WNT signaling in neuronal maturation and synaptogenesis

The Wnt Signaling Pathway in Development and Disease

Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325 · see citing works

Neuropathological alterations in Alzheimer disease

Serrano-Pozo, A., Frosch, M. P., Masliah, E., & Hyman, B. T. (2011) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006189 · Cited by 3,345 · see citing works

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

Harold, D., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Hamshere, M. L., Pahwa, J. S., Moskvina, V., Dowzell, K., Williams, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.440 · Cited by 3,326 · see citing works

Pathways towards and Away from Alzheimer’s Disease

Mattson, M. P. (2004) · Nature · doi:10.1038/nature02621 · Cited by 3,052 · see citing works

Trk Receptors: Roles in Neuronal Signal Transduction

Huang, E. J., & Reichardt, L. F. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161629 · Cited by 2,537 · see citing works

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

the European Alzheimer's Disease Initiative Investigators, Lambert, J.-C., Heath, S., Even, G., Campion, D., Sleegers, K., Hiltunen, M., Combarros, O., Zelenika, D., Bullido, M. J., et al. (2009) · Nature Genetics · doi:10.1038/ng.439 · Cited by 2,234 · see citing works

MECHANISMS OF WNT SIGNALING IN DEVELOPMENT

Wodarz, A., & Nusse, R. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.59 · Cited by 2,017 · see citing works

The establishment of polarity by hippocampal neurons in culture.

Dotti, C., Sullivan, C., & Banker, G. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-04-01454.1988 · Cited by 1,862 · see citing works

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

Palop, J. J., & Mucke, L. (2010) · Nature Neuroscience · doi:10.1038/nn.2583 · Cited by 1,651 · see citing works

Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

Glinka, A., Wu, W., Delius, H., Monaghan, A. P., Blumenstock, C., & Niehrs, C. (1998) · Nature · doi:10.1038/34848 · Cited by 1,608 · see citing works

Natural Oligomers of the Alzheimer Amyloid-β Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway

Shankar, G. M., Bloodgood, B. L., Townsend, M., Walsh, D. M., Selkoe, D. J., & Sabatini, B. L. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4970-06.2007 · Cited by 1,592 · see citing works

Wnt Signaling: Multiple Pathways, Multiple Receptors, and Multiple Transcription Factors

Gordon, M. D., & Nusse, R. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.r600015200 · Cited by 1,333 · see citing works

Towards an integrated view of Wnt signaling in development

van Amerongen, R., & Nusse, R. (2009) · Development · doi:10.1242/dev.033910 · Cited by 1,168 · see citing works

Microtubule assembly, organization and dynamics in axons and dendrites

Conde, C., & Cáceres, A. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2631 · Cited by 1,086 · see citing works

Epidemiology of Alzheimer DiseasePreprint

Mayeux, R. P., & Stern, Y. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006239 · Cited by 1,070 · see citing works

Abnormal dendritic spines in fragile X knockout mice: Maturation and pruning deficits

Comery, T. A., Harris, J. B., Willems, P. J., Oostra, B. A., Irwin, S. A., Weiler, I. J., & Greenough, W. T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5401 · Cited by 1,046 · see citing works

Neurotrophins regulate dendritic growth in developing visual cortex

McAllister, A. K., Lo, D. C., & Katz, L. C. (1995) · Neuron · doi:10.1016/0896-6273(95)90171-x · Cited by 959 · see citing works

Decreased nuclear β‐catenin, tau hyperphosphorylation and neurodegeneration in GSK‐3β conditional transgenic mice

Lucas, J. J., Hernández, F., Gómez‐Ramos, P., Morán, M. A., Hen, R., & Avila, J. (2001) · The EMBO Journal · doi:10.1093/emboj/20.1.27 · Cited by 903 · see citing works

Dishevelled: The hub of Wnt signaling

Gao, C., & Chen, Y. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.11.021 · Cited by 751 · see citing works

Dendritic Anomalies in Disorders Associated with Mental Retardation

Kaufmann, W. E. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.10.981 · Cited by 733 · see citing works

The Journal of Neurosci

(2014) · doi:10.1523/jneurosci · Cited by 715 · see citing works

Serine Phosphorylation-regulated Ubiquitination and Degradation of β-Catenin

Orford, K. W., Crockett, C., Jensen, J. P., Weissman, A. M., & Byers, S. W. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.40.24735 · Cited by 714 · see citing works

