The DOI matches its Crossref record; 167 of the 167 references it cites were found in a registry or an index.
Osteoporosis, inflammation and ageing
Open accessAbstract
Osteoporosis is a condition characterized by low bone mass and increased bone fragility, putting patients at risk of fractures, which are major causes of morbidity substantially in older people. Osteoporosis is currently attributed to various endocrine, metabolic and mechanical factors. However, emerging clinical and molecular evidence suggests that inflammation also exerts significant influence on bone turnover, inducing osteoporosis. Numerous proinflammatory cytokines have been implicated in the regulation of osteoblasts and osteoclasts, and a shift towards an activated immune profile has been hypothesized as important risk factor. Chronic inflammation and the immune system remodelling characteristic of ageing, as well as of other pathological conditions commonly associated with osteoporosis, may be determinant pathogenetic factors. The present article will review the current perspectives on the interaction between bone and immune system in the elderly, providing an interpretation of osteoporosis in the light of inflamm-ageing.
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“Exposure to chronically elevated inflammation processes has also been increasingly recognized as a significant health risk with links to increased risks for osteoporosis, 38,39 cardiovascular disease, [40][41][42][43][44][45] and cognitive decline.[46][47][48]”
From Socio‐economic differentials in peripheral biology: Cumulative allostatic load (2010) · cites this paper as [39]
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Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394
Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358
Bone Resorption by Osteoclasts
Teitelbaum, S. L. (2000) · Science · doi:10.1126/science.289.5484.1504 · Cited by 3,962
Osteoblastic cells regulate the haematopoietic stem cell niche
Calvi, L. M., Adams, G. B., Weibrecht, K. W., Weber, J. M., Olson, D. P., Knight, M. C., Martin, R. P., Schipani, E., Pajevic, P. D., Bringhurst, F. R., et al. (2003) · Nature · doi:10.1038/nature02040 · Cited by 3,559
Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance
Sallusto, F., Geginat, J., & Lanzavecchia, A. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104702 · Cited by 3,067
Manolagas, S. C. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.2.0395 · Cited by 2,639
Yudkin, J. S., Stehouwer, C. D. A., Emeis, J. J., & Coppack, S. W. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.4.972 · Cited by 2,465
Franceschi, C., Capri, M., Monti, D., Giunta, S., Olivieri, F., Sevini, F., Panourgia, M. P., Invidia, L., Celani, L., Scurti, M., et al. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.016 · Cited by 2,087
Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche
Arai, F., Hirao, A., Ohmura, M., Sato, H., Matsuoka, S., Takubo, K., Ito, K., Koh, G. Y., & Suda, T. (2004) · Cell · doi:10.1016/j.cell.2004.07.004 · Cited by 1,958
Kong, Y.-Y., Feige, U., Sarosi, I., Bolon, B., Tafuri, A., Morony, S., Capparelli, C., Li, J., Elliott, R., McCabe, S., et al. (1999) · Nature · doi:10.1038/46303 · Cited by 1,856
Research works printed but not linked: 1
- Moschen AR, Kaser A, Enrich B, Ludwiczek O, Gabriel M, Obrist P, Wolf AM, Tilg H: RANKL/OPG system is activated in inflammatory bowel disease and relates to the state of bone loss. Gut. 2005, 54: 479-87. 10.1136/gut.2004.044370. · DOI
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Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
Ferrucci, L., & Fabbri, E. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0064-2 · Cited by 3,690
The aging of the immune system
Weiskopf, D., Weinberger, B., & Grubeck-Loebenstein, B. (2009) · Transplant International · doi:10.1111/j.1432-2277.2009.00927.x · Cited by 908
Interaction between bone and immune cells: Implications for postmenopausal osteoporosis
Fischer, V., & Haffner-Luntzer, M. (2022) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2021.05.014 · Cited by 759
Socio‐economic differentials in peripheral biology: Cumulative allostatic load
Seeman, T., Epel, E., Gruenewald, T., Karlamangla, A., & McEwen, B. S. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05341.x · Cited by 579
Kim, J. H., Yi, Y., Kim, M., & Cho, J. Y. (2016) · Journal of Ginseng Research · doi:10.1016/j.jgr.2016.08.004 · Cited by 589
“Osteoporosis occurs as a result of a variety of endocrine, metabolic, and mechanical factors [34].”
Background
Metadata
- Authors
- Ginaldi, L., Di Benedetto, M. C., & De Martinis, M.
- Affiliations
- University of L'Aquila (IT)
- Corresponding author
- Ginaldi, Lia
- ORCID
- Ginaldi, Lia
- Venue
- Immunity & Ageing
- Published
- 2005-11-04
- Volume
- 2
- Issue
- 1
- Pages
- 14-14
- ISSN
- 1742-4933 (ISSN-L)
- PMC
- PMC1308846
- OpenAlex
- W2168242208
- Cited by
- 412
- References
- 164
- Citations by year
- 2026: 21 · 2025: 27 · 2024: 31 · 2023: 28 · 2022: 37 · 2021: 33 · 2020: 44 · 2019: 29 · 2018: 28 · 2017: 22 · 2016: 10 · 2015: 12 · 2014: 16 · 2013: 14 · 2012: 10
- FWCI
- 2.52
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Immunity & Ageing (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Keywords
- osteoporosis, chronic inflammation, aging, bone turnover, inflammatory cytokines, osteoblasts, osteoclasts, bone-immune interaction, fracture risk, older adults
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