Cited by 412Bone Metabolism and DiseasesBone health and osteoporosis researchRheumatoid Arthritis Research and Therapies

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Osteoporosis, inflammation and ageing

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Ginaldi, Lia, Di Benedetto, Maria Cristina, De Martinis, Massimo·2005·Immunity & Ageing

DOI 10.1186/1742-4933-2-14PMC PMC1308846

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Abstract

Osteoporosis is a condition characterized by low bone mass and increased bone fragility, putting patients at risk of fractures, which are major causes of morbidity substantially in older people. Osteoporosis is currently attributed to various endocrine, metabolic and mechanical factors. However, emerging clinical and molecular evidence suggests that inflammation also exerts significant influence on bone turnover, inducing osteoporosis. Numerous proinflammatory cytokines have been implicated in the regulation of osteoblasts and osteoclasts, and a shift towards an activated immune profile has been hypothesized as important risk factor. Chronic inflammation and the immune system remodelling characteristic of ageing, as well as of other pathological conditions commonly associated with osteoporosis, may be determinant pathogenetic factors. The present article will review the current perspectives on the interaction between bone and immune system in the elderly, providing an interpretation of osteoporosis in the light of inflamm-ageing.

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Authors: Ginaldi, L., Di Benedetto, M. C., & De Martinis, M.
Affiliations: University of L'Aquila (IT)
Corresponding author: Ginaldi, Lia
ORCID: Ginaldi, Lia
Venue: Immunity & Ageing
Publisher: Springer Science and Business Media LLC
Published: 2005-11-04
Volume: 2
Issue: 1
Pages: 14-14
ISSN: 1742-4933 (ISSN-L)
DOI: 10.1186/1742-4933-2-14
PMC: PMC1308846
OpenAlex: W2168242208
Cited by: 412
References: 164
Citations by year: 2026: 21 · 2025: 27 · 2024: 31 · 2023: 28 · 2022: 37 · 2021: 33 · 2020: 44 · 2019: 29 · 2018: 28 · 2017: 22 · 2016: 10 · 2015: 12 · 2014: 16 · 2013: 14 · 2012: 10
FWCI: 2.52
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Immunity & Ageing (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Keywords: osteoporosis, chronic inflammation, aging, bone turnover, inflammatory cytokines, osteoblasts, osteoclasts, bone-immune interaction, fracture risk, older adults

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Osteoporosis, inflammation and ageing

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