Mapk/Erk activation in an animal model of social deficits shows a possible link to autism
Open accessAbstract
BACKGROUND: There is converging preclinical and clinical evidence to suggest that the extracellular signal-regulated kinase (ERK) signaling pathway may be dysregulated in autism spectrum disorders. METHOD: We evaluated Mapk/Erk1/2, cellular proliferation and apoptosis in BTBR mice, as a preclinical model of Autism. We had previously generated 410 F2 mice from the cross of BTBR with B6. At that time, six different social behaviors in all F2 mice were evaluated and scored. In this study, eight mice at each extreme of the social behavioral spectrum were selected and the expression and activity levels of Mapk/Erk in the prefrontal cortex and cerebellum of these mice were compared. Finally, we compared the Mapk/Erk signaling pathway in brain and lymphocytes of the same mice, testing for correlation in the degree of kinase activation across these separate tissues. RESULTS: Levels of phosphorylated Erk (p-Erk) were significantly increased in the brains of BTBR versus control mice. We also observed a significant association between juvenile social behavior and phosphorylated mitogen-activated protein kinase kinase (p-Mek) and p-Erk levels in the prefrontal cortex but not in the cerebellum. In contrast, we did not find a significant association between social behavior and total protein levels of either Mek or Erk. We also tested whether steady-state levels of Erk activation in the cerebral cortex in individual animals correlated with levels of Erk activation in lymphocytes, finding a significant relationship for this signaling pathway. CONCLUSION: These observations suggest that dysregulation of the ERK signaling pathway may be an important mediator of social behavior, and that measuring activation of this pathway in peripheral lymphocytes may serve as a surrogate marker for central nervous system (CNS) ERK activity, and possibly autistic behavior.
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Dysregulation of MAPK signaling has been reported in transgenic mice carrying the 16p11.2 microdeletion and in other mouse models of social impairment.
“The dysregulation of MAPK signaling has also been reported in transgenic mice carrying the ASD-associated microdeletion of 16p11.2 (Blizinsky et al., 2016; Pucilowska et al., 2015) and in other mouse models of social impairment (Faridar et al., 2014).”
From Getting to the cores of autism (2019) · cites this paper as Faridar et al., 2014
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1 retracted
RETRACTED: The developmental pattern of the RAS/RAF/Erk1/2 pathway in the BTBR autism mouse model
Yin, A., Qiu, Y., Jia, B., Song, T., Yu, Y., Alberts, I. L., & Zhong, M. (2014) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2014.01.006 · Cited by 9 · see citing works
RetractedFunctional impact of global rare copy number variation in autism spectrum disorders
Pinto, D., Pagnamenta, A. T., Klei, L., Anney, R., Merico, D., Regan, R., Conroy, J., Magalhaes, T. R., Correia, C., Abrahams, B. S., et al. (2010) · Nature · doi:10.1038/nature09146 · Cited by 2,013 · cited 1× · see citing works
“involved in RAS (Rat Sarcoma)/MAPK signaling and kinase activation in ASD individuals [3].”
