Oxytocin-Induced Antinociception in the Spinal Cord is Mediated by a Subpopulation of Glutamatergic Neurons in Lamina I-II Which Amplify GABAergic Inhibition

The oxytocin receptor system: structure, function, and regulation

Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089 · see citing works

Direct hypothalamo-autonomic connections

Saper, C. B., Loewy, A. D., Swanson, L. W., & Cowan, W. M. (1976) · Brain Research · doi:10.1016/0006-8993(76)90738-1 · Cited by 1,199 · see citing works

An Electron Microscopic Study

Jitsukawa, K., Sueki, H., Sato, S., & Anzai, T. (1987) · American Journal of Dermatopathology · doi:10.1097/00000372-198704000-00003 · Cited by 1,130 · see citing works

Neurochemical organization of the hypothalamic projection to the spinal cord in the rat

Cechetto, D. F., & Saper, C. B. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902720410 · Cited by 346 · see citing works

The distribution of oxytocin‐ and neurophysin‐stained fibers in the spinal cord of the rat and monkey

Swanson, L. W., & McKellar, S. (1979) · Journal of Comparative Neurology · doi:10.1002/cne.901880108 · Cited by 336 · see citing works

Activation of Silent Synapses by Rapid Activity-Dependent Synaptic Recruitment of AMPA Receptors

Liao, D., Scannevin, R. H., & Huganir, R. L. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-16-06008.2001 · Cited by 286 · see citing works

Silent glutamatergic synapses and nociception in mammalian spinal cord

Li, P., & Zhuo, M. (1998) · Nature · doi:10.1038/31496 · Cited by 267 · see citing works

125I-labelled d(CH2)5[Tyr(Me)2,Thr4,Tyr-NH29]OVT: a selective oxytocin receptor ligand

Elands, J., Barberis, C., Jard, S., Tribollet, E., Dreifuss, J.-J., Bankowski, K., Manning, M., & Sawyer, W. H. (1988) · European Journal of Pharmacology · doi:10.1016/0014-2999(88)90778-9 · Cited by 245 · see citing works

Region-Specific Developmental Specialization of GABA–Glycine Cosynapses in Laminas I–II of the Rat Spinal Dorsal Horn

Keller, A. F., Coull, J. A. M., Chéry, N., Poisbeau, P., & Koninck, Y. D. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-20-07871.2001 · Cited by 227 · see citing works

Oxytocin mediates stress‐induced analgesia in adult mice

Robinson, D. A., Wei, F., Wang, G. D., Li, P., Kim, S. J., Vogt, S. K., Muglia, L. J., & Zhuo, M. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2001.013492 · Cited by 148 · see citing works

Oxytocinergic innervation of autonomic nuclei controlling penile erection in the rat

Véronneau-Longueville, F., Rampin, O., Freund‐Mercier, M. J., Tang, Y., Calas, A., Marson, L., McKenna, K. E., Stoeckel, M. E., Benoît, G., & Giuliano, F. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00262-6 · Cited by 140 · see citing works

Anti-nociceptive effects of oxytocin in rats and mice

Lundeberg, T., Uvnäs‐Moberg, K., Ågren, G., & BRUZELIUS, G. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90262-3 · Cited by 139 · see citing works

Oxytocin and electrical stimulation of the paraventricular hypothalamic nucleus produce antinociceptive effects that are reversed by an oxytocin antagonist

Miranda-Cardenas, Y., Rojas‐Piloni, G., Martı́nez-Lorenzana, G., Rodríguez-Jiménez, J., López-Hidalgo, M. A., Freund‐Mercier, M. J., & Condés‐Lara, M. (2006) · Pain · doi:10.1016/j.pain.2006.01.029 · Cited by 131 · see citing works

Oxytocin decreases carrageenan induced inflammation in rats

Petersson, M., Wiberg, U., Lundeberg, T., & Uvnäs‐Moberg, K. (2001) · Peptides · doi:10.1016/s0196-9781(01)00469-7 · Cited by 130 · see citing works

‘Deaf, mute and whispering’ silent synapses: their role in synaptic plasticity

Voronin, L. L., & Cherubini, E. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.058966 · Cited by 125 · see citing works

Untitled work

(1981) · PubMed · Cited by 117 · see citing works

Involvement of oxytocin in spinal antinociception in rats with inflammation

Yu, S.-Q., Lundeberg, T., & Yu, L. (2003) · Brain Research · doi:10.1016/s0006-8993(03)03019-1 · Cited by 98 · see citing works

Paraventricular hypothalamic influences on spinal nociceptive processing

Condés‐Lara, M., Rojas‐Piloni, G., Martı́nez-Lorenzana, G., Rodríguez-Jiménez, J., López-Hidalgo, M. A., & Freund‐Mercier, M. J. (2006) · Brain Research · doi:10.1016/j.brainres.2006.01.050 · Cited by 94 · see citing works

Oxytocin Modulates Glutamatergic Synaptic Transmission between Cultured Neonatal Spinal Cord Dorsal Horn Neurons

Jo, Y.-H., Stoeckel, M.-E., Freund-Mercier, M.-J., & Schlichter, R. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-07-02377.1998 · Cited by 90 · see citing works

