Targeted blockade in lethal West Nile virus encephalitis indicates a crucial role for very late antigen (VLA)-4-dependent recruitment of nitric oxide-producing macrophages

Getts, Daniel R; Terry, Rachael L; Getts, Meghann Teague; Müller, Marcus; Rana, Sabita; Deffrasnes, Celine; Ashhurst, Thomas Myles; Radford, Jane; Hofer, Markus; Thomas, Shane; Campbell, Iain L; King, Nicholas JC

doi:10.1186/1742-2094-9-246

Targeted blockade in lethal West Nile virus encephalitis indicates a crucial role for very late antigen (VLA)-4-dependent recruitment of nitric oxide-producing macrophages

Infiltration of Ly6C hi monocytes from the blood is a hallmark of viral encephalitis. In mice with lethal encephalitis caused by West Nile virus (WNV), an emerging neurotropic flavivirus, inhibition of Ly6C hi monocyte trafficking into the brain by anti-very late antigen (VLA)-4 integrin antibody…