Alzheimer’s disease
Piniella‐Matamoros, B., Marín‐Prida, J., & Pentón‐Rol, G. (2021) · Journal of Biosciences · doi:10.1007/s12038-021-00161-7 · Cited by 34
Phoenixin-20 Ameliorates Lipopolysaccharide-Induced Activation of Microglial NLRP3 Inflammasome
Zeng, X., Li, Y., Ma, S., Tang, Y., & Li, H. (2020) · Neurotoxicity Research · doi:10.1007/s12640-020-00225-w · Cited by 33
Nguyen, P. L., Bui, B. P., Duong, M. T. H., Lee, K., Ahn, H., & Cho, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22169061 · Cited by 33
Lu, Y., Liu, M., Guo, X., Wang, P., Zeng, F., Wang, H., Tang, J. Y., Qin, Z., & Tao, T. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14099 · Cited by 33
Iannucci, J., Rao, H. V., & Grammas, P. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-00987-z · Cited by 33
Olcum, M., Tüfekçi, K. U., Durur, D. Y., Tastan, B., atay, I. N. G., Genç, K., & Genç, Ş. (2021) · Antioxidants · doi:10.3390/antiox10050745 · Cited by 31
Pulukool, S. K., Bhagavatham, S. K. S., Kannan, V., Sukumar, P., Dandamudi, R. B., Ghaisas, S., Kunchala, H., Saieesh, D., Naik, A. A., Pargaonkar, A., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-89137-z · Cited by 31
Yang, C., Sui, G., Wang, L., Chen, Z., & Wang, F. (2021) · Journal of Molecular Neuroscience · doi:10.1007/s12031-021-01921-8 · Cited by 32
Sepulveda-Diaz, J. E., Ouidja, M. O., Socías, S. B., Hamadat, S., Guerreiro, S., Raisman‐Vozari, R., & Michel, P. P. (2016) · Glia · doi:10.1002/glia.23032 · Cited by 31
Myricetin suppresses traumatic brain injury-induced inflammatory response via EGFR/AKT/STAT pathway
Wang, C., Ouyang, S., Zhu, X., Jiang, Y., Lu, Z., & Gong, P. (2023) · Scientific Reports · doi:10.1038/s41598-023-50144-x · Cited by 30
Kosar, M., Sykes, D. A., Viray, A. E. G., Vitale, R. M., Sarott, R. C., Ganzoni, R. L. Z., Onion, D., Tobias, J. M., Leippe, P., Ullmer, C., et al. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.2c13629 · Cited by 31
Xiao, Q., Yu, W., Tian, Q., Fu, X. L., Wang, X., Gu, M., & Lü, Y. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.04.050 · Cited by 30
Chrysanthou, M., Estruch, I. M., Rietjens, I. M. C. M., Wichers, H. J., & Hoppenbrouwers, T. (2022) · Nutrients · doi:10.3390/nu14020363 · Cited by 31
Lamie, P. F., Abdel‐Fattah, M. M., & Philoppes, J. N. (2022) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2022.2126464 · Cited by 29
Bi, Y., Li, M., Wang, Y., Yao, J., Wang, Y., Wang, S., Zhuang, L., Liu, S., Li, Z., Hao, Z., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156240 · Cited by 28
Lim, J. S., Oh, J., Yun, H. S., Lee, J. S., Hahn, D., & Kim, J. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114633 · Cited by 28
Advanced patient-specific microglia cell models for pre-clinical studies in Alzheimer’s disease
Cuní‐López, C., Stewart, R., Oikari, L. E., Nguyen, T. H., Roberts, T. L., Sun, Y., Guo, C. C., Lupton, M. K., White, A. R., & Quek, H. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03037-3 · Cited by 28
Reflectin as a Material for Neural Stem Cell Growth
Phan, L., Kautz, R., Arulmoli, J., Kim, I. H., Le, D. T. T., Shenk, M. A., Pathak, M. M., Flanagan, L. A., Tombola, F., & Gorodetsky, A. A. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b08717 · Cited by 28
Quarta, A., Blon, D. L., D’aes, T., Pieters, Z., Taj, S. H., Miró‐Mur, F., Luyckx, E., Breedam, E. V., Daans, J., Goossens, H., et al. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.09.009 · Cited by 29
Intracellular Alpha-Synuclein and Immune Cell Function
Grozdanov, V., & Danzer, K. M. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.562692 · Cited by 27
Transcriptional response of murine microglia in Alzheimer’s disease and inflammation