BackgroundAssociation between Microdeletion and Microduplication at 16p11.2 and Autism
Weiss, L. A., Shen, Y., Korn, J. M., Arking, D. E., Miller, D. T., Fossdal, R., Saemundsen, E., Stefansson, H., Ferreira, M. A. R., Green, T., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa075974 · Cited by 1,666 · see citing works
ERK and cell death: mechanisms of ERK-induced cell death--apoptosis, autophagy and senescence
Cagnol, S., & Chambard, J. (2010) · The FEBS Journal · doi:10.1111/j.1742-4658.2009.07366.x · Cited by 1,290 · see citing works
Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice
Tsai, P. T., Hull, C., Chu, Y., Greene-Colozzi, E., Sadowski, A. R., Leech, J. M., Steinberg, J., Crawley, J. N., Regehr, W. G., & Sahin, M. (2012) · Nature · doi:10.1038/nature11310 · Cited by 888 · see citing works
Autism‐like behavioral phenotypes in BTBR T+tf/J mice
McFarlane, H. G., Kusek, G. K., Yang, M., Phoenix, J. L., Bolivar, V. J., & Crawley, J. N. (2008) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2007.00330.x · Cited by 812 · see citing works
Zoghbi, H. Y., & Bear, M. F. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a009886 · Cited by 797 · see citing works
Recurrent 16p11.2 microdeletions in autism
Kumar, R. A., KaraMohamed, S., Sudi, J., Conrad, D. F., Brune, C., Badner, J. A., Gilliam, T. C., Nowak, N. J., Cook, E. H., Dobyns, W. B., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm376 · Cited by 731 · see citing works
Association Between Microdeletion and Microduplication at 16p11.2 and Autism
Weiss, L. A., Shen, Y., Korn, J. M., Arking, D. E., Miller, D. T., Fossdal, R., Sæmundsen, E., Stefánsson, H., Ferreira, M. A. R., Green, T. J., et al. (2008) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000316305.61461.6f · Cited by 647 · see citing works
Extracellular-signal-regulated kinase signalling in neurons
Grewal, S., York, R. D., & Stork, P. A. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)00010-0 · Cited by 555 · see citing works
Autism-related deficits via dysregulated eIF4E-dependent translational control
Gkogkas, C. G., Khoutorsky, A., Ran, I., Rampakakis, E., Nevarko, T., Weatherill, D. B., Vasuta, C., Yee, S., Truitt, M., Dallaire, P., et al. (2013) · Nature · doi:10.1038/nature11628 · Cited by 522 · see citing works
The Pathophysiology of Fragile X (and What It Teaches Us about Synapses)
Bhakar, A. L., Dölen, G., & Bear, M. F. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153138 · Cited by 370 · see citing works
Ebisuya, M., Kondoh, K., & Nishida, E. (2005) · Journal of Cell Science · doi:10.1242/jcs.02505 · Cited by 331 · see citing works
Loss of Tsc1 In Vivo Impairs Hippocampal mGluR-LTD and Increases Excitatory Synaptic Function
Bateup, H. S., Takasaki, K. T., Saulnier, J. L., Denefrio, C. L., & Sabatini, B. L. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1617-11.2011 · Cited by 204 · see citing works
An Essential Role for a MEK-C/EBP Pathway during Growth Factor-Regulated Cortical Neurogenesis
Ménard, C., Hein, P., Paquin, A., Savelson, A., Yang, X. M., Lederfein, D., Barnabé‐Heider, F., Mir, A. A., Sterneck, E., Peterson, A. C., et al. (2002) · Neuron · doi:10.1016/s0896-6273(02)01026-7 · Cited by 203 · see citing works
MAP'ing CNS Development and Cognition: An ERKsome Process
Samuels, I. S., Saitta, S. C., & Landreth, G. E. (2009) · Neuron · doi:10.1016/j.neuron.2009.01.001 · Cited by 200 · see citing works
Stephenson, D. T., O'Neill, S. M., Narayan, S., Tiwari, A., Arnold, E., Samaroo, H. D., Du, F., Ring, R. H., Campbell, B., Pletcher, M., et al. (2011) · Molecular Autism · doi:10.1186/2040-2392-2-7 · Cited by 180 · see citing works
MEK Is a Key Regulator of Gliogenesis in the Developing Brain