Semaphorin 3A is a chemoattractant for cortical apical dendrites

Polleux, F., Morrow, T. A., & Ghosh, A. (2000) · Nature · doi:10.1038/35007001 · Cited by 699 · see citing works

Axonal Remodeling and Synaptic Differentiation in the Cerebellum Is Regulated by WNT-7a Signaling

Hall, A. C., Lucas, F. R., & Salinas, P. C. (2000) · Cell · doi:10.1016/s0092-8674(00)80689-3 · Cited by 687 · see citing works

Neuronal Polarity

Craig, A. M., & Banker, G. A. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.001411 · Cited by 678 · see citing works

WNTS in the vertebrate nervous system: from patterning to neuronal connectivity

Ciani, L., & Salinas, P. C. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1665 · Cited by 631 · see citing works

Emerging roles of Wnts in the adult nervous system

Inestrosa, N. C., & Arenas, E. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2755 · Cited by 611 · see citing works

β-Amyloid fibrils induce tau phosphorylation and loss of microtubule binding

Busciglio, J., Lorenzo, A., Yeh, J., & Yankner, B. A. (1995) · Neuron · doi:10.1016/0896-6273(95)90232-5 · Cited by 595 · see citing works

Opposing Roles for Endogenous BDNF and NT-3 in Regulating Cortical Dendritic Growth

McAllister, A. K., Katz, L. C., & Lo, D. C. (1997) · Neuron · doi:10.1016/s0896-6273(00)80316-5 · Cited by 570 · see citing works

NGF-Induced Axon Growth Is Mediated by Localized Inactivation of GSK-3β and Functions of the Microtubule Plus End Binding Protein APC

Zhou, F., Zhou, J., Dedhar, S., Wu, Y.-H., & Snider, W. D. (2004) · Neuron · doi:10.1016/j.neuron.2004.05.011 · Cited by 528 · see citing works

Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

Zhang, Z., Hartmann, H., Do, V. M., Abramowski, D., Sturchler, C., Staufenbiel, M., Sommer, B., van de Wetering, M., Clevers, H. C., Säftig, P., et al. (1998) · Nature · doi:10.1038/27208 · Cited by 511 · see citing works

Dendritic arbor development and synaptogenesis

Cline, H. T. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00182-3 · Cited by 499 · see citing works

Regulation of Dendritic Growth and Remodeling by Rho, Rac, and Cdc42

Threadgill, R., Bobb, K., & Ghosh, A. (1997) · Neuron · doi:10.1016/s0896-6273(00)80376-1 · Cited by 492 · see citing works

Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development

Rosso, S. B., Sussman, D., Wynshaw-Boris, A., & Salinas, P. C. (2005) · Nature Neuroscience · doi:10.1038/nn1374 · Cited by 485 · cited 10× · see citing works

Activity-dependent dendritic arborization mediated by CaM-kinase I activation and enhanced CREB-dependent transcription of Wnt-2

Wayman, G. A., Impey, S., Marks, D., Saneyoshi, T., Grant, W. F., Derkach, V., & Soderling, T. R. (2006) · Neuron · doi:10.1016/j.neuron.2006.05.008 · Cited by 466 · see citing works

Distribution of Active Glycogen Synthase Kinase 3β (GSK-3β) in Brains Staged for Alzheimer Disease Neurofibrillary Changes

Pei, J.-J., Braak, E., Braak, H., Grundke-Iqbal, I., Iqbal, K., Winblad, B., & Cowburn, R. F. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199909000-00011 · Cited by 459 · see citing works

β-catenin is critical for dendritic morphogenesis

Yu, X., & Malenka, R. C. (2003) · Nature Neuroscience · doi:10.1038/nn1132 · Cited by 454 · see citing works

Morphogens, their identification and regulation

Tabata, T., & Takei, Y. (2004) · Development · doi:10.1242/dev.01043 · Cited by 447 · see citing works

Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3β phosphorylation

Zumbrunn, J., Kinoshita, K., Hyman, A. A., & Näthke, I. S. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00002-1 · Cited by 438 · see citing works

Three decades of Wnts: a personal perspective on how a scientific field developed