Shippy, D. C., Watters, J. J., & Ulland, T. K. (2022) · BMC Genomics · doi:10.1186/s12864-022-08417-8 · Cited by 27
Regulation of microglial migration, phagocytosis, and neurite outgrowth by HO‐1/CO signaling
Scheiblich, H., & Bicker, G. (2014) · Developmental Neurobiology · doi:10.1002/dneu.22253 · Cited by 27
Polymeric nanoparticles for efficient nose-to-brain delivery
Bolon, M., Fieux, M., Monge, C., & Richard, S. (2025) · Nanoscale · doi:10.1039/d5nr00870k · Cited by 26
Wu, T., Li, Y., Xue, L., Liu, X., & Tang, M. X. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.111672 · Cited by 26
Mizuno, T. M., Lew, P. S., & Jhanji, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312668 · Cited by 27
VanderZwaag, J., Halvorson, T., Dolhan, K., Šimončičová, E., Ben‐Azu, B., & Tremblay, M. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03772-0 · Cited by 28
Thrombin Inhibition Reduces the Expression of Brain Inflammation Markers upon Systemic LPS Treatment
Stein, E. S., Shimon, M. B., Artan-Furman, A., Golderman, V., Chapman, J., & Maggio, N. (2018) · Neural Plasticity · doi:10.1155/2018/7692182 · Cited by 26
Zhang, C., Sajith, A. M., Xu, X., Jiang, J., Bowen, J. P., Kulkarni, A. A., & Hao, J. (2022) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2022.116645 · Cited by 25
Kosar, M., Sarott, R. C., Sykes, D. A., Viray, A. E. G., Vitale, R. M., Tomašević, N., Li, X., Ganzoni, R. L. Z., Kicin, B., Reichert, L., et al. (2024) · ACS Central Science · doi:10.1021/acscentsci.3c01461 · Cited by 25
Scheiblich, H., Roloff, F., Singh, V., Stangel, M., Stern, M. K., & Bicker, G. (2014) · Brain Research · doi:10.1016/j.brainres.2014.03.048 · Cited by 25
Kong, C., Jia, L., & Jia, J. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.174744 · Cited by 24
Kim, D., Quang, T. H., Tiên, N. T., Kim, K.-W., Kim, Y., Ngân, N. T. T., Cường, N. X., Nam, N. H., & Oh, H. (2022) · Archives of Pharmacal Research · doi:10.1007/s12272-022-01370-w · Cited by 24
Bacteria reduce flagellin synthesis to evade microglia-astrocyte-driven immunity in the brain
Sun, H., Wan, X., Fan, Y., Liu, P., Song, Y., Zhu, N., Duan, Z., Wang, Q., Chen, F., Zhou, C., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111033 · Cited by 24
Jin, L., Lucente, J. D., Mendiola, U. R., Tang, X., Zivkovic, A. M., Lebrilla, C. B., & Maezawa, I. (2023) · Glia · doi:10.1002/glia.24345 · Cited by 24
Neiva, I., Malva, J. O., & Valero, J. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00202 · Cited by 24
Dezfulian, M. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.04.012 · Cited by 24
Microglia Reactivity: Heterogeneous Pathological Phenotypes
Hirbec, H., Rassendren, F., & Audinat, É. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9658-2_4 · Cited by 24
Direct analysis of in vitro grown microorganisms and mammalian cells by ambient mass spectrometry
Chingin, K., Liang, J., & Chen, H. (2013) · RSC Advances · doi:10.1039/c3ra46327c · Cited by 23
Kim, K.-W., Kim, H. J., Sohn, J. H., Yim, J. H., Kim, Y., & Oh, H. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.11.010 · Cited by 23
Benito, A., Hajji, N., O’Neill, K., Keun, H. C., & Syed, N. (2020) · Metabolites · doi:10.3390/metabo10090346 · Cited by 23
Microglia isolation from aging mice for cell culture: A beginner’s guide
Vijaya, A. K., Iešmantaitė, M., Mela, V., Baltriukienė, D., & Burokas, A. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1082180 · Cited by 23
Hambali, A., Jusril, N. A., Hashim, N. F. M., Manan, N. A., Adam, S. K., Mehat, M. Z., Adenan, M. I., Stanslas, J., & Hamid, H. A. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-230875 · Cited by 23
Primary microglia cell cultures in translational research: Strengths and limitations
