Neuromodulation by Oxytocin and Vasopressin

Stoop, Ron

doi:10.1016/j.neuron.2012.09.025

Cited by 506Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

Neuromodulation by Oxytocin and Vasopressin

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Stoop, Ron·2012·Neuron

DOI 10.1016/j.neuron.2012.09.025

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Abstract

Oxytocin (OT) and vasopressin (VP) are two closely related neuropeptides, widely known for their peripheral hormonal effects. Specific receptors have also been found in the brain, where their neuromodulatory actions have meanwhile been described in a large number of regions. Recently, it has become possible to study their endogenous neuropeptide release with the help of OT/VP promoter-driven expression of fluorescent proteins and light-activated ion channels. In this review, I summarize the neuromodulatory effects of OT and VP in different brain regions by grouping these into different behavioral systems, highlighting their concerted, and at times opposite, effects on different aspects of behavior.

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Despite similar chemical structures of OT, AVP, and their receptors, the two peptides can have distinct or even opposing roles in many behavioral and physiological functions.
“Although the chemical structures of OT and AVP as well as their receptors are quite similar, OT and AVP can have distinct or even opposing actions.”
From Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery (2018) · cites this paper as [5]
The amygdala has a sexually dimorphic distribution and expression of oxytocin receptors in nonprimate mammals.
“The amygdala has a sexually dimorphic distribution and expression of OXT receptors in nonprimate mammals (12, 13)”
From Oxytocin, the peptide that bonds the sexes also divides them (2016) · cites this paper as [12]
The change from Leu8-OT to Pro8-OT has been identified as a more dramatic change in the molecular architecture of OT than the change from mesotocin to consensus mammalian OT, with the potential for significant functional changes in the mechanisms of OT binding and signaling.
“The change from Leu8-OT to Pro8-OT has been identified as a more dramatic change in the molecular architecture of OT than the change from mesotocin to consensus mammalian OT (in which Isoleucine in replaced by Leucine at position 8; Stoop, 2012), with the potential for significant functional changes in the mechanisms of OT binding and signaling.”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Stoop, 2012
The PVN receives projections from both MeA Ucn3 and CRF-R2 cells.
“For example, the PVN, which we found received projections from both the MeA Ucn3 and CRF-R2 cells, is a region producing and secreting arginine vasopressin and oxytocin 26 .”
From Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics (2016) · cites this paper as [26]
The PVN produces and secretes arginine vasopressin and oxytocin.
“For example, the PVN, which we found received projections from both the MeA Ucn3 and CRF-R2 cells, is a region producing and secreting arginine vasopressin and oxytocin 26 .”
From Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics (2016) · cites this paper as [26]

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Authors: Stoop, R.
Affiliations: Centre Hospitalier Universitaire Vaudois (CH)
Corresponding author: Stoop, Ron
ORCID: Stoop, Ron
Venue: Neuron
Publisher: Elsevier BV
Published: 2012-10
Volume: 76
Issue: 1
Pages: 142-159
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2012.09.025
OpenAlex: W2045659750
Cited by: 506
References: 155
Citations by year: 2026: 26 · 2025: 18 · 2024: 20 · 2023: 24 · 2022: 33 · 2021: 47 · 2020: 64 · 2019: 38 · 2018: 47 · 2017: 46 · 2016: 39 · 2015: 31 · 2014: 38 · 2013: 35
FWCI: 4.71
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 368 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
IRIS (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Topics: Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: oxytocin, vasopressin, neuromodulation, neuropeptide receptors, brain regions, behavior, fluorescent protein reporter, light-activated ion channels
MeSH terms: Animals, Brain, Humans, Oxytocin, Vasopressins, Neurotransmitter Agents

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Neuromodulation by Oxytocin and Vasopressin

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