Palmitate Induces an Anti-Inflammatory Response in Immortalized Microglial BV-2 and IMG Cell Lines that Decreases TNFα Levels in mHypoE-46 Hypothalamic Neurons in Co-Culture

On the Dependency of Cellular Protein Levels on mRNA Abundance

Liu, Y., Beyer, A., & Aebersold, R. (2016) · Cell · doi:10.1016/j.cell.2016.03.014 · Cited by 3,221 · see citing works

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

Tang, Y., & Le, W. (2016) · Molecular Neurobiology · doi:10.1007/s12035-014-9070-5 · Cited by 2,190 · see citing works

Microglial <scp>M1/M2</scp> polarization and metabolic states

Orihuela, R., McPherson, C. A., & Harry, G. J. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13139 · Cited by 2,070 · see citing works

Obesity is associated with hypothalamic injury in rodents and humans.

Thaler, J. P., Yi, C.-X., Schur, E. A., Guyenet, S. J., Hwang, B. H., Dietrich, M. O., Zhao, X., Sarruf, D. A., Izgur, V., Maravilla, K. R., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59660 · Cited by 1,857 · see citing works

Control of Synaptic Strength by Glial TNFα

Beattie, E. C., Stellwagen, D., Morishita, W., Bresnahan, J. C., Ha, B. K., Von Zastrow, M., Beattie, M. S., & Malenka, R. C. (2002) · Science · doi:10.1126/science.1067859 · Cited by 1,344 · see citing works

Consumption of a Fat-Rich Diet Activates a Proinflammatory Response and Induces Insulin Resistance in the Hypothalamus

De Souza, C. T., Araujo, E. P., Bordin, S., Ashimine, R., Zollner, R. L., Boschero, A. C., Saad, M. J. A., & Velloso, L. A. (2005) · Endocrinology · doi:10.1210/en.2004-1520 · Cited by 1,171 · see citing works

Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity

Milanski, M., Degasperi, G., Coope, A., Morari, J., Denis, R., Cintra, D. E., Tsukumo, D. M. L., Anhe, G., Amaral, M. E., Takahashi, H. K., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.2760-08.2009 · Cited by 1,125 · see citing works

Immortalization of murine microglial cells by a v-raf / v-myc carrying retrovirus

Blasi, E., Barluzzi, R., Bocchini, V., Mazzolla, R., & Bistoni, F. (1990) · Journal of Neuroimmunology · doi:10.1016/0165-5728(90)90073-v · Cited by 1,053 · see citing works

Microglial Activation and its Implications in the Brain Diseases

Dheen, S. T., Kaur, C., & Ling, E. (2007) · Current Medicinal Chemistry · doi:10.2174/092986707780597961 · Cited by 954 · see citing works

Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain

Colton, C. A. (2009) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-009-9164-4 · Cited by 871 · see citing works

Obesity and neuroinflammation: A pathway to cognitive impairment

Miller, A. A., & Spencer, S. J. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.04.001 · Cited by 788 · see citing works

The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation.

Henn, A. (2009) · ALTEX · doi:10.14573/altex.2009.2.83 · Cited by 660 · see citing works

Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function.

Valdearcos, M., Robblee, M. M., Benjamin, D. I., Nomura, D. K., Xu, A. W., & Koliwad, S. K. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.11.018 · Cited by 629 · see citing works

Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways

Huang, S., Rutkowsky, J. M., Snodgrass, R. G., Ono‐Moore, K. D., Schneider, D. A., Newman, J. W. I., Adams, S. H., & Hwang, D. H. (2012) · Journal of Lipid Research · doi:10.1194/jlr.d029546 · Cited by 591 · see citing works

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

Posey, K. A., Clegg, D. J., Printz, R. L., Byun, J., Morton, G. J., Vivekanandan-Giri, A., Pennathur, S., Baskin, D. G., Heinecke, J. W., Woods, S. C., et al. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90377.2008 · Cited by 586 · see citing works

High-Fat Diet Induces Apoptosis of Hypothalamic Neurons

Moraes, J. C., Coope, A., Morari, J., Cintra, D. E., Roman, E. A., Pauli, J. R., Romanatto, T., Carvalheira, J. B. C., de Oliveira, A. L. R., Saad, M. J. A., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005045 · Cited by 427 · see citing works

A comparative review of cell culture systems for the study of microglial biology in Alzheimer’s disease

