Cited by 87Genetic and phenotypic traits in livestockGenetic Mapping and Diversity in Plants and AnimalsAnimal Genetics and Reproduction

The DOI matches its Crossref record; 360 of the 362 references it cites were found in a registry or an index.

Genetics of the phenotypic evolution in sheep: a molecular look at diversity-driving genes

Open access

Kalds, Peter, Zhou, Shiwei, Gao, Yawei, Cai, Bei, Huang, Shuhong, Chen, Yulin, Wang, Xiaolong·2022·Genetics Selection Evolution

DOI 10.1186/s12711-022-00753-3PMC PMC9463822

Open this paper in CoChat — free account Open PDF

Abstract

Background: After domestication, the evolution of phenotypically-varied sheep breeds has generated rich biodiversity. This wide phenotypic variation arises as a result of hidden genomic changes that range from a single nucleotide to several thousands of nucleotides. Thus, it is of interest and significance to reveal and understand the genomic changes underlying the phenotypic variation of sheep breeds in order to drive selection towards economically important traits. Review: Various traits contribute to the emergence of variation in sheep phenotypic characteristics, including coat color, horns, tail, wool, ears, udder, vertebrae, among others. The genes that determine most of these phenotypic traits have been investigated, which has generated knowledge regarding the genetic determinism of several agriculturally-relevant traits in sheep. In this review, we discuss the genomic knowledge that has emerged in the past few decades regarding the phenotypic traits in sheep, and our ultimate aim is to encourage its practical application in sheep breeding. In addition, in order to expand the current understanding of the sheep genome, we shed light on research gaps that require further investigation. Conclusions: Although significant research efforts have been conducted in the past few decades, several aspects of the sheep genome remain unexplored. For the full utilization of the current knowledge of the sheep genome, a wide practical application is still required in order to boost sheep productive performance and contribute to the generation of improved sheep breeds. The accumulated knowledge on the sheep genome will help advance and strengthen sheep breeding programs to face future challenges in the sector, such as climate change, global human population growth, and the increasing demand for products of animal origin.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1186/s12711-022-00753-3

Cites

360 of 360 references verified0 citation errors · 0 not checkable

Statistics

Fig. 1 Phenotype variation in sheep breeds. A representative example of phenotypic diversity in the Chinese sheep population (approximately 42 different indigenous breeds). Moreover, several imported sheep breeds (approximately 8) can be found in China, and over 21 improved and crossed breeds were generated by breeding local and imported breeds to yield multipurpose breeds for improved meat and wool production, as well as other productive traits. Images used herein were adapted with permission from Animal Genetic Resources in China: Sheep and Goats [217]CC BY · PubMed Central

Fig. 2 Phenotype variation in sheep tails. Representative examples of common sheep tail patterns. The figure was conceived by Peter Kalds and designed by Guangyuan CaoCC BY · PubMed Central

Fig. 3 Phenotype variation in sheep caudal vertebrae. Representative examples of caudal vertebrae among Chinese sheep breeds. From up to bottom, Tibetan (thin/short tail), Hu (fat/short tail), Lanping Black-bone (thin/moderate length tail), Tong (fat/long tail), and Tan sheep (fat/long tail)CC BY · PubMed Central

Fig. 4 Phenotype variation in sheep horns. a Polled phenotype, b scurred phenotype, c horned phenotype (curled tightly close to the face), d horned phenotype (spiral and horizontal extension; found in Chinese Tibetan sheep), and e horned phenotype (multi-spiral and up-forwarded; found in Hungarian Racka sheep). Photo credits and courtesies are shown in Additional file 2: Table S14CC BY · PubMed Central

Fig. 5 Phenotype of Soay sheep at different developmental stages. Soay sheep are a well-studied sheep population which have significantly contributed to the understanding of the genomic background of various important phenotypic traits. Photo credits are shown in Additional file 2: Table S14CC BY · PubMed Central

Fig. 6 Polyceraty (multi-horned phenotype) in sheep. Representative examples of different sheep breeds. Photo credits are shown in Additional file 2: Table S14CC BY · PubMed Central

Fig. 7 An example of a sheep population from the United Kingdom with different horn patterns. Polledness (hornlessness), hornedness (a pair of horns), and polyceraty (multi-hornedness; more than a pair of horns) are shown. Figure copyright and published with the consent of Fiona Osbaldstone (fi@fionaosbaldstoneillustrator.co.uk)CC BY · PubMed Central

Fig. 8 Other phenotypic traits in sheep. Representative examples of a dewlaps, b dropped ears, c pricked ears, d long ears, e short ears, f Roman noses, g curly fleeces, h manes, and i wattles. Photo credits and courtesies are shown in Additional file 2: Table S14CC BY · PubMed Central

