Cocaine-mediated downregulation of microglial miR-124 expression involves promoter DNA methylation.
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Cocaine activates microglia by downregulating miR-124 and upregulating its targets, leading to neuroinflammation.
“Psychostimulants such as cocaine have been shown to activate microglia by downregulating miR-124, leading, in turn, to neuroinflammation.”
From Engineered Extracellular Vesicles Loaded With miR-124 Attenuate Cocaine-Mediated Activation of Microglia (2020) · cites this paper as Guo et al., 2016
Cocaine downregulates expression of miR-124 in microglia with concomitant upregulation of its targets KLF4 and TLR4.
“Cocaine has been shown to downregulate expression of miR-124 in microglia with concomitant upregulation of its targets – KLF4 and TLR4 (Guo et al., 2016; Periyasamy et al., 2017).”
From Engineered Extracellular Vesicles Loaded With miR-124 Attenuate Cocaine-Mediated Activation of Microglia (2020) · cites this paper as Guo et al., 2016
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Cites
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Stansley, B., Post, J., & Hensley, K. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-115 · Cited by 419 · see citing works
An updated role of microRNA-124 in central nervous system disorders: a review
Sun, Y., Luo, Z.-M., Guo, X.-M., Su, D.-F., & Liu, X. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00193 · Cited by 223 · see citing works
<i>miR‐124</i> Contributes to the functional maturity of microglia
Svahn, A. J., Giacomotto, J., Graeber, M. B., Rinkwitz, S., & Becker, T. S. (2016) · Developmental Neurobiology · doi:10.1002/dneu.22328 · Cited by 42 · see citing works
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Cited by
Sorted by citations
Chivero, E. T., Liao, K., Niu, F., Tripathi, A., Tian, C., Buch, S., & Hu, G. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00573 · Cited by 69 · see citing works
Self-citation
- Authors
- Guo, M.-L., Periyasamy, P., Liao, K., Kook, Y. H., Niu, F., Callen, S. E., & Buch, S.
- Affiliations
- Department of Pharmacology and Experimental Neuroscience, Nebraska Medical Center, University of Nebraska Medical Center, Omaha, NE, USA
- Venue
- Epigenetics
- Publisher
- Informa UK Limited
- Published
- 2016-11-01
- Volume
- 11
- Issue
- 11
- Pages
- 819-830
- ISSN
- 1559-2294
- 1559-2308
- Cited by
- 39
- References
- 4
- Language
- en
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