Nusse, R., & VARMUS, H. E. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.146 · Cited by 412 · see citing works

The Drosophila Wnt, Wingless, Provides an Essential Signal for Pre- and Postsynaptic Differentiation

Packard, M. C., Koo, E. S., Gorczyca, M. G., Sharpe, J., Cumberledge, S., & Budnik, V. (2002) · Cell · doi:10.1016/s0092-8674(02)01047-4 · Cited by 410 · see citing works

Induction of Dickkopf-1, a Negative Modulator of the Wnt Pathway, Is Associated with Neuronal Degeneration in Alzheimer's Brain

Caricasole, A., Copani, A., Caraci, F., Aronica, E., Rozemüller, A. J. M., Caruso, A., Storto, M., Gaviraghi, G., Terstappen, G. C., & Nicoletti, F. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1381-04.2004 · Cited by 394 · see citing works

Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity.

Takashima, A., Noguchi, K., Sato, K., Hoshino, T., & Imahori, K. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.16.7789 · Cited by 381 · see citing works

JNK1 Is Required for Maintenance of Neuronal Microtubules and Controls Phosphorylation of Microtubule-Associated Proteins

Chang, L., Jones, Y., Ellisman, M. H., Goldstein, L. S. B., & Karin, M. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00094-7 · Cited by 375 · see citing works

Spatial learning deficit in transgenic mice that conditionally over‐express GSK‐3β in the brain but do not form tau filaments

Hernández, F., Borrell, J., Guaza, C., Avila, J., & Lucas, J. J. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01269.x · Cited by 372 · see citing works

CaMKIIβ Functions As an F-Actin Targeting Module that Localizes CaMKIIα/β Heterooligomers to Dendritic Spines

Shen, K., Teruel, M. N., Subramanian, K., & Meyer, T. (1998) · Neuron · doi:10.1016/s0896-6273(00)80569-3 · Cited by 350 · see citing works

Glycogen synthase kinase‐3 inhibition is integral to long‐term potentiation

Hooper, C., Markevich, V. A., Plattner, F., Killick, R., Schofield, E., Engel, T., Hernández, F., Anderton, B. H., Rosenblum, K., Bliss, T., et al. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05245.x · Cited by 345 · see citing works

Control of β-Catenin Stability

Salic, A., Lee, E., Mayer, L., & Kirschner, M. W. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80446-3 · Cited by 335 · see citing works

Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by β-amyloid fibrils

Ferrari, G. V. D., Chacón, M. A., Barría, M. I., Garrido, J., Godoy, J. A., Olivares, G. H., Reyes, A. E., Alvarez, A. R., Bronfman, M., & Inestrosa, N. C. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001208 · Cited by 331 · see citing works

Selective Regulation of Neurite Extension and Synapse Formation by the β but not the α Isoform of CaMKII

Fink, C. C., Bayer, K.-U., Myers, J. W., Ferrell, J. E., Schulman, H., & Meyer, T. (2003) · Neuron · doi:10.1016/s0896-6273(03)00428-8 · Cited by 328 · see citing works

Nuclear Notch1 signaling and the regulation of dendritic development

Redmond, L., Oh, S.-R., Hicks, C. D., Weinmaster, G., & Ghosh, A. (2000) · Nature Neuroscience · doi:10.1038/71104 · Cited by 313 · see citing works

The Control of Dendrite Development

Jan, Y. N., & Jan, L. Y. (2003) · Neuron · doi:10.1016/s0896-6273(03)00631-7 · Cited by 313 · see citing works

Inhibition of GSK-3β leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium

Lucas, F. R., Goold, R., Gordon‐Weeks, P. R., & Salinas, P. C. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.10.1351 · Cited by 301 · see citing works

Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation

Chen, J., Park, C. S., & Tang, S.-J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511920200 · Cited by 298 · see citing works

How do dendrites take their shape?