Production of 5α-Reduced Neurosteroids Is Developmentally Regulated and Shapes GABAAMiniature IPSCs in Lamina II of the Spinal Cord

Keller, A. F., Breton, J., Schlichter, R., & Poisbeau, P. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4642-03.2004 · Cited by 90 · see citing works

[3H]-[Thr4,Gly7]OT: a highly selective ligand for central and peripheral OT receptors

Elands, J., Barberis, C., & Jard, S. (1988) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1988.254.1.e31 · Cited by 88 · see citing works

Localization of Oxytocin Binding Sites in the Thoracic and Upper Lumbar Spinal Cord of the Adult and Postnatal Rat: A Histoautoradiographic Study

Reiter, M. K., Krémarik, P., Freund‐Mercier, M. J., Stoeckel, M. E., Desaulles, E., & FELTZ, P. (1994) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1994.tb00251.x · Cited by 85 · see citing works

Oxytocinergic innervation of the rat spinal cord. An electron microscopic study

Rousselot, P., Papadopoulos, G. C., Merighi, A., Poulain, D. A., & Theodosis, D. T. (1990) · Brain Research · doi:10.1016/0006-8993(90)90825-v · Cited by 78 · see citing works

Oxytocin actions on afferent evoked spinal cord neuronal activities in neuropathic but not in normal rats

Condés‐Lara, M., Maie, I. A. S., & Dickenson, A. H. (2005) · Brain Research · doi:10.1016/j.brainres.2005.03.020 · Cited by 71 · see citing works

GABA-mediated oxytocinergic inhibition in dorsal horn neurons by hypothalamic paraventricular nucleus stimulation

Rojas-Piloni, G., López-Hidalgo, M., Martínez-Lorenzana, G., Rodríguez-Jiménez, J., & Condés-Lara, M. (2007) · Brain Research · doi:10.1016/j.brainres.2006.12.045 · Cited by 67 · see citing works

Angiotensin-converting enzyme in discrete forebrain areas of spontaneously hypertensive rats

Chevillard, C., Niwa, M., & Saavedra, J. M. (1984) · Brain Research · doi:10.1016/0006-8993(84)90611-5 · Cited by 58 · see citing works

Actions of oxytocin and interactions with glutamate on spontaneous and evoked dorsal spinal cord neuronal activities

Condés‐Lara, M., Marina, N., Martı́nez-Lorenzana, G., Luis‐Delgado, O. E., & Freund‐Mercier, M. J. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02690-8 · Cited by 58 · see citing works

Stimulation of the hypothalamic paraventricular nucleus produces analgesia not mediated by vasopressin or endogenous opioids

Yirmiya, R., Ben‐Eliyahu, S., Shavit, Y., Marek, P., & Liebeskind, J. C. (1990) · Brain Research · doi:10.1016/0006-8993(90)90354-e · Cited by 55 · see citing works

Vasopressin and oxytocin in the rat spinal cord: analysis of their role in the control of nociception

Millan, M. J., Schmauss, C., Millan, M. H., & Herz, A. (1984) · Brain Research · doi:10.1016/0006-8993(84)90610-3 · Cited by 53 · see citing works

Oxytocin modulates the effects of galanin in carrageenan-induced hyperalgesia in rats

Lundeberg, T., Meister, B., Björkstrand, E., & Uvnäs‐Moberg, K. (1993) · Brain Research · doi:10.1016/0006-8993(93)91456-3 · Cited by 49 · see citing works

Effects of hypothalamic paraventricular nucleus: electrical stimulation produce marked analgesia in rats.

Shiraishi, T., Onoe, M., Kojima, T., Sameshima, Y., & 影山, 照. (1995) · PubMed · Cited by 40 · see citing works

Olfactory cues from an oxytocin-injected male rat can induce anti-nociception in its cagemates

Ågren, G., Uvnäs‐Moberg, K., & Lundeberg, T. (1997) · Neuroreport · doi:10.1097/00001756-199709290-00013 · Cited by 36 · see citing works

Speaking Out of Turn: A Role for Silent Synapses in Pain

Kerchner, G. A., Li, P., & Zhuo, M. (1999) · IUBMB Life · doi:10.1080/713803505 · Cited by 27 · see citing works

Intrathecal oxytocin facilitates the spinal nociceptive flexor reflex in the rat

Xu, X., & Wiesenfeld‐Hallin, Z. (1994) · Neuroreport · doi:10.1097/00001756-199403000-00003 · Cited by 14 · see citing works

Oxytocin: The Great Facilitator of Life

Lee, H.-J., Macbeth, A. H., Pagani, J., & Young, W. S. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.001 · Cited by 1,037 · see citing works

Neuromodulation by Oxytocin and Vasopressin

Stoop, R. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.025 · Cited by 506 · see citing works

Oxytocin and Vasopressin Agonists and Antagonists as Research Tools and Potential Therapeutics

Manning, M., Misicka, A., Olma, A., Bankowski, K., Stoev, S., Chini, B., Durroux, T., Mouillac, B., Corbani, M., & Guillon, G. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02303.x · Cited by 423 · see citing works

REVIEW: Oxytocin: Crossing the Bridge between Basic Science and Pharmacotherapy

Viéro, C., Shibuya, I., Kitamura, N., Verkhratsky, A., Fujihara, H., Katoh, A., Ueta, Y., Zingg, H. H., Chvátal, A., Syková, E., et al. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00185.x · Cited by 250 · see citing works

Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents

Wahis, J., Baudon, A., Althammer, F., Kerspern, D., Goyon, S., Hagiwara, D., Lefèvre, A., Barteczko, L., Boury‐Jamot, B., Bellanger, B., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00800-0 · Cited by 192 · see citing works

Oxytocin-Induced Analgesia and Scratching Are Mediated by the Vasopressin-1A Receptor in the Mouse

Schorscher-Petcu, A., Sotocinal, S., Ciura, S., Dupre, A., Ritchie, J., Sorge, R. E., Crawley, J. N., Hu, S.-B., Nishimori, K., Young, L. J., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1594-10.2010 · Cited by 189 · see citing works

Role of different brain areas in peripheral nerve injury-induced neuropathic pain

Jaggi, A. S., & Singh, N. (2011) · Brain Research · doi:10.1016/j.brainres.2011.01.002 · Cited by 147 · see citing works

Oxytocin and Pain Perception: From Animal Models to Human Research

Boll, S., de Minas, A. C. A., Raftogianni, A., Herpertz, S. C., & Grinevich, V. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.09.041 · Cited by 137 · see citing works

Oxytocin enhances cranial visceral afferent synaptic transmission to the solitary tract nucleus

Peters, J. H., McDougall, S. J., Kellett, D. O., Jordan, D., Llewellyn-Smith, I. J., & Andresen, M. C. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3419-08.2008 · Cited by 135 · see citing works

Molecular Mechanisms of Oxytocin Signaling at the Synaptic Connection

Bakos, J., Srancikova, A., Havranek, T., & Bacova, Z. (2018) · Neural Plasticity · doi:10.1155/2018/4864107 · Cited by 104 · see citing works

Neurohormonal effects of oxytocin and vasopressin receptor agonists on spinal pain processing in male rats

Juif, P.-E., & Poisbeau, P. (2013) · Pain · doi:10.1016/j.pain.2013.05.003 · Cited by 101 · see citing works

The search for novel analgesics: targets and mechanisms

Yaksh, T. L., Woller, S. A., Ramachandran, R., & Sorkin, L. S. (2015) · F1000Prime Reports · doi:10.12703/p7-56 · Cited by 100 · see citing works

Oxytocin Signaling in Pain: Cellular, Circuit, System, and Behavioral Levels

Poisbeau, P., Grinevich, V., & Charlet, A. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_14 · Cited by 92 · see citing works

Chronic pain after childbirth

Landau, R., Bollag, L. A., & Ortner, C. M. (2013) · International Journal of Obstetric Anesthesia · doi:10.1016/j.ijoa.2013.01.008 · Cited by 82 · see citing works

Identification of oxytocin receptor in the dorsal horn and nociceptive dorsal root ganglion neurons

Moreno-López, Y., Martı́nez-Lorenzana, G., Condés‐Lara, M., & Rojas‐Piloni, G. (2012) · Neuropeptides · doi:10.1016/j.npep.2012.09.008 · Cited by 80 · see citing works

The analgesic effects of oxytocin in the peripheral and central nervous system

Xin, Q., Bai, B., & Liu, W. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2016.12.021 · Cited by 81 · see citing works

Activation of hypothalamic oxytocin neurons following tactile stimuli in rats

Okabe, S., Yoshida, M., Takayanagi, Y., & Onaka, T. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.05.055 · Cited by 82 · see citing works

Oxytocin Relieves Neuropathic Pain Through GABA Release and Presynaptic TRPV1 Inhibition in Spinal Cord

Sun, W., Zhou, Q., Ba, X., Feng, X., Hu, X. X., Cheng, X., Liu, T., Guo, J., Xiao, L., Jin, J., et al. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00248 · Cited by 73 · see citing works

Oxytocin-induced membrane hyperpolarization in pain-sensitive dorsal root ganglia neurons mediated by Ca2+/nNOS/NO/KATP pathway

Gong, L., Gao, F., Li, J., Li, J., Yu, X., Ma, X., Zheng, W., Cui, S., Liu, K., Zhang, M., et al. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2014.12.058 · Cited by 74 · see citing works

Oxytocin and vasopressin: Social neuropeptides with complex neuromodulatory functions

Benarroch, E. E. (2013) · Neurology · doi:10.1212/wnl.0b013e31828cfb15 · Cited by 74 · see citing works

Paraventricular oxytocinergic hypothalamic prevention or interruption of long-term potentiation in dorsal horn nociceptive neurons: Electrophysiological and behavioral evidence

DelaTorre, S., Rojas‐Piloni, G., Martı́nez-Lorenzana, G., Rodríguez-Jiménez, J., Villanueva, L., & Condés‐Lara, M. (2009) · Pain · doi:10.1016/j.pain.2009.05.002 · Cited by 74 · see citing works

Visualization of Oxytocin Release that Mediates Paired Pulse Facilitation in Hypothalamic Pathways to Brainstem Autonomic Neurons

Piñol, R. A., Jameson, H. S., Popratiloff, A. S., Lee, N. H., & Mendelowitz, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112138 · Cited by 67 · see citing works

Neuropeptide oxytocin enhances μ opioid receptor signaling as a positive allosteric modulator

