Arginine vasopressin in cerebrospinal fluid is a marker of sociality in nonhuman primates
Open accessAbstract
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by core social impairments. ASD remains poorly understood because of the difficulty in studying disease biology directly in patients and the reliance on mouse models that lack clinically relevant, complex social cognition abilities. We use ethological observations in rhesus macaques to identify male monkeys with naturally occurring low sociality. These monkeys showed differences in specific neuropeptide and kinase signaling pathways compared to socially competent male monkeys. Using a discovery and replication design, we identified arginine vasopressin (AVP) in cerebrospinal fluid (CSF) as a key marker of group differences in monkey sociality; we replicated these findings in an independent monkey cohort. We also confirmed in an additional monkey cohort that AVP concentration in CSF is a stable trait-like measure. Next, we showed in a small pediatric cohort that CSF AVP concentrations were lower in male children with ASD compared to age-matched male children without ASD (but with other medical conditions). We demonstrated that CSF AVP concentration was sufficient to accurately distinguish ASD cases from medical controls. These data suggest that AVP and its signaling pathway warrant consideration in future research studies investigating new targets for diagnostics and drug development in ASD.
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Male rhesus macaques in large groups that have naturally impaired social functioning have decreased vasopressin in cerebrospinal fluid.
“Similarly, male rhesus macaques in large groups that have naturally impaired social functioning have decreased AVP in cerebrospinal fluid (166).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [166]
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- Authors
- Parker, K. J., Garner, J. P., Oztan, O., Tarara, E. R., Li, J., Sclafani, V., Del Rosso, L. A., Chun, K., Berquist, S. W., Chez, M. G., Partap, S., Hardan, A. Y., Sherr, E. H., & Capitanio, J. P.
- Affiliations
- Stanford Medicine (US)
- University of California, Davis (US)
- University of California, San Francisco (US)
- California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA.
- Sutter Medical Center (US)
- Stanford University (US)
- Corresponding author
- Parker, Karen J.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2018-05-02
- Volume
- 10
- Issue
- 439
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC6714978
- OpenAlex
- W2799619998
- Cited by
- 64
- References
- 54
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 9 · 2023: 6 · 2022: 11 · 2021: 10 · 2020: 8 · 2019: 7 · 2018: 6
- FWCI
- 10.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Lincoln Repository (University of Lincoln) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- National Institutes of Health (R21HD079095, P51OD011107, R24OD010962)
- Simons Foundation (274472, 342873)
- The Mosbacher Family Fund for Autism Research
- Stanford University’s Bio-X NeuroVentures Program
- Weston Havens Foundation
- Stanford University Child Health Research Institute
- Katherine D. McCormick Fund
- The Yani Calmidis Memorial Fund for Autism Research
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- vasopressin, cerebrospinal fluid, autism spectrum disorder, sociality, rhesus monkeys, neuropeptides, kinase signaling pathways, social behavior, biomarkers, diagnostic biomarkers, children with autism, boys
- MeSH terms
- Animals, Arginine Vasopressin, Macaca mulatta, Male, Primates, Social Behavior, Signal Transduction, Biomarkers
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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