Li, X., Newbern, J. M., Wu, Y., Morgan-Smith, M., Zhong, J., Charron, J., & Snider, W. D. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.031 · Cited by 171 · see citing works
ERK2 Contributes to the Control of Social Behaviors in Mice
Satoh, Y., Endo, S., Nakata, T., Kobayashi, Y., Yamada, K., Ikeda, T., Takeuchi, A., Hiramoto, T., Watanabe, Y., & Kazama, T. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2349-11.2011 · Cited by 145 · see citing works
Ellegood, J., Babineau, B. A., Henkelman, R. M., Lerch, J. P., & Crawley, J. N. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2012.12.029 · Cited by 135 · see citing works
Chapter 26 Role of Akt and Erk Signaling in the Neurogenesis Following Brain Ischemia
Shioda, N., Han, F., & Fukunaga, K. (2009) · International review of neurobiology · doi:10.1016/s0074-7742(09)85026-5 · Cited by 132 · see citing works
Pucilowska, J., Puzerey, P. A., Karlo, J. C., Galan, R. F., & Landreth, G. E. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1107-12.2012 · Cited by 99 · see citing works
Wang, X., Snape, M., Klann, E., Stone, J. G., Singh, A., Petersen, R. B., Castellani, R. J., Casadesús, G., Smith, M. A., & Zhu, X. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07722.x · Cited by 91 · see citing works
Chévere-Torres, I., Kaphzan, H., Bhattacharya, A., Kang, A., Maki, J. M., Gambello, M. J., Arbiser, J. L., Santini, E., & Klann, E. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.12.028 · Cited by 83 · see citing works
Seese, R. R., Maske, A. R., LYNCH, G. S., & Gall, C. M. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.13 · Cited by 62 · see citing works
Jones-Davis, D. M., Yang, M., Rider, E., Osbun, N. C., da Gente, G. J., Li, J., Katz, A. M., Weber, M. D., Sen, S., Crawley, J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061829 · Cited by 61 · see citing works
Self-citationSilingardi, D., Angelucci, A., Pasquale, R. D., Borsotti, M., Squitieri, G., Brambilla, R., Putignano, E., Pizzorusso, T., & Berardi, N. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00084 · Cited by 55 · see citing works
The Autism Genome Project, Anney, R. J. L., Kenny, E. M., O'Dushlaine, C., Yaspan, B. L., Parkhomenka, E., Buxbaum, J. D., Sutcliffe, J., Gill, M., Gallagher, L., et al. (2011) · European Journal of Human Genetics · doi:10.1038/ejhg.2011.75 · Cited by 43 · see citing works
Yang, K., Cao, F., Sheikh, A. M., Malik, M. N., Wen, G. Y., Wei, H., Brown, W. T., & Li, X. (2012) · Brain Structure and Function · doi:10.1007/s00429-012-0420-7 · Cited by 43 · see citing works
Mi, R., Ma, J., Zhang, D., Li, L., & Zhang, H. (2009) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/s1673-8527(08)60124-1 · Cited by 34 · see citing works
Experience‐dependent activation of extracellular signal‐related kinase (ERK) in the olfactory bulb
Mirich, J. M., Illig, K. R., & Brunjes, P. C. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20325 · Cited by 20 · see citing works
Kroll, J., Becker, K., Kuphal, S., Hein, R., Hofstädter, F., & Bosserhoff, A. (2008) · PubMed · doi:10.14670/hh-23.391 · Cited by 19 · see citing works
(2007) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2007.00355.x · Cited by 12 · see citing works
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Horder, J., Petrinovic, M. M., Méndez, M. A., Bruns, A., Takumi, T., Spooren, W. P. J. M., Barker, G. J., Künnecke, B., & Murphy, D. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0155-1 · Cited by 308 · see citing works
Getting to the cores of autism
Iakoucheva, L. M., Muotri, A. R., & Sebat, J. (2019) · Cell · doi:10.1016/j.cell.2019.07.037 · Cited by 260 · see citing works
“, 2015) and in other mouse models of social impairment (Faridar et al., 2014).”