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep
Clop, A., Marcq, F., Takeda, H., Pirottin, D., Tordoir, X., Bibé, B., Bouix, J., Caiment, F., Elsen, J.-M., Eychenne, F., et al. (2006) · Nature Genetics · doi:10.1038/ng1810 · Cited by 1,260
Genome-Wide Analysis of the World's Sheep Breeds Reveals High Levels of Historic Mixture and Strong Recent Selection
Kijas, J., Lenstra, J. A., Hayes, B. J., Boitard, S., Porto-Neto, L. R., Cristobal, M. S., Servin, B., McCulloch, R. J., Whan, V., Gietzen, K., et al. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001258 · Cited by 936
FGF5 as a regulator of the hair growth cycle: Evidence from targeted and spontaneous mutations
Hébert, J. M., Rosenquist, T., Götz, J., & Martin, G. R. (1994) · Cell · doi:10.1016/0092-8674(94)90276-3 · Cited by 589
Revealing the History of Sheep Domestication Using Retrovirus Integrations
Chessa, B., Pereira, F., Arnaud, F., Amorim, A., Goyache, F., Mainland, I. L., Kao, R. R., Pemberton, J. M., Beraldi, D., Stear, M. J., et al. (2009) · Science · doi:10.1126/science.1170587 · Cited by 545
The sheep genome illuminates biology of the rumen and lipid metabolism
Jiang, Y., Xie, M., Chen, W., Talbot, R., Maddox, J. F., Faraut, T., Wu, C., Muzny, D. M., Li, Y., Zhang, W., et al. (2014) · Science · doi:10.1126/science.1252806 · Cited by 514
Self-citation
Large-scale ruminant genome sequencing provides insights into their evolution and distinct traits
Chen, L., Qiu, Q., Jiang, Y., Wang, K., Lin, Z., Li, Z., Bibi, F., Yang, Y., Wang, J., Nie, W., et al. (2019) · Science · doi:10.1126/science.aav6202 · Cited by 441
Self-citation
Whole-genome resequencing of wild and domestic sheep identifies genes associated with morphological and agronomic traits
Li, X., Yang, J. H., Shen, M., Xie, X.-L., Liu, G., Xu, Y., Lv, F., Yang, H., Yang, Y., Liu, C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16485-1 · Cited by 374
Self-citation
Life history trade-offs at a single locus maintain sexually selected genetic variation
Johnston, S. E., Gratten, J., Bérénos, C., Pilkington, J. G., Clutton-Brock, T. H., Pemberton, J. M., & Slate, J. (2013) · Nature · doi:10.1038/nature12489 · Cited by 343
Convergent genomic signatures of domestication in sheep and goats
Alberto, F. J., Boyer, F., Orozco-terWengel, P., Streeter, I., Servin, B., de Villemereuil, P., Benjelloun, B., Librado, P., Biscarini, F., Colli, L., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03206-y · Cited by 339
A gene duplication affecting expression of the ovine ASIP gene is responsible for white and black sheepPreprint
Norris, B. J., & Whan, V. (2008) · Genome Research · doi:10.1101/gr.072090.107 · Cited by 307

Show all 362 references

Research works printed but not linked: 7

Ryder ML. Fleece colour in sheep and its inheritance. Anim Breed Abstr. 1980;48:305–24.
Dýrmundsson ÓR. Four-hornedness; a rare peculiarity still found in Icelandic sheep. Icelandic Sheep Breeders North Am Newsl. 2005;9:6–8.
Posbergh C, Huson H. Making Moorit: Mutations in TYRP1 are responsible for brown coat color in different United States sheep breeds. In: Proceedings of the 11th World Congress on Genetics Applied to Livestock Production: 11–16 February 2018; Auckland; 2018.
Humphreys D. On a new variety in the breeds of sheep. Philos Trans R Soc Lond. 1813;103:88–95.
Craven A, Scobie D, Ashby M, Nixon A. Wool follicle characteristics in sheep with differing ventral wool length phenotypes. Proc New Zeal Soc Anim Prod. 2008;68:49–52.
China National Commission of Animal Genetic Resources. Animal genetic resources in China: sheep and goats. Beijing: China Agriculture Press; 2011.
Duijvesteijn N, Weerasinghe S, van der Werf JHJ. Production accuracies for polled and horned merino sheep using different genetic models. Proc Assoc Adv Anim Breed Genet. 2017;22:349–52.