Meguro, Y., Miyano, K., Hirayama, S., Yoshida, Y., Ishibashi, N., Ogino, T., Fujii, Y., Manabe, S., Eto, M., Nonaka, M., et al. (2018) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2018.04.002 · Cited by 68 · see citing works

Oxytocin - A Multifunctional Analgesic for Chronic Deep Tissue Pain

Goodin, B. R., Ness, T. J., & Robbins, M. T. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612820666141027111843 · Cited by 66 · see citing works

Antinociceptive Action of Oxytocin Involves Inhibition of Potassium Channel Currents in Lamina Ii Neurons of the Rat Spinal Cord

Breton, J., Poisbeau, P., & Darbon, P. (2009) · Molecular Pain · doi:10.1186/1744-8069-5-63 · Cited by 63 · see citing works

Preclinical Toxicity Screening of Intrathecal Oxytocin in Rats and Dogs

Yaksh, T. L., Hobo, S., Peters, C. M., Osborn, K. G., Richter, P. J., Rossi, S. S., Grafe, M. R., & Eisenach, J. C. (2014) · Anesthesiology · doi:10.1097/aln.0000000000000148 · Cited by 63 · see citing works

Bilateral Descending Hypothalamic Projections to the Spinal Trigeminal Nucleus Caudalis in Rats

Abdallah, K., Artola, A., Monconduit, L., Dallel, R., & Luccarini, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073022 · Cited by 62 · see citing works

The Analgesic Effect of Oxytocin in Humans: A Double‐Blind, Placebo‐Controlled Cross‐Over Study Using Laser‐Evoked Potentials

Paloyelis, Y., Krahé, C., Maltezos, S., Williams, S. C., Howard, M. A., & Fotopoulou, A. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12347 · Cited by 61 · see citing works

Neuroprotective Effects of Oxytocin Hormone after an Experimental Stroke Model and the Possible Role of Calpain-1

Moghadam, S. E., Tameh, A. A., Vahidinia, Z., Atlasi, M. A., Bafrani, H. H., & Naderian, H. (2017) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2017.10.020 · Cited by 60 · see citing works

Long-Lasting Spinal Oxytocin Analgesia Is Ensured by the Stimulation of Allopregnanolone Synthesis Which Potentiates GABAAReceptor-Mediated Synaptic Inhibition

Juif, P., Breton, J., Rajalu, M., Charlet, A., Goumon, Y., & Poisbeau, P. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3084-12.2013 · Cited by 58 · see citing works

The psychophysiology of music-based interventions and the experience of pain

Arnold, C. A., Bagg, M. K., & Harvey, A. R. (2024) · Frontiers in Psychology · doi:10.3389/fpsyg.2024.1361857 · Cited by 64 · see citing works

Oxytocin and analgesia: future trends

González‐Hernández, A., Rojas‐Piloni, G., & Condés‐Lara, M. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2014.09.004 · Cited by 57 · see citing works

Oxytocin Inhibits the Membrane Depolarization-Induced Increase in Intracellular Calcium in Capsaicin Sensitive Sensory Neurons: A Peripheral Mechanism of Analgesic Action

Hobo, S., Hayashida, K.-I., & Eisenach, J. C. (2012) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e31823b1bc8 · Cited by 52 · see citing works

Naturally occurring variations in maternal care modulate the effects of repeated neonatal pain on behavioral sensitivity to thermal pain in the adult offspring

Walker, C., Xu, Z., Rochford, J. M., & Johnston, C. C. (2008) · Pain · doi:10.1016/j.pain.2008.08.004 · Cited by 52 · see citing works

Pain, Parental Involvement, and Oxytocin in the Neonatal Intensive Care Unit

Filippa, M., Poisbeau, P., Mairesse, J., Monaci, M. G., Baud, O., Hüppi, P. S., Grandjean, D., & Kuhn, P. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.00715 · Cited by 56 · see citing works

The sweetest pill to swallow: how patient neurobiology can be harnessed to maximise placebo effects.

Jubb, J., & Bensing, J. (2013) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.09.006 · Cited by 57 · see citing works

Distribution and identity of neurons expressing the oxytocin receptor in the mouse spinal cord

Wrobel, L. J., Schorscher-Petcu, A., Dupré, A., Yoshida, M., Nishimori, K., & Tribollet, E. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.03.033 · Cited by 49 · see citing works

Synaptic modulation and inward current produced by oxytocin in substantia gelatinosa neurons of adult rat spinal cord slices

Jiang, C., Fujita, T., & Kumamoto, E. (2013) · Journal of Neurophysiology · doi:10.1152/jn.00609.2013 · Cited by 46 · see citing works

Oxytocin in Women’s Health and Disease

Liu, N., Yang, H.-P., Han, L., & Ma, M. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.786271 · Cited by 46 · see citing works

Oxytocin, but not vassopressin, modulates nociceptive responses in dorsal horn neurons

Rojas‐Piloni, G., Mejía-Rodríguez, R., Martı́nez-Lorenzana, G., & Condés‐Lara, M. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.03.076 · Cited by 43 · see citing works

Intranasal Oxytocin Administration is Associated With Enhanced Endogenous Pain Inhibition and Reduced Negative Mood States