BackgroundFundamental Elements in Autism: From Neurogenesis and Neurite Growth to Synaptic Plasticity
Gilbert, J. P., & Man, H. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00359 · Cited by 274 · see citing works
ERK/MAPK signalling in the developing brain: Perturbations and consequences
Iroegbu, J. D., Ijomone, O. K., Femi-Akinlosotu, O. M., & Ijomone, O. M. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.10.009 · Cited by 206 · see citing works
Prenatal Origins of ASD: The When, What, and How of ASD Development
Courchesne, E., Gazestani, V., & Lewis, N. E. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.03.005 · Cited by 191 · see citing works
The BTBR mouse model of idiopathic autism – Current view on mechanisms
Meyza, K. Z., & Blanchard, D. C. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.12.037 · Cited by 189 · see citing works
Wen, Y., Alshikho, M. J., & Herbert, M. R. (2016) · PLOS ONE · doi:10.1371/journal.pone.0153329 · Cited by 150 · see citing works
Wong, H., & Hoeffer, C. A. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.04.010 · Cited by 128 · see citing works
ERK/MAPK signaling and autism spectrum disorders
Vithayathil, J., Pucilowska, J., & Landreth, G. E. (2018) · Progress in brain research · doi:10.1016/bs.pbr.2018.09.008 · Cited by 101 · see citing works
Pucilowska, J., Vithayathil, J., Pagani, M., Kelly, C. L., Karlo, J. C., Robol, C., Morella, I., Gozzi, A., Brambilla, R., & Landreth, G. E. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0515-17.2018 · Cited by 89 · see citing works
Layer specific and general requirements for ERK/MAPK signaling in the developing neocortex
Xing, L., Larsen, R. S., Bjorklund, G. R., Li, X., Wu, Y., Philpot, B. D., Snider, W. D., & Newbern, J. M. (2016) · eLife · doi:10.7554/elife.11123 · Cited by 80 · see citing works
Characterizing autism spectrum disorders by key biochemical pathways
Subramanian, M. P., Timmerman, C., Schwartz, J. L., Pham, D. L., & Meffert, M. K. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00313 · Cited by 71 · see citing works
Szczurkowska, J., Pischedda, F., Pinto, B., Managò, F., Haas, C. A., Summa, M., Bertorelli, R., Papaleo, F., Schäfer, M. K. E., Piccoli, G., et al. (2018) · Brain · doi:10.1093/brain/awy190 · Cited by 75 · see citing works
iTRAQ‐Based Proteomic Analysis Reveals Protein Profile in Plasma from Children with Autism
Shen, L., Zhang, K., Feng, C., Chen, Y., Li, S., Iqbal, J., Liao, L., Zhao, Y., & Zhai, J. (2017) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201700085 · Cited by 69 · see citing works
Arginine vasopressin in cerebrospinal fluid is a marker of sociality in nonhuman primates
Parker, K. J., Garner, J. P., Oztan, O., Tarara, E. R., Li, J., Sclafani, V., Del Rosso, L. A., Chun, K., Berquist, S. W., Chez, M. G., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aam9100 · Cited by 64 · see citing works
Autism Spectrum Disorder: Signaling Pathways and Prospective Therapeutic Targets
Baranova, J., Dragunas, G., Botelho, M. C. S., Ayub, A. L. P., Bueno-Alves, R., Alencar, R. R., Papaiz, D. D., Sogayar, M. C., Ulrich, H., & Correa, R. G. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-00882-7 · Cited by 59 · see citing works
Chao, O. Y.-H., Yunger, R., & Yang, Y. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.03.014 · Cited by 51 · see citing works
Loss of Adenylyl Cyclase Type-5 in the Dorsal Striatum Produces Autistic-Like Behaviors
Kim, H., Lee, Y., Park, J.-Y., Kim, J.-E., Kim, T.-K., Choi, J., Lee, J.-E., Lee, E.-H., Kim, D., Kim, K.-S., et al. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-0256-x · Cited by 50 · see citing works