Scott, E. K., & Luo, L. (2001) · Nature Neuroscience · doi:10.1038/86006 · Cited by 292 · see citing works

Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1ΔE9 mouse model of Alzheimer's disease

Toledo, E. M., & Inestrosa, N. C. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.72 · Cited by 290 · see citing works

Wnt signaling function in Alzheimer’s disease

Ferrari, G. V. D., & Inestrosa, N. C. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00021-7 · Cited by 288 · see citing works

Regulation of Cortical Dendrite Development by Slit-Robo Interactions

Whitford, K. L., Marillat, V., Stein, E., Goodman, C. S., Tessier‐Lavigne, M., Chédotal, A., & Ghosh, A. (2002) · Neuron · doi:10.1016/s0896-6273(01)00566-9 · Cited by 277 · see citing works

Lithium protects cultured neurons against β‐amyloid‐induced neurodegeneration

Alvarez, G., Muñoz-Montaño, J. R., Satrústegui, J., Ávila, J., Bogónez, E., & Díaz‐Nido, J. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00685-7 · Cited by 270 · see citing works

Common genetic variation within the Low-Density Lipoprotein Receptor-Related Protein 6 and late-onset Alzheimer's disease

Ferrari, G. V. D., Papassotiropoulos, A., Biechele, T. L., DeVriéze, F. W., Ávila, M. E., Major, M. B., Myers, A., Sáez, K. L., Henríquez, J. P., Zhao, A. S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603523104 · Cited by 266 · see citing works

Molecular Control of Cortical Dendrite Development

Whitford, K. L., Dijkhuizen, P. A., Polleux, F., & Ghosh, A. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142932 · Cited by 266 · see citing works

Wnt signaling during synaptic development and plasticity

Budnik, V., & Salinas, P. C. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.12.002 · Cited by 264 · see citing works

Amyloid-β Binds to the Extracellular Cysteine-rich Domain of Frizzled and Inhibits Wnt/β-Catenin Signaling

Magdesian, M. H., Carvalho, M., Mendes, F. A., Saraiva, L. M., Juliano, M. A., Juliano, L., Garcia-Abreu, J., & Ferreira, S. T. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707108200 · Cited by 251 · see citing works

Signaling Mechanisms Underlying Reversible, Activity-Dependent Dendrite Formation

Vaillant, A., Zanassi, P., Walsh, G. S., Aumont, A., Alonso, Á., & Miller, F. D. (2002) · Neuron · doi:10.1016/s0896-6273(02)00717-1 · Cited by 242 · see citing works

Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release

Ahmad‐Annuar, A., Ciani, L., Simeonidis, I., Herreros, J., Fredj, N. B., Rosso, S. B., Hall, A. C., Brickley, S. G., & Salinas, P. C. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200511054 · Cited by 233 · see citing works

Phosphorylation of tau antagonizes apoptosis by stabilizing β-catenin, a mechanism involved in Alzheimer's neurodegeneration

Li, H.-L., Wang, H.-H., Liu, S.-J., Deng, Y.-Q., Zhang, Y.-J., Tian, Q., Wang, X.-C., Chen, X., Yang, Y., Zhang, J.-Y., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609303104 · Cited by 225 · see citing works

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt–PCP–JNK pathway

Killick, R., Ribe, E. M., Al-Shawi, R., Malik, B., Hooper, C., Fernandes, C., Dobson, R., Nolan, P. M., Lourdusamy, A., Furney, S., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2012.163 · Cited by 222 · see citing works

Dishevelled promotes axon differentiation by regulating atypical protein kinase C

Zhang, X., Zhu, J., Yang, G.-Y., Wang, Q.-J., Qian, L., Chen, Y.-M., Chen, F., Tao, Y., Hu, H.-S., Wang, T., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1603 · Cited by 220 · see citing works

A divergent canonical WNT-signaling pathway regulates microtubule dynamics

Ciani, L., Krylova, O. Y., Smalley, M. J., Dale, T. C., & Salinas, P. C. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200309096 · Cited by 217 · see citing works

Wnt-7a Modulates the Synaptic Vesicle Cycle and Synaptic Transmission in Hippocampal Neurons*

Cerpa, W., Godoy, J., Alfaro, I. E., Farías, G., Metcalfe, M., Fuentealba, R., Bonansco, C., & Inestrosa, N. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m705943200 · Cited by 216 · see citing works

Wnt signaling in neuroprotection and stem cell differentiation

Toledo, E. M., Colombres, M., & Inestrosa, N. C. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.08.001 · Cited by 211 · see citing works