Sorted by citations

Whole-body adipose tissue multi-omic analyses in sheep reveal molecular mechanisms underlying local adaptation to extreme environments
Xu, Y., Wang, B., Jing, J.-N., Ma, R., Luo, Y.-H., Li, X., Yan, Z., Liu, Y.-J., Gao, L., Ren, Y., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-04523-9 · Cited by 83
Heritability and recursive influence of host genetics on the rumen microbiota drive body weight variance in male Hu sheep lambs
Wang, W., Zhang, Y., Zhang, X., Li, C., Yuan, L., Zhang, D., Zhao, Y., Li, X., Cheng, J., Lin, C., et al. (2023) · Microbiome · doi:10.1186/s40168-023-01642-7 · Cited by 73
Meat of Sheep: Insights into Mutton Evaluation, Nutritive Value, Influential Factors, and Interventions
Ding, W., Yanan, L., Xu, B., Chen, P., Li, J., Jian, F., Yu, G., & Huang, S. (2024) · Agriculture · doi:10.3390/agriculture14071060 · Cited by 59
Self-citation
Phenotype transition from wild mouflon to domestic sheep
Mereu, P., Pirastru, M., Sanna, D., Bassu, G., Naitana, S., & Leoni, G. G. (2024) · Genetics Selection Evolution · doi:10.1186/s12711-023-00871-6 · Cited by 35
Whole-Genome Resequencing Reveals Selection Signal Related to Sheep Wool Fineness
Zhang, W., Jin, M., Li, T., Lu, Z., Wang, H., Yuan, Z., & Wei, C. (2023) · Animals · doi:10.3390/ani13182944 · Cited by 30
Genetic advancements and future directions in ruminant livestock breeding: from reference genomes to multiomics innovations
Xu, S., Akhatayeva, Z., Liu, J., Feng, X., Yu, Y., Badaoui, B., Esmailizadeh, A., Kantanen, J., Amills, M., Lenstra, J. A., et al. (2024) · Science China Life Sciences · doi:10.1007/s11427-024-2744-4 · Cited by 32
Single-cell sequencing reveals the reproductive variations between primiparous and multiparous Hu ewes
Ge, T., Wen, Y., Li, B., Huang, X., Jiang, S., & Zhang, E. (2023) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-023-00941-1 · Cited by 26
Whole Genome Resequencing Reveals Selection Signals Related to Wool Color in Sheep
Zhang, W., Jin, M., Lu, Z., Li, T., Wang, H., Yuan, Z., & Wei, C. (2023) · Animals · doi:10.3390/ani13203265 · Cited by 24
Genomic Landscape of Copy Number Variations and Their Associations with Climatic Variables in the World’s Sheep
Salehian-Dehkordi, H., Huang, J.-H., Pirany, N., Mehrban, H., Lv, X., Sun, W., Esmailizadeh, A., & Lv, F. (2023) · Genes · doi:10.3390/genes14061256 · Cited by 20
Genetic insights into fiber quality, coat color and adaptation in Changthangi and Muzzafarnagri sheep: A comparative skin transcriptome analysis
Vasu, M., Ahlawat, S., Chhabra, P., Sharma, U., Arora, R., Sharma, R., Mir, M. A., & Singh, M. K. (2023) · Gene · doi:10.1016/j.gene.2023.147826 · Cited by 16
High-density SNP markers elucidate the genetic divergence and population structure of Noticiana sheep breed in the Mediterranean context
Chessari, G., Criscione, A., Tolone, M., Bordonaro, S., Rizzuto, I., Riggio, S., Macaluso, V., Moscarelli, A., Portolano, B., Sardina, M. T., et al. (2023) · Frontiers in Veterinary Science · doi:10.3389/fvets.2023.1127354 · Cited by 13
Transcriptomic and Metabolomic Analyses Reveal Molecular Regulatory Networks for Pigmentation Deposition in Sheep
Zhang, M., Xu, X., Chen, Y., Wei, C., Zhan, S., Cao, J., Guo, J., Dai, D., Wang, L., Zhong, T., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158248 · Cited by 13
Self-citation
Selection signatures of wool color in Gangba sheep revealed by genome-wide SNP discovery
Zhang, W., Luosang, C., Yuan, C., Guo, T., Wei, C., Liu, J., & Lu, Z. (2024) · BMC Genomics · doi:10.1186/s12864-024-10464-2 · Cited by 15
Ovine HOXB13: expanding the gene repertoire of sheep tail patterning and implications in genetic improvement
Kalds, P., Huang, S., Chen, Y., & Wang, X. (2022) · Communications Biology · doi:10.1038/s42003-022-04199-7 · Cited by 12
Self-citation
Genomic analyses of Asiatic Mouflon in Iran provide insights into the domestication and evolution of sheep
Wang, D.-F., Orozco‐terWengel, P., Salehian-Dehkordi, H., Esmailizadeh, A., & Lv, F. (2025) · Genetics Selection Evolution · doi:10.1186/s12711-025-00978-y · Cited by 10
Understanding key genetic make-up of different coat colour in Bayinbuluke sheep through a comparative transcriptome profiling analysis
Zhang, L., Liang, L., Zhang, X., Li, W. R., Li, H., & He, S. (2023) · Small Ruminant Research · doi:10.1016/j.smallrumres.2023.107028 · Cited by 10
DNA MARKERS AND MICROSATELLITE CODE (review)
Глазко, В. И. (2023) · Sel skokhozyaistvennaya Biologiya · doi:10.15389/agrobiology.2023.2.223eng · Cited by 9