Stansley, B., Post, J., & Hensley, K. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-115 · Cited by 419 · see citing works

Tumor Necrosis Factor-α Mediates One Component of Competitive, Experience-Dependent Plasticity in Developing Visual Cortex

Kaneko, M., Stellwagen, D., Malenka, R. C., & Stryker, M. P. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.023 · Cited by 405 · see citing works

Role of microglia in CNS inflammation

Graeber, M. B., Li, W., & Rodriguez, M. L. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.08.033 · Cited by 392 · see citing works

Comprehensive Profiling of Plasma Fatty Acid Concentrations in Young Healthy Canadian Adults

Abdelmagid, S. A., Clarke, S. E., Nielsen, D. E., Badawi, A. F., El‐Sohemy, A., Mutch, D. M., & David, W. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0116195 · Cited by 363 · see citing works

Hypothalamic nutrient sensing in the control of energy homeostasis

Blouet, C., & Schwartz, G. J. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.12.024 · Cited by 321 · see citing works

The role of TNF and its receptors in Alzheimer's disease

Perry, R. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00291-3 · Cited by 298 · see citing works

MCP‐1 (CCL2) protects human neurons and astrocytes from NMDA or HIV‐tat‐induced apoptosis

Eugenin, E. A., D’Aversa, T. G., Lopez, L., Calderon, T. M., & Berman, J. W. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01775.x · Cited by 288 · see citing works

Saturated Fatty Acids Do Not Directly Stimulate Toll-Like Receptor Signaling

Erridge, C., & Samani, N. J. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.194050 · Cited by 258 · see citing works

Western Diet Modulates Insulin Signaling, c-Jun N-Terminal Kinase Activity, and Insulin Receptor Substrate-1ser307 Phosphorylation in a Tissue-Specific Fashion

Prada, P. O., Zecchin, H. G., Gasparetti, A. L., Torsoni, M. A., Ueno, M., Hirata, A. E., do Amaral, M. E. C., Höehr, N. F., Boschero, A. C., & Saad, M. J. A. (2005) · Endocrinology · doi:10.1210/en.2004-0767 · Cited by 244 · see citing works

IL-4, IL-10 and IL-13 modulate Aβ(1–42)-induced cytokine and chemokine production in primary murine microglia and a human monocyte cell line

Szczepanik, A. M. (2001) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(00)00404-5 · Cited by 243 · see citing works

Inhibition of Hypothalamic Inflammation Reverses Diet-Induced Insulin Resistance in the Liver

Milanski, M., Arruda, A. P., Coope, A., Ignácio-Souza, L. M., Nuñez, C. E. C., Roman, E. A., Romanatto, T., Pascoal, L. B., Caricilli, A. M., Torsoni, M. A., et al. (2012) · Diabetes · doi:10.2337/db11-0390 · Cited by 228 · see citing works

Elevation of tumor necrosis factor in head injury

Goodman, J. C., Robertson, C. S., Grossman, R. G., & Narayan, R. K. (1990) · Journal of Neuroimmunology · doi:10.1016/0165-5728(90)90105-v · Cited by 224 · see citing works

High fat induces acute and chronic inflammation in the hypothalamus: effect of high-fat diet, palmitate and TNF-α on appetite-regulating NPY neurons

Dalvi, P. S., Chalmers, J. A., Luo, V., Han, D.-Y., Wellhauser, L., Liu, Y., Tran, D. Q., Castel, J., Luquet, S. H., Wheeler, M. B., et al. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.183 · Cited by 223 · see citing works

Generation of a Phenotypic Array of Hypothalamic Neuronal Cell Models to Study Complex Neuroendocrine Disorders

Belsham, D. D., Cai, F., Cui, H., Smukler, S. R., Salapatek, A. M., & Shkreta, L. (2003) · Endocrinology · doi:10.1210/en.2003-0946 · Cited by 214 · see citing works

Increased Brain Fatty Acid Uptake in Metabolic Syndrome

Karmi, A., Iozzo, P., Viljanen, A. P. M., Hirvonen, J., Fielding, B. A., Virtanen, K. A., Oikonen, V., Kemppainen, J., Viljanen, T., Guiducci, L., et al. (2010) · Diabetes · doi:10.2337/db09-0138 · Cited by 205 · see citing works

Low-Grade Hypothalamic Inflammation Leads to Defective Thermogenesis, Insulin Resistance, and Impaired Insulin Secretion

Arruda, A. P., Milanski, M., Coope, A., Torsoni, A. S., Ropelle, E. R., de Carvalho, D. P., Carvalheira, J. B. C., & Velloso, L. A. (2011) · Endocrinology · doi:10.1210/en.2010-0659 · Cited by 203 · see citing works

CNS Infiltration of Peripheral Immune Cells: D-Day for Neurodegenerative Disease?