Goodin, B. R., Anderson, A. J. B., Freeman, E. L., Bulls, H. W., Robbins, M. T., & Ness, T. J. (2014) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000166 · Cited by 43 · see citing works

Selective L4 Dorsal Root Ganglion Stimulation Evokes Pain Relief and Changes of Inflammatory Markers: Part I Profiling of Saliva and Serum Molecular Patterns

Gravius, N., Chaudhry, S. R., Muhammad, S., Boström, A., Gravius, S., Randau, T. M., Scheele, D., Westhofen, P., Kruppenbacher, J. P., Stoffel‐Wagner, B., et al. (2018) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.12866 · Cited by 41 · see citing works

Gentle stroking stimuli induce affiliative responsiveness to humans in male rats

Okabe, S., Takayanagi, Y., Yoshida, M., & Onaka, T. (2020) · Scientific Reports · doi:10.1038/s41598-020-66078-7 · Cited by 38 · see citing works

An oxytocinergic neural pathway that stimulates thermogenic and cardiac sympathetic outflow

Fukushima, A., Kataoka, N., & Nakamura, K. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111380 · Cited by 41 · see citing works

Analgesic strategies aimed at stimulating the endogenous production of allopregnanolone

Poisbeau, P., Keller, A. F., Aouad, M., Kamoun, N., Groyer, G., & Schumacher, M. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00174 · Cited by 35 · see citing works

Endogenous oxytocin exerts anti-nociceptive and anti-inflammatory effects in rats

Nishimura, H., Yoshimura, M., Shimizu, M., Sanada, K., Sonoda, S., Nishimura, K., Baba, K., Ikeda, N., Motojima, Y., Maruyama, T., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03879-8 · Cited by 34 · see citing works

Fluorescent Visualisation of Oxytocin in the Hypothalamo‐neurohypophysial/‐spinal Pathways After Chronic Inflammation in Oxytocin‐Monomeric Red Fluorescent Protein 1 Transgenic Rats

Matsuura, T., Kawasaki, M., Hashimoto, H., Ishikura, T., Yoshimura, M., Ohkubo, J., Maruyama, T., Motojima, Y., Sabanai, K., Mori, T., et al. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12290 · Cited by 33 · see citing works

Possible Involvement of the Rat Hypothalamo‐Neurohypophysial/‐Spinal Oxytocinergic Pathways in Acute Nociceptive Responses

Matsuura, T., Kawasaki, M., Hashimoto, H., Yoshimura, M., Motojima, Y., Saito, R., Ueno, H., Maruyama, T., Ishikura, T., Sabanai, K., et al. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12396 · Cited by 32 · see citing works

Oxytocin, GABA, and TRPV1, the Analgesic Triad?

González‐Hernández, A., & Charlet, A. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00398 · Cited by 32 · see citing works

Neuropathic Pain Up-Regulates Hypothalamo-Neurohypophysial and Hypothalamo-Spinal Oxytocinergic Pathways in Oxytocin-Monomeric Red Fluorescent Protein 1 Transgenic Rat

Nishimura, H., Kawasaki, M., Suzuki, H., Matsuura, T., Motojima, Y., Ohnishi, H., Yamanaka, Y., Yoshimura, M., Maruyama, T., Saito, R., et al. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.02.027 · Cited by 31 · see citing works

How Sex Hormones Affect Migraine: An Interdisciplinary Preclinical Research Panel Review

Godley, F. A., Meitzen, J., Nahman‐Averbuch, H., O’Neal, M. A., Yeomans, D. C., Santoro, N. F., Riggins, N., & Edvinsson, L. I. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14020184 · Cited by 30 · see citing works

Pain during menopause

Strand, N. H., D'Souza, R. S., Gomez, D. A., Whitney, M. A., Attanti, S., Anderson, M. A., Moeschler, S. M., Chadwick, A. L., & Maloney, J. A. (2024) · Maturitas · doi:10.1016/j.maturitas.2024.108135 · Cited by 30 · see citing works

Oxytocin inhibits the rat medullary dorsal horn Sp5c/C1 nociceptive transmission through OT but not V 1A receptors

García-Boll, E., Martı́nez-Lorenzana, G., Condés‐Lara, M., & González‐Hernández, A. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.11.031 · Cited by 30 · see citing works

Intranasal Oxytocin Attenuates Reactive and Ongoing, Chronic Pain in a Model of Mild Traumatic Brain Injury

Meidahl, A. C., Eisenried, A., Klukinov, M., Cao, L., Tzabazis, A., & Yeomans, D. C. (2017) · Headache The Journal of Head and Face Pain · doi:10.1111/head.13248 · Cited by 30 · see citing works

Pharmacological rescue of nociceptive hypersensitivity and oxytocin analgesia impairment in a rat model of neonatal maternal separation

Melchior, M., Juif, P., Gazzo, G., Petit-Demoulière, N., Chavant, V., Lacaud, A., Goumon, Y., Charlet, A., Lelièvre, V., & Poisbeau, P. (2018) · Pain · doi:10.1097/j.pain.0000000000001375 · Cited by 29 · see citing works

Facing the experience of pain: A neuropsychological perspective

Fabbro, F., & Crescentini, C. (2013) · Physics of Life Reviews · doi:10.1016/j.plrev.2013.12.010 · Cited by 29 · see citing works