Analysing the genetic diversity of three sheep breeds in Turkey and nearby countries using 50 K SNPs data
Bayraktar, M. (2024) · Animal Biotechnology · doi:10.1080/10495398.2024.2329106 · Cited by 9
Impacts of Population Size and Domestication Process on Genetic Diversity and Genetic Load in Genus Ovis
Wang, D., Salehian-Dehkordi, H., Suo, L.-D., & Lv, F. (2023) · Genes · doi:10.3390/genes14101977 · Cited by 6
A comprehensive genome-wide analysis for signatures of selection in goat (genus Capra) revealed new candidate genes for environmental adaptation and productive traits
Pallotti, S., Garcia, A. F. R., Deiana, G., Antonini, M., Zhou, J., Sun, H., Renieri, C., & Napolioni, V. (2025) · BMC Genomics · doi:10.1186/s12864-025-12133-4 · Cited by 6
Detection of homozygosity and heterozygosity regions in mediterranean sheep breeds revealed by high-density SNP array
Carta, F., Chessari, G., Sardina, M. T., Riggio, S., Senczuk, G., Cesarani, A., Criscione, A., & Mastrangelo, S. (2026) · Journal of Animal Science · doi:10.1093/jas/skag014 · Cited by 6
Sheep litter size heredity basis using genome‐wide selective analysis
Cui, W., Wang, H., Li, J., Lv, D., Xu, J., Liu, M. C., & Yin, G. (2024) · Reproduction in Domestic Animals · doi:10.1111/rda.14689 · Cited by 6
Coat colour in marsupials: genetic variants at the ASIP locus determine grey and black fur of the brushtail possum
Bond, D. M., Veale, A. J., Alexander, A. M., & Hore, T. A. (2024) · Royal Society Open Science · doi:10.1098/rsos.240806 · Cited by 6
Population structure and selective signature of Kirghiz sheep by Illumina Ovine SNP50 BeadChip
Yang, R., Han, Z., Zhou, W., Li, X., Zhang, X., Zhu, L., Wang, J., Li, X., Zhang, C.-L., Han, Y., et al. (2024) · PeerJ · doi:10.7717/peerj.17980 · Cited by 6
Comparative evolutionary and structural analyses of the TYRP1 gene reveal molecular mechanisms of biological functions in mammals
Ali, H., Mahmood, M., Adnan, M., Afzal, G., Perveen, S., Akhtar, R. W., Jabeen, R., Asif, A. R., Faryal, S., Rahman, A., et al. (2023) · Journal of King Saud University - Science · doi:10.1016/j.jksus.2023.102772 · Cited by 6
A multi-tissue atlas of genetic regulatory effects in sheepPreprint
Gong, M., Zhuang, Z., Sun, X., Xu, Y., Zhang, H.-H., Wang, Y., Guan, D., Li, R., Lu, X., Bai, Z., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.03.686346 · Cited by 9
Self-citation
A review on omics approaches, towards understanding environmental resilience of indigenous Nguni sheep: Implications for their conservation and breeding programs in South Africa
Nxumalo, N., Rhode, C., Kunene, N. W., & Molotsi, A. (2024) · Ecological Genetics and Genomics · doi:10.1016/j.egg.2024.100305 · Cited by 5
ДНК МАРКЕРЫ И «МИКРОСАТЕЛЛИТНЫЙ КОД» (обзор)
Афанасьева, Ф. Н. П. З. И. К. И. В. А., & ГЛАЗКО, В. И. (2023) · Sel skokhozyaistvennaya Biologiya · doi:10.15389/agrobiology.2023.2.223rus · Cited by 5
New Insights into Polymorphisms in Candidate Genes Associated with Incidence of Postparturient Endometritis in Ossimi Sheep (Ovis aries)
Safhi, F. A., & Ateya, A. I. (2023) · Agriculture · doi:10.3390/agriculture13122273 · Cited by 5
Assessing the performance of Moghani crossbred lambs derived from different mating systems with Texel and Booroola sheep
Talebi, R., Mardi, M., Zeinalabedini, M., Kazemi, M., Fabre, S., & Ghaffari, M. R. (2024) · PLoS ONE · doi:10.1371/journal.pone.0301629 · Cited by 5
Unravelling the signatures of selection for climate adaptation in worldwide sheep breeds
Saravanan, K. A., Tiwari, J., Khan, K. D., Sahana, V. N., Yadav, A. K., Alex, R., Gowane, G. R., Misra, S. S., & Kumar, A. (2026) · Small Ruminant Research · doi:10.1016/j.smallrumres.2026.107701 · Cited by 7
The identification of a novel SNP in the resistin (RETN) gene associated with growth traits in Karakul and Awassi sheep
Aljubouri, T. R. S., & Al‐Shuhaib, M. B. S. (2023) · Tropical Animal Health and Production · doi:10.1007/s11250-023-03595-3 · Cited by 5
Study on the expression patterns of inner root sheath-specific genes in Tan sheep hair follicle during different developmental stages
Shi, A., Lv, J., Ma, Q., Liu, Z., Ma, L., Zhou, J., & Tao, J. (2024) · Gene · doi:10.1016/j.gene.2024.148751 · Cited by 5
Chromosomal-level reference genome assembly of muskox (Ovibos moschatus) from Banks Island in the Canadian Arctic, a resource for conservation genomics