Rezai-Zadeh, K. P., Gate, D., & Town, T. (2009) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-009-9166-2 · Cited by 194 · see citing works

Microglia are the major source of TNF-α and TGF-β1 in postnatal glial cultures; regulation by cytokines, lipopolysaccharide, and vitronectin

Welser-Alves, J. V., & Milner, R. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2013.04.007 · Cited by 169 · see citing works

Hypothalamic fatty acid metabolism: A housekeeping pathway that regulates food intake

López, M., Lelliott, C. J., & Vidal‐Puig, A. (2007) · BioEssays · doi:10.1002/bies.20539 · Cited by 144 · see citing works

Microglia expressing interleukin‐13 undergo cell death and contribute to neuronal survival in vivo

Shin, W. H., Lee, D., Park, K. W., Kim, S. U., Yang, M., Joe, E.-H., & Jin, B. K. (2004) · Glia · doi:10.1002/glia.10357 · Cited by 142 · see citing works

MAPK and NF-κB pathways are involved in bisphenol A-induced TNF-α and IL-6 production in BV2 microglial cells

Zhu, J., Jiang, L., Liu, Y., Qian, W., Liu, J., Zhou, J., Gao, R., Xiao, H., & Wang, J. (2015) · Inflammation · doi:10.1007/s10753-014-9971-5 · Cited by 122 · see citing works

Neuroprotective activity of chemokines against N-methyl-d-aspartate or β-amyloid-induced toxicity in culture

Bruno, V., Copani, A., Besong, G. E., Scoto, G. M., & Nicoletti, F. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00367-8 · Cited by 118 · see citing works

High glucose stimulates TNFα and MCP-1 expression in rat microglia via ROS and NF-κB pathways

Quan, Y., Jiang, C., Xue, B., Zhu, S., & Wang, X. (2011) · Acta Pharmacologica Sinica · doi:10.1038/aps.2010.174 · Cited by 114 · see citing works

Interleukin‐13 and ‐4 induce death of activated microglia

Yang, M., Park, E. J., Sohn, S., Kwon, H. J., Shin, W., Pyo, H., Jin, B.-K., Choi, K. S., Jou, I., & Joe, E.-H. (2002) · Glia · doi:10.1002/glia.10057 · Cited by 108 · see citing works

GLP-1 secretion by microglial cells and decreased CNS expression in obesity

Kappe, C., Tracy, L. M., Patrone, C., Iverfeldt, K., & Sjöholm, Å. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-276 · Cited by 107 · see citing works

Different Serum Free Fatty Acid Profiles in NAFLD Subjects and Healthy Controls after Oral Fat Load

Gambino, R., Bugianesi, E., Rosso, C., Mezzabotta, L., Pinach, S., Alemanno, N., Saba, F., & Cassader, M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17040479 · Cited by 101 · see citing works

Glia: silent partners in energy homeostasis and obesity pathogenesis

Douglass, J. D., Dorfman, M. D., & Thaler, J. P. (2016) · Diabetologia · doi:10.1007/s00125-016-4181-3 · Cited by 94 · see citing works

Central Insulin Signaling Is Attenuated by Long-Term Insulin Exposure via Insulin Receptor Substrate-1 Serine Phosphorylation, Proteasomal Degradation, and Lysosomal Insulin Receptor Degradation

Mayer, C., & Belsham, D. D. (2009) · Endocrinology · doi:10.1210/en.2009-0838 · Cited by 85 · see citing works

The effect of microglia on embryonic dopaminergic neuronal survival in vitro: diffusible signals from neurons and glia change microglia from neurotoxic to neuroprotective

Zietlow, R., Dunnett, S. B., & Fawcett, J. W. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00583.x · Cited by 82 · see citing works

IL-13 Production by Regulatory T Cells Protects against Experimental Autoimmune Encephalomyelitis Independently of Autoantigen