Oxytocin activates calcium signaling in rat sensory neurons through a protein kinase C-dependent mechanism

Ayar, A., Özcan, M., Alçin, E., Serhatlioğlu, İ., Özcan, S., Kutlu, S., & Keleştimur, H. (2013) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-013-0278-z · Cited by 28 · see citing works

Sex Difference of Angiotensin IV–, LVV-Hemorphin 7–, and Oxytocin-Induced Antiallodynia at the Spinal Level in Mice With Neuropathic Pain

Chow, L., Chen, Y.-H., Lai, C., Lin, T.-Y., Chen, Y., Kao, J., & Huang, E. Y. (2018) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000002795 · Cited by 28 · see citing works

Phase 1 Safety Assessment of Intrathecal Oxytocin

Eisenach, J. C., Tong, C., & Curry, R. (2015) · Anesthesiology · doi:10.1097/aln.0000000000000539 · Cited by 25 · see citing works

Oxytocin as neuro-hormone and neuro-regulator exert neuroprotective properties: A mechanistic graphical review

Kamrani-Sharif, R., Hayes, A. W., Gholami, M., Salehirad, M., Khani, M. A., Motaghinejad, M., & Emanuele, E. (2023) · Neuropeptides · doi:10.1016/j.npep.2023.102352 · Cited by 27 · see citing works

The Comprehensive Neural Mechanism of Oxytocin in Analgesia

Yang, L., Chen, K., Yin, X., Liu, D., & Zhu, L. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210826142107 · Cited by 26 · see citing works

The story of O – is oxytocin the mediator of the placebo response?

Enck, P., & Klosterhalfen, S. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01285.x · Cited by 25 · see citing works

Oxytocin down‐regulates mesenteric afferent sensitivity via the enteric OTR / nNOS / NO /KATP pathway in rat

Li, J., Xue, B., Han, T., Huang, K., Gong, L., Ma, X., Liu, K., Cui, S., Zhang, M., Kunze, W., et al. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12469 · Cited by 25 · see citing works

Nociception, pain, neuroplasticity and the practice of Osteopathic Manipulative Medicine

Pelletier, R., Bourbonnais, D., & Higgins, J. (2017) · International journal of osteopathic medicine · doi:10.1016/j.ijosm.2017.08.001 · Cited by 26 · see citing works

The role of oxytocin, vasopressin, and their receptors at nociceptors in peripheral pain modulation

Zheng, H., Lim, J. Y., Kim, Y., Jung, S. T., & Hwang, S. W. (2021) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2021.100942 · Cited by 23 · see citing works

GABAA receptor antagonism in the ventrocaudal periaqueductal gray increases anxiety in the anxiety-resistant postpartum rat

Miller, S. M., Piasecki, C. C., Peabody, M. F., & Lonstein, J. S. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.03.007 · Cited by 22 · see citing works

Functional interactions between the paraventricular hypothalamic nucleus and raphe magnus. A comparative study of an integrated homeostatic analgesic mechanism

Condés‐Lara, M., Rojas‐Piloni, G., Martı́nez-Lorenzana, G., Diez-Martínez, D. C., & Rodríguez-Jiménez, J. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.02.032 · Cited by 23 · see citing works

A new hypothesis linking oxytocin to menstrual migraine

Bharadwaj, V. N., Porreca, F., Cowan, R. P., Kori, S. H., Silberstein, S. D., & Yeomans, D. C. (2021) · Headache The Journal of Head and Face Pain · doi:10.1111/head.14152 · Cited by 23 · see citing works

Intrathecal Oxytocin Inhibits Visceromotor Reflex and Spinal Neuronal Responses to Noxious Distention of the Rat Urinary Bladder

Engle, M., Ness, T. J., & Robbins, M. T. (2012) · Regional Anesthesia & Pain Medicine · doi:10.1097/aap.0b013e318266352d · Cited by 21 · see citing works

Oxytocin mediates neuroprotection against hypoxic-ischemic injury in hippocampal CA1 neuron of neonatal rats

Wu, Z., Xie, C., Kuang, H., Wu, J., Chen, X., Liu, H., & Liu, T. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108488 · Cited by 21 · see citing works

Paraventricular hypothalamic nucleus stimulation modulates nociceptive responses in dorsal horn wide dynamic range neurons

Condés‐Lara, M., Martı́nez-Lorenzana, G., Rodríguez-Jiménez, J., & Rojas‐Piloni, G. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.08.027 · Cited by 20 · see citing works

Oxytocin produces thermal analgesia via vasopressin-1a receptor by modulating TRPV1 and potassium conductance in the dorsal root ganglion neurons

Han, R. T., Kim, H.-B., Kim, Y., Choi, K.-M., Park, G. Y., Lee, P. R., Lee, J., Kim, H. Y., Park, C., Kang, Y., et al. (2018) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2018.22.2.173 · Cited by 19 · see citing works

Peripheral oxytocin restores light touch and nociceptor sensory afferents towards normal after nerve injury

Boada, M. D., Gutierrez, S., & Eisenach, J. C. (2019) · Pain · doi:10.1097/j.pain.0000000000001495 · Cited by 19 · see citing works

Oxytocin Is a Positive Allosteric Modulator of κ-Opioid Receptors but Not δ-Opioid Receptors in the G Protein Signaling Pathway

