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Osteoporosis, inflammation and ageing
Open accessAbstract
Osteoporosis is a condition characterized by low bone mass and increased bone fragility, putting patients at risk of fractures, which are major causes of morbidity substantially in older people. Osteoporosis is currently attributed to various endocrine, metabolic and mechanical factors. However, emerging clinical and molecular evidence suggests that inflammation also exerts significant influence on bone turnover, inducing osteoporosis. Numerous proinflammatory cytokines have been implicated in the regulation of osteoblasts and osteoclasts, and a shift towards an activated immune profile has been hypothesized as important risk factor. Chronic inflammation and the immune system remodelling characteristic of ageing, as well as of other pathological conditions commonly associated with osteoporosis, may be determinant pathogenetic factors. The present article will review the current perspectives on the interaction between bone and immune system in the elderly, providing an interpretation of osteoporosis in the light of inflamm-ageing.
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“Exposure to chronically elevated inflammation processes has also been increasingly recognized as a significant health risk with links to increased risks for osteoporosis, 38,39 cardiovascular disease, [40][41][42][43][44][45] and cognitive decline.[46][47][48]”
From Socio‐economic differentials in peripheral biology: Cumulative allostatic load (2010) · cites this paper as [39]
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Metadata
- Authors
- Ginaldi, L., Di Benedetto, M. C., & De Martinis, M.
- Affiliations
- University of L'Aquila (IT)
- Corresponding author
- Ginaldi, Lia
- ORCID
- Ginaldi, Lia
- Venue
- Immunity & Ageing
- Published
- 2005-11-04
- Volume
- 2
- Issue
- 1
- Pages
- 14-14
- ISSN
- 1742-4933 (ISSN-L)
- PMC
- PMC1308846
- OpenAlex
- W2168242208
- Cited by
- 412
- References
- 164
- Citations by year
- 2026: 21 · 2025: 27 · 2024: 31 · 2023: 28 · 2022: 37 · 2021: 33 · 2020: 44 · 2019: 29 · 2018: 28 · 2017: 22 · 2016: 10 · 2015: 12 · 2014: 16 · 2013: 14 · 2012: 10
- FWCI
- 2.52
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Immunity & Ageing (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Keywords
- osteoporosis, chronic inflammation, aging, bone turnover, inflammatory cytokines, osteoblasts, osteoclasts, bone-immune interaction, fracture risk, older adults
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