Gąssowska-Dobrowolska, M., Kolasa, A., Cieślik, M., Dominiak, A., Friedland, K., & Adamczyk, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063209 · Cited by 45 · see citing works
Cheng, N., Alshammari, F., Hughes, E., Khanbabaei, M., & Rho, J. M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179409 · Cited by 39 · see citing works
Sokol, D. K., Maloney, B., Westmark, C. J., & Lahiri, D. K. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00165 · Cited by 38 · see citing works
Sciara, A., Beasley, B., Crawford, J. D., Anderson, E. P., Carrasco, T., Zheng, S., Ordway, G. A., & Chandley, M. (2020) · Autism Research · doi:10.1002/aur.2284 · Cited by 41 · see citing works
Lutz, A.-K., Arévalo, A. P., Ioannidis, V., Stirmlinger, N., Demestre, M., Delorme, R., Bourgeron, T., & Boeckers, T. M. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.773571 · Cited by 37 · see citing works
Autism-like behavior caused by deletion of vaccinia-related kinase 3 is improved by TrkB stimulation
Kang, M.-S., Choi, T.-Y., Ryu, H. G., Lee, D., Lee, S., Choi, S., & Kim, K. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20160974 · Cited by 29 · see citing works
Wink, L. K., Adams, R. E., Horn, P. S., Tessier, C. R., Bantel, A. P., Hong, M. P., Shaffer, R. C., Pedapati, E. V., & Erickson, C. A. (2018) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-018-3562-5 · Cited by 30 · see citing works
Albert‐Gascó, H., Sánchez‐Sarasúa, S., Ma, S., Díaz, C. G., Gundlach, A. L., Sánchez‐Pérez, A. M., & Olucha-Bordonau, F. E. (2018) · Brain Structure and Function · doi:10.1007/s00429-018-1763-5 · Cited by 25 · see citing works
Blázquez, G., Castañé, A., Saavedra, A., Masana, M., Alberch, J., & Pérez‐Navarro, E. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00317 · Cited by 20 · see citing works
Morcom, L. R., Edwards, T. J. C., Rider, E., Jones, D. M., Lim, J. W. C., Chen, K., Dean, R. J., Bunt, J., Ye, Y., Gobius, I., et al. (2021) · eLife · doi:10.7554/elife.61618 · Cited by 20 · see citing works
Self-citationMurari, K., Abushaibah, A., Rho, J. M., Turner, R. W., & Cheng, N. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2023.104565 · Cited by 19 · see citing works
Establishment of animal models and behavioral studies for autism spectrum disorders
Jiao, D., Xu, Y., Tian, F., Zhou, Y., Chen, D., & Wang, Y. (2024) · Journal of International Medical Research · doi:10.1177/03000605241245293 · Cited by 18 · see citing works
Maternal elevated salt consumption and the development of autism spectrum disorder in the offspring
Afroz, K. F., & Alviña, K. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1666-2 · Cited by 16 · see citing works
Shen, Y., Li, N., Sun, S., Dong, L., Wang, Y., Chang, L., Zhang, X., & Wang, F. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.986571 · Cited by 15 · see citing works
Eissa, N., Awad, M. A., Thomas, S. D., Venkatachalam, K., Jayaprakash, P., Zhong, S., Stark, H., & Sadek, B. S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010526 · Cited by 15 · see citing works
Brandenburg, C., Griswold, A. J., Booven, D. J. V., Kilander, M. B. C., Frei, J. A., Nestor, M. W., Dykxhoorn, D. M., Pericak‐Vance, M. A., & Blatt, G. J. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.944837 · Cited by 12 · see citing works
Oztan, O., Talbot, C. F., Argilli, E., Maness, A. C., Simmons, S. M. V., Mohsin, N., Rosso, L. A. D., Garner, J. P., Sherr, E. H., Capitanio, J. P., et al. (2021) · Molecular Autism · doi:10.1186/s13229-021-00442-w · Cited by 12 · see citing works