Lok, S., Lau, T. N. H., Trost, B., Tong, A. H. Y., Paton, T., Wintle, R. F., Engstrom, M. D., Gunn, A., & Scherer, S. W. (2024) · Scientific Reports · doi:10.1038/s41598-024-67270-9 · Cited by 4
Isabelline coloration: a heretofore unrecognized chromatic aberration in bighorn sheep
Bleich, V. C. (2024) · California Fish and Wildlife Journal · doi:10.51492/cfwj.110.8 · Cited by 4
Colour phenotypes, genotypes and colorimetry of unprocessed North American Huacaya alpaca fibre, and comparisons with some other common natural fibres
Baxter, B. P., Edens, L., & Wear, J. L. (2025) · Small Ruminant Research · doi:10.1016/j.smallrumres.2025.107558 · Cited by 3
Analysis of Population Structure and Selection Signatures in Two Iraqi Fat‐Tailed Sheep Breeds
Bayraktar, M., Shoshin, O., Saravanan, K. A., AL-Thuwaini, T. M., Gökçe, G., Fadhil, Z. H., & Güney, M. Ç. (2025) · Veterinary Medicine and Science · doi:10.1002/vms3.70584 · Cited by 3
Genetics underlying phenotypic diversity in South African sheep breeds
Visser, C., Retief, A. E., & Molotsi, A. (2025) · Small Ruminant Research · doi:10.1016/j.smallrumres.2025.107499 · Cited by 3
Whole-Genome Resequencing Identifies Candidate Genes for Tail Fat Deposition in Sheep
Zhang, X., Li, Y., Zhao, Y., Guo, P., Cai, Y., Xu, H., Cao, X., Li, Q., Ma, X., Zhang, D., et al. (2025) · Animals · doi:10.3390/ani15203046 · Cited by 2
Deciphering the Regulatory Network of Tail Fat Deposition in Large- and Small-Tailed Han Sheep Through Transcriptome and MicroRNAome Profiling
Wang, G., Tian, L., Zhang, S. H., He, Z., Zhao, F., Chang, M., Han, W., Ye, D., Gao, J., Li, S., et al. (2026) · Biology · doi:10.3390/biology15020179 · Cited by 3
Melanophilin Polymorphism in Ferrets of Different Color
Kosovsky, G. Y., Глазко, В. И., Abramov, O. I., & Glazko, T. T. (2023) · Doklady Biochemistry and Biophysics · doi:10.1134/s1607672923700655 · Cited by 2
Tissue-specific and functional loci analysis of CASP14 gene in the sheep horn
Lu, X., Zhang, G., Yang, H., Shan, M., Zhang, X., Wang, Y., Bai, J., & Pan, Z. (2024) · PLoS ONE · doi:10.1371/journal.pone.0310464 · Cited by 4
A review of thoracolumbar vertebrae number variation in sheep breeding
Yıldırır, M., Malmakov, N., Mussayeva, A., Оразымбетова, З., Бахтыбеккызы, Ш., Öner, Y., Bekitayeva, А. K., Omashev, K. B., & Арынгазиев, Б. (2024) · Small Ruminant Research · doi:10.1016/j.smallrumres.2024.107405 · Cited by 2
A 3‐bp deletion in the SLC45A2 gene is associated with loss of fleece pigmentation in black‐fleeced Suffolk sheep
Tearle, R. G., Chen, T., & Brien, F. D. (2024) · Animal Genetics · doi:10.1111/age.13495 · Cited by 2
Revised phylogeny of mouflon based on expanded sampling of mitogenomes
Mereu, P., Pirastru, M., Miranda, P. M., Atağ, G., Vural, K. B., Wilkens, B., Soares, A. E. R., Kaptan, D., Zedda, M., Columbano, N., et al. (2025) · PLoS ONE · doi:10.1371/journal.pone.0323354 · Cited by 2
A single-cell atlas of the single versus multiple parous Hu Sheep ovaryPreprint
Ge, T., Wen, Y., Li, B., Huang, X., Jiang, S., & Zhang, E. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.22.541677 · Cited by 2
Genetic polymorphism of follicle stimulating hormone beta (FSHβ) gene and its association with body weight, scrotal measurements and seminal quality traits in indigenous goats
Khan, A., Thakur, M. S., Joshi, S., Shukla, S. N., Khare, A., Khare, V., Vandre, R. K., & Sharma, M. (2024) · Indian Journal of Experimental Biology · doi:10.56042/ijeb.v62i05.4242 · Cited by 1
Genetic influence on behavior and welfare of sheep
Dwyer, C. M. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-22201-6.00007-4 · Cited by 1
Genetic lineage analysis of black goat subpopulations in southern areas of China: Correlation of SNPs and methylation sites in their differentially expressed genes
Wu, H., Qin, B., Yang, G., Shao, Q., Zhu, J., Zhou, Y., Gao, Y., Zhang, L., Wang, B., Ji, P., et al. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.147064 · Cited by 1
Self-citation
Mouflon and Domestic Sheep Phylogeny: Ancestry, Domestication, and Evolutionary Dynamics
Mereu, P., Pirastru, M., Scarpa, F., Zedda, M., Bogliolo, L., Naitana, S., & Leoni, G. G. (2025) · Life · doi:10.3390/life15091446 · Cited by 1
Genomic scan of selective sweeps in an alpaca population subjected to directional selection for fibre quality traits
Arias, K. D., More, M. J., Goyache, F., Cruz, A., Burgos, A., Gutiérrez, G., Cervantes, I., & Gutiérrez, J. P. (2025) · animal · doi:10.1016/j.animal.2025.101674 · Cited by 1