Ochoa‐Repáraz, J., Rynda, A., Ascón, M. A., Yang, X., Kochetkova, I., Riccardi, C., Callis, G. M., Trunkle, T., & Pascual, D. W. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.2.954 · Cited by 73 · see citing works

Characterization of a novel adult murine immortalized microglial cell line and its activation by amyloid-beta

McCarthy, R. C., Lu, D., Alkhateeb, A. A., Gardeck, A. M., Lee, C., & Wessling‐Resnick, M. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0484-z · Cited by 67 · see citing works

Potential role of IL-13 in neuroprotection and cortical excitability regulation in multiple sclerosis

Rossi, S., Mancino, R., Bergami, A., Mori, F., Castelli, M., Chiara, V. D., Studer, V., Mataluni, G., Sancesario, G. M., Parisi, V., et al. (2011) · Multiple Sclerosis Journal · doi:10.1177/1352458511410342 · Cited by 66 · see citing works

Differential effects of omega-3 fatty acid docosahexaenoic acid and palmitate on the circadian transcriptional profile of clock genes in immortalized hypothalamic neurons

Greco, J. A., Oosterman, J. E., & Belsham, D. D. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00100.2014 · Cited by 55 · see citing works

Diet-induced cellular neuroinflammation in the hypothalamus: Mechanistic insights from investigation of neurons and microglia

Tran, D. Q., Tse, E. K., Kim, M. H., & Belsham, D. D. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.05.015 · Cited by 54 · see citing works

The Saturated Fatty Acid Palmitate Induces Human Monocytic Cell Toxicity Toward Neuronal Cells: Exploring a Possible Link Between Obesity-Related Metabolic Impairments and Neuroinflammation

Little, J. P., Madeira, J. M., & Klegeris, A. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-111262 · Cited by 44 · see citing works

Leptin differentially regulates NPY secretion in hypothalamic cell lines through distinct intracellular signal transduction pathways

Dhillon, S. S., & Belsham, D. D. (2011) · Regulatory Peptides · doi:10.1016/j.regpep.2011.01.005 · Cited by 41 · see citing works

LPS-induced CCL2 expression and macrophage influx into the murine central nervous system is polyamine-dependent

Puntambekar, S. S., Davis, D. S., Hawel, L., Crane, J., Byus, C. V., & Carson, M. J. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.12.016 · Cited by 39 · see citing works

Induction of Gnrh mRNA expression by the ω-3 polyunsaturated fatty acid docosahexaenoic acid and the saturated fatty acid palmitate in a GnRH-synthesizing neuronal cell model, mHypoA-GnRH/GFP

Tran, D. Q., Ramos, E. H., & Belsham, D. D. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.02.019 · Cited by 39 · see citing works

Upregulation of Glutaredoxin-1 Activates Microglia and Promotes Neurodegeneration: Implications for Parkinson's Disease

Miller, O. G., Behring, J. B., Siedlak, S. L., Jiang, S., Matsui, R., Bachschmid, M. M., Zhu, X., & Mieyal, J. J. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6598 · Cited by 38 · see citing works

The role of cytokines in inflammatory conditions of the central nervous system

Selmaj, K. W. (1992) · Seminars in Neuroscience · doi:10.1016/1044-5765(92)90005-m · Cited by 36 · see citing works

Expression of MCP-1 in the Hippocampus of SHRSP with Ischemia-Related Delayed Neuronal Death

Sakurai‐Yamashita, Y., Shigematsu, K., Yamashita, K., & Niwa, M. (2006) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-006-9077-1 · Cited by 36 · see citing works

Beneficial Effects of Metformin and/or Salicylate on Palmitate- or TNFα-Induced Neuroinflammatory Marker and Neuropeptide Gene Regulation in Immortalized NPY/AgRP Neurons

Ye, W., Ramos, E. H., Wong, B. C., & Belsham, D. D. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166973 · Cited by 35 · see citing works

Hypothalamic inflammation and thermogenesis: the brown adipose tissue connection

Arruda, A. P., Milanski, M., & Velloso, L. A. (2011) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-011-9325-z · Cited by 24 · see citing works

Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain

Parker, A., Romano, S., Ansorge, R., Aboelnour, A., Le Gall, G., Savva, G. M., Pontifex, M. G., Telatin, A., Baker, D., Jones, E., et al. (2022) · Microbiome · doi:10.1186/s40168-022-01243-w · Cited by 368 · see citing works

A global perspective on the crosstalk between saturated fatty acids and Toll-like receptor 4 in the etiology of inflammation and insulin resistance

Ли, Б., Leung, J. C. K., Chan, L. Y. Y., Yiu, W. H., & Tang, S. C. W. (2019) · Progress in Lipid Research · doi:10.1016/j.plipres.2019.101020 · Cited by 146 · see citing works

Long Non-coding RNA TUG1 Sponges Mir-145a-5p to Regulate Microglial Polarization After Oxygen-Glucose Deprivation

Wang, H., Liao, S., Li, H., Chen, Y., & Yu, J. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00215 · Cited by 79 · see citing works

Transcriptomic characterization of microglia activation in a rat model of ischemic stroke

Deng, W., Mandeville, E. T., Terasaki, Y., Li, W., Holder, J. C., Chuang, A. T., Ning, M., Arai, K., Lo, E. H., & Xing, C. (2020) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x20932870 · Cited by 69 · see citing works

Chinese Medicine Formula Kai-Xin-San Ameliorates Neuronal Inflammation of CUMS-Induced Depression-like Mice and Reduces the Expressions of Inflammatory Factors via Inhibiting TLR4/IKK/NF-κB Pathways on BV2 Cells

Qu, S., Liu, M., Cao, C., Wei, C., Meng, X.-E., Lou, Q., Wang, B., Li, X., She, Y., Wang, Q., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.626949 · Cited by 63 · see citing works

Distinct metabolic patterns during microglial remodeling by oleate and palmitate

Chausse, B., Kakimoto, P. A., Caldeira-da-Silva, C. C., Chaves-Filho, A. B., Yoshinaga, M. Y., da Silva, R. P., Miyamoto, S., & Kowaltowski, A. J. (2019) · Bioscience Reports · doi:10.1042/bsr20190072 · Cited by 59 · see citing works

Appetite Regulation of TLR4-Induced Inflammatory Signaling

Li, Y., Jiang, Q., & Wang, L. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.777997 · Cited by 54 · see citing works

Direct and indirect effects of lipids on microglia function

Leyrolle, Q., Layé, S., & Nadjar, A. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134348 · Cited by 50 · see citing works

PPARγ activation ameliorates cognitive impairment and chronic microglial activation in the aftermath of r-mTBI

Pearson, A., Koprivica, M., Eisenbaum, M., Ortiz, C., Browning, M., Vincennie, T., Tinsley, C., MULLAN, M. J., Crawford, F., & Ojo, J. O. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03173-w · Cited by 39 · see citing works

Tumour necrosis factor α induces neuroinflammation and insulin resistance in immortalised hypothalamic neurones through independent pathways

Clemenzi, M. N., Wellhauser, L., Aljghami, M. E., & Belsham, D. D. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12678 · Cited by 25 · see citing works

Deletion of PTEN in microglia ameliorates chronic neuroinflammation following repetitive mTBI

Pearson, A., Ortiz, C., Eisenbaum, M., Arrate, C., Browning, M., MULLAN, M. J., Bachmeier, C. J., Crawford, F., & Ojo, J. O. (2023) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2023.103855 · Cited by 22 · see citing works

Unraveling brain palmitic acid: Origin, levels and metabolic fate

Smith, M. E., & Bazinet, R. P. (2024) · Progress in Lipid Research · doi:10.1016/j.plipres.2024.101300 · Cited by 21 · see citing works

Brain Innate Immune Response in Diet-Induced Obesity as a Paradigm for Metabolic Influence on Inflammatory Signaling

Macedo, F. P., dos Santos, L. S., Glezer, I., & da Cunha, F. M. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00342 · Cited by 16 · see citing works

Palmitate lipotoxicity is closely associated with the fatty acid-albumin complexes in BV-2 microglia

Yang, Y., Yu, Q., Li, B., Yang, Z., Zhang, S., & Yuan, F. (2023) · PLOS ONE · doi:10.1371/journal.pone.0281189 · Cited by 15 · see citing works

Extracellular vesicles released from microglia after palmitate exposure impact brain function

de Paula, G. C., Aldana, B. I., Battistella, R., Fernández‐Calle, R., Bjure, A., Lundgaard, I., Deierborg, T., & Duarte, J. M. N. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03168-7 · Cited by 13 · see citing works

Maternal high fat diet consumption reduces liver alpha7 nicotinic cholinergic receptor expression and impairs insulin signalling in the offspring

COSTA, S. O., de Souza, C. M., LANZA, P. G., Sartori, J. O., Ignácio-Souza, L. M., Candreva, T., Rodrigues, H. G., Torsoni, A. S., Milanski, M., & Torsoni, M. A. (2020) · Scientific Reports · doi:10.1038/s41598-019-56880-3 · Cited by 13 · see citing works

Palmitate‐mediated induction of neuropeptide Y expression occurs through intracellular metabolites and not direct exposure to proinflammatory cytokines

Tran, A., He, W., Chen, J. T. C., Wellhauser, L., Hopperton, K. E., Bazinet, R. P., & Belsham, D. D. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15504 · Cited by 12 · see citing works

Hypothalamic Microglia as Dual Hubs Orchestrating Local and Systemic Homeostasis in the Periphery–Central–Periphery Axis

Liu, Y., Jiang, Q., Huang, Y., Zhang, X., Kang, H., Yu, C., Xia, Y., Liu, Y., & Zhang, H. (2025) · Cells · doi:10.3390/cells14221780 · Cited by 10 · see citing works

Palmitate Stimulates Expression of the von Willebrand Factor and Modulates Toll-like Receptors Level and Activity in Human Umbilical Vein Endothelial Cells (HUVECs)

Seliga, A. K., Zabłocki, K., & Bandorowicz‐Pikuła, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010254 · Cited by 8 · see citing works

Modeling hypothalamic pathophysiology in vitro for metabolic, circadian, and sleep disorders

Leal, H., Carvalhas-Almeida, C., Álvaro, A. R., & Cavadas, C. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.01.001 · Cited by 9 · see citing works

Heterochronic Fecal Microbiota Transfer Reverses Hallmarks of the Aging Murine Gut, Eye and BrainPreprint

Parker, A., Romano, S., Ansorge, R., Aboelnoer, A., Gall, G. L., Savva, G. M., Telatin, A., Jones, E. J., Baker, D., Rudder, S. J., et al. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3811833 · Cited by 8 · see citing works

Palmitate alters miRNA content of small extracellular vesicles secreted from NPY/AgRP-expressing hypothalamic neurons

McIlwraith, E. K., & Belsham, D. D. (2023) · Brain Research · doi:10.1016/j.brainres.2023.148367 · Cited by 5 · see citing works

Characterization of IMG Microglial Cell Line as a Valuable In Vitro Tool for NLRP3 Inflammasome Studies

Viil, J., Somelar, K., Jaako, K., Anier, K., & Zharkovsky, A. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01285-6 · Cited by 5 · see citing works

Hypothalamic Cell Models

Dalvi, P. S., Loganathan, N., McIlwraith, E. K., Tran, A., & Belsham, D. D. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819801-8.00002-8 · Cited by 3 · see citing works

Immortalization and Characterization of GFAP-expressing Glial Cells from the Adult Mouse Hypothalamus, Cortex, and Brain Stem

Loganathan, N., Lieu, C. V., & Belsham, D. D. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.05.022 · Cited by 2 · see citing works

Microglial Feimin Alleviates Cognitive Impairment in High‐Fat Diet‐Fed Mice

Gao, R., Xiong, Z., Su, W., Deng, J., Zhai, B., Zhu, G., Zhang, M., Zeng, Q., Qiu, J., Bian, Z., et al. (2025) · Advanced Science · doi:10.1002/advs.202512023 · Cited by 1 · see citing works

The Effects of Western-diet, Palmitate, and TNFα on Hypothalamic Circadian Rhythms, NPY Expression, Neuroinflammation, and Cellular Insulin Sensitivity

Clemenzi, M. N. (2019) · TSpace (University of Toronto)

Microgliosis driven by palmitate exposure alters energy metabolism and extracellular vesicles release that impact behavior and systemic metabolismPreprint

de Paula, G. C., Aldana, B. I., Battistella, R., Fernández‐Calle, R., Bjure, A., Lundgaard, I., Deierborg, T., & Duarte, J. M. N. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.04.587954

Additional file 1 of Extracellular vesicles released from microglia after palmitate exposure impact brain function

de Paula, G. C., Aldana, B., Battistella, R., Fernández‐Calle, R., Bjure, A., Lundgaard, I., Deierborg, T., & Duarte, J. M. N. (2024) · Figshare · doi:10.6084/m9.figshare.26750003