Wnt-3a overcomes β-amyloid toxicity in rat hippocampal neurons

Alvarez, A. R., Godoy, J. A., Müllendorff, K., Olivares, G. H., Bronfman, M., & Inestrosa, N. C. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.02.028 · Cited by 211 · see citing works

Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca 2+ /Calmodulin-dependent protein kinase II

Ciani, L., Boyle, K. A., Dickins, E. M., Sahores, M., Anane, D., Lopes, D. M., Gibb, A. J., & Salinas, P. C. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018132108 · Cited by 209 · see citing works

The role of Wnt signaling in neuronal dysfunction in Alzheimer's Disease

Inestrosa, N. C., & Toledo, E. M. (2008) · Molecular Neurodegeneration · doi:10.1186/1750-1326-3-9 · Cited by 206 · see citing works

Wnt-5a/JNK Signaling Promotes the Clustering of PSD-95 in Hippocampal Neurons

Farı́as, G. G., Alfaro, I. E., Cerpa, W. F., Grabowski, C. P., Godoy, J. A., Bonansco, C., & Inestrosa, N. C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808986200 · Cited by 200 · see citing works

WNT-3, Expressed by Motoneurons, Regulates Terminal Arborization of Neurotrophin-3-Responsive Spinal Sensory Neurons

Krylova, O. Y., Herreros, J., Cleverley, K., Ehler, E., Henríquez, J. P., Hughes, S. M., & Salinas, P. C. (2002) · Neuron · doi:10.1016/s0896-6273(02)00860-7 · Cited by 199 · see citing works

Wingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses

Varela-Nallar, L., Alfaro, I. E., Serrano, F. G., Parodi, J., & Inestrosa, N. C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010011107 · Cited by 197 · see citing works

The secreted Wnt antagonist Dickkopf-1 is required for amyloid β-mediated synaptic loss

Purro, S. A., Dickins, E. M., & Salinas, P. C. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.4562-11.2012 · Cited by 195 · see citing works

Peroxisome proliferator-activated receptor γ is expressed in hippocampal neurons and its activation prevents β-amyloid neurodegeneration: role of Wnt signaling

Inestrosa, N. C., Godoy, J. A., Quintanilla, R. A., KOENIG, C., & Bronfman, M. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.09.032 · Cited by 187 · see citing works

Wnt Signaling: Role in Alzheimer Disease and Schizophrenia

Inestrosa, N. C., Montecinos-Oliva, C., & Fuenzalida, M. (2012) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-012-9417-5 · Cited by 186 · see citing works

C. elegans LIN-18 Is a Ryk Ortholog and Functions in Parallel to LIN-17/Frizzled in Wnt Signaling

Inoue, T., Oz, H. S., Wiland, D., Gharib, S., Deshpande, R., Hill, R. J., Katz, W. S., & Sternberg, P. W. (2004) · Cell · doi:10.1016/j.cell.2004.09.001 · Cited by 183 · see citing works

Constitutively Active Cytoplasmic c-Jun N-Terminal Kinase 1 Is a Dominant Regulator of Dendritic Architecture: Role of Microtubule-Associated Protein 2 as an Effector

Björkblom, B., Östman, N., Hongisto, V., Komarovski, V., Filén, J., Nyman, T. A., Kallunki, T., Courtney, M. J., & Coffey, E. T. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1517-05.2005 · Cited by 182 · see citing works

Wnt genes and vertebrate development

Parr, B. A., & McMahon, A. P. (1994) · Current Opinion in Genetics & Development · doi:10.1016/0959-437x(94)90067-d · Cited by 173 · see citing works

Wnt Regulates Axon Behavior through Changes in Microtubule Growth Directionality: A New Role for Adenomatous Polyposis Coli

Purro, S. A., Ciani, L., Flight, M. H., Stamatakou, E., Siomou, E., & Salinas, P. C. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2320-08.2008 · Cited by 171 · see citing works

Increased Dickkopf‐1 expression in transgenic mouse models of neurodegenerative disease

Rosi, M. C., Luccarini, I., Grossi, C., Fiorentini, A., Spillantini, M. G., Prisco, A., Scali, C., Gianfriddo, M., Caricasole, A., Terstappen, G. C., et al. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06566.x · Cited by 167 · see citing works

Protein kinase C inhibits amyloid β‐peptide neurotoxicity by acting on members of the Wnt pathway