Pesti, I., Légrádi, Á., & Farkas, E. (2024) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2024.03.005 · Cited by 23
Kim, D. J., & Kim, Y. S. (2015) · Mediators of Inflammation · doi:10.1155/2015/729509 · Cited by 22
Finan, G. M., Realubit, R. B., Chung, S., Lütjohann, D., Wang, N., Cirrito, J. R., Karan, C., & Kim, T. (2016) · Cell chemical biology · doi:10.1016/j.chembiol.2016.10.015 · Cited by 22
Khalil, M., Bazzi, A., Zeineddine, D., Jomaa, W., Daher, A., & Awada, R. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113748 · Cited by 22
Ge, X., Wang, Y., Yu, S., Cao, X., Chen, Y., Cheng, Q., & Ding, F. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.716177 · Cited by 22
Pozzobon, M., D’Agostino, S., Roubelakis, M. G., Cargnoni, A., Gramignoli, R., Wolbank, S., Gindraux, F., Bollini, S., Kerdjoudj, H., Fénelon, M., et al. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.961987 · Cited by 22
Basha, S. C., Ramaiah, M. J., & Rao, K. S. J. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221070 · Cited by 23
Ugbaja, S. C., Lawal, I. A., Kumalo, H. M., & Lawal, M. M. (2021) · Current Drug Targets · doi:10.2174/1389450122666210809100050 · Cited by 22
Mangino, G., Famiglietti, M., Capone, C., Veroni, C., Percario, Z. A., Leone, S., Fiorucci, G., Lülf, S., Romeo, G., Agresti, C., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130189 · Cited by 22
Magnetofection is superior to other chemical transfection methods in a microglial cell line
Smolders, S., Kessels, S., Smolders, S., Poulhès, F., Zelphati, O., Sapet, C., & Brône, B. (2017) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2017.09.017 · Cited by 21
Strategies and Tools for Studying Microglial-Mediated Synapse Elimination and Refinement
Morini, R., Bizzotto, M., Perrucci, F., Filipello, F., & Matteoli, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.640937 · Cited by 22
Kwon, J., Arsenis, C., Suessmilch, M., McColl, A., Cavanagh, J., & MORRIS, B. J. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01127-x · Cited by 20
Age and sex differences in primary microglia culture: A comparative study
Ngwa, C., Qi, S., Mamun, A. A., Xu, Y., Sharmeen, R., & Liu, F. (2021) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2021.109359 · Cited by 22
Lin, L., Zheng, S., Lai, J., Ye, D., Huang, Q., Wu, Z., Chen, X., & Wang, S. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03419-3 · Cited by 20
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Metadata
- Authors
- Stansley, B., Post, J., & Hensley, K.
- Affiliations
- University of Toledo Medical Center (US)
- Corresponding author
- Hensley, Kenneth
- ORCID
- Stansley, Branden
- Venue
- Journal of Neuroinflammation
- Published
- 2012-05-31
- Volume
- 9
- Issue
- 1
- Pages
- 115-115
- ISSN
- 1742-2094 (ISSN-L)
- PMC
- PMC3407712
- OpenAlex
- W2164594351
- Cited by
- 419
- References
- 40
- Citations by year
- 2026: 29 · 2025: 27 · 2024: 27 · 2023: 32 · 2022: 49 · 2021: 46 · 2020: 42 · 2019: 30 · 2018: 25 · 2017: 32 · 2016: 29 · 2015: 16 · 2014: 21 · 2013: 12 · 2012: 2
- FWCI
- 8.22
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Neuroinflammation (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Institutes of Health (5r21ns066279-03)
- National Institute on Aging (R01AG031553)
- National Institute on Drug Abuse (DA7606, R01DA007606)
- National Institute of Neurological Disorders and Stroke (R21-NS066279)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- microglia, Alzheimer's disease, primary microglia, BV-2 cells, N9 cells, microglial activation, neuroinflammation, amyloid plaques, neurofibrillary tangles
- MeSH terms
- Alzheimer Disease, Animals, Cell Line, Transformed, Cells, Cultured, Humans, Microglia, Cell Culture Techniques
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