Self-citationLeemans, M., Špirhanzlová, P., Couderq, S., Mével, S. L., Grimaldi, A. G., Duvernois‐Berthet, E., DEMENEIX, B. A., & Fini, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032588 · Cited by 11 · see citing works
Yao, Y., Uddin, M. N., MANLEY, K. M., & Lawrence, D. A. (2022) · Cell Biochemistry and Function · doi:10.1002/cbf.3684 · Cited by 10 · see citing works
Initial analysis of peripheral lymphocytic extracellular signal related kinase activation in autism
Erickson, C. A., Ray, B., Wink, L. K., Bayon, B. L., Pedapati, E. V., Shaffer, R. C., Schaefer, T. L., & Lahiri, D. K. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.09.003 · Cited by 10 · see citing works
Extracerebral Dysfunction in Animal Models of Autism Spectrum Disorder
Hill‐Yardin, E. L., McKeown, S. J., Novarino, G., & Grabrucker, A. M. (2017) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-319-52498-6_9 · Cited by 8 · see citing works
Zhang, X., Xue, H., Zhu, C., Ji, C., Li, Y. M., & Liu, W. T. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1829127 · Cited by 6 · see citing works
Lymphocytic Extracellular Signal–Regulated Kinase Dysregulation in Autism Spectrum Disorder
Erickson, C. A., Tessier, C. R., Groß, C., Pedapati, E. V., Wink, L. K., Dominick, K. C., Shaffer, R. C., Rosselot, H., Hong, M. P., Bantel, A. P., et al. (2023) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2022.09.437 · Cited by 6 · see citing works
Is autism a PIN1 deficiency syndrome? A proposed etiological role for glyphosate
Seneff, S., Kyriakopoulos, A. M., & Nigh, G. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16140 · Cited by 6 · see citing works
Zhong, G., Fang, Z., Sun, T., Ying, M., Wang, A., Chen, Y., Wang, H., Ma, C., Wang, C., Ge, R., et al. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167319 · Cited by 5 · see citing works
Scribble Controls Social Motivation Behavior through the Regulation of the ERK/Mnk1 Pathway
Moreau, M. M., Pietropaolo, S., Ezan, J., Robert, B. J. A., Miraux, S., Maître, M., Cho, Y. H., Crusio, W. E., Montcouquiol, M., & Sans, N. (2022) · Cells · doi:10.3390/cells11101601 · Cited by 7 · see citing works
Grabrucker, S., & Grabrucker, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804562-6.00009-9 · Cited by 3 · see citing works
Hypothalamic TrkB.FL overexpression improves metabolic outcomes in the BTBR mouse model of autism
Anderson, J. M., Boardman, A. A., Bates, R., Zou, X., Huang, W., & Cao, L. (2023) · PLoS ONE · doi:10.1371/journal.pone.0282566 · Cited by 3 · see citing works
Bruno, J. L., Plank, J. R., Leder, S., Lake, E. M. R., Finn, E. S., & Green, T. (2025) · Molecular Autism · doi:10.1186/s13229-025-00686-w · Cited by 2 · see citing works
Darvish, H., Omidvar, M. E., Ghaedi, E., & Ghaedi, H. (2020) · Meta Gene · doi:10.1016/j.mgene.2020.100784 · Cited by 2 · see citing works
Scribble controls social behaviors through the regulation of the ERK/Mnk1 pathwayPreprint
Moreau, M. M., Pietropaolo, S., Ezan, J., Robert, B. J. A., Miraux, S., Maître, M., Cho, Y. H., Crusio, W. E., Montcouquiol, M., & Sans, N. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.10.289397 · Cited by 2 · see citing works
Genetic etiology and neurobiological mechanisms of autism spectrum disorders
ZHANG, J., XiangBin, J. I. A., Xia, K., Guo, H., & Li, J. (2024) · Scientia Sinica Vitae · doi:10.1360/ssv-2024-0105 · Cited by 1 · see citing works