Garrido, J., Godoy, J. A., Alvarez, A. R., Bronfman, M., & Inestrosa, N. C. (2002) · The FASEB Journal · doi:10.1096/fj.02-0327fje · Cited by 163 · see citing works

Synaptic adhesion molecules and PSD-95

Han, K., & Kim, E. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.10.011 · Cited by 163 · see citing works

Signaling mechanisms underlying dendrite formation

Miller, F. D., & Kaplan, D. R. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00072-2 · Cited by 160 · see citing works

Regulation of NMDA-Receptor Synaptic Transmission by Wnt Signaling

Cerpa, W. F., Gambrill, A. C., Inestrosa, N. C., & Barría, A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6311-10.2011 · Cited by 147 · see citing works

Members of the Wnt, Fz, and Frp gene families expressed in postnatal mouse cerebral cortex

Shimogori, T., VanSant, J., Paik, E. K., & Grove, E. A. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20135 · Cited by 137 · see citing works

Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation

Davis, E. K., Zou, Y., & Ghosh, A. (2008) · Neural Development · doi:10.1186/1749-8104-3-32 · Cited by 135 · see citing works

Neuronal microtubules: when the MAP is the roadblock

Baas, P. W., & Qiang, L. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.02.001 · Cited by 131 · see citing works

Wnt signaling promotes AChR aggregation at the neuromuscular synapse in collaboration with agrin

Henríquez, J. P., Webb, A., Bence, M., Bildsoe, H., Sahores, M., Hughes, S. M., & Salinas, P. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806300105 · Cited by 129 · see citing works

Fragile X mental retardation protein control of neuronal mRNA metabolism: Insights into mRNA stability

De Rubeis, S., & Bagni, C. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.09.013 · Cited by 126 · see citing works

Wnt-5a Modulates Recycling of Functional GABAA Receptors on Hippocampal Neurons

Cuitiño, L., Godoy, J. A., Farı́as, G. G., Couve, A., Bonansco, C., Fuenzalida, M., & Inestrosa, N. C. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5736-09.2010 · Cited by 125 · see citing works

Dishevelled-1 Regulates Microtubule Stability

Krylova, O. Y., Messenger, M. J., & Salinas, P. C. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.1.83 · Cited by 120 · see citing works

Wnt-5aoccludes Aβ oligomer-induced depression of glutamatergic transmission in hippocampal neurons

Cerpa, W. F., Farı́as, G. G., Godoy, J. A., Fuenzalida, M., Bonansco, C., & Inestrosa, N. C. (2010) · Molecular Neurodegeneration · doi:10.1186/1750-1326-5-3 · Cited by 118 · see citing works

Trolox and 17β-Estradiol Protect against Amyloid β-Peptide Neurotoxicity by a Mechanism That Involves Modulation of the Wnt Signaling Pathway

Quintanilla, R. A., Muñoz, F. J., Metcalfe, M., Hitschfeld, M., Olivares, G. H., Godoy, J. A., & Inestrosa, N. C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411936200 · Cited by 113 · see citing works

Wnt-7a Induces Presynaptic Colocalization of α7-Nicotinic Acetylcholine Receptors and Adenomatous Polyposis Coli in Hippocampal Neurons

Farías, G. G., Vallés, A. S., Colombres, M., Godoy, J. A., Toledo, E. M., Lukas, R. J., Barrantes, F. J., & Inestrosa, N. C. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3934-06.2007 · Cited by 108 · see citing works

WNTs in synapse formation and neuronal circuitry

Park, M., & Shen, K. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.145 · Cited by 106 · see citing works

Microtubule‐associated protein 1B function during normal development, regeneration, and pathological conditions in the nervous system

González-Billault, C. E., Jimenez-Mateos, E. M., Cáceres, A., Díaz‐Nido, J., Wandosell, F. G., & Ávila, J. (2003) · Journal of Neurobiology · doi:10.1002/neu.10283 · Cited by 104 · see citing works

Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells

Caruso, A., Motolese, M., Iacovelli, L., Caraci, F., Copani, A., Nicoletti, F., Terstappen, G. C., Gaviraghi, G., & Caricasole, A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03867.x · Cited by 101 · see citing works

