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Cited by 93Hippo pathway signaling and YAP/TAZCellular Mechanics and InteractionsGenomics and Chromatin Dynamics

Framework to function: mechanosensitive regulators of gene transcription

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Finch-Edmondson, Megan, Sudol, Marius·2016·Cellular & Molecular Biology Letters
DOI 10.1186/s11658-016-0028-7PMC PMC5415767
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Abstract

Mechanobiology has shifted our understanding of fundamental cellular and physiological functions. Changes to the stiffness of the extracellular matrix, cell rigidity, or shape of the cell environment were considered in the past to be a consequence of aging or pathological processes. We now understand that these factors can actually be causative biological mediators of cell growth to control organ size. Mechanical cues are known to trigger a relatively fast translocation of specific transcriptional co-factors such as MRTFs, YAP and TAZ from the cytoplasm to the cell nucleus to initiate discrete transcriptional programs. The focus of this review is the molecular mechanisms by which biophysical stimuli that induce changes in cytoplasmic actin dynamics are communicated within cells to elicit gene-specific transcription via nuclear localisation or activation of specialized transcription factors, namely MRTFs and the Hippo pathway effectors YAP and TAZ. We propose here that MRTFs, YAP and TAZ closely collaborate as mechano-effectors.

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Cited by

Sorted by citations

Authors
Finch-Edmondson, M., & Sudol, M.
Affiliations
National University of Singapore (SG)
Corresponding author
Sudol, Marius
ORCID
Sudol, Marius
Venue
Cellular & Molecular Biology Letters
Publisher
Springer Science and Business Media LLC
Published
2016-12
Volume
21
Issue
1
Pages
28-28
ISSN
  • 1425-8153 (ISSN-L)
  • 1689-1392
DOI
10.1186/s11658-016-0028-7
PMC
PMC5415767
OpenAlex
W2560115947
Cited by
93
References
9
Citations by year
2026: 6 · 2025: 8 · 2024: 11 · 2023: 10 · 2022: 10 · 2021: 12 · 2020: 19 · 2019: 6 · 2018: 6 · 2017: 5
FWCI
0.61
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Cellular & Molecular Biology Letters (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • National University of Singapore (submittedVersion)
Funders
  • Mechanobiology Institute, National University of Singapore (R-714-018-006-271)
  • Department of Physiology, National University of Singapore (R185000270)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords
mechanobiology, gene transcription, extracellular matrix stiffness, cell rigidity, MRTF, YAP, TAZ, Hippo signaling pathway, actin dynamics, nuclear translocation, transcriptional cofactors, organ size control
MeSH terms
Myocardin, Actins, Animals, Humans, Nuclear Proteins, Transcription Factors, Transcription, Genetic, Trans-Activators, Mechanotransduction, Cellular, Epithelial-Mesenchymal Transition

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