Additional file 5 of Extracellular vesicles released from microglia after palmitate exposure impact brain function

de Paula, G. C., Aldana, B., Battistella, R., Fernández‐Calle, R., Bjure, A., Lundgaard, I., Deierborg, T., & Duarte, J. M. N. (2024) · Figshare · doi:10.6084/m9.figshare.26750015

Additional file 7 of Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain

Parker, A., Romano, S., Ansorge, R., Aboelnour, A., Le Gall, G., Savva, G. M., Pontifex, M. G., Telatin, A., Baker, D., Jones, E. J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19695986

Additional file 5 of Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain

Parker, A., Romano, S., Ansorge, R., Aboelnour, A., Le Gall, G., Savva, G. M., Pontifex, M. G., Telatin, A., Baker, D., Jones, E. J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19695980

Additional file 2 of Extracellular vesicles released from microglia after palmitate exposure impact brain function

de Paula, G. C., Aldana, B., Battistella, R., Fernández‐Calle, R., Bjure, A., Lundgaard, I., Deierborg, T., & Duarte, J. M. N. (2024) · Figshare · doi:10.6084/m9.figshare.26750006

Additional file 4 of Extracellular vesicles released from microglia after palmitate exposure impact brain function

de Paula, G. C., Aldana, B., Battistella, R., Fernández‐Calle, R., Bjure, A., Lundgaard, I., Deierborg, T., & Duarte, J. M. N. (2024) · Figshare · doi:10.6084/m9.figshare.26750012

Additional file 3 of Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain

Parker, A., Romano, S., Ansorge, R., Aboelnour, A., Le Gall, G., Savva, G. M., Pontifex, M. G., Telatin, A., Baker, D., Jones, E. J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19695974

Additional file 6 of Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain

Parker, A., Romano, S., Ansorge, R., Aboelnour, A., Le Gall, G., Savva, G. M., Pontifex, M. G., Telatin, A., Baker, D., Jones, E. J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19695983

Additional file 2 of Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain

Parker, A., Romano, S., Ansorge, R., Aboelnour, A., Le Gall, G., Savva, G. M., Pontifex, M. G., Telatin, A., Baker, D., Jones, E. J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19695971

Additional file 4 of Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain

Parker, A., Romano, S., Ansorge, R., Aboelnour, A., Le Gall, G., Savva, G. M., Pontifex, M. G., Telatin, A., Baker, D., Jones, E. J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19695977

Additional file 3 of Extracellular vesicles released from microglia after palmitate exposure impact brain function

de Paula, G. C., Aldana, B., Battistella, R., Fernández‐Calle, R., Bjure, A., Lundgaard, I., Deierborg, T., & Duarte, J. M. N. (2024) · Figshare · doi:10.6084/m9.figshare.26750009

Optimization of cryoprotected nano-isoliquiritigenin by DoE: in vitro neuroprotective effect for intranasal applications

Manin, S., Barbalace, M. C., Gigliobianco, M. R., Bonaccorso, A., Carbone, C., Faro, M. J. L., Ciulla, M., Pellitteri, R., Lorenzini, A., Rinaldi, I., et al. (2026) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2026.109024

The Role of Inflammatory Cytokines in the Palmitate-mediated Dysregulation of NPY in Hypothalamic Neurons

Tran, A. X. (2020) · TSpace (University of Toronto)

Exposure to the Saturated Free Fatty Acid Palmitate Alters BV-2 Microglia Inflammatory Response

Tracy, L. M., Bergqvist, F., Ivanova, E. V., Jacobsen, K. T., & Iverfeldt, K. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-0068-7 · Cited by 63 · see citing works

The Effects of Saturated Fatty Acid Palmitate on Neuropeptide Gene Expression, Signal Transduction, and Insulin Signaling in an Immortalized Hypothalamic Neuronal Cell Model, mHypoA-NPY/GFP

Wong, B. C. (2015) · TSpace (University of Toronto)

Role of Cell Surface Receptors in Palmitic Acid-Induced Expression of IL-1β in Microglial Cells

Jadeja, V., Ma, S., & Zhou, H. (2026) · Lipidology · doi:10.3390/lipidology3020015

Palmitic Acid Regulation of Microglial Immune Function

Jadeja, V. (2026) · Seton Hall University eRepository (Seton Hall University)