Role of the Wnt receptor Frizzled-1 in presynaptic differentiation and function
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BACKGROUND: The Wnt signaling pathway regulates several fundamental developmental processes and recently has been shown to be involved in different aspects of synaptic differentiation and plasticity. Some Wnt signaling components are localized at central synapses, and it is thus possible that this pathway could be activated at the synapse. RESULTS: We examined the distribution of the Wnt receptor Frizzled-1 in cultured hippocampal neurons and determined that this receptor is located at synaptic contacts co-localizing with presynaptic proteins. Frizzled-1 was found in functional synapses detected with FM1-43 staining and in synaptic terminals from adult rat brain. Interestingly, overexpression of Frizzled-1 increased the number of clusters of Bassoon, a component of the active zone, while treatment with the extracellular cysteine-rich domain (CRD) of Frizzled-1 decreased Bassoon clustering, suggesting a role for this receptor in presynaptic differentiation. Consistent with this, treatment with the Frizzled-1 ligand Wnt-3a induced presynaptic protein clustering and increased functional presynaptic recycling sites, and these effects were prevented by co-treatment with the CRD of Frizzled-1. Moreover, in synaptically mature neurons Wnt-3a was able to modulate the kinetics of neurotransmitter release. CONCLUSION: Our results indicate that the activation of the Wnt pathway through Frizzled-1 occurs at the presynaptic level, and suggest that the synaptic effects of the Wnt signaling pathway could be modulated by local activation through synaptic Frizzled receptors.
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Frizzled-mediated Wnt/β-catenin signaling plays an important role in synaptic plasticity.
“Frizzled-mediated Wnt/β-catenin signaling has been shown to play an important role in synaptic plasticity (Chen et al., 2006; Varela-Nallar et al., 2010; Varela-Nallar et al., 2009).”
From The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease (2011) · cites this paper as Varela-Nallar et al., 2009
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Genetics in the Pathogenesis and Treatment of Panic and Anxiety
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- Authors
- Varela-Nallar, L., Grabowski, C. P., Alfaro, I. E., Alvarez, A. R., & Inestrosa, N. C.
- Affiliations
- Pontificia Universidad Católica de Chile (CL)
- Corresponding author
- Inestrosa, Nibaldo C
- Venue
- Neural Development
- Published
- 2009-11-02
- Volume
- 4
- Issue
- 1
- Pages
- 41-41
- ISSN
- 1749-8104 (ISSN-L)
- PMC
- PMC2779803
- OpenAlex
- W2129879090
- Cited by
- 97
- References
- 44
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 3 · 2018: 9 · 2017: 3 · 2016: 9 · 2015: 10 · 2014: 12 · 2013: 15 · 2012: 5
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Neural Development (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Americanae (AECID Library) (submittedVersion, cc-by-nc-nd)
- Americanae (AECID Library) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-nd)
- Funders
- University of Washington
- Comisión Nacional de Investigación Científica y Tecnológica
- National Cancer Institute
- Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- Frizzled-1, Wnt signaling, presynaptic differentiation, synaptic plasticity, bassoon, active zone, Wnt3a, cysteine-rich domain, hippocampal neurons, presynaptic proteins
- MeSH terms
- Aging, Animals, Cell Differentiation, Cells, Cultured, Hippocampus, Kinetics, Neurons, Synapses, Synaptic Vesicles, Synaptosomes, Signal Transduction, Rats, Sprague-Dawley, Presynaptic Terminals, Receptors, Neurotransmitter, Neurotransmitter Agents, Receptors, G-Protein-Coupled, Wnt Proteins, Frizzled Receptors, Rats, Wnt3 Protein
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