Expression profiling, functional characterization, and potential functional variants of the COL7A1 gene in sheep horn development
Zhang, S., Li, H., Meng, Z., Liu, F., Hu, Y., Yang, H., Mei, Q., You, X., Wang, Q., Pan, Z., et al. (2025) · Genomics · doi:10.1016/j.ygeno.2025.111133 · Cited by 1
Comparative histomorphometric and transcriptomic analysis reveals potential genetic determinants of pelage variation between hairy and coarse-woolly sheep
Liang, Q., De-jun, J., Wang, X., Xu, P., Zhang, J., Ge, C., Zheng, Y., Gao, T., Shi, Y., Xu, Z., et al. (2025) · BMC Genomics · doi:10.1186/s12864-025-12260-y · Cited by 1
Self-citation
Transcriptome Analysis of Adipose Tissues from Five Sheep Breeds Reveals Key Genes Involved in Fat Deposition
Yu, Y., Liu, S., Yang, J., & Xu, S. (2026) · Genes · doi:10.3390/genes17010093 · Cited by 1
3D Geometric Morphometric Analysis on Sexual Dimorphism in the Sella Turcica in Romanov Sheep Using CT Scan
Kılıçlı, İ. B., Mavili, E. D., Aksoy, E., Yunus, H. A., Ünal, İ., Batur, B., Melnyk, O. O., & Bakıcı, C. (2026) · Veterinary Medicine and Science · doi:10.1002/vms3.70915 · Cited by 1
Transcriptome Analysis Reveals a Follicular Microenvironment Melanogenesis Axis in Black-to-White Coat-Color Transition of Junken Meat Sheep
Xi, B., Zhao, S., Qian, Y., Zhou, H., Zhang, W., Chen, Y., Cheng, R., Wang, Z., Yang, H., & Liu, J. (2026) · Biology · doi:10.3390/biology15131042 · Cited by 1
Self-citation
Geographical distribution and phenotypic characterization of Malin sheep in three selected states of Peninsular Malaysia
Mahdzar, S. N., Bakar, M. A. A., Zulkifli, N. A., Noor, M. M., Rahman, M. H. A., Mohd‐Assaad, N., & Razak, S. A. (2023) · Journal of Animal Science and Technology · doi:10.5187/jast.2023.e80 · Cited by 1
Tissue-specific and functional loci analysis of CASP14 gene in the sheep hornPreprint
Lu, X., Zhang, G., Yang, H., Shan, M., Zhang, X., Wang, Y., Bai, J., & Pan, Z. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.03.611085 · Cited by 1
Ten years afeter Beijing: what more do caribbean women want...?
Massiah, J. (2006) · Journal of Eastern Caribbean studies
Assessment of morphological features of skin and hair cover of Karakul lambs (South of Kazakhstan)
Lakhanova, K., Kedelbaev, B., Kydyrbaeva, A. E., Korazbekova, K., & Rustenov, A. (2023) · Tropical Animal Health and Production · doi:10.1007/s11250-023-03836-5
Morphological Characterization of Kage and Baruwal Sheep (Ovis aries Linnaeus, 1758) Breeds in Nepal
Adhikari, S., & Kadariya, I. P. (2024) · AgroEnvironmental Sustainability · doi:10.59983/s2024020103
Application of CRISPR–Cas Technology in Drug Development
Altaf, S., Saleem, F., Ikram, H. M., Iftikhar, A., & Anwar, H. (2024) · Springer eBooks · doi:10.1007/978-981-97-0814-7_8
Melanophilin polymorphism in ferrets of different colors
Kosovsky, G. Y., Глазко, В. И., Abramov, O. I., & Glazko, T. T. (2024) · Доклады Российской академии наук Науки о жизни · doi:10.31857/s2686738924010197
Genome-wide association study for polledness, horn shape, and wool traits in Original Valachian sheep
Mészárosová, M., Mészáros, G., Moravčíková, N., Pavlík, I., Margetín, M., & Kasarda, R. (2024) · Archives animal breeding/Archiv für Tierzucht · doi:10.5194/aab-67-373-2024
РЕЗУЛЬТАТЫ ИСПОЛЬЗОВАНИЯ В ВОСПРОИЗВОДСТВЕ СТАДА БАРАНОВ-ПРОИЗВОДИТЕЛЕЙ С ДЛИННЫМ ТУЛОВИЩЕМ, В ПОЗВОНОЧНИКЕ КОТОРЫХ ЕСТЬ ДОПОЛНИТЕЛЬНЫЕ ПОЗВОНКИ
Malmakov, N., Мусаева, А., Omashev, K. B., Арынгазиев, Б., Оразымбетова, З., Бахтыбеккызы, Ш., & Sagdat, Y. (2025) · Izdenister natigeler · doi:10.37884/4-2024/05
The Relationship of Genetic Polymorphisms in the Fifth Exon of the Prolactin Gene with Productive and Growth Traits in Iraqi Awassi Sheep
Dakheel, M. H., Al-Sarai, T. M., & Al-Soudani, H. M. (2025) · IOP Conference Series Earth and Environmental Science · doi:10.1088/1755-1315/1487/1/012157
Genomic Analysis of Hair Sheep From West/Central Africa Reveals Unique Genetic Diversity and Ancestral Links to Breed Formation in the Caribbean
Wiener, P., Friedrich, J., Marr, M. M., Simo, G., Tanya, V. N., Ballingall, K. T., Flegontov, P., Rosen, B. D., Sallé, G., Spangler, G., et al. (2025) · Molecular Ecology · doi:10.1111/mec.17796
Heterogeneity of Variances in Milk Yield in Murrah Buffaloes
Júnior, R. N. C. C., de Araújo, C. V., Marques, J. R. F., Gomes, M. D. N. B., da Silva, W. C., Belo, T. S., Sousa, C. E. L., da Silva, É. B. R., Marques, L. C., Silva, M. M. D., et al. (2025) · Animals · doi:10.3390/ani15182686
Functional genes for wool traits and coat colors