Miyano, K., Yoshida, Y., Hirayama, S., Takahashi, H., Ono, H., Meguro, Y., Manabe, S., Komatsu, A., Nonaka, M., Mizuguchi, T., et al. (2021) · Cells · doi:10.3390/cells10102651 · Cited by 17 · see citing works

Plasticity and Function of Spinal Oxytocin and Vasopressin Signaling during Recovery from Surgery with Nerve Injury

Severino, A. L., Chen, R., Hayashida, K., Aschenbrenner, C. A., Sun, H., Peters, C. M., Gutierrez, S., Pan, B., & Eisenach, J. C. (2018) · Anesthesiology · doi:10.1097/aln.0000000000002290 · Cited by 17 · see citing works

Recurrent antinociception induced by intrathecal or peripheral oxytocin in a neuropathic pain rat model

González‐Hernández, A., Monteros-Zúñiga, A. E. D. L., Martı́nez-Lorenzana, G., & Condés‐Lara, M. (2019) · Experimental Brain Research · doi:10.1007/s00221-019-05651-7 · Cited by 16 · see citing works

Sex-specific and social experience-dependent oxytocin–endocannabinoid interactions in the nucleus accumbens: implications for social behaviour

Borie, A. M., Young, L. J., & Liu, R. C. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0057 · Cited by 17 · see citing works

Leptin and Associated Mediators of Immunometabolic Signaling: Novel Molecular Outcome Measures for Neurostimulation to Treat Chronic Pain

Kinfe, T. M., Buchfelder, M., Chaudhry, S. R., Chakravarthy, K. V., Deer, T. R., Russo, M. A., Georgius, P., Hurlemann, R., Rasheed, M. A., Muhammad, S., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194737 · Cited by 17 · see citing works

Comparison of the induction of c- fos -eGFP and Fos protein in the rat spinal cord and hypothalamus resulting from subcutaneous capsaicin or formalin injection

Motojima, Y., Matsuura, T., Yoshimura, M., Hashimoto, H., Saito, R., Ueno, H., Maruyama, T., Sonoda, S., Suzuki, H., Kawasaki, M., et al. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.05.015 · Cited by 15 · see citing works

Genetic and epigenetic signatures associated with plasma oxytocin levels in children and adolescents with autism spectrum disorder

Siecinski, S. K., Giamberardino, S. N., Spanos, M., Hauser, A. C., Gibson, J., Chandrasekhar, T., Trelles, M. D. P., Rockhill, C., Palumbo, M. L., Cundiff, A. W., et al. (2023) · Autism Research · doi:10.1002/aur.2884 · Cited by 14 · see citing works

The neurohypophysial oxytocin and arginine vasopressin system is activated in a knee osteoarthritis rat model

Nishimura, H., Kawasaki, M., Suzuki, H., Matsuura, T., Baba, K., Motojima, Y., Yamanaka, Y., Fujitani, T., Ohnishi, H., Tsukamoto, M., et al. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12892 · Cited by 14 · see citing works

Orexin B Modulates Spontaneous Excitatory and Inhibitory Transmission in Lamina II Neurons of Adult Rat Spinal Cord

Wang, C., Fujita, T., & Kumamoto, E. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.04.048 · Cited by 14 · see citing works

Pituitary Hormones and Orofacial Pain

Dussor, G. O., Boyd, J. T., & Akopian, A. N. (2018) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2018.00042 · Cited by 15 · see citing works

The potential role of serotonergic mechanisms in the spinal oxytocin-induced antinociception

Godínez‐Chaparro, B., Martı́nez-Lorenzana, G., Rodríguez-Jiménez, J., Manzano‐García, A., Rojas‐Piloni, G., Condés‐Lara, M., & González‐Hernández, A. (2016) · Neuropeptides · doi:10.1016/j.npep.2016.07.002 · Cited by 13 · see citing works

Effects of exogenous oxytocin and atosiban antagonist on GABA in different region of brain

Thakur, P., Shrivastava, R., & Shrivastava, V. K. (2019) · IBRO Reports · doi:10.1016/j.ibror.2019.04.001 · Cited by 13 · see citing works

Can oxytocin inhibit stress-induced hyperalgesia?

Li, Y.-X., An, H. Y., Wen, Z., Tao, Z.-Y., & Cao, D. (2019) · Neuropeptides · doi:10.1016/j.npep.2019.101996 · Cited by 13 · see citing works

Neurotensin inhibits background K+ channels and facilitates glutamatergic transmission in rat spinal cord dorsal horn

Kadiri, N., Rodeau, J., Schlichter, R., & Hugel, S. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07846.x · Cited by 12 · see citing works

Up‐regulation of oxytocin receptors on peripheral sensory neurons mediates analgesia in chemotherapy‐induced neuropathic pain

Li, L., Li, P., Guo, J., Wu, Y., Zeng, Q., Li, N., Huang, X., He, Y., Ai, W., Sun, W., et al. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16042 · Cited by 12 · see citing works

Anti‐nociceptive effects of oxytocin receptor modulation in healthy volunteers–A randomized, double‐blinded, placebo‐controlled study

Manresa, J. A. B., Schliessbach, J., Vuilleumier, P. H., Müller, M., Mußhoff, F., Stamer, U. M., Stüber, F., Arendt‐Nielsen, L., & Curatolo, M. (2021) · European Journal of Pain · doi:10.1002/ejp.1781 · Cited by 11 · see citing works

Cellular Mechanisms for Antinociception Produced by Oxytocin and Orexins in the Rat Spinal Lamina II—Comparison with Those of Other Endogenous Pain Modulators

Kumamoto, E. (2019) · Pharmaceuticals · doi:10.3390/ph12030136 · Cited by 11 · see citing works

Oxytocin via oxytocin receptor excites neurons in the endopiriform nucleus of juvenile mice

Biggs, L. M., & Hammock, E. A. D. (2022) · Scientific Reports · doi:10.1038/s41598-022-15390-5 · Cited by 11 · see citing works

Correction: Bilateral Descending Hypothalamic Projections to the Spinal Trigeminal Nucleus Caudalis in Rats

Abdallah, K., Artola, A., Monconduit, L., Dallel, R., & Luccarini, P. (2013) · PLoS ONE · doi:10.1371/annotation/7c794f90-1101-4196-8b10-4e3e320a7aac · Cited by 11 · see citing works

BDNF/TrkB signaling pathway and WDR neurons: Core factors inducing central sensitization of neuropathic pain

Zhong, Y., & Huang, C. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123796 · Cited by 10 · see citing works

Profile of dorsal root ganglion neurons: study of oxytocin expression

Noguri, T., Hatakeyama, D., Kitahashi, T., Oka, K., & Ito, E. (2022) · Molecular Brain · doi:10.1186/s13041-022-00927-6 · Cited by 10 · see citing works

Ultrastructural Evidence for Oxytocin and Oxytocin Receptor at the Spinal Dorsal Horn: Mechanism of Nociception Modulation

Martı́nez-Lorenzana, G., Palma‐Tirado, L., Cifuentes-Díaz, C., González‐Hernández, A., & Condés‐Lara, M. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.09.004 · Cited by 10 · see citing works

Development of a fluorescent peptide for the highly sensitive and selective detection of oxytocin

Suzuki, Y. (2017) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2017.07.080 · Cited by 10 · see citing works

Toward Understanding Myometrial Regulation: Metabolomic Investigation Reveals New Pathways of Oxytocin and Ritodrine Activity on the Myometrium

Bafor, E. E., Rowan, E. G., & Edrada‐Ebel, R. (2016) · Reproductive Sciences · doi:10.1177/1933719116667224 · Cited by 9 · see citing works

Neurotensin Attenuates Nociception by Facilitating Inhibitory Synaptic Transmission in the Mouse Spinal Cord

Zhang, M., Feng, Y., Qiu, X.-T., Chen, T., Bai, Y., Feng, J.-M., Wang, J.-D., Chen, Y., Zhang, M., Duan, H.-K., et al. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.775215 · Cited by 9 · see citing works

Characterization of an Aplysia vasotocin signaling system and actions of posttranslational modifications and individual residues of the ligand on receptor activity

Xu, J.-P., Ding, X., Guo, S., Wang, H.-Y., Liu, W., Jiang, H.-M., Li, Y., Fu, P., Chen, P., Mei, Y.-S., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1132066 · Cited by 9 · see citing works

Presynaptic glutamatergic transmission and feedback system of oxytocinergic neurons in the hypothalamus of a rat model of adjuvant arthritis

Fujitani, T., Matsuura, T., Kawasaki, M., Suzuki, H., Nishimura, H., Baba, K., Yamanaka, Y., Ohnishi, H., Ueta, Y., & Sakai, A. (2020) · Molecular Pain · doi:10.1177/1744806920943334 · Cited by 8 · see citing works

Hypothalamospinal oxytocinergic antinociception is mediated by GABAergic and opiate neurons that reduce A-delta and C fiber primary afferent excitation of spinal cord cells

Condés‐Lara, M., Rojas‐Piloni, G., Martı́nez-Lorenzana, G., López-Hidalgo, M. A., & Rodríguez-Jiménez, J. (2008) · Brain Research · doi:10.1016/j.brainres.2008.10.030 · Cited by 71 · see citing works

Molecular Pain BioMed Central

Vergnano, A. M., Freund‐Mercier, M. J., Schlichter, R., & Poisbeau, P. (2008)

Actions of oxytocin on rat spinal dorsal horn lamina II neurons - cellular mechanisms for antinociception

Jiang, C., Fujita, T., Xu, Z.-H., Ohtsubo, S., Matsushita, A., & Kumamoto, E. (2014) · PAIN RESEARCH · doi:10.11154/pain.29.215

Cellular Mechanisms for Antinociception Produced by Oxytocin and Orexins in the Rat Spinal Lamina II—Comparison with Those of Other Endogenous Pain Modulators

Kumamoto, E. (2019) · Pharmaceuticals · doi:10.3390/ph12030136 · Cited by 11 · see citing works

Antinociceptive Action of Oxytocin Involves Inhibition of Potassium Channel Currents in Lamina Ii Neurons of the Rat Spinal Cord

Breton, J., Poisbeau, P., & Darbon, P. (2009) · Molecular Pain · doi:10.1186/1744-8069-5-63 · Cited by 63 · see citing works