Self-citationLong, J., Liao, X., Tang, Z., Han, K., Chen, J., Wang, X., Liu, J., Zhang, Y., & Zhang, H. (2025) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-025-01052-5 · Cited by 1 · see citing works
Verma, J., Singh, R. K., Paul, S., Gupta, S., Gupta, A. K., Sharma, A. K., Kumar, M., Mehan, S., Samant, R., & Tongra, M. (2026) · Metabolic Brain Disease · doi:10.1007/s11011-026-01866-0 · Cited by 1 · see citing works
Intracellular Pathways Associated with the Etiology of Autism
Russo, A. J. (2017) · InTech eBooks · doi:10.5772/67206
Fan, R., Gong, X., YU, Z., Lin, S., Ruan, Y., Qian, L., Si, Z., Li, L., Zhou, W., & Liu, Y. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176866 · Cited by 1 · see citing works
Rodent Models for ASD Biomarker Development
Lee, H. H. C., & Şahin, M. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-69491-2_8 · Cited by 1 · see citing works
RETRACTED ARTICLE: Regional patterning of co-expressed genes in autistic brains
Izadi, F. (2019) · Network Modeling Analysis in Health Informatics and Bioinformatics · doi:10.1007/s13721-019-0187-3 · Cited by 1 · see citing works
RetractedLack of dcf1 leads to neuronal migration delay, axonal swollen and autism-related deficitsPreprint
Feng, R., Chen, Y., Sun, Y., Luo, G., Guo, J., Liu, Q., Wu, J., Ju, X.-C., & Wen, T. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.02.20.958934
Kondaurova, E. M., Григорьева, Ю. Д., Belokopytova, I. I., Kulikova, E. A., Tsybko, A. S., Хоцкин, Н. В., Ilchibaeva, T. V., Popova, N. K., & Naumenko, V. S. (2025) · Neurochemical Journal · doi:10.1134/s1819712425700400
Oztan, O., Talbot, C. F., Argilli, E., Maness, A. C., Simmons, S. M. V., Mohsin, N., Rosso, L. A. D., Garner, J. P., Sherr, E. H., Capitanio, J. P., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14936229
Self-citationKnockdown of Ddx3x in mPFC induces autistic-like phenotype in mice via altered synaptic plasticity
Zhuang, H., Cao, X., Tang, X., Liang, Z., Wang, H., Liu, Q., Yan, X., Lin, X., Su, X., Wang, M., et al. (2026) · Translational Psychiatry · doi:10.1038/s41398-026-03945-3
Anadu, V. E., Oyerinde, T. O., Gbayisomore, T. J., Oyeniran, D. A., Adeniran, F. T., Ijomone, O. K., & Ijomone, O. M. (2026) · Metabolic Brain Disease · doi:10.1007/s11011-026-01921-w
Xin, L., Guo, R., Sun, J., Su, Y., Cai, J., Li, W., Wan, Z., & Wang, J. (2026) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2026.2723920
- Authors
- Faridar, A., Jones-Davis, D., Rider, E., Li, J., Gobius, I., Morcom, L., Richards, L. J., Sen, S., & Sherr, E. H.
- Affiliations
- University of California, San Francisco (US)
- The University of Queensland (AU)
- Corresponding author
- Sherr, Elliott H
- Venue
- Molecular Autism
- Published
- 2014-12
- Volume
- 5
- Issue
- 1
- Pages
- 57-57
- ISSN
- 2040-2392 (ISSN-L)
- PMC
- PMC4396809
- OpenAlex
- W2111840774
- Cited by
- 63
- References
- 33
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 6 · 2023: 3 · 2022: 6 · 2021: 6 · 2020: 6 · 2019: 5 · 2018: 9 · 2017: 9 · 2016: 4 · 2015: 1
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Molecular Autism (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Pfizer
- Medical Research Council
- National Health and Medical Research Council (1048849)
- National Institute of Neurological Disorders and Stroke (R01NS058721)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- ERK signaling, ERK1/2 MAPK, autism spectrum disorder, social behavior deficits, BTBR mice, prefrontal cortex, cerebellum, MEK phosphorylation, lymphocytes, kinase activation, surrogate markers, cell proliferation, apoptosis
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