Li, M.-H., & Salehian-Dehkordi, H. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-43994-0.00016-2
Functional genes regulating appendage development
Li, M.-H., & Salehian-Dehkordi, H. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-43994-0.00017-4
Microsatellite-based genetic diversity assessment of Donggala cattle (Bos indicus) in Indonesia: Insights for conservation and breeding
Duma, Y., Agung, P. P., Tanari, M., Malewa, A. D., Mumu, M. I., Said, S., Saputra, F., Kaiin, E. M., Gunawan, M., Maulana, T., et al. (2025) · Veterinary World · doi:10.14202/vetworld.2025.2981-2990
RXFP2 gene variation drives horn sexual differences and polledness in sheep
Hu, X., Han, B., Liu, D., Li, X., Chen, C., Xu, T., Bao, G., Su, W., Li, G., Li, R., et al. (2026) · Genomics · doi:10.1016/j.ygeno.2026.111249
Transposable Elements Regulate Tail Development and Fat Deposition in Sheep Fetuses
Liang, Q., Yang, H., Dong, H., Andersson, G., Bongcam‐Rudloff, E., Wan, P., Kulatayev, B. T., Rouzi, M., Min, Y., & Han, J. (2025) · Animals · doi:10.3390/ani15243654
Exploring climate adaptation in European Merino sheep: a landscape genomics approach
Civita, M. D., Wiener, P., Marr, M., Persichilli, C., Senczuk, G., Pilla, F., Clark, E. L., & Friedrich, J. (2025) · animal · doi:10.1016/j.animal.2025.101728
Additional file 1 of Heritability and recursive influence of host genetics on the rumen microbiota drive body weight variance in male Hu sheep lambs
Wang, W., Zhang, Y., Zhang, X., Li, C., Yuan, L., Zhang, D., Zhao, Y., Li, X., Cheng, J., Lin, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26613464
Additional file 2 of Single-cell sequencing reveals the reproductive variations between primiparous and multiparous Hu ewes
Ge, T., Wen, Y., Li, B., Huang, X., Jiang, S., & Zhang, E. (2024) · Figshare · doi:10.6084/m9.figshare.26639695
Additional file 1 of Single-cell sequencing reveals the reproductive variations between primiparous and multiparous Hu ewes
Ge, T., Wen, Y., Li, B., Huang, X., Jiang, S., & Zhang, E. (2024) · Figshare · doi:10.6084/m9.figshare.26639692
Sheep domestication and major post-domestication breeding
Li, M., & Dehkordi, H. S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-43994-0.00022-8
Domestic sheep (Ovis aries)
Li, M., & Dehkordi, H. S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-43994-0.00013-7
Environmentally independent histological markers of wool quality: a comparative study of Gentile di Puglia and Sarda breeds
Topputi, R., Molina, G., Ventriglia, G., Quiroz-Valiente, J., Guillermo, M. Á. R., Bruno, S., Ciani, E., Guerra, L., Cesarani, A., Landi, V., et al. (2026) · Frontiers in Animal Science · doi:10.3389/fanim.2025.1670137
Measures of size and shape in West African Dwarf and Red Sokoto goats
Isaac, U. C., & Ojukwu, C. M. (2026) · Discover Animals · doi:10.1007/s44338-026-00165-3
Origem e Domesticação dos Ovinos
de Carvalho, F. C., Júnior, G. A. F., Lima, F. R. G., & Silva, K. D. M. (2026) · Even3 Publicações eBooks · doi:10.29327/5786743
First breed-pool whole genome sequencing of egyptian sheep: a comprehensive genomic atlas revealing diversity and candidate genes for production and adaptation
Hassanine, N. N. A. M., Amin, A. H., Hafez, E. S. E., Ahmed, M. M. M., Ismail, A. H., Mohamed, A. Z., Halim, H. A. E., El-Sayed, G. M., Adss, I. A., Radwan, K. H., et al. (2026) · BMC Biotechnology · doi:10.1186/s12896-026-01199-x
Large-scale low-coverage whole-genome sequencing reveals the genetic architecture of wool and growth traits in fine-wool sheep
Shi, J., Lin, C., Wei, P., Huang, J., Tulafu, H., Yan, N., Wang, S. K., Pan, Z., & Wu, W. (2026) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2026.07.006
Comparative Transcriptomic Profiling Identifies Region- and Phenotypic-Background-Associated Transcriptional Programs Linked to Coat-Color Variation in Junken Meat Sheep
Xi, B., Zhao, S., Qian, Y., Zhang, W., Chen, Y., Wang, Z., Yang, H., & Liu, J. (2026) · Biology · doi:10.3390/biology15171457
Self-citation
Facial classification of five Huacaya alpaca biotypes using deep learningPreprint
Ticona, J., Quenaya, A., Mamani-Pari, D., & Maquera, G. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.7441892
Whole-genome resequencing of the Kazakh coarse-wool fat-tailed sheep identifies functional variants in disease-associated genes
Бакытбекович, С. Д., Orkara, S., Pokharel, K., Sandybayev, N. T., Khamzina, S., Ibragimov, P., & Хамзина, А. (2026) · Frontiers in Veterinary Science · doi:10.3389/fvets.2026.1936482