Role of the Wnt receptor Frizzled-1 in presynaptic differentiation and function

Varela-Nallar, L., Grabowski, C. P., Alfaro, I. E., Alvarez, A. R., & Inestrosa, N. C. (2009) · Neural Development · doi:10.1186/1749-8104-4-41 · Cited by 97 · see citing works

Wnt-3a and Dickkopf-1 Stimulate Neurite Outgrowth in Ewing Tumor Cells via a Frizzled3- and c-Jun N-Terminal Kinase-Dependent Mechanism

Endo, Y., Beauchamp, E. M., Woods, D. M., Taylor, W. G., Toretsky, J. A., Üren, A., & Rubin, J. S. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01780-07 · Cited by 97 · see citing works

Frizzled‐1 is involved in the neuroprotective effect of Wnt3a against Aβ oligomers

Chacón, M. A., Varela‐Nallar, L., & Inestrosa, N. C. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21497 · Cited by 87 · see citing works

Wnt5a Mediates Nerve Growth Factor-Dependent Axonal Branching and Growth in Developing Sympathetic Neurons

Bodmer, D., Levine‐Wilkinson, S., Richmond, A. J., Hirsh, S., & Kuruvilla, R. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1445-09.2009 · Cited by 86 · see citing works

Wnt/β-Catenin Signaling Suppresses Rapsyn Expression and Inhibits Acetylcholine Receptor Clustering at the Neuromuscular Junction

Wang, J., Ruan, N.-J., Qian, L., Lei, W., Chen, F., & Luo, Z. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709939200 · Cited by 85 · see citing works

Insulin, IGF-1 and GLP-1 signaling in neurodegenerative disorders: targets for disease modification?

Bassil, F., Fernagut, P., Bézard, E., et al. (2014) · HAL (Le Centre pour la Communication Scientifique Directe) · doi:10.1016/j.pneurobio · Cited by 82 · see citing works

Wnt signaling involvement in β-amyloid-dependent neurodegeneration

Inestrosa, N. C., Ferrari, G. V. D., Garrido, J. L. V., Alvarez, A. R., Olivares, G. H., Barría, M. I., Bronfman, M., & Chacón, M. A. (2002) · Neurochemistry International · doi:10.1016/s0197-0186(02)00056-6 · Cited by 80 · see citing works

Acetylcholinesterase-amyloid-β-peptide interaction and Wnt signaling involvement in Aβ neurotoxicity

Inestrosa, N. C., Alvarez, A. R., Godoy, J. A., et al. (2000) · Acta Neurologica Scandinavica · doi:10.1034/j.1600-0404.2000.00308.x · Cited by 72 · see citing works

Microtubule Stabilization by Bone Morphogenetic Protein Receptor-Mediated Scaffolding of c-Jun N-Terminal Kinase Promotes Dendrite Formation

Podkowa, M., Zhao, X., Chow, C.-W., Coffey, E. T., Davis, R. J., & Attisano, L. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01166-09 · Cited by 71 · see citing works

Canonical Wnt3a Modulates Intracellular Calcium and Enhances Excitatory Neurotransmission in Hippocampal Neurons

Ávila, M. E., Sepúlveda, F. J., Burgos, C. F., Moraga‐Cid, G., Parodí, J., Moon, R. T., Aguayo, L. G., Opazo, C., & Ferrari, G. V. D. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.103028 · Cited by 68 · see citing works

The Wnt5/Planar Cell Polarity Pathway Regulates Axonal Development of theDrosophilaMushroom Body Neuron

Shimizu, K., Sato, M., & Tabata, T. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0154-11.2011 · Cited by 63 · see citing works

Phospho-β-Catenin Accumulation in Alzheimer's Disease and in Aggresomes Attributable to Proteasome Dysfunction

Ghanevati, M., & Miller, C. A. (2005) · Journal of Molecular Neuroscience · doi:10.1385/jmn:25:1:079 · Cited by 63 · see citing works

Phosphorylation of microtubule-associated proteins MAP2a,b and MAP2c at Ser136 by proline-directed kinases in vivo and in vitro.

Berling, B., Wille, H., Röll, B., et al. (1994) · PubMed · Cited by 55 · see citing works

LIN-44/Wnt Directs Dendrite Outgrowth through LIN-17/Frizzled in C. elegans Neurons

Kirszenblat, L., Pattabiraman, D., & Hilliard, M. A. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001157 · Cited by 41 · see citing works

Wnt-5a Is a Synaptogenic Factor with Neuroprotective Properties against Aβ Toxicity

Varela‐Nallar, L., Parodí, J., Farı́as, G. G., & Inestrosa, N. C. (2012) · Neurodegenerative Diseases · doi:10.1159/000333360 · Cited by 32 · see citing works

Wnt5a Controls Neurite Development in Olfactory Bulb Interneurons

Pino, D., Choe, Y., & Pleasure, S. J. (2011) · ASN NEURO · doi:10.1042/an20100038 · Cited by 31 · see citing works

Dishevelled promotes neurite outgrowth in neuronal differentiating neuroblastoma 2A cells, via a DIX-domain dependent pathway

Fan, S., Ramirez, S. H., Garcia, T. M., & Dewhurst, S. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.09.003 · Cited by 29 · see citing works

Signalling through the Type 1 Insulin-Like Growth Factor Receptor (IGF1R) Interacts with Canonical Wnt Signalling to Promote Neural Proliferation in Developing Brain

Hu, Q., Lee, S. Y., OʼKusky, J. R., & Ye, P. (2012) · ASN NEURO · doi:10.1042/an20120009 · Cited by 23 · see citing works

The ASD Living Biology: from cell proliferation to clinical phenotype

Courchesne, E., Pramparo, T., Gazestani, V. H., Lombardo, M. V., Pierce, K., & Lewis, N. E. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0056-y · Cited by 333 · see citing works

Wnt signaling in the nervous system and in Alzheimer's disease

Inestrosa, N. C., & Varela-Nallar, L. (2014) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjt051 · Cited by 324 · see citing works

From nerve net to nerve ring, nerve cord and brain — evolution of the nervous system

Arendt, D., Tosches, M. A., & Marlow, H. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.15 · Cited by 279 · see citing works

Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling

Durak, O., Gao, F., Kaeser-Woo, Y. J., Rueda, R., Martorell, A. J., Nott, A., Liu, C. Y., Watson, L. A., & Tsai, L.-H. (2016) · Nature Neuroscience · doi:10.1038/nn.4400 · Cited by 243 · see citing works

Effects of cannabidiol interactions with Wnt/β-catenin pathway and PPARγ on oxidative stress and neuroinflammation in Alzheimer's disease

Vallée, A., Lecarpentier, Y., Guillevin, R., & Vallée, J.-N. (2017) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmx073 · Cited by 226 · see citing works

Two Classes of Secreted Synaptic Organizers in the Central Nervous System

Yuzaki, M. (2018) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021317-121322 · Cited by 125 · see citing works

Mutations modifying sporadic Alzheimer’s disease age of onset

Vélez, J. I., Lopera, F., Patel, H. R., Johar, A. S., Cai, Y., Rivera, D., Tobón, C., Villegas, A., Sepulveda‐Falla, D., Lehmann, S. G., et al. (2016) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32493 · Cited by 19 · see citing works

MicroRNA Profiling in Aging Brain of PSEN1/PSEN2 Double Knockout Mice

Ham, S., Kim, T. K., Lee, S., Tang, Y.-P., & Im, H.-I. (2018) · Molecular Neurobiology · doi:10.1007/s12035-017-0753-6 · Cited by 12 · see citing works

Synaptogenesis in the Rat Cerebellum: Effects of Early Hypo- and Hyperthyroidism

Nicholson, J. L., & Altman, J. (1972) · Science · doi:10.1126/science.176.4034.530 · Cited by 198 · see citing works

Transition between synaptic branch formation and synaptogenesis is regulated by the lin-4 microRNA

Xu, Y. F., & Quinn, C. C. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2016.10.010 · Cited by 13 · see citing works

Molecular mechanisms of synaptogenesis

Qi, C., Luo, L.-D., Feng, I., & Ma, S. (2022) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2022.939793 · Cited by 54 · see citing works

Parental adversity: Impact across generations

Matthews, S. G. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.03.016 · Cited by 4 · see citing works

Cloning and Characterization of Rat BAT3 cDNA

Ozaki, T., Hanaoka, E., Naka, M., et al. (1999) · DNA and Cell Biology · doi:10.1089/104454999315222 · Cited by 22 · see citing works