Authors: Kalds, P., Zhou, S., Gao, Y., Cai, B., Huang, S., Chen, Y., & Wang, X.
Affiliations: Arish University (EG)
Northwest A&F University (CN)
Ministry of Agriculture and Rural Affairs (CN)
Corresponding author: Chen, Yulin
Wang, Xiaolong
ORCID: Kalds, Peter
Zhou, Shiwei
Gao, Yawei
Huang, Shuhong
Chen, Yulin
Wang, Xiaolong
Venue: Genetics Selection Evolution
Publisher: Springer Science and Business Media LLC
Published: 2022-09-09
Volume: 54
Issue: 1
Pages: 61-61
ISSN: 0999-193X (ISSN-L)
1297-9686
DOI: 10.1186/s12711-022-00753-3
PMC: PMC9463822
OpenAlex: W4295031434
Cited by: 85
References: 362
Citations by year: 2026: 15 · 2025: 25 · 2024: 24 · 2023: 19 · 2022: 1
FWCI: 2.73
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (tdm)
creativecommons.org/licenses/by/4.0 (vor)
Locations: Genetics Selection Evolution (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
HAL (submittedVersion, other-oa)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Key Technologies Research and Development Program (2018YFD0502100)
China Agriculture Research System (CARS-39-12)
Local Grants (NXTS2018-001, 2018KJXX-009)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Animal Genetics and Reproduction
Keywords: sheep, phenotypic variability, sheep breeds, coat color, wool traits, udder traits, ear traits, sheep genome, sheep breeding, domestication
MeSH terms: Domestication, Animals, Humans, Mammary Glands, Animal, Nucleotides, Phenotype, Sheep, Wool, Genomics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Genetics of the phenotypic evolution in sheep: a molecular look at diversity-driving genes

Abstract

Overview

Integrity